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Protein

Major pollen allergen Ole e 1

Gene
N/A
Organism
Olea europaea (Common olive)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in recognition between pollen-stigma and pollen tube-style cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Ole e 1
Alternative name(s):
Allergen Ole e I
Allergen: Ole e 1
OrganismiOlea europaea (Common olive)
Taxonomic identifieri4146 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesOleaceaeOleeaeOlea

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Major allergen from olive pollen. Important in Mediterranean countries.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi8 – 81V → A: 90% loss of IgG binding. 1 Publication
Mutagenesisi9 – 91S → A: Loss of IgG binding. 1 Publication
Mutagenesisi10 – 101Q → A: Loss of IgG binding. 1 Publication
Mutagenesisi11 – 111F → A: Loss of IgG binding. 1 Publication
Mutagenesisi26 – 261F → A: 70% loss of IgG binding. 1 Publication
Mutagenesisi29 – 291E → A: Loss of IgG binding. 1 Publication
Mutagenesisi30 – 301L → A: 50% loss of IgG binding. 1 Publication
Mutagenesisi32 – 321E → A: Loss of IgG binding. 1 Publication
Mutagenesisi33 – 331F → A: Loss of IgG binding. 1 Publication
Mutagenesisi34 – 341I → A: 50% loss of IgG binding. 1 Publication
Mutagenesisi49 – 491G → A: 50% loss of IgG binding. 1 Publication
Mutagenesisi50 – 501D → A: 60% loss of IgG binding. 1 Publication
Mutagenesisi51 – 511V → A: 50% loss of IgG binding. 1 Publication
Mutagenesisi55 – 551E → A: Loss of IgG binding. 1 Publication
Mutagenesisi56 – 561V → A: Loss of IgG binding. 1 Publication
Mutagenesisi57 – 571G → A: Loss of IgG binding. 1 Publication
Mutagenesisi58 – 581Y → A: Loss of IgG binding. 1 Publication
Mutagenesisi59 – 591T → A: Loss of IgG binding. 1 Publication
Mutagenesisi60 – 601R → A: 60% loss of IgG binding. 1 Publication
Mutagenesisi65 – 651Y → A: 70% loss of IgG binding. 1 Publication
Mutagenesisi67 – 671M → A: 50% loss of IgG binding. 1 Publication
Mutagenesisi70 – 701E → A: Loss of IgG binding. 1 Publication
Mutagenesisi107 – 1071L → A: Loss of IgG binding. 1 Publication
Mutagenesisi108 – 1081N → A: Loss of IgG binding. 1 Publication
Mutagenesisi109 – 1091T → A: Loss of IgG binding. 1 Publication
Mutagenesisi110 – 1101V → A: Loss of IgG binding. 1 Publication
Mutagenesisi112 – 1121G → A: Loss of IgG binding. 1 Publication
Mutagenesisi119 – 1191P → A: 70% loss of IgG binding. 1 Publication
Mutagenesisi120 – 1201L → A: Loss of IgG binding. 1 Publication
Mutagenesisi123 – 1231F → A: Loss of IgG binding. 1 Publication
Mutagenesisi125 – 1251K → A: 80% loss of IgG binding. 1 Publication
Mutagenesisi133 – 1331Q → A: 50% loss of IgG binding and 40% loss if IgE binding. 1 Publication
Mutagenesisi134 – 1341V → A: 30% loss of IgG binding and 50% loss if IgE binding. 1 Publication
Mutagenesisi135 – 1351Y → A: No loss of IgG binding and 40% loss if IgE binding. 1 Publication
Mutagenesisi136 – 14510Missing : Decreased IgE binding. 1 Publication
Mutagenesisi136 – 1361N → A: 40% loss of IgG binding and 60% loss if IgE binding. 1 Publication
Mutagenesisi137 – 1371K → A: 20% loss of IgG binding and 80% loss if IgE binding. 1 Publication
Mutagenesisi138 – 1381L → A: 70% loss of IgG binding and 90% loss if IgE binding. 1 Publication
Mutagenesisi139 – 1391G → A: 30% loss of IgG binding and 90% loss if IgE binding. 1 Publication
Mutagenesisi140 – 1401M → A: 50% loss of IgG binding and 50% loss if IgE binding. 1 Publication
Mutagenesisi141 – 1455Missing : Decreased IgE binding. 1 Publication
Mutagenesisi141 – 1411Y → A: 90% loss of IgG binding and 95% loss if IgE binding. 2 Publications
Mutagenesisi142 – 1421P → A: 20% loss of IgG binding and 95% loss if IgE binding. 1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei482. Ole e 1.
483. Ole e 1.0101.
487. Ole e 1.0105.
488. Ole e 1.0106.
489. Ole e 1.0107.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Major pollen allergen Ole e 1PRO_0000215113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi19 ↔ 901 Publication
Disulfide bondi22 ↔ 1311 Publication
Disulfide bondi43 ↔ 781 Publication
Glycosylationi111 – 1111N-linked (GlcNAc...) (high mannose and complex)CAR_000182

