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P19967

- CYB5R_DROME

UniProt

P19967 - CYB5R_DROME

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Protein
Cytochrome b5-related protein
Gene
Cyt-b5-r, CG13279
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in muscle cell metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme axial ligand) By similarity
Metal bindingi82 – 821Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b5-related protein
Alternative name(s):
Protein TU-36B
Gene namesi
Name:Cyt-b5-r
ORF Names:CG13279
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000406. Cyt-b5-r.

Subcellular locationi

GO - Cellular componenti

  1. lipid particle Source: FlyBase
  2. mitochondrion Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Cytochrome b5-related protein
PRO_0000166018Add
BLAST

Proteomic databases

PaxDbiP19967.

Expressioni

Tissue specificityi

Muscle.

Gene expression databases

BgeeiP19967.

Interactioni

Protein-protein interaction databases

BioGridi61015. 3 interactions.
IntActiP19967. 1 interaction.
MINTiMINT-1665002.
STRINGi7227.FBpp0080486.

Structurei

3D structure databases

ProteinModelPortaliP19967.
SMRiP19967. Positions 27-102.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 10085Cytochrome b5 heme-binding
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG86814.
GeneTreeiENSGT00520000056604.
InParanoidiP19967.
OMAiRECNHIE.
OrthoDBiEOG7FNC7D.
PhylomeDBiP19967.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR012171. Fatty_acid/sphinglp_desaturase.
IPR005804. Fatty_acid_desaturase-1.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19967-1 [UniParc]FASTAAdd to Basket

« Hide

MVIEEWKKSG IATKFPTYRN SALITTHSWQ KGKRQDDGAE GLWRINDGIY    50
DFTSFIDKHP GGPFWIRETK GTDITEAFEA HHLTTAPEKM IAKYKVRDAA 100
EPRIYTLTLE EGGFYKTLKE RVREQLKTID KRPKKKSDLI HLGLVVSLYL 150
LGIASAKYNS LLALVLASVA LCWTVIVSHN YFHRRDNWQM YAFNLGMMNF 200
AAWRVSHALS HHIYPNSYFD LELSMFEPLL CWVPNPHIKS KLMRYVSWVT 250
EPVAYALAFF IQMGTRIFYS LRHTNILYWH DLLPLTIPIA IYLGTGGSLG 300
IWICVRQWLA MTSIASFSFC LIGLNAAHHD PEIYHEGDAN REDRDWGLFQ 350
VDTIIDRGDL KWSQFLVLTH FGDHVLHHLF PTLDHGLLPA LYPVLYQTLD 400
EFKGHLRECN HIEHMIGQHK QLLRIEPNPR APGAGK 436
Length:436
Mass (Da):50,355
Last modified:June 21, 2005 - v2
Checksum:i77C77E49C6218A02
GO

Sequence cautioni

The sequence CAA33113.1 differs from that shown. Reason: Frameshift at position 348.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti202 – 2021A → P.
Natural varianti213 – 2131I → T.
Natural varianti344 – 3441R → G.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2202FD → LN in CAA33113. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15008 Genomic DNA. Translation: CAA33113.1. Frameshift.
AE014134 Genomic DNA. Translation: AAF53567.1.
AY058287 mRNA. Translation: AAL13516.1.
PIRiS05441.
RefSeqiNP_001260514.1. NM_001273585.1.
NP_477154.1. NM_057806.5.
UniGeneiDm.4208.

Genome annotation databases

EnsemblMetazoaiFBtr0080932; FBpp0080486; FBgn0000406.
FBtr0331931; FBpp0304264; FBgn0000406.
GeneIDi35008.
KEGGidme:Dmel_CG13279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15008 Genomic DNA. Translation: CAA33113.1 . Frameshift.
AE014134 Genomic DNA. Translation: AAF53567.1 .
AY058287 mRNA. Translation: AAL13516.1 .
PIRi S05441.
RefSeqi NP_001260514.1. NM_001273585.1.
NP_477154.1. NM_057806.5.
UniGenei Dm.4208.

3D structure databases

ProteinModelPortali P19967.
SMRi P19967. Positions 27-102.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 61015. 3 interactions.
IntActi P19967. 1 interaction.
MINTi MINT-1665002.
STRINGi 7227.FBpp0080486.

Proteomic databases

PaxDbi P19967.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0080932 ; FBpp0080486 ; FBgn0000406 .
FBtr0331931 ; FBpp0304264 ; FBgn0000406 .
GeneIDi 35008.
KEGGi dme:Dmel_CG13279.

Organism-specific databases

CTDi 35008.
FlyBasei FBgn0000406. Cyt-b5-r.

Phylogenomic databases

eggNOGi NOG86814.
GeneTreei ENSGT00520000056604.
InParanoidi P19967.
OMAi RECNHIE.
OrthoDBi EOG7FNC7D.
PhylomeDBi P19967.

Miscellaneous databases

ChiTaRSi Cyt-b5-r. drosophila.
GenomeRNAii 35008.
NextBioi 791390.

Gene expression databases

Bgeei P19967.

Family and domain databases

Gene3Di 3.10.120.10. 1 hit.
InterProi IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR012171. Fatty_acid/sphinglp_desaturase.
IPR005804. Fatty_acid_desaturase-1.
[Graphical view ]
Pfami PF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view ]
PIRSFi PIRSF015921. FA_sphinglp_des. 1 hit.
SUPFAMi SSF55856. SSF55856. 1 hit.
PROSITEi PS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a muscle specific gene which is adjacent to the Drosophila myosin heavy-chain gene and can encode a cytochrome b related protein."
    Levin R.J., Boychuk P.L., Croniger C.M., Kazzaz J.A., Rozek C.E.
    Nucleic Acids Res. 17:6349-6367(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Head.

Entry informationi

Entry nameiCYB5R_DROME
AccessioniPrimary (citable) accession number: P19967
Secondary accession number(s): Q9VJI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 21, 2005
Last modified: July 9, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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