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Protein

60S acidic ribosomal protein P1

Gene

Rplp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

GO - Biological processi

  • cellular response to cAMP Source: RGD
  • cellular response to Thyroid stimulating hormone Source: RGD
  • cytoplasmic translation Source: GO_Central
  • positive regulation of protein kinase activity Source: GO_Central
  • positive regulation of translation Source: RGD
  • translational elongation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P1
Gene namesi
Name:Rplp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi621774. Rplp1.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: RGD
  • preribosome, large subunit precursor Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 11411360S acidic ribosomal protein P1PRO_0000157688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei101 – 1011PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP19944.
PRIDEiP19944.

PTM databases

iPTMnetiP19944.
PhosphoSiteiP19944.

Expressioni

Gene expression databases

GenevisibleiP19944. RN.

Interactioni

Subunit structurei

Heterodimer with RPLP2 at the lateral ribosomal stalk of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi1199657. 1 interaction.
250822. 2 interactions.
MINTiMINT-4577352.
STRINGi10116.ENSRNOP00000018820.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L12P family.Curated

Phylogenomic databases

eggNOGiKOG1762. Eukaryota.
COG2058. LUCA.
GeneTreeiENSGT00550000074698.
HOGENOMiHOG000229898.
HOVERGENiHBG002291.
InParanoidiP19944.
KOiK02942.
OMAiTSELACI.
OrthoDBiEOG7M0NVC.
PhylomeDBiP19944.
TreeFamiTF312932.

Family and domain databases

HAMAPiMF_01478. Ribosomal_L12_arch.
InterProiIPR027534. Ribosomal_L12.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA
60 70 80 90 100
LANVNIGSLI CNVGAGGPAP AAGAAPAGGP APSAAAAPAE EKKVEAKKEE
110
SEESEDDMGF GLFD
Length:114
Mass (Da):11,498
Last modified:February 1, 1991 - v1
Checksum:i27596FB8DCA06D99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15097 mRNA. Translation: CAA33200.1.
BC058151 mRNA. Translation: AAH58151.1.
PIRiS08022. R5RT12.
RefSeqiNP_001007605.1. NM_001007604.2.
XP_003752993.1. XM_003752945.2.
UniGeneiRn.973.

Genome annotation databases

EnsembliENSRNOT00000018820; ENSRNOP00000018820; ENSRNOG00000013874.
GeneIDi100360522.
140661.
KEGGirno:100360522.
rno:140661.
UCSCiRGD:621774. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15097 mRNA. Translation: CAA33200.1.
BC058151 mRNA. Translation: AAH58151.1.
PIRiS08022. R5RT12.
RefSeqiNP_001007605.1. NM_001007604.2.
XP_003752993.1. XM_003752945.2.
UniGeneiRn.973.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1199657. 1 interaction.
250822. 2 interactions.
MINTiMINT-4577352.
STRINGi10116.ENSRNOP00000018820.

PTM databases

iPTMnetiP19944.
PhosphoSiteiP19944.

Proteomic databases

PaxDbiP19944.
PRIDEiP19944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018820; ENSRNOP00000018820; ENSRNOG00000013874.
GeneIDi100360522.
140661.
KEGGirno:100360522.
rno:140661.
UCSCiRGD:621774. rat.

Organism-specific databases

CTDi6176.
RGDi621774. Rplp1.

Phylogenomic databases

eggNOGiKOG1762. Eukaryota.
COG2058. LUCA.
GeneTreeiENSGT00550000074698.
HOGENOMiHOG000229898.
HOVERGENiHBG002291.
InParanoidiP19944.
KOiK02942.
OMAiTSELACI.
OrthoDBiEOG7M0NVC.
PhylomeDBiP19944.
TreeFamiTF312932.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP19944.

Gene expression databases

GenevisibleiP19944. RN.

Family and domain databases

HAMAPiMF_01478. Ribosomal_L12_arch.
InterProiIPR027534. Ribosomal_L12.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal proteins P0, P1, and P2 and a proposal for a uniform nomenclature for mammalian and yeast ribosomal proteins."
    Wool I.G., Chan Y.-L., Glueck A., Suzuki K.
    Biochimie 73:861-870(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiRLA1_RAT
AccessioniPrimary (citable) accession number: P19944
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 6, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.