Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S acidic ribosomal protein P0

Gene

Rplp0

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

GO - Molecular functioni

  • peptide binding Source: RGD

GO - Biological processi

  • cellular response to cAMP Source: RGD
  • cellular response to phorbol 13-acetate 12-myristate Source: RGD
  • cellular response to Thyroid stimulating hormone Source: RGD
  • lactation Source: RGD
  • response to selenium ion Source: RGD
  • ribosome biogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P0
Alternative name(s):
60S ribosomal protein L10E
Gene namesi
Name:Rplp0
Synonyms:Arbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi621247. Rplp0.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • membrane Source: RGD
  • nucleus Source: UniProtKB
  • ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 31731760S acidic ribosomal protein P0PRO_0000154761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei304 – 3041PhosphoserineCombined sources
Modified residuei307 – 3071PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19945.
PRIDEiP19945.

PTM databases

iPTMnetiP19945.
PhosphoSiteiP19945.

Expressioni

Gene expression databases

GenevisibleiP19945. RN.

Interactioni

Subunit structurei

P0 forms a pentameric complex by interaction with dimers of P1 and P2. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APEX1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi249011. 2 interactions.
IntActiP19945. 1 interaction.
MINTiMINT-4565744.
STRINGi10116.ENSRNOP00000001518.

Structurei

3D structure databases

ProteinModelPortaliP19945.
SMRiP19945. Positions 261-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L10P family.Curated

Phylogenomic databases

eggNOGiKOG0815. Eukaryota.
COG0244. LUCA.
GeneTreeiENSGT00390000017839.
HOGENOMiHOG000210987.
HOVERGENiHBG000711.
InParanoidiP19945.
KOiK02941.
OMAiIGTNDNP.
OrthoDBiEOG71K63M.
PhylomeDBiP19945.
TreeFamiTF300849.

Family and domain databases

InterProiIPR030670. L10E_eukaryotes.
IPR001790. Ribosomal_L10P.
[Graphical view]
PfamiPF00466. Ribosomal_L10. 1 hit.
[Graphical view]
PIRSFiPIRSF039087. L10E. 1 hit.

Sequencei

Sequence statusi: Complete.

P19945-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREDRATWK SNYFLKIIQL LDDYPKCFIV GADNVGSKQM QQIRMSLRGK
60 70 80 90 100
AVVLMGKNTM MRKAIRGHLE NNPALEKLLP HIRGNVGFVF TKEDLTEIRD
110 120 130 140 150
MLLANKVPAA ARAGAIAPCE VTVPAQNTGL GPEKTSFFQA LGITTKISRG
160 170 180 190 200
TIEILSDVQL IKTGDKVGAS EATLLNMLNI SPFSFGLIIQ QVFDNGSIYS
210 220 230 240 250
PEVLDITEQA LHTRFLEGVR NVASVCLQIG YPTVASVPHS IINGYKRVLA
260 270 280 290 300
LSVETDYTFP LAEKVKAFLA DPSAFAAAAP VAAATTAAPA AAAAPAKVEA
310
KEESEESDED MGFGLFD
Length:317
Mass (Da):34,215
Last modified:February 1, 1995 - v2
Checksum:i7B842971C0E027EC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti281 – 2811V → L in CAA33199 (PubMed:1742361).Curated
Sequence conflicti287 – 2871A → L in CAA33199 (PubMed:1742361).Curated
Sequence conflicti294 – 2941Missing in CAA33199 (PubMed:1742361).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15096 mRNA. Translation: CAA33199.1.
Z29530 mRNA. Translation: CAA82647.1.
BC062028 mRNA. Translation: AAH62028.1.
PIRiS08021. R5RT10.
RefSeqiNP_071797.1. NM_022402.2.
UniGeneiRn.1079.

Genome annotation databases

EnsembliENSRNOT00000001518; ENSRNOP00000001518; ENSRNOG00000001148.
GeneIDi64205.
KEGGirno:64205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15096 mRNA. Translation: CAA33199.1.
Z29530 mRNA. Translation: CAA82647.1.
BC062028 mRNA. Translation: AAH62028.1.
PIRiS08021. R5RT10.
RefSeqiNP_071797.1. NM_022402.2.
UniGeneiRn.1079.

3D structure databases

ProteinModelPortaliP19945.
SMRiP19945. Positions 261-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249011. 2 interactions.
IntActiP19945. 1 interaction.
MINTiMINT-4565744.
STRINGi10116.ENSRNOP00000001518.

PTM databases

iPTMnetiP19945.
PhosphoSiteiP19945.

Proteomic databases

PaxDbiP19945.
PRIDEiP19945.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001518; ENSRNOP00000001518; ENSRNOG00000001148.
GeneIDi64205.
KEGGirno:64205.

Organism-specific databases

CTDi6175.
RGDi621247. Rplp0.

Phylogenomic databases

eggNOGiKOG0815. Eukaryota.
COG0244. LUCA.
GeneTreeiENSGT00390000017839.
HOGENOMiHOG000210987.
HOVERGENiHBG000711.
InParanoidiP19945.
KOiK02941.
OMAiIGTNDNP.
OrthoDBiEOG71K63M.
PhylomeDBiP19945.
TreeFamiTF300849.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP19945.

Gene expression databases

GenevisibleiP19945. RN.

Family and domain databases

InterProiIPR030670. L10E_eukaryotes.
IPR001790. Ribosomal_L10P.
[Graphical view]
PfamiPF00466. Ribosomal_L10. 1 hit.
[Graphical view]
PIRSFiPIRSF039087. L10E. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal proteins P0, P1, and P2 and a proposal for a uniform nomenclature for mammalian and yeast ribosomal proteins."
    Wool I.G., Chan Y.-L., Glueck A., Suzuki K.
    Biochimie 73:861-870(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. Loedemel O., Molven A., Houge G.
    Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Myeloid.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. Lubec G., Diao W.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 17-38; 84-92; 135-146 AND 150-162, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304 AND SER-307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRLA0_RAT
AccessioniPrimary (citable) accession number: P19945
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1995
Last modified: June 8, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.