Post-translational modificationi

N-glycosylated; contains high mannose (Man(7)-GlcNAc) and partially fucosylated complex glycans (GlcNAc-Man(3)-Xyl-GlcNAc). Complex glycans may contribute to the antigenicity. Exists both in a glycosylated and in a non-glycosylated form. Ole e 1 and Ole e 1.0103 are the only non-glycosylated isoallergens.
A second potential glycosylation site exists at position 50 in cv. Bella de Espana and cv. Hojiblanca.

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

UniCarbKBiP19963.

Expressioni

Tissue specificityi

Expressed in tapetum and pollen grains. Not detected in petals, roots or leaves.1 Publication

Developmental stagei

Expressed at late stages of pollen development. Up-regulated during pollen germination and pollen tube growth.2 Publications

Family & Domainsi

Domaini

Regions 91-102 and 109-130 are immunodominant T-cell epitopes. Mutations in the C-terminus (135-145) reduce allergenic activity but do not change the ability to stimulate allergen-specific T-cells.

Sequence similaritiesi

Belongs to the Ole e I family.Curated

Family and domain databases

InterProiIPR006040. Allegen_Ole_e_I_CS.
IPR006041. Pollen_Ole_e1_allergen.
[Graphical view]
PANTHERiPTHR31614:SF2. PTHR31614:SF2. 1 hit.
PROSITEiPS00925. OLEEI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19963-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EDIPQPPVSQ FHIQGQVYCD TCRAGFITEL SEFIPGASLR LQCKDKENGD
60 70 80 90 100
VTFTEVGYTR AEGLYSMLVE RDHKNEFCEI TLISSGRKDC NEIPTEGWAK
110 120 130 140
PSLKFKLNTV NGTTRTVNPL GFFKKEALPK CAQVYNKLGM YPPNM
Length:145
Mass (Da):16,330
Last modified:October 1, 1993 - v2
Checksum:i3F11F04E01C12C84
GO

Sequence cautioni

The sequence CAA73036.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA73037.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA73038.1 differs from that shown. Reason: Erroneous initiation. Curated

