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Protein

Elafin

Gene

PI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: ProtInc
  • serine-type endopeptidase inhibitor activity Source: ProtInc
  • structural constituent of epidermis Source: CAFA

GO - Biological processi

  • antimicrobial humoral response Source: Reactome
  • copulation Source: InterPro
  • cornification Source: Reactome
  • peptide cross-linking Source: CAFA

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides
R-HSA-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiI17.002

Names & Taxonomyi

Protein namesi
Recommended name:
Elafin
Alternative name(s):
Elastase-specific inhibitor
Short name:
ESI
Peptidase inhibitor 3
Short name:
PI-3
Protease inhibitor WAP3
Skin-derived antileukoproteinase
Short name:
SKALP
WAP four-disulfide core domain protein 14
Gene namesi
Name:PI3
Synonyms:WAP3, WFDC14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000124102.4
HGNCiHGNC:8947 PI3
MIMi182257 gene
neXtProtiNX_P19957

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5266
OpenTargetsiENSG00000124102
PharmGKBiPA33283

Polymorphism and mutation databases

BioMutaiPI3
DMDMi119262

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
PropeptideiPRO_000004135723 – 602 PublicationsAdd BLAST38
ChainiPRO_000004135861 – 117ElafinAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 105
Disulfide bondi83 ↔ 109
Disulfide bondi92 ↔ 104
Disulfide bondi98 ↔ 113

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP19957
PaxDbiP19957
PeptideAtlasiP19957
PRIDEiP19957

PTM databases

iPTMnetiP19957
PhosphoSitePlusiP19957

Miscellaneous databases

PMAP-CutDBiP19957

Expressioni

Gene expression databases

BgeeiENSG00000124102
CleanExiHS_PI3
GenevisibleiP19957 HS

Organism-specific databases

HPAiCAB009449
HPA017737

Interactioni

Protein-protein interaction databases

BioGridi111284, 3 interactors
IntActiP19957, 1 interactor
MINTiP19957
STRINGi9606.ENSP00000243924

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi65 – 69Combined sources5
Beta strandi73 – 75Combined sources3
Beta strandi81 – 84Combined sources4
Helixi95 – 97Combined sources3
Beta strandi98 – 101Combined sources4
Beta strandi103 – 106Combined sources4
Beta strandi108 – 114Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FLEX-ray1.90I61-117[»]
2RELNMR-A61-117[»]
6ATUX-ray2.40A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R61-117[»]
ProteinModelPortaliP19957
SMRiP19957
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19957

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 54SVP-1 clotting 1Add BLAST26
Repeati55 – 72SVP-1 clotting 2Add BLAST18
Domaini69 – 117WAPPROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 722 X tandem repeats of SVP-1 like motifAdd BLAST44

Domaini

Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JDCZ Eukaryota
ENOG410XX92 LUCA
GeneTreeiENSGT00530000064218
HOGENOMiHOG000115819
HOVERGENiHBG018073
InParanoidiP19957
OMAiLIRCAMM
OrthoDBiEOG091G12MK
PhylomeDBiP19957
TreeFamiTF340462

Family and domain databases

Gene3Di4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR002098 SVP_I
IPR019541 Trappin_transglut-bd_rpt
IPR008197 WAP_dom
PfamiView protein in Pfam
PF10511 Cementoin, 2 hits
PF00095 WAP, 1 hit
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
PROSITEiView protein in PROSITE
PS00313 SVP_I, 2 hits
PS51390 WAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASSFLIVV VFLIAGTLVL EAAVTGVPVK GQDTVKGRVP FNGQDPVKGQ
60 70 80 90 100
VSVKGQDKVK AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG
110
IKKCCEGSCG MACFVPQ
Length:117
Mass (Da):12,270
Last modified:December 1, 1992 - v3
Checksum:iA51D46257E5B03EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91 – 92RC → CP AA sequence (PubMed:2039600).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05294717T → M. Corresponds to variant dbSNP:rs17333103Ensembl.1
Natural variantiVAR_02469534T → P. Corresponds to variant dbSNP:rs2664581Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18538 mRNA Translation: CAA79223.1
D13156 Genomic DNA Translation: BAA02441.1
S58717 Genomic DNA Translation: AAB26371.1
L10343 Genomic DNA Translation: AAA36483.1
CR542234 mRNA Translation: CAG47030.1
AL049767 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75873.1
CH471077 Genomic DNA Translation: EAW75874.1
BC010952 mRNA Translation: AAH10952.1
CCDSiCCDS13344.1
PIRiJH0614
RefSeqiNP_002629.1, NM_002638.3
UniGeneiHs.112341

Genome annotation databases

EnsembliENST00000243924; ENSP00000243924; ENSG00000124102
GeneIDi5266
KEGGihsa:5266
UCSCiuc002xng.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiELAF_HUMAN
AccessioniPrimary (citable) accession number: P19957
Secondary accession number(s): E1P618, Q6FG74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 1, 1992
Last modified: April 25, 2018
This is version 179 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health