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Protein

Hydrogenase 1 maturation protease

Gene

hyaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19NickelBy similarity1
Metal bindingi65NickelBy similarity1
Metal bindingi96NickelBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: GO_Central
  • protein processing Source: EcoCyc

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease
LigandMetal-binding, Nickel

Enzyme and pathway databases

BioCyciEcoCyc:EG10471-MONOMER

Protein family/group databases

MEROPSiA31.002

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase 1 maturation protease (EC:3.4.23.-)
Gene namesi
Name:hyaD
Ordered Locus Names:b0975, JW0957
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10471 hyaD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002019421 – 195Hydrogenase 1 maturation proteaseAdd BLAST195

Proteomic databases

PaxDbiP19930
PRIDEiP19930

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi4260045, 21 interactors
DIPiDIP-9960N
IntActiP19930, 22 interactors
STRINGi316385.ECDH10B_1045

Structurei

3D structure databases

ProteinModelPortaliP19930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A31 family.Curated

Phylogenomic databases

eggNOGiENOG4108USZ Bacteria
COG0680 LUCA
HOGENOMiHOG000278719
InParanoidiP19930
KOiK03605
OMAiMGAKKMS
PhylomeDBiP19930

Family and domain databases

Gene3Di3.40.50.1450, 1 hit
InterProiView protein in InterPro
IPR004419 Pept_A31_hyd_express
IPR023430 Pept_HybD-like_dom_sf
IPR000671 Peptidase_A31
PANTHERiPTHR30302 PTHR30302, 1 hit
PfamiView protein in Pfam
PF01750 HycI, 1 hit
PRINTSiPR00446 HYDRGNUPTAKE
SUPFAMiSSF53163 SSF53163, 1 hit
TIGRFAMsiTIGR00140 hupD, 1 hit
TIGR00072 hydrog_prot, 1 hit

Sequencei

Sequence statusi: Complete.

P19930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQRVVVMG LGNLLWADEG FGVRVAERLY AHYHWPEYVE IVDGGTQGLN
60 70 80 90 100
LLGYVESASH LLILDAIDYG LEPGTLRTYA GERIPAYLSA KKMSLHQNSF
110 120 130 140 150
SEVLALADIR GHLPAHIALV GLQPAMLDDY GGSLSELARE QLPAAEQAAL
160 170 180 190
AQLAAWGIVP QPANESRCLN YDCLSMENYE GVRLRQYRMT QEEQG
Length:195
Mass (Da):21,546
Last modified:February 1, 1991 - v1
Checksum:i119B3BAB53A9186F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34825 Genomic DNA Translation: AAA24000.1
U00096 Genomic DNA Translation: AAC74060.1
AP009048 Genomic DNA Translation: BAA35740.1
PIRiJV0075 QQECHD
RefSeqiNP_415494.1, NC_000913.3
WP_000003671.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74060; AAC74060; b0975
BAA35740; BAA35740; BAA35740
GeneIDi945575
KEGGiecj:JW0957
eco:b0975
PATRICifig|1411691.4.peg.1299

Similar proteinsi

Entry informationi

Entry nameiHYAD_ECOLI
AccessioniPrimary (citable) accession number: P19930
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: March 28, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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