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Protein

Apolipoprotein C-I

Gene

Apoc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.By similarity

GO - Biological processi

  • lipid transport Source: UniProtKB-KW
  • lipoprotein metabolic process Source: RGD
  • regulation of lipid transport Source: RGD

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-8866423 VLDL assembly
R-RNO-8964046 VLDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-I
Short name:
Apo-CI
Short name:
ApoC-I
Alternative name(s):
Apolipoprotein C1
Liver regeneration-related protein LRRG04
Cleaved into the following chain:
Gene namesi
Name:Apoc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2134 Apoc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000000201827 – 88Apolipoprotein C-IAdd BLAST62
ChainiPRO_000039184629 – 88Truncated apolipoprotein C-IBy similarityAdd BLAST60

Proteomic databases

PaxDbiP19939
PRIDEiP19939

PTM databases

iPTMnetiP19939
PhosphoSitePlusiP19939

Expressioni

Gene expression databases

BgeeiENSRNOG00000018426
GenevisibleiP19939 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040585

Structurei

3D structure databases

ProteinModelPortaliP19939
SMRiP19939
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7EM Eukaryota
ENOG410ZDUT LUCA
GeneTreeiENSGT00390000011584
HOGENOMiHOG000034001
HOVERGENiHBG050547
InParanoidiP19939
KOiK22286
OMAiELPAKMW
PhylomeDBiP19939
TreeFamiTF330940

Family and domain databases

InterProiView protein in InterPro
IPR006781 ApoC-I
PANTHERiPTHR16565 PTHR16565, 1 hit
PfamiView protein in Pfam
PF04691 ApoC-I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFIALPVL IVVVAMALEG PAPAQAAPDF SSAMESLPDK LKEFGNTLED
60 70 80
KARAAIEHIK QKEIMIKTRN WFSETLNKMK EKLKTTFA
Length:88
Mass (Da):9,861
Last modified:February 1, 1991 - v1
Checksum:i4A4D70D836B30EE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15512 mRNA Translation: CAA33536.1
AY327505 mRNA Translation: AAP97737.1
BC098670 mRNA Translation: AAH98670.1
PIRiS05307
RefSeqiNP_001103466.1, NM_001109996.1
NP_036956.1, NM_012824.2
XP_017443603.1, XM_017588114.1
XP_017445495.1, XM_017590006.1
UniGeneiRn.8887

Genome annotation databases

EnsembliENSRNOT00000046169; ENSRNOP00000040585; ENSRNOG00000018426
ENSRNOT00000091647; ENSRNOP00000068542; ENSRNOG00000018426
GeneIDi108348160
25292
KEGGirno:108348160
rno:25292
UCSCiRGD:2134 rat

Similar proteinsi

Entry informationi

Entry nameiAPOC1_RAT
AccessioniPrimary (citable) accession number: P19939
Secondary accession number(s): Q53ZD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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