Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lymphocyte-specific protein 1

Gene

Lsp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in mediating neutrophil activation and chemotaxis.1 Publication

GO - Molecular functioni

  • actin binding Source: MGI
  • signal transducer activity Source: InterPro

GO - Biological processi

  • apoptotic process Source: MGI
  • chemotaxis Source: MGI
  • cytoskeleton organization Source: MGI
  • defense response Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte-specific protein 1
Alternative name(s):
52 kDa phosphoprotein
Short name:
pp52
Lymphocyte-specific antigen WP34
S37 protein
Gene namesi
Name:Lsp1
Synonyms:Pp52, S37, Wp34
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96832. Lsp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi195S → A: No effect on phosphorylation by PKC, PKA, MAPKAPK2 and CaMK2. 1 Publication1
Mutagenesisi243S → A: Complete loss of phosphorylation by MAPKAPK2, partial loss of phosphorylation by PKA, no effect on phosphorylation by PKC and CaMK2. 1 Publication1
Mutagenesisi243S → E: Complete loss of phosphorylation by MAPKAPK2, partial loss of phosphorylation by PKA, no effect on phosphorylation by PKC and CaMK2. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845041 – 330Lymphocyte-specific protein 1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphoserine; by CK2Sequence analysis1
Modified residuei78Phosphoserine; by CK2Sequence analysis1
Modified residuei166PhosphothreonineCombined sources1
Modified residuei168PhosphoserineCombined sources1
Modified residuei179PhosphoserineBy similarity1
Modified residuei180PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei243Phosphoserine; by MAPKAPK2Combined sources1 Publication1
Modified residuei318N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated by casein kinase II, protein kinase C and MAPKAPK2. Phosphorylation by PKC induces translocation from membrane to cytoplasm. Phosphorylation by MAPKAPK2 may regulate neutrophil chemotaxis.3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP19973.
MaxQBiP19973.
PaxDbiP19973.
PeptideAtlasiP19973.
PRIDEiP19973.

PTM databases

iPTMnetiP19973.
PhosphoSitePlusiP19973.

Expressioni

Tissue specificityi

Isoform 1 is expressed in normal mouse B and T-lymphocytes and in transformed B-cells but not (or in smaller amounts) in nine T-lymphoma lines tested. Isoform 2 is expressed in non-lymphoid cell lines (myocytes, stromal cells, fibroblasts).

Gene expression databases

BgeeiENSMUSG00000018819.
CleanExiMM_LSP1.
ExpressionAtlasiP19973. baseline and differential.
GenevisibleiP19973. MM.

Interactioni

GO - Molecular functioni

  • actin binding Source: MGI

Protein-protein interaction databases

BioGridi201211. 2 interactors.
IntActiP19973. 1 interactor.
STRINGi10090.ENSMUSP00000018963.

Structurei

3D structure databases

ProteinModelPortaliP19973.
SMRiP19973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000111324.
HOVERGENiHBG001610.
InParanoidiP19973.
KOiK14957.
OMAiRLTAQWS.
OrthoDBiEOG091G0I0H.
PhylomeDBiP19973.
TreeFamiTF336257.

Family and domain databases

InterProiIPR006018. Caldesmon_LSP.
IPR002211. Lymphspecific.
[Graphical view]
PANTHERiPTHR18949. PTHR18949. 1 hit.
PfamiPF02029. Caldesmon. 1 hit.
[Graphical view]
PRINTSiPR01083. LYMPHSPCIFIC.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19973-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAAIDPRC EEQEELHAED SEGLTTQWRE EDEEEAAREQ RQRERERQLQ
60 70 80 90 100
DQDKDKEDDG GHSLEQPGQQ TLISLKSSEL DEDEGFGDWS QKPEPRQQFW
110 120 130 140 150
GNEGTAEGTE PSQSERPEEK QTEESSHQAK VHLEESNLSY REPDPEDAVG
160 170 180 190 200
GSGEAEEHLI RHQVRTPSPL ALEDTVELSS PPLSPTTKLA DRTESLNRSI
210 220 230 240 250
KKSNSVKKSQ PTLPISTIDE RLQQYTQATE SSGRTPKLSR QPSIELPSMA
260 270 280 290 300
VASTKTLWET GEVQSQSASK TPSCQDIVAG DMSKKSLWEQ KGGSKISSTI
310 320 330
KSTPSGKRYK FVATGHGKYE KVLVDEGSAP
Length:330
Mass (Da):36,714
Last modified:February 1, 1996 - v2
Checksum:iCCC27150F02859FB
GO
Isoform 2 (identifier: P19973-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MAEAAIDPRCEEQEELHAEDSEG → MNGPALLRRNASKRGLEKLLR