Polymorphismi

Several isoforms of the allergen exist due to polymorphism.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31I → V in Ole e 1.0102, Ole e 1.0103 and Ole e 1.0105.
Natural varianti8 – 81V → I in Ole e I.4.
Natural varianti12 – 121H → Y in Ole e I.4.
Natural varianti13 – 131I → V in strain: cv. Zard; variant 2. In Ole e I.4.
Natural varianti14 – 141Q → I in strain: cv. Bella de Espana; variants 1 and 2, cv. Loaime, cv. Lucio, cv. Menara; variants 1 and 2, cv. Picholine marocaine and cv. Picual; variant 1.
Natural varianti15 – 151G → L in strain: cv. Picual; variant 1.
Natural varianti15 – 151G → Q in strain: cv. Arbequina; variants 1 and 2 and cv. Bella de Espana; variant 3.
Natural varianti15 – 151G → R in strain: cv. Bella de Espana; variants 1 and 2, cv. Menara; variants 1 and 2 and cv. Picholine marocaine.
Natural varianti15 – 151G → S in strain: cv. Picual; variant 3.
Natural varianti15 – 151G → W in strain: cv. Loaime and cv. Picual; variant 2.
Natural varianti16 – 161Q → A in strain: cv. Arbequina; variant 1.
Natural varianti16 – 161Q → D in strain: cv. Arbequina; variant 2, cv. Bella de Espana; variant 3 and cv. Picual; variant 3.
Natural varianti16 – 161Q → R in strain: cv. Acebuche.
Natural varianti16 – 161Q → T in strain: cv. Bella de Espana; variants 1 and 2, cv. Loaime, cv. Menara; variants 1 and 2, cv. Picholine marocaine and cv. Picual; variants 1 and 2.
Natural varianti17 – 171V → I in strain: cv. Rowghani; variant 3 and cv. Zard; variant 2.
Natural varianti17 – 171V → S in strain: cv. Arbequina; variant 2, cv. Bella de Espana; variant 3, cv. Hojiblanca and cv. Picual; variant 3.
Natural varianti17 – 171V → T in strain: cv. Acebuche.
Natural varianti18 – 181Y → F in strain: cv. Bella de Espana; variant 1.
Natural varianti18 – 181Y → H in strain: cv. Menara; variant 2.
Natural varianti18 – 181Y → S in strain: cv. Bella de Espana; variant 2 and cv. Picual; variant 2.
Natural varianti18 – 181Y → V in strain: cv. Acebuche.
Natural varianti19 – 191C → Q in strain: cv. Bella de Espana; variant 2.
Natural varianti19 – 191C → R in strain: cv. Arbequina; variant 2 and cv. Bella de Espana; variant 1.
Natural varianti19 – 191C → S in strain: cv. Bella de Espana; variant 3.
Natural varianti19 – 191C → T in strain: cv. Acebuche.
Natural varianti20 – 201D → G in strain: cv. Acebuche and cv. Bella de Espana; variant 3.
Natural varianti20 – 201D → V in strain: cv. Bella de Espana; variant 1.
Natural varianti21 – 211T → H in strain: cv. Bella de Espana; variant 3.
Natural varianti21 – 211T → Y in strain: cv. Acebuche.
Natural varianti23 – 231R → C in strain: cv. Bella de Espana; variant 2.
Natural varianti23 – 231R → P.
Natural varianti24 – 241A → S in strain: cv. Rowghani; variant 3. In Ole e 1.0105.
Natural varianti24 – 241A → T in Ole e I.4.
Natural varianti25 – 251G → R in strain: cv. Bella de Espana; variants 1, 2 and 3 and cv. Rowghani; variants 3 and 4. In Ole e 1.0105, Ole e I.3 and Ole e I.4.
Natural varianti28 – 281T → A in strain: cv. Zard; variant 2; 50% loss of IgG binding. 1 Publication
Natural varianti30 – 301L → F in Ole e I.4.
Natural varianti35 – 351P → L in strain: cv. Zard; variant 2.
Natural varianti38 – 381S → G in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Hojiblanca and cv. Zard; variant 2. In Ole e I.4.
Natural varianti39 – 391L → V in strain: cv. Arbequina; variants 1 and 2, cv. Bella de Espana; variants 1, 2 and 3, cv. Hojiblanca, cv. Loaime, cv. Lucio, cv. Menara; variants 1 and 2, cv. Picholine marocaine, cv. Picual; variants 1 and 2, cv. Rowghani; variants 2, 3 and 4 and cv. Zard; variants 1 and 2. In Ole e 1.0102, Ole e 1.0103, Ole e 1.0105, Ole e I.3 and Ole e I.4.
Natural varianti44 – 441K → R in strain: cv. Rowghani; variants 2, 3 and 4 and cv. Zard; variants 1 and 2. In Ole e 1.0105.
Natural varianti45 – 451D → E in strain: cv. Zard; variant 1 and cv. Rowghani; variants 2 and 3. In Ole e 1.0105.
Natural varianti46 – 461K → G in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Hojiblanca and cv. Rowghani; variant 4. In Ole e I.3 and Ole e I.4.
