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P19968

- NUZM_NEUCR

UniProt

P19968 - NUZM_NEUCR

Protein

NADH-ubiquinone oxidoreductase 21.3 kDa subunit

Gene

20H10.080

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (07 Jun 2005)
      Previous versions | rss
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    Functioni

    Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).
    NADH + acceptor = NAD+ + reduced acceptor.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase 21.3 kDa subunit (EC:1.6.5.3, EC:1.6.99.3)
    Gene namesi
    ORF Names:20H10.080, NCU08930
    OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
    Taxonomic identifieri367110 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
    ProteomesiUP000001805: Chromosome 2, Linkage Group V

    Subcellular locationi

    Mitochondrion inner membrane
    Note: Importation into mitochondrion is membrane potential dependent.

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201NADH-ubiquinone oxidoreductase 21.3 kDa subunitPRO_0000118737Add
    BLAST

    Interactioni

    Subunit structurei

    Complex I is composed of about 40 different subunits.

    Protein-protein interaction databases

    STRINGi5141.NCU08930.1.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG68678.
    HOGENOMiHOG000187575.
    OMAiWDVHKYE.
    OrthoDBiEOG7ZGXFN.

    Family and domain databases

    InterProiIPR016813. NADH_Ub_cplx-1_21kDa_fun.
    [Graphical view]
    PIRSFiPIRSF022976. NADH_Oxi_21kDa. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P19968-1 [UniParc]FASTAAdd to Basket

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    MASKVVTGVV KTTAGGVVPV SQKYTVQSVG VWERIRRAFA IDPNRSNGVP    50
    LVPYNRNPSP GSLDPLAYDD PVTIPAGDIA DNPYWKRDAR RNYPRLSVVG 100
    QAEAVALLSV GSASHPRVEL VGENGSKQLV AAQEAGKTGG LAKYFEGTGV 150
    EAGKLVLAET GGLPPLPSGE KLGEGGKWDV YKYQLAEEPS YSEAYPCRSF 200
    S 201
    Length:201
    Mass (Da):21,333
    Last modified:June 7, 2005 - v2
    Checksum:i2CA69243970E35FD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti22 – 221Q → QQ(PubMed:12655011)Curated
    Sequence conflicti114 – 1141S → T in AAA33570. (PubMed:2137337)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32244 mRNA. Translation: AAA33570.1.
    BX294024 Genomic DNA. Translation: CAD70991.1.
    CM002240 Genomic DNA. Translation: EAA31561.1.
    PIRiA34051.
    RefSeqiXP_960797.1. XM_955704.1.
    UniGeneiNcr.12948.

    Genome annotation databases

    EnsemblFungiiEFNCRT00000008129; EFNCRP00000008118; EFNCRG00000008116.
    GeneIDi3876955.
    KEGGincr:NCU08930.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32244 mRNA. Translation: AAA33570.1 .
    BX294024 Genomic DNA. Translation: CAD70991.1 .
    CM002240 Genomic DNA. Translation: EAA31561.1 .
    PIRi A34051.
    RefSeqi XP_960797.1. XM_955704.1.
    UniGenei Ncr.12948.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5141.NCU08930.1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii EFNCRT00000008129 ; EFNCRP00000008118 ; EFNCRG00000008116 .
    GeneIDi 3876955.
    KEGGi ncr:NCU08930.

    Phylogenomic databases

    eggNOGi NOG68678.
    HOGENOMi HOG000187575.
    OMAi WDVHKYE.
    OrthoDBi EOG7ZGXFN.

    Family and domain databases

    InterProi IPR016813. NADH_Ub_cplx-1_21kDa_fun.
    [Graphical view ]
    PIRSFi PIRSF022976. NADH_Oxi_21kDa. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure, in vitro expression and import into mitochondria of a 29/21-kDa subunit of complex I from Neurospora crassa."
      Videira A., Tropschug M., Werner S.
      Biochem. Biophys. Res. Commun. 166:280-285(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
      Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
      Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
    3. "The genome sequence of the filamentous fungus Neurospora crassa."
      Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.
      , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
      Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

    Entry informationi

    Entry nameiNUZM_NEUCR
    AccessioniPrimary (citable) accession number: P19968
    Secondary accession number(s): Q7RVC1, Q871L0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: June 7, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3