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P19974

- CYC21_CAEEL

UniProt

P19974 - CYC21_CAEEL

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Protein

Cytochrome c 2.1

Gene

cyc-2.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Heme (covalent)1 PublicationPROSITE-ProRule annotation
Binding sitei23 – 231Heme (covalent)1 PublicationPROSITE-ProRule annotation
Metal bindingi24 – 241Iron (heme axial ligand)
Metal bindingi85 – 851Iron (heme axial ligand)

GO - Molecular functioni

  1. electron carrier activity Source: UniProtKB
  2. heme binding Source: UniProtKB
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. electron transport chain Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c 2.1
Gene namesi
Name:cyc-2.1
ORF Names:E04A4.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiE04A4.7; CE16968; WBGene00017121; cyc-2.1.

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 111110Cytochrome c 2.1PRO_0000108271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Post-translational modificationi

Binds 1 heme group per subunit.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19974.

Interactioni

Protein-protein interaction databases

BioGridi42372. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP19974.
SMRiP19974. Positions 7-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiCOG3474.
InParanoidiP19974.
KOiK08738.
PhylomeDBiP19974.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19974-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDIPAGDYE KGKKVYKQRC LQCHVVDSTA TKTGPTLHGV IGRTSGTVSG
60 70 80 90 100
FDYSAANKNK GVVWTKETLF EYLLNPKKYI PGTKMVFAGL KKADERADLI
110
KYIEVESAKS L
Length:111
Mass (Da):12,233
Last modified:January 23, 2007 - v2
Checksum:iD4161D25AC5EBEDB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661K → R in CCD68708. (PubMed:9851916)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081039 Genomic DNA. Translation: CCD68708.1.
PIRiT32611.
RefSeqiNP_500629.1. NM_068228.5.
UniGeneiCel.23397.

Genome annotation databases

GeneIDi177243.
KEGGicel:CELE_E04A4.7.

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081039 Genomic DNA. Translation: CCD68708.1 .
PIRi T32611.
RefSeqi NP_500629.1. NM_068228.5.
UniGenei Cel.23397.

3D structure databases

ProteinModelPortali P19974.
SMRi P19974. Positions 7-104.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 42372. 3 interactions.

Proteomic databases

PaxDbi P19974.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 177243.
KEGGi cel:CELE_E04A4.7.

Organism-specific databases

CTDi 177243.
WormBasei E04A4.7 ; CE16968 ; WBGene00017121 ; cyc-2.1.

Phylogenomic databases

eggNOGi COG3474.
InParanoidi P19974.
KOi K08738.
PhylomeDBi P19974.

Miscellaneous databases

NextBioi 895954.
PROi P19974.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The primary structure of cytochrome c from the nematode Caenorhabditis elegans."
    Vanfleteren J.R., Evers E.A.I.M., van de Werken G., van Beeumen J.J.
    Biochem. J. 271:613-620(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-111, ACETYLATION AT SER-2.
    Strain: Bristol N2.

Entry informationi

Entry nameiCYC21_CAEEL
AccessioniPrimary (citable) accession number: P19974
Secondary accession number(s): O44479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3