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P19974 (CYC21_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c 2.1
Gene names
Name:cyc-2.1
ORF Names:E04A4.7
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length111 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Subcellular location

Mitochondrion intermembrane space. Note: Loosely associated with the inner membrane.

Post-translational modification

Binds 1 heme group per subunit.

Sequence similarities

Belongs to the cytochrome c family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 111110Cytochrome c 2.1
PRO_0000108271

Sites

Metal binding241Iron (heme axial ligand)
Metal binding851Iron (heme axial ligand)
Binding site201Heme (covalent) Ref.2
Binding site231Heme (covalent) Ref.2

Amino acid modifications

Modified residue21N-acetylserine Ref.2

Experimental info

Sequence conflict661K → R in CCD68708. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P19974 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: D4161D25AC5EBEDB

FASTA11112,233
        10         20         30         40         50         60 
MSDIPAGDYE KGKKVYKQRC LQCHVVDSTA TKTGPTLHGV IGRTSGTVSG FDYSAANKNK 

        70         80         90        100        110 
GVVWTKETLF EYLLNPKKYI PGTKMVFAGL KKADERADLI KYIEVESAKS L 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
[2]"The primary structure of cytochrome c from the nematode Caenorhabditis elegans."
Vanfleteren J.R., Evers E.A.I.M., van de Werken G., van Beeumen J.J.
Biochem. J. 271:613-620(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-111, ACETYLATION AT SER-2.
Strain: Bristol N2.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081039 Genomic DNA. Translation: CCD68708.1.
PIRT32611.
RefSeqNP_500629.1. NM_068228.5.
UniGeneCel.23397.

3D structure databases

ProteinModelPortalP19974.
SMRP19974. Positions 7-104.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid42372. 3 interactions.

Proteomic databases

PaxDbP19974.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID177243.
KEGGcel:CELE_E04A4.7.

Organism-specific databases

CTD177243.
WormBaseE04A4.7; CE16968; WBGene00017121; cyc-2.1.

Phylogenomic databases

eggNOGCOG3474.
InParanoidP19974.
KOK08738.
PhylomeDBP19974.

Family and domain databases

Gene3D1.10.760.10. 1 hit.
InterProIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERPTHR11961. PTHR11961. 1 hit.
PfamPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSPR00604. CYTCHRMECIAB.
SUPFAMSSF46626. SSF46626. 1 hit.
PROSITEPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio895954.
PROP19974.

Entry information

Entry nameCYC21_CAEEL
AccessionPrimary (citable) accession number: P19974
Secondary accession number(s): O44479
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase