Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P19974

- CYC21_CAEEL

UniProt

P19974 - CYC21_CAEEL

Protein

Cytochrome c 2.1

Gene

cyc-2.1

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201Heme (covalent)1 PublicationPROSITE-ProRule annotation
    Binding sitei23 – 231Heme (covalent)1 PublicationPROSITE-ProRule annotation
    Metal bindingi24 – 241Iron (heme axial ligand)
    Metal bindingi85 – 851Iron (heme axial ligand)

    GO - Molecular functioni

    1. electron carrier activity Source: UniProtKB
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. electron transport chain Source: UniProtKB

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c 2.1
    Gene namesi
    Name:cyc-2.1
    ORF Names:E04A4.7
    OrganismiCaenorhabditis elegans
    Taxonomic identifieri6239 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000001940: Chromosome IV

    Organism-specific databases

    WormBaseiE04A4.7; CE16968; WBGene00017121; cyc-2.1.

    Subcellular locationi

    Mitochondrion intermembrane space
    Note: Loosely associated with the inner membrane.

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell
    2. respiratory chain Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 111110Cytochrome c 2.1PRO_0000108271Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Post-translational modificationi

    Binds 1 heme group per subunit.

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP19974.

    Interactioni

    Protein-protein interaction databases

    BioGridi42372. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP19974.
    SMRiP19974. Positions 7-104.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    InParanoidiP19974.
    KOiK08738.
    PhylomeDBiP19974.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19974-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDIPAGDYE KGKKVYKQRC LQCHVVDSTA TKTGPTLHGV IGRTSGTVSG    50
    FDYSAANKNK GVVWTKETLF EYLLNPKKYI PGTKMVFAGL KKADERADLI 100
    KYIEVESAKS L 111
    Length:111
    Mass (Da):12,233
    Last modified:January 23, 2007 - v2
    Checksum:iD4161D25AC5EBEDB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661K → R in CCD68708. (PubMed:9851916)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081039 Genomic DNA. Translation: CCD68708.1.
    PIRiT32611.
    RefSeqiNP_500629.1. NM_068228.5.
    UniGeneiCel.23397.

    Genome annotation databases

    GeneIDi177243.
    KEGGicel:CELE_E04A4.7.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FO081039 Genomic DNA. Translation: CCD68708.1 .
    PIRi T32611.
    RefSeqi NP_500629.1. NM_068228.5.
    UniGenei Cel.23397.

    3D structure databases

    ProteinModelPortali P19974.
    SMRi P19974. Positions 7-104.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 42372. 3 interactions.

    Proteomic databases

    PaxDbi P19974.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 177243.
    KEGGi cel:CELE_E04A4.7.

    Organism-specific databases

    CTDi 177243.
    WormBasei E04A4.7 ; CE16968 ; WBGene00017121 ; cyc-2.1.

    Phylogenomic databases

    eggNOGi COG3474.
    InParanoidi P19974.
    KOi K08738.
    PhylomeDBi P19974.

    Miscellaneous databases

    NextBioi 895954.
    PROi P19974.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
      The C. elegans sequencing consortium
      Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Bristol N2.
    2. "The primary structure of cytochrome c from the nematode Caenorhabditis elegans."
      Vanfleteren J.R., Evers E.A.I.M., van de Werken G., van Beeumen J.J.
      Biochem. J. 271:613-620(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-111, ACETYLATION AT SER-2.
      Strain: Bristol N2.

    Entry informationi

    Entry nameiCYC21_CAEEL
    AccessioniPrimary (citable) accession number: P19974
    Secondary accession number(s): O44479
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Caenorhabditis elegans
      Caenorhabditis elegans: entries, gene names and cross-references to WormBase
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3