Natural varianti46 – 461K → I.
Natural varianti46 – 461K → R in strain: cv. Arbequina; variants 1 and 2.
Natural varianti46 – 461K → S in strain: cv. Zard; variant 2.
Natural varianti47 – 471E → K in strain: cv. Rowghani; variant 2 and cv. Zard; variants 1 and 2.
Natural varianti48 – 481N → K in strain: cv. Zard; variant 2.
Natural varianti50 – 501D → K in Ole e I.4.
Natural varianti50 – 501D → N in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Hojiblanca and cv. Zard; variant 2.
Natural varianti50 – 501D → S in strain: cv. Rowghani; variant 4. In Ole e I.3.
Natural varianti51 – 511V → I in strain: cv. Arbequina; variants 1 and 2, cv. Hojiblanca, cv. Loaime, cv. Lucio, cv. Menara; variants 1 and 2, cv. Picholine marocaine, cv. Picual; variants 1 and 2, cv. Rowghani, variants 2, 3 and 4 and cv. Zard; variants 1 and 2. In Ole e 1.0105, Ole e I.3 and Ole e I.4.
Natural varianti56 – 561V → I in strain: cv. Rowghani; variant 3. In Ole e 1.0102, 1.0103 and 1.0105.
Natural varianti58 – 581Y → S in strain: cv. Rowghani; variant 4.
Natural varianti69 – 691V → I in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Rowghani; variant 4 and cv. Zard; variant 2. In Ole e I.3 and Ole e I.4.
Natural varianti75 – 751N → D in strain: cv. Rowghani; variant 4. In Ole e I.3.
Natural varianti80 – 801I → V in strain: cv. Zard; variant 2.
Natural varianti81 – 811T → N in strain: cv. Zard; variant 2.
Natural varianti82 – 821L → S in strain: cv. Zard; variant 2.
Natural varianti83 – 831I → L in strain: cv. Bella de Espana; variants 1, 2 and 3 and cv. Zard; variant 2. In Ole e I.4.
Natural varianti86 – 861G → S in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Rowghani; variant 4 and cv. Zard; variant 2. In Ole e I.3 and Ole e I.4.
Natural varianti87 – 871R → S.
Natural varianti91 – 911N → D in strain: cv. Arbequina; variants 1 and 2, cv. Bella de Espana; variants 1, 2 and 3, cv. Hojiblanca, cv. Loaime, cv. Picual; variants 1 and 2, cv. Rowghani; variants 3 and 4 and cv. Zard; variant 2. In Ole e 1.0105, Ole e I.3 and Ole e I.4.
Natural varianti95 – 951T → I in strain: cv. Rowghani; variant 3 and cv. Zard; variant 2. In Ole e 1.0105.
Natural varianti95 – 951T → V in strain: cv. Bella de Espana; variants 1, 2 and 3 and cv. Rowghani; variant 4. In Ole e I.3.
Natural varianti99 – 991A → V in strain: cv. Acebuche, cv. Arbequina; variants 1 and 2, cv. Bella de Espana; variants 1, 2 and 3, cv. Hojiblanca, cv. Picual; variant 3, cv. Rowghani; variants 1 and 4 and cv. Zard; variant 2. In Ole e I.2, Ole e I.3 and Ole e I.4.
Natural varianti100 – 1001K → R in strain: cv. Zard; variant 2.
Natural varianti103 – 1031L → V in Ole e I.4.
Natural varianti104 – 1041K → R in strain: cv. Zard; variant 2.
Natural varianti106 – 1061K → I in strain: cv. Acebuche, cv. Arbequina; variant 1 and 2, cv. Hojiblanca, cv. Loaime, cv. Lucio, cv. Menara; variants 1 and 2, cv. Picholine marocaine, cv. Picual; variants 1, 2 and 3, cv. Rowghani; variants 1, 2 and 3 and cv. Zard; variant 1. In Ole e 1.0102, Ole e 1.0103, Ole e 1.0105, Ole e I.2 and Ole e I.4. 1 Publication
Natural varianti106 – 1061K → L in strain: cv. Zard; variant 2.
Natural varianti106 – 1061K → M in strain: cv. Bella de Espana; variants 1, 2 and 3 and cv. Rowghani; variant 4. In Ole e I.3.
Natural varianti108 – 1081N → S in Ole e 1.0103.
Natural varianti111 – 1111N → D.
Natural varianti115 – 1151R → C in strain: cv. Zard; variant 2.
Natural varianti117 – 1171V → I in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Hojiblanca, cv. Rowghani; variant 2 and cv. Zard; variants 1 and 2. In Ole e I.3 and Ole e I.4.
Natural varianti118 – 1181N → K in strain: cv. Zard; variant 2.
Natural varianti121 – 1211G → R in Ole e 1.0102.
Natural varianti123 – 1231F → Y in strain: cv. Zard; variant 1 and cv. Rowghani; variant 2. In Ole e 1.0102 and Ole e 1.0103.
Natural varianti125 – 1251K → N in strain: cv. Zard; variant 2.
Natural varianti126 – 1261E → K in strain: cv. Zard; variant 2.
