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Protein

Hydrogenase 1 maturation protease

Gene

hyaD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protease involved in the C-terminal processing of HyaB, the large subunit of hydrogenase 1.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191NickelBy similarity
Metal bindingi65 – 651NickelBy similarity
Metal bindingi96 – 961NickelBy similarity

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: GO_Central
  • protein processing Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Keywords - Ligandi

Metal-binding, Nickel

Enzyme and pathway databases

BioCyciEcoCyc:EG10471-MONOMER.
ECOL316407:JW0957-MONOMER.

Protein family/group databases

MEROPSiA31.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrogenase 1 maturation protease (EC:3.4.23.-)
Gene namesi
Name:hyaD
Ordered Locus Names:b0975, JW0957
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10471. hyaD.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Hydrogenase 1 maturation proteasePRO_0000201942Add
BLAST

Proteomic databases

PaxDbiP19930.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hyaBP0ACD83EBI-552940,EBI-851493

Protein-protein interaction databases

BioGridi4260045. 8 interactions.
DIPiDIP-9960N.
IntActiP19930. 22 interactions.
MINTiMINT-1321337.
STRINGi511145.b0975.

Structurei

3D structure databases

ProteinModelPortaliP19930.
SMRiP19930. Positions 5-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A31 family.Curated

Phylogenomic databases

eggNOGiENOG4108USZ. Bacteria.
COG0680. LUCA.
HOGENOMiHOG000278719.
InParanoidiP19930.
KOiK03605.
OMAiHQTGFQD.
PhylomeDBiP19930.

Family and domain databases

Gene3Di3.40.50.1450. 1 hit.
InterProiIPR004419. Pept_A31_hyd_express.
IPR023430. Pept_HybD-like_dom.
IPR000671. Peptidase_A31.
[Graphical view]
PfamiPF01750. HycI. 1 hit.
[Graphical view]
PRINTSiPR00446. HYDRGNUPTAKE.
SUPFAMiSSF53163. SSF53163. 1 hit.
TIGRFAMsiTIGR00140. hupD. 1 hit.
TIGR00072. hydrog_prot. 1 hit.

Sequencei

Sequence statusi: Complete.

P19930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQRVVVMG LGNLLWADEG FGVRVAERLY AHYHWPEYVE IVDGGTQGLN
60 70 80 90 100
LLGYVESASH LLILDAIDYG LEPGTLRTYA GERIPAYLSA KKMSLHQNSF
110 120 130 140 150
SEVLALADIR GHLPAHIALV GLQPAMLDDY GGSLSELARE QLPAAEQAAL
160 170 180 190
AQLAAWGIVP QPANESRCLN YDCLSMENYE GVRLRQYRMT QEEQG
Length:195
Mass (Da):21,546
Last modified:February 1, 1991 - v1
Checksum:i119B3BAB53A9186F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34825 Genomic DNA. Translation: AAA24000.1.
U00096 Genomic DNA. Translation: AAC74060.1.
AP009048 Genomic DNA. Translation: BAA35740.1.
PIRiJV0075. QQECHD.
RefSeqiNP_415494.1. NC_000913.3.
WP_000003671.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74060; AAC74060; b0975.
BAA35740; BAA35740; BAA35740.
GeneIDi945575.
KEGGiecj:JW0957.
eco:b0975.
PATRICi32117171. VBIEscCol129921_1009.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34825 Genomic DNA. Translation: AAA24000.1.
U00096 Genomic DNA. Translation: AAC74060.1.
AP009048 Genomic DNA. Translation: BAA35740.1.
PIRiJV0075. QQECHD.
RefSeqiNP_415494.1. NC_000913.3.
WP_000003671.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP19930.
SMRiP19930. Positions 5-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260045. 8 interactions.
DIPiDIP-9960N.
IntActiP19930. 22 interactions.
MINTiMINT-1321337.
STRINGi511145.b0975.

Protein family/group databases

MEROPSiA31.002.

Proteomic databases

PaxDbiP19930.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74060; AAC74060; b0975.
BAA35740; BAA35740; BAA35740.
GeneIDi945575.
KEGGiecj:JW0957.
eco:b0975.
PATRICi32117171. VBIEscCol129921_1009.

Organism-specific databases

EchoBASEiEB0466.
EcoGeneiEG10471. hyaD.

Phylogenomic databases

eggNOGiENOG4108USZ. Bacteria.
COG0680. LUCA.
HOGENOMiHOG000278719.
InParanoidiP19930.
KOiK03605.
OMAiHQTGFQD.
PhylomeDBiP19930.

Enzyme and pathway databases

BioCyciEcoCyc:EG10471-MONOMER.
ECOL316407:JW0957-MONOMER.

Miscellaneous databases

PROiP19930.

Family and domain databases

Gene3Di3.40.50.1450. 1 hit.
InterProiIPR004419. Pept_A31_hyd_express.
IPR023430. Pept_HybD-like_dom.
IPR000671. Peptidase_A31.
[Graphical view]
PfamiPF01750. HycI. 1 hit.
[Graphical view]
PRINTSiPR00446. HYDRGNUPTAKE.
SUPFAMiSSF53163. SSF53163. 1 hit.
TIGRFAMsiTIGR00140. hupD. 1 hit.
TIGR00072. hydrog_prot. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHYAD_ECOLI
AccessioniPrimary (citable) accession number: P19930
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.