P19923 (KPPR2_CUPNH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribulokinase, chromosomal
Short name=PRK
Short name=PRKase
EC=2.7.1.19

Alternative name(s):
Phosphopentokinase

Gene names

Name:	cfxP
Ordered Locus Names:	H16_B1389

Organism

Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) [Complete proteome] [HAMAP]

Taxonomic identifier

381666 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus › Cupriavidus necator

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate.
Pathway	Carbohydrate biosynthesis; Calvin cycle.
Subunit structure	Homooctamer.
Sequence similarities	Belongs to the phosphoribulokinase family.

Ontologies

Keywords
Biological process	Calvin cycle
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological_process	reductive pentose-phosphate cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribulