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Protein

60S acidic ribosomal protein P1

Gene

Rplp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

GO - Biological processi

  • cellular response to cAMP Source: RGD
  • cellular response to Thyroid stimulating hormone Source: RGD
  • cytoplasmic translation Source: GO_Central
  • positive regulation of protein kinase activity Source: GO_Central
  • positive regulation of translation Source: RGD
  • translational elongation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P1
Gene namesi
Name:Rplp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621774. Rplp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001576882 – 11460S acidic ribosomal protein P1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei101PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP19944.
PRIDEiP19944.

PTM databases

iPTMnetiP19944.
PhosphoSitePlusiP19944.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013874.
GenevisibleiP19944. RN.

Interactioni

Subunit structurei

Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi1199657. 1 interactor.
250822. 2 interactors.
IntActiP19944. 1 interactor.
MINTiMINT-4577352.
STRINGi10116.ENSRNOP00000018820.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1762. Eukaryota.
COG2058. LUCA.
GeneTreeiENSGT00550000074698.
HOGENOMiHOG000229898.
HOVERGENiHBG002291.
InParanoidiP19944.
KOiK02942.
OMAiQELLCTY.
OrthoDBiEOG091G17EU.
PhylomeDBiP19944.
TreeFamiTF312932.

Family and domain databases

HAMAPiMF_01478. Ribosomal_L12_arch. 1 hit.
InterProiView protein in InterPro
IPR027534. Ribosomal_L12.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA
60 70 80 90 100
LANVNIGSLI CNVGAGGPAP AAGAAPAGGP APSAAAAPAE EKKVEAKKEE
110
SEESEDDMGF GLFD
Length:114
Mass (Da):11,498
Last modified:February 1, 1991 - v1
Checksum:i27596FB8DCA06D99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15097 mRNA. Translation: CAA33200.1.
BC058151 mRNA. Translation: AAH58151.1.
PIRiS08022. R5RT12.
RefSeqiNP_001007605.1. NM_001007604.2.
XP_003752993.1. XM_003752945.2.
XP_017456174.1. XM_017600685.1.
XP_017456175.1. XM_017600686.1.
UniGeneiRn.156311.
Rn.973.

Genome annotation databases

EnsembliENSRNOT00000018820; ENSRNOP00000018820; ENSRNOG00000013874.
GeneIDi100360522.
140661.
KEGGirno:100360522.
rno:140661.
UCSCiRGD:621774. rat.

Similar proteinsi

Entry informationi

Entry nameiRLA1_RAT
AccessioniPrimary (citable) accession number: P19944
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families