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Protein

Elafin

Gene

PI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

GO - Molecular functioni

  • endopeptidase inhibitor activity Source: ProtInc
  • serine-type endopeptidase inhibitor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124102-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.
R-HSA-6809371. Formation of the cornified envelope.

Protein family/group databases

MEROPSiI17.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Elafin
Alternative name(s):
Elastase-specific inhibitor
Short name:
ESI
Peptidase inhibitor 3
Short name:
PI-3
Protease inhibitor WAP3
Skin-derived antileukoproteinase
Short name:
SKALP
WAP four-disulfide core domain protein 14
Gene namesi
Name:PI3
Synonyms:WAP3, WFDC14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:8947. PI3.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5266.
OpenTargetsiENSG00000124102.
PharmGKBiPA33283.

Polymorphism and mutation databases

BioMutaiPI3.
DMDMi119262.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
PropeptideiPRO_000004135723 – 602 PublicationsAdd BLAST38
ChainiPRO_000004135861 – 117ElafinAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi76 ↔ 105
Disulfide bondi83 ↔ 109
Disulfide bondi92 ↔ 104
Disulfide bondi98 ↔ 113

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP19957.
PaxDbiP19957.
PeptideAtlasiP19957.
PRIDEiP19957.

PTM databases

iPTMnetiP19957.
PhosphoSitePlusiP19957.

Miscellaneous databases

PMAP-CutDBP19957.

Expressioni

Gene expression databases

BgeeiENSG00000124102.
CleanExiHS_PI3.
GenevisibleiP19957. HS.

Organism-specific databases

HPAiCAB009449.
HPA017737.

Interactioni

Protein-protein interaction databases

BioGridi111284. 3 interactors.
MINTiMINT-1519171.
STRINGi9606.ENSP00000243924.

Structurei

Secondary structure

1117
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi65 – 69Combined sources5
Beta strandi73 – 75Combined sources3
Beta strandi81 – 84Combined sources4
Helixi95 – 97Combined sources3
Beta strandi98 – 101Combined sources4
Beta strandi103 – 106Combined sources4
Beta strandi108 – 114Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FLEX-ray1.90I61-117[»]
2RELNMR-A61-117[»]
ProteinModelPortaliP19957.
SMRiP19957.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19957.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 54SVP-1 clotting 1Add BLAST26
Repeati55 – 72SVP-1 clotting 2Add BLAST18
Domaini69 – 117WAPPROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 722 X tandem repeats of SVP-1 like motifAdd BLAST44

Domaini

Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins.

Sequence similaritiesi

Contains 1 WAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JDCZ. Eukaryota.
ENOG410XX92. LUCA.
GeneTreeiENSGT00530000064218.
HOGENOMiHOG000115819.
HOVERGENiHBG018073.
InParanoidiP19957.
OMAiLIRCAMM.
OrthoDBiEOG091G12MK.
PhylomeDBiP19957.
TreeFamiTF340462.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR002098. SVP_I.
IPR019541. Trappin_transglut-bd_rpt.
IPR008197. WAP_dom.
[Graphical view]
PfamiPF10511. Cementoin. 2 hits.
PF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS00313. SVP_I. 2 hits.
PS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19957-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRASSFLIVV VFLIAGTLVL EAAVTGVPVK GQDTVKGRVP FNGQDPVKGQ
60 70 80 90 100
VSVKGQDKVK AQEPVKGPVS TKPGSCPIIL IRCAMLNPPN RCLKDTDCPG
110
IKKCCEGSCG MACFVPQ
Length:117
Mass (Da):12,270
Last modified:December 1, 1992 - v3
Checksum:iA51D46257E5B03EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91 – 92RC → CP AA sequence (PubMed:2039600).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05294717T → M.Corresponds to variant rs17333103dbSNPEnsembl.1
Natural variantiVAR_02469534T → P.Corresponds to variant rs2664581dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18538 mRNA. Translation: CAA79223.1.
D13156 Genomic DNA. Translation: BAA02441.1.
S58717 Genomic DNA. Translation: AAB26371.1.
L10343 Genomic DNA. Translation: AAA36483.1.
CR542234 mRNA. Translation: CAG47030.1.
AL049767 Genomic DNA. Translation: CAB53524.1.
CH471077 Genomic DNA. Translation: EAW75873.1.
CH471077 Genomic DNA. Translation: EAW75874.1.
BC010952 mRNA. Translation: AAH10952.1.
CCDSiCCDS13344.1.
PIRiJH0614.
RefSeqiNP_002629.1. NM_002638.3.
UniGeneiHs.112341.