Show »
Length:328
Mass (Da):36,548
Checksum:i43522E589AF1F6F0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125 – 127SSH → RQV in BAC27463 (PubMed:16141072).Curated3
Sequence conflicti155 – 156AE → PK (PubMed:3263441).Curated2
Sequence conflicti158 – 163Missing in AAH03796 (PubMed:15489334).Curated6
Sequence conflicti160I → T (PubMed:3263441).Curated1
Sequence conflicti168S → N (PubMed:3263441).Curated1
Sequence conflicti253S → G (PubMed:3263441).Curated1
Sequence conflicti283S → T (PubMed:7775393).Curated1
Sequence conflicti283S → T (PubMed:8537319).Curated1
Isoform 2 (identifier: P19973-2)
Sequence conflicti16L → Q in AAB37543 (PubMed:8838798).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0043131 – 23MAEAA…EDSEG → MNGPALLRRNASKRGLEKLL R in isoform 2. 4 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90316 mRNA. Translation: AAA65108.1.
S74179 mRNA. Translation: AAB32257.1.
M89956 mRNA. Translation: AAB48537.1.
D49691 mRNA. Translation: BAA08541.1.
AL603651 Genomic DNA. Translation: CAM23282.1.
AL603651 Genomic DNA. Translation: CAM23283.1.
BC003796 mRNA. Translation: AAH03796.1.
U30942, U30939, U30941 Genomic DNA. Translation: AAB37542.1.
U30942, U30940, U30941 Genomic DNA. Translation: AAB37543.1.
AK031587 mRNA. Translation: BAC27463.1.
CCDSiCCDS40193.1. [P19973-2]
CCDS52450.1. [P19973-1]
PIRiA30533.
A46521.
RefSeqiNP_001129543.1. NM_001136071.2. [P19973-1]
NP_001258437.1. NM_001271508.1.
NP_001258439.1. NM_001271510.1. [P19973-1]
NP_062264.1. NM_019391.3. [P19973-2]
UniGeneiMm.234003.

Genome annotation databases

EnsembliENSMUST00000018963; ENSMUSP00000018963; ENSMUSG00000018819. [P19973-1]
ENSMUST00000038946; ENSMUSP00000040637; ENSMUSG00000018819. [P19973-2]
ENSMUST00000105968; ENSMUSP00000101588; ENSMUSG00000018819. [P19973-1]
GeneIDi16985.
KEGGimmu:16985.
UCSCiuc009knb.3. mouse. [P19973-1]
uc009knf.2. mouse. [P19973-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90316 mRNA. Translation: AAA65108.1.
S74179 mRNA. Translation: AAB32257.1.
M89956 mRNA. Translation: AAB48537.1.
D49691 mRNA. Translation: BAA08541.1.
AL603651 Genomic DNA. Translation: CAM23282.1.
AL603651 Genomic DNA. Translation: CAM23283.1.
BC003796 mRNA. Translation: AAH03796.1.
U30942, U30939, U30941 Genomic DNA. Translation: AAB37542.1.
U30942, U30940, U30941 Genomic DNA. Translation: AAB37543.1.
AK031587 mRNA. Translation: BAC27463.1.
CCDSiCCDS40193.1. [P19973-2]
CCDS52450.1. [P19973-1]
PIRiA30533.
A46521.
RefSeqiNP_001129543.1. NM_001136071.2. [P19973-1]
NP_001258437.1. NM_001271508.1.
NP_001258439.1. NM_001271510.1. [P19973-1]
NP_062264.1. NM_019391.3. [P19973-2]
UniGeneiMm.234003.

3D structure databases

ProteinModelPortaliP19973.
SMRiP19973.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201211. 2 interactors.
IntActiP19973. 1 interactor.
STRINGi10090.ENSMUSP00000018963.

PTM databases

iPTMnetiP19973.
PhosphoSitePlusiP19973.

Proteomic databases

EPDiP19973.
MaxQBiP19973.
PaxDbiP19973.
PeptideAtlasiP19973.
PRIDEiP19973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018963; ENSMUSP00000018963; ENSMUSG00000018819. [P19973-1]
ENSMUST00000038946; ENSMUSP00000040637; ENSMUSG00000018819. [P19973-2]
ENSMUST00000105968; ENSMUSP00000101588; ENSMUSG00000018819. [P19973-1]
GeneIDi16985.
KEGGimmu:16985.
UCSCiuc009knb.3. mouse. [P19973-1]
uc009knf.2. mouse. [P19973-2]

Organism-specific databases

CTDi4046.
MGIiMGI:96832. Lsp1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00730000111324.
HOVERGENiHBG001610.
InParanoidiP19973.
KOiK14957.
OMAiRLTAQWS.
OrthoDBiEOG091G0I0H.
PhylomeDBiP19973.
TreeFamiTF336257.

Miscellaneous databases

PROiP19973.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018819.
CleanExiMM_LSP1.
ExpressionAtlasiP19973. baseline and differential.
GenevisibleiP19973. MM.

Family and domain databases

InterProiIPR006018. Caldesmon_LSP.
IPR002211. Lymphspecific.
[Graphical view]
PANTHERiPTHR18949. PTHR18949. 1 hit.
PfamiPF02029. Caldesmon. 1 hit.
[Graphical view]
PRINTSiPR01083. LYMPHSPCIFIC.
ProtoNetiSearch...

Entry informationi

Entry nameiLSP1_MOUSE
AccessioniPrimary (citable) accession number: P19973
Secondary accession number(s): A2A6J5
, A2A6J6, P97339, Q04950, Q62022, Q62023, Q62024, Q8CD28, Q99L65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.