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Protein

Cytochrome b5-related protein

Gene

Cyt-b5-r

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in muscle cell metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi82Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b5-related protein
Alternative name(s):
Protein TU-36B
Gene namesi
ORF Names:CG13279
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000406 Cyt-b5-r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660181 – 436Cytochrome b5-related proteinAdd BLAST436

Proteomic databases

PaxDbiP19967
PRIDEiP19967

Expressioni

Tissue specificityi

Muscle.

Gene expression databases

BgeeiFBgn0000406
ExpressionAtlasiP19967 baseline and differential
GenevisibleiP19967 DM

Interactioni

Protein-protein interaction databases

BioGridi61015, 3 interactors
IntActiP19967, 1 interactor
STRINGi7227.FBpp0304264

Structurei

3D structure databases

ProteinModelPortaliP19967
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 100Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST85

Phylogenomic databases

eggNOGiKOG4232 Eukaryota
ENOG410XVSZ LUCA
InParanoidiP19967
OMAiMFEPLLC
OrthoDBiEOG091G140M
PhylomeDBiP19967

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR005804 FA_desaturase_dom
IPR012171 Fatty_acid_desaturase
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF00487 FA_desaturase, 1 hit
PIRSFiPIRSF015921 FA_sphinglp_des, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

P19967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIEEWKKSG IATKFPTYRN SALITTHSWQ KGKRQDDGAE GLWRINDGIY
60 70 80 90 100
DFTSFIDKHP GGPFWIRETK GTDITEAFEA HHLTTAPEKM IAKYKVRDAA
110 120 130 140 150
EPRIYTLTLE EGGFYKTLKE RVREQLKTID KRPKKKSDLI HLGLVVSLYL
160 170 180 190 200
LGIASAKYNS LLALVLASVA LCWTVIVSHN YFHRRDNWQM YAFNLGMMNF
210 220 230 240 250
AAWRVSHALS HHIYPNSYFD LELSMFEPLL CWVPNPHIKS KLMRYVSWVT
260 270 280 290 300
EPVAYALAFF IQMGTRIFYS LRHTNILYWH DLLPLTIPIA IYLGTGGSLG
310 320 330 340 350
IWICVRQWLA MTSIASFSFC LIGLNAAHHD PEIYHEGDAN REDRDWGLFQ
360 370 380 390 400
VDTIIDRGDL KWSQFLVLTH FGDHVLHHLF PTLDHGLLPA LYPVLYQTLD
410 420 430
EFKGHLRECN HIEHMIGQHK QLLRIEPNPR APGAGK
Length:436
Mass (Da):50,355
Last modified:June 21, 2005 - v2
Checksum:i77C77E49C6218A02
GO

Sequence cautioni

The sequence CAA33113 differs from that shown. Reason: Frameshift at position 348.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219 – 220FD → LN in CAA33113 (PubMed:2549511).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti202A → P. 1
Natural varianti213I → T. 1
Natural varianti344R → G. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15008 Genomic DNA Translation: CAA33113.1 Frameshift.
AE014134 Genomic DNA Translation: AAF53567.1
AY058287 mRNA Translation: AAL13516.1
PIRiS05441
RefSeqiNP_001260514.1, NM_001273585.1
NP_477154.1, NM_057806.5
UniGeneiDm.4208

Genome annotation databases

EnsemblMetazoaiFBtr0080932; FBpp0080486; FBgn0000406
FBtr0331931; FBpp0304264; FBgn0000406
GeneIDi35008
KEGGidme:Dmel_CG13279

Similar proteinsi

Entry informationi

Entry nameiCYB5R_DROME
AccessioniPrimary (citable) accession number: P19967
Secondary accession number(s): Q9VJI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase

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