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P19968 (NUZM_NEUCR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase 21.3 kDa subunit

EC=1.6.5.3
EC=1.6.99.3
Gene names
ORF Names:20H10.080, NCU08930
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) [Reference proteome]
Taxonomic identifier367110 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

NADH + acceptor = NAD+ + reduced acceptor.

Subunit structure

Complex I is composed of about 40 different subunits.

Subcellular location

Mitochondrion inner membrane. Note: Importation into mitochondrion is membrane potential dependent.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   LigandNAD
Ubiquinone
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201NADH-ubiquinone oxidoreductase 21.3 kDa subunit
PRO_0000118737

Experimental info

Sequence conflict221Q → QQ Ref.2
Sequence conflict1141S → T in AAA33570. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P19968 [UniParc].

Last modified June 7, 2005. Version 2.
Checksum: 2CA69243970E35FD

FASTA20121,333
        10         20         30         40         50         60 
MASKVVTGVV KTTAGGVVPV SQKYTVQSVG VWERIRRAFA IDPNRSNGVP LVPYNRNPSP 

        70         80         90        100        110        120 
GSLDPLAYDD PVTIPAGDIA DNPYWKRDAR RNYPRLSVVG QAEAVALLSV GSASHPRVEL 

       130        140        150        160        170        180 
VGENGSKQLV AAQEAGKTGG LAKYFEGTGV EAGKLVLAET GGLPPLPSGE KLGEGGKWDV 

       190        200 
YKYQLAEEPS YSEAYPCRSF S 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure, in vitro expression and import into mitochondria of a 29/21-kDa subunit of complex I from Neurospora crassa."
Videira A., Tropschug M., Werner S.
Biochem. Biophys. Res. Commun. 166:280-285(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence."
Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.
Nucleic Acids Res. 31:1944-1954(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.
[3]"The genome sequence of the filamentous fungus Neurospora crassa."
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D. expand/collapse author list , Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.
Nature 422:859-868(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32244 mRNA. Translation: AAA33570.1.
BX294024 Genomic DNA. Translation: CAD70991.1.
CM002240 Genomic DNA. Translation: EAA31561.1.
PIRA34051.
RefSeqXP_960797.1. XM_955704.1.
UniGeneNcr.12948.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5141.NCU08930.1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiEFNCRT00000008129; EFNCRP00000008118; EFNCRG00000008116.
GeneID3876955.
KEGGncr:NCU08930.

Phylogenomic databases

eggNOGNOG68678.
HOGENOMHOG000187575.
OMAWDVHKYE.
OrthoDBEOG7ZGXFN.

Family and domain databases

InterProIPR016813. NADH_Ub_cplx-1_21kDa_fun.
[Graphical view]
PIRSFPIRSF022976. NADH_Oxi_21kDa. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNUZM_NEUCR
AccessionPrimary (citable) accession number: P19968
Secondary accession number(s): Q7RVC1, Q871L0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 7, 2005
Last modified: February 19, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program