P19974 (CYC21_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c 2.1

Gene names

Name:	cyc-2.1
ORF Names:	E04A4.7

Organism

Caenorhabditis elegans [Reference proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Subcellular location	Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.
Post-translational modification	Binds 1 heme group per subunit.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from direct assay Ref.2. Source: UniProtKB
Cellular_component	mitochondrial intermembrane space Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred by curator Ref.2. Source: UniProtKB
Molecular_function	electron carrier activity Inferred from direct assay Ref.2. Source: UniProtKB heme binding Inferred by curator Ref.2. Source: UniProtKB iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 111	110	Cytochrome c 2.1		PRO_0000108271
Sites
	Metal binding	24	1	Iron (heme axial ligand)
	Metal binding	85	1	Iron (heme axial ligand)
	Binding site	20	1	Heme (covalent) Ref.2
	Binding site	23	1	Heme (covalent) Ref.2
Amino acid modifications
	Modified residue	2	1	N-acetylserine Ref.2
Experimental info
	Sequence conflict	66	1	K → R in CCD68708. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P19974 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: D4161D25AC5EBEDB	FASTA	111	12,233
	10 20 30 40 50 60 MSDIPAGDYE KGKKVYKQRC LQCHVVDSTA TKTGPTLHGV IGRTSGTVSG FDYSAANKNK 70 80 90 100 110 GVVWTKETLF EYLLNPKKYI PGTKMVFAGL KKADERADLI KYIEVESAKS L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"The primary structure of cytochrome c from the nematode Caenorhabditis elegans." Vanfleteren J.R., Evers E.A.I.M., van de Werken G., van Beeumen J.J. Biochem. J. 271:613-620(1990) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-111, ACETYLATION AT SER-2. Strain: Bristol N2.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBL GenBank DDBJ	FO081039 Genomic DNA. Translation: CCD68708.1.
PIR	T32611.
RefSeq	NP_500629.1. NM_068228.5.
3D structure databases
ProteinModelPortal	P19974.
SMR	P19974. Positions 7-104.
ModBase	Search...
Proteomic databases
PaxDb	P19974.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	177243.
KEGG	cel:CELE_E04A4.7.
Organism-specific databases
CTD	177243.
WormBase	E04A4.7; CE16968; WBGene00017121; cyc-2.1.
Phylogenomic databases
eggNOG	COG3474.
InParanoid	P19974.
KO	K08738.
Family and domain databases
InterPro	IPR002327. Cyt_c_1A/1B. IPR009056. Cyt_c_dom. IPR003088. Cyt_c_I. [Graphical view]
PANTHER	PTHR11961. PTHR11961. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
SUPFAM	SSF46626. Cytochrome_c. 1 hit.
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	895954.

Entry information

Entry name

CYC21_CAEEL

Accession

Primary (citable) accession number: P19974
Secondary accession number(s): O44479

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project