Genome annotation databases

EnsembliENST00000243924; ENSP00000243924; ENSG00000124102.
GeneIDi5266.
KEGGihsa:5266.
UCSCiuc002xng.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z18538 mRNA. Translation: CAA79223.1.
D13156 Genomic DNA. Translation: BAA02441.1.
S58717 Genomic DNA. Translation: AAB26371.1.
L10343 Genomic DNA. Translation: AAA36483.1.
CR542234 mRNA. Translation: CAG47030.1.
AL049767 Genomic DNA. Translation: CAB53524.1.
CH471077 Genomic DNA. Translation: EAW75873.1.
CH471077 Genomic DNA. Translation: EAW75874.1.
BC010952 mRNA. Translation: AAH10952.1.
CCDSiCCDS13344.1.
PIRiJH0614.
RefSeqiNP_002629.1. NM_002638.3.
UniGeneiHs.112341.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FLEX-ray1.90I61-117[»]
2RELNMR-A61-117[»]
ProteinModelPortaliP19957.
SMRiP19957.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111284. 3 interactors.
MINTiMINT-1519171.
STRINGi9606.ENSP00000243924.

Protein family/group databases

MEROPSiI17.002.

PTM databases

iPTMnetiP19957.
PhosphoSitePlusiP19957.

Polymorphism and mutation databases

BioMutaiPI3.
DMDMi119262.

Proteomic databases

MaxQBiP19957.
PaxDbiP19957.
PeptideAtlasiP19957.
PRIDEiP19957.

Protocols and materials databases

DNASUi5266.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000243924; ENSP00000243924; ENSG00000124102.
GeneIDi5266.
KEGGihsa:5266.
UCSCiuc002xng.4. human.

Organism-specific databases

CTDi5266.
DisGeNETi5266.
GeneCardsiPI3.
HGNCiHGNC:8947. PI3.
HPAiCAB009449.
HPA017737.
MIMi182257. gene.
neXtProtiNX_P19957.
OpenTargetsiENSG00000124102.
PharmGKBiPA33283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JDCZ. Eukaryota.
ENOG410XX92. LUCA.
GeneTreeiENSGT00530000064218.
HOGENOMiHOG000115819.
HOVERGENiHBG018073.
InParanoidiP19957.
OMAiLIRCAMM.
OrthoDBiEOG091G12MK.
PhylomeDBiP19957.
TreeFamiTF340462.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124102-MONOMER.
ReactomeiR-HSA-6803157. Antimicrobial peptides.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

EvolutionaryTraceiP19957.
GeneWikiiElafin.
GenomeRNAii5266.
PMAP-CutDBP19957.
PROiP19957.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124102.
CleanExiHS_PI3.
GenevisibleiP19957. HS.

Family and domain databases

Gene3Di4.10.75.10. 1 hit.
InterProiIPR002098. SVP_I.
IPR019541. Trappin_transglut-bd_rpt.
IPR008197. WAP_dom.
[Graphical view]
PfamiPF10511. Cementoin. 2 hits.
PF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 1 hit.
PROSITEiPS00313. SVP_I. 2 hits.
PS51390. WAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELAF_HUMAN
AccessioniPrimary (citable) accession number: P19957
Secondary accession number(s): E1P618, Q6FG74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 170 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.