Natural varianti132 – 1321A → P in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Rowghani; variant 4 and cv. Zard; variant 2. In Ole e I.3 and Ole e I.4.
Natural varianti135 – 1351Y → F in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Rowghani; variant 4 and cv. Zard; variant 2. In Ole e I.3 and Ole e I.4.
Natural varianti139 – 1391G → D in strain: cv. Rowghani; variant 2.
Natural varianti144 – 1441N → D in strain: cv. Bella de Espana; variants 1, 2 and 3, cv. Rowghani; variant 4 and cv. Zard; variant 2.
Natural varianti144 – 1441N → T in strain: cv. Picual; variant 3.
Natural varianti145 – 1451M → HGMSR in strain: cv. Acebuche.
Natural varianti145 – 1451M → L in strain: cv. Zard; variant 2.
Natural varianti145 – 1451M → WNVTI in strain: cv. Picual; variant 3.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12426 mRNA. Translation: CAA73036.1. Different initiation.
Y12427 mRNA. Translation: CAA73037.1. Different initiation.
Y12428 mRNA. Translation: CAA73038.1. Different initiation.
AF500908 mRNA. Translation: AAQ07442.1.
AF515277 mRNA. Translation: AAQ08186.1.
AF515278 mRNA. Translation: AAQ08187.1.
AF515279 mRNA. Translation: AAQ08188.1.
AF515280 mRNA. Translation: AAQ08189.1.
AF515281 mRNA. Translation: AAQ08190.1.
AF532753 mRNA. Translation: AAQ10267.1.
AF532754 mRNA. Translation: AAQ10268.1.
AF532755 mRNA. Translation: AAQ10269.1.
AF532756 mRNA. Translation: AAQ10270.1.
AF532757 mRNA. Translation: AAQ10271.1.
AF532758 mRNA. Translation: AAQ10272.1.
AF532759 mRNA. Translation: AAQ10273.1.
AF532760 mRNA. Translation: AAQ10274.1.
AF532761 mRNA. Translation: AAQ10275.1.
AF532762 mRNA. Translation: AAQ10276.1.
AF532763 mRNA. Translation: AAQ10277.1.
AF532764 mRNA. Translation: AAQ10278.1.
AF532765 mRNA. Translation: AAQ10279.1.
AF532766 mRNA. Translation: AAQ10280.1.
AF532767 mRNA. Translation: AAQ10281.1.
AY137467 mRNA. Translation: AAN18042.1.
AY137468 mRNA. Translation: AAN18043.1.
AY137469 mRNA. Translation: AAN18044.1.
AY159880 Genomic DNA. Translation: AAO22132.1.
AY159881 Genomic DNA. Translation: AAO22133.1.
EF541386 mRNA. Translation: ABP58632.1.
EF541387 mRNA. Translation: ABP58633.1.
EF541388 mRNA. Translation: ABP58634.1.
EF541389 mRNA. Translation: ABP58635.1.
EF541390 mRNA. Translation: ABP58636.1.
EF541391 mRNA. Translation: ABP58637.1.
S75766 mRNA. Translation: AAB32652.2.
PIRiA36153.
A53806.
D53806.
S36872.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12426 mRNA. Translation: CAA73036.1. Different initiation.
Y12427 mRNA. Translation: CAA73037.1. Different initiation.
Y12428 mRNA. Translation: CAA73038.1. Different initiation.
AF500908 mRNA. Translation: AAQ07442.1.
AF515277 mRNA. Translation: AAQ08186.1.
AF515278 mRNA. Translation: AAQ08187.1.
AF515279 mRNA. Translation: AAQ08188.1.
AF515280 mRNA. Translation: AAQ08189.1.
AF515281 mRNA. Translation: AAQ08190.1.
AF532753 mRNA. Translation: AAQ10267.1.
AF532754 mRNA. Translation: AAQ10268.1.
AF532755 mRNA. Translation: AAQ10269.1.
AF532756 mRNA. Translation: AAQ10270.1.
AF532757 mRNA. Translation: AAQ10271.1.
AF532758 mRNA. Translation: AAQ10272.1.
AF532759 mRNA. Translation: AAQ10273.1.
AF532760 mRNA. Translation: AAQ10274.1.
AF532761 mRNA. Translation: AAQ10275.1.
AF532762 mRNA. Translation: AAQ10276.1.
AF532763 mRNA. Translation: AAQ10277.1.
AF532764 mRNA. Translation: AAQ10278.1.
AF532765 mRNA. Translation: AAQ10279.1.
AF532766 mRNA. Translation: AAQ10280.1.
AF532767 mRNA. Translation: AAQ10281.1.
AY137467 mRNA. Translation: AAN18042.1.
AY137468 mRNA. Translation: AAN18043.1.
AY137469 mRNA. Translation: AAN18044.1.
AY159880 Genomic DNA. Translation: AAO22132.1.
AY159881 Genomic DNA. Translation: AAO22133.1.
EF541386 mRNA. Translation: ABP58632.1.
EF541387 mRNA. Translation: ABP58633.1.
EF541388 mRNA. Translation: ABP58634.1.
EF541389 mRNA. Translation: ABP58635.1.
EF541390 mRNA. Translation: ABP58636.1.
EF541391 mRNA. Translation: ABP58637.1.
S75766 mRNA. Translation: AAB32652.2.
PIRiA36153.
A53806.
D53806.
S36872.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei482. Ole e 1.
483. Ole e 1.0101.
487. Ole e 1.0105.
488. Ole e 1.0106.
489. Ole e 1.0107.

