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Protein

Cytochrome b5-related protein

Gene

Cyt-b5-r

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in muscle cell metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi82Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b5-related protein
Alternative name(s):
Protein TU-36B
Gene namesi
ORF Names:CG13279
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0000406. Cyt-b5-r.

Subcellular locationi

GO - Cellular componenti

  • integral component of membrane Source: InterPro
  • lipid particle Source: FlyBase
  • mitochondrion Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660181 – 436Cytochrome b5-related proteinAdd BLAST436

Proteomic databases

PaxDbiP19967.
PRIDEiP19967.

Expressioni

Tissue specificityi

Muscle.

Gene expression databases

BgeeiFBgn0000406.
ExpressionAtlasiP19967. baseline.
GenevisibleiP19967. DM.

Interactioni

Protein-protein interaction databases

BioGridi61015. 3 interactors.
IntActiP19967. 1 interactor.
MINTiMINT-1665002.
STRINGi7227.FBpp0304264.

Structurei

3D structure databases

ProteinModelPortaliP19967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 100Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Contains 1 cytochrome b5 heme-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4232. Eukaryota.
ENOG410XVSZ. LUCA.
GeneTreeiENSGT00520000056604.
InParanoidiP19967.
OMAiPEIYHEG.
OrthoDBiEOG091G140M.
PhylomeDBiP19967.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR005804. FA_desaturase_dom.
IPR012171. Fatty_acid_desaturase.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIEEWKKSG IATKFPTYRN SALITTHSWQ KGKRQDDGAE GLWRINDGIY
60 70 80 90 100
DFTSFIDKHP GGPFWIRETK GTDITEAFEA HHLTTAPEKM IAKYKVRDAA
110 120 130 140 150
EPRIYTLTLE EGGFYKTLKE RVREQLKTID KRPKKKSDLI HLGLVVSLYL
160 170 180 190 200
LGIASAKYNS LLALVLASVA LCWTVIVSHN YFHRRDNWQM YAFNLGMMNF
210 220 230 240 250
AAWRVSHALS HHIYPNSYFD LELSMFEPLL CWVPNPHIKS KLMRYVSWVT
260 270 280 290 300
EPVAYALAFF IQMGTRIFYS LRHTNILYWH DLLPLTIPIA IYLGTGGSLG
310 320 330 340 350
IWICVRQWLA MTSIASFSFC LIGLNAAHHD PEIYHEGDAN REDRDWGLFQ
360 370 380 390 400
VDTIIDRGDL KWSQFLVLTH FGDHVLHHLF PTLDHGLLPA LYPVLYQTLD
410 420 430
EFKGHLRECN HIEHMIGQHK QLLRIEPNPR APGAGK
Length:436
Mass (Da):50,355
Last modified:June 21, 2005 - v2
Checksum:i77C77E49C6218A02
GO

Sequence cautioni

The sequence CAA33113 differs from that shown. Reason: Frameshift at position 348.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219 – 220FD → LN in CAA33113 (PubMed:2549511).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti202A → P.1
Natural varianti213I → T.1
Natural varianti344R → G.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15008 Genomic DNA. Translation: CAA33113.1. Frameshift.
AE014134 Genomic DNA. Translation: AAF53567.1.
AY058287 mRNA. Translation: AAL13516.1.
PIRiS05441.
RefSeqiNP_001260514.1. NM_001273585.1.
NP_477154.1. NM_057806.5.
UniGeneiDm.4208.

Genome annotation databases

EnsemblMetazoaiFBtr0080932; FBpp0080486; FBgn0000406.
FBtr0331931; FBpp0304264; FBgn0000406.
GeneIDi35008.
KEGGidme:Dmel_CG13279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15008 Genomic DNA. Translation: CAA33113.1. Frameshift.
AE014134 Genomic DNA. Translation: AAF53567.1.
AY058287 mRNA. Translation: AAL13516.1.
PIRiS05441.
RefSeqiNP_001260514.1. NM_001273585.1.
NP_477154.1. NM_057806.5.
UniGeneiDm.4208.

3D structure databases

ProteinModelPortaliP19967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi61015. 3 interactors.
IntActiP19967. 1 interactor.
MINTiMINT-1665002.
STRINGi7227.FBpp0304264.

Proteomic databases

PaxDbiP19967.
PRIDEiP19967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0080932; FBpp0080486; FBgn0000406.
FBtr0331931; FBpp0304264; FBgn0000406.
GeneIDi35008.
KEGGidme:Dmel_CG13279.

Organism-specific databases

CTDi35008.
FlyBaseiFBgn0000406. Cyt-b5-r.

Phylogenomic databases

eggNOGiKOG4232. Eukaryota.
ENOG410XVSZ. LUCA.
GeneTreeiENSGT00520000056604.
InParanoidiP19967.
OMAiPEIYHEG.
OrthoDBiEOG091G140M.
PhylomeDBiP19967.

Miscellaneous databases

ChiTaRSiCyt-b5-r. fly.
GenomeRNAii35008.
PROiP19967.

Gene expression databases

BgeeiFBgn0000406.
ExpressionAtlasiP19967. baseline.
GenevisibleiP19967. DM.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
IPR018506. Cyt_B5_heme-BS.
IPR005804. FA_desaturase_dom.
IPR012171. Fatty_acid_desaturase.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
[Graphical view]
PIRSFiPIRSF015921. FA_sphinglp_des. 1 hit.
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiPS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYB5R_DROME
AccessioniPrimary (citable) accession number: P19967
Secondary accession number(s): Q9VJI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 21, 2005
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.