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Protein

Apolipoprotein C-I

Gene

Apoc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.By similarity

GO - Biological processi

  • lipid transport Source: UniProtKB-KW
  • lipoprotein metabolic process Source: RGD
  • regulation of lipid transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-I
Short name:
Apo-CI
Short name:
ApoC-I
Alternative name(s):
Apolipoprotein C1
Liver regeneration-related protein LRRG04
Cleaved into the following chain:
Gene namesi
Name:Apoc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2134. Apoc1.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

  • high-density lipoprotein particle Source: RGD
  • very-low-density lipoprotein particle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 8862Apolipoprotein C-IPRO_0000002018Add
BLAST
Chaini29 – 8860Truncated apolipoprotein C-IBy similarityPRO_0000391846Add
BLAST

Proteomic databases

PaxDbiP19939.
PRIDEiP19939.

PTM databases

iPTMnetiP19939.
PhosphoSiteiP19939.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018426.
GenevisibleiP19939. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040585.

Structurei

3D structure databases

ProteinModelPortaliP19939.
SMRiP19939. Positions 28-84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7EM. Eukaryota.
ENOG410ZDUT. LUCA.
GeneTreeiENSGT00390000011584.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP19939.
OMAiTWITENI.
PhylomeDBiP19939.
TreeFamiTF330940.

Family and domain databases

InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFIALPVL IVVVAMALEG PAPAQAAPDF SSAMESLPDK LKEFGNTLED
60 70 80
KARAAIEHIK QKEIMIKTRN WFSETLNKMK EKLKTTFA
Length:88
Mass (Da):9,861
Last modified:February 1, 1991 - v1
Checksum:i4A4D70D836B30EE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15512 mRNA. Translation: CAA33536.1.
AY327505 mRNA. Translation: AAP97737.1.
BC098670 mRNA. Translation: AAH98670.1.
PIRiS05307.
RefSeqiNP_001103466.1. NM_001109996.1.
NP_036956.1. NM_012824.2.
UniGeneiRn.8887.

Genome annotation databases

EnsembliENSRNOT00000046169; ENSRNOP00000040585; ENSRNOG00000018426.
ENSRNOT00000091647; ENSRNOP00000068542; ENSRNOG00000018426.
GeneIDi25292.
KEGGirno:25292.
UCSCiRGD:2134. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15512 mRNA. Translation: CAA33536.1.
AY327505 mRNA. Translation: AAP97737.1.
BC098670 mRNA. Translation: AAH98670.1.
PIRiS05307.
RefSeqiNP_001103466.1. NM_001109996.1.
NP_036956.1. NM_012824.2.
UniGeneiRn.8887.

3D structure databases

ProteinModelPortaliP19939.
SMRiP19939. Positions 28-84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040585.

PTM databases

iPTMnetiP19939.
PhosphoSiteiP19939.

Proteomic databases

PaxDbiP19939.
PRIDEiP19939.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046169; ENSRNOP00000040585; ENSRNOG00000018426.
ENSRNOT00000091647; ENSRNOP00000068542; ENSRNOG00000018426.
GeneIDi25292.
KEGGirno:25292.
UCSCiRGD:2134. rat.

Organism-specific databases

CTDi341.
RGDi2134. Apoc1.

Phylogenomic databases

eggNOGiENOG410J7EM. Eukaryota.
ENOG410ZDUT. LUCA.
GeneTreeiENSGT00390000011584.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP19939.
OMAiTWITENI.
PhylomeDBiP19939.
TreeFamiTF330940.

Miscellaneous databases

PROiP19939.

Gene expression databases

BgeeiENSRNOG00000018426.
GenevisibleiP19939. RN.

Family and domain databases

InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOC1_RAT
AccessioniPrimary (citable) accession number: P19939
Secondary accession number(s): Q53ZD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.