PTM databases

UniCarbKBiP19963.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR006040. Allegen_Ole_e_I_CS.
IPR006041. Pollen_Ole_e1_allergen.
[Graphical view]
PANTHERiPTHR31614:SF2. PTHR31614:SF2. 1 hit.
PROSITEiPS00925. OLEEI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The amino acid sequence of Ole e I, the major allergen from olive tree (Olea europaea) pollen."
    Villalba M., Batanero E., Lopez-Otin C., Sanchez L.M., Monsalve R.I., Gonzalez de la Pena M.A., Lahoz C., Rodriguez R.
    Eur. J. Biochem. 216:863-869(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Pollen.
  2. "Cloning and expression of Ole e I, the major allergen from olive tree pollen. Polymorphism analysis and tissue specificity."
    Villalba M., Batanero E., Monsalve R.I., Gonzalez de la Pena M.A., Lahoz C., Rodriguez R.
    J. Biol. Chem. 269:15217-15222(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS OLE E I.2; OLE E I.3 AND OLE E I.4.
    Tissue: Pollen.
  3. "Cloning and expression of the panallergen profilin and the major allergen (Ole e 1) from olive tree pollen."
    Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R.
    J. Allergy Clin. Immunol. 100:365-372(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS OLE E 1.0102; OLE E 1.0103 AND OLE E 1.0105.
    Tissue: Pollen.
  4. "Isolation of three allergenic fractions of the major allergen from Olea europea pollen and N-terminal amino acid sequence."
    Villalba M., Lopez-Otin C., Martin-Orozco E., Monsalve R.I., Palomino P., Lahoz C., Rodriguez R.
    Biochem. Biophys. Res. Commun. 172:523-528(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-28, VARIANTS.
    Tissue: Pollen.
  5. "Differential expression and sequence polymorphism of the olive pollen allergen Ole e 1 in two Iranian cultivars."
    Soleimani A., Morales S., Jimenez-Lopez J.C., Castro A.J., Rodriguez-Garcia M.I., de Dios Alche J.
    Iran. J. Allergy Asthma Immunol. 12:18-28(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-145, VARIANTS.
    Strain: cv. Rowghani and Zard.
  6. "Olive cultivar origin is a major cause of polymorphism for Ole e 1 pollen allergen."
    Hamman-Khalifa A., Castro A.J., Jimenez-Lopez J.C., Rodriguez-Garcia M.I., Alche J.D.
    BMC Plant Biol. 8:10-10(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 14-145, VARIANTS.
    Strain: cv. Acebuche, cv. Arbequina, cv. Bella de Espana, cv. Hojiblanca, cv. Loaime, cv. Lucio, cv. Menara, cv. Picholine marocaine and cv. Picual.
  7. "cDNA sequence analysis of the main olive allergen, Ole e I."
    Lombardero M., Barbas J.A., del Prado J., Carreira J.
    Clin. Exp. Allergy 24:765-770(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-145, GLYCOSYLATION.
    Tissue: Pollen.
  8. "Assignment of the disulfide bonds of Ole e 1, a major allergen of olive tree pollen involved in fertilization."
    Gonzalez E., Monsalve R.I., Puente X.S., Villalba M., Rodriguez R.
    J. Pept. Res. 55:18-23(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, DISULFIDE BONDS.
  9. "Olive pollen allergy: searching for immunodominant T-cell epitopes on the Ole e 1 molecule."
    Cardaba B., Del Pozo V., Jurado A., Gallardo S., Cortegano I., Arrieta I., Del Amo A., Tramon P., Florido F., Sastre J., Palomino P., Lahoz C.
    Clin. Exp. Allergy 28:413-422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  10. "The major olive pollen allergen (Ole e I) shows both gametophytic and sporophytic expression during anther development, and its synthesis and storage takes place in the RER."
    Alche J.D., Castro A.J., Olmedilla A., Fernandez M.C., Rodriguez R., Villalba M., Rodriguez-Garcia M.I.
    J. Cell Sci. 112:2501-2509(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  11. "Beta(1,2)-xylose and alpha(1,3)-fucose residues have a strong contribution in IgE binding to plant glycoallergens."
    van Ree R., Cabanes-Macheteau M., Akkerdaas J., Milazzo J.-P., Loutelier-Bourhis C., Rayon C., Villalba M., Koppelman S., Aalberse R., Rodriguez R., Faye L., Lerouge P.
    J. Biol. Chem. 275:11451-11458(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCAN STRUCTURE.
  12. "Ole e 1, the major allergen from olive (Olea europaea L.) pollen, increases its expression and is released to the culture medium during in vitro germination."
    Alche J.D., M'rani-Alaoui M., Castro A.J., Rodriguez-Garcia M.I.
    Plant Cell Physiol. 45:1149-1157(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.
  13. "Analysis of IgE and IgG B-cell immunodominant regions of Ole e 1, the main allergen from olive pollen."
    Gonzalez E.M., Villalba M., Quiralte J., Batanero E., Roncal F., Albar J.P., Rodriguez R.
    Mol. Immunol. 43:570-578(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF VAL-8; SER-9; GLN-10; PHE-11; PHE-26; GLU-29; LEU-30; GLU-32; PHE-33; ILE-34; GLY-49; ASP-50; VAL-51; GLU-55; VAL-56; GLY-57; TYR-58; THR-59; ARG-60; TYR-65; MET-67; GLU-70; LEU-107; ASN-108; THR-109; VAL-110; GLY-112; PRO-119; LEU-120; PHE-123; LYS-125; GLN-133; VAL-134; TYR-135; ASN-136; LYS-137; LEU-138; GLY-139; MET-140; TYR-141 AND PRO-142, CHARACTERIZATION OF VARIANT ALA-28.
  14. "Hypoallergenic mutants of Ole e 1, the major olive pollen allergen, as candidates for allergy vaccines."
    Marazuela E.G., Rodriguez R., Barber D., Villalba M., Batanero E.
    Clin. Exp. Allergy 37:251-260(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF TYR-141; 136-ASN--MET-145 AND 141-TYR--MET-145, ALLERGEN.
  15. "Vegetable proteomics: the detection of Ole e 1 isoallergens by peptide matching of MALDI MS/MS spectra of underivatized and dansylated glycopeptides."
    Napoli A., Aiello D., Di Donna L., Moschidis P., Sindona G.
    J. Proteome Res. 7:2723-2732(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, VARIANT ILE-106.
    Strain: cv. Villacidro.
  16. Cited for: REVIEW, NOMENCLATURE.

Entry informationi

Entry nameiALL1_OLEEU
AccessioniPrimary (citable) accession number: P19963
Secondary accession number(s): A5A5K8
, A5A5K9, A5A5L0, A5A5L1, A5A5L2, A5A5L3, O24166, O24167, O24168, Q41243, Q5DTB9, Q5DTC0, Q5DTC2, Q5DVQ3, Q5DVQ4, Q5DVQ5, Q5DVQ6, Q5DVQ7, Q5DVQ9, Q5DVR0, Q5DVR4, Q5DVR6, Q5DVS1, Q5DVS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1993
Last modified: March 16, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Replacement of several other amino acids by Ala has little or no effect on IgG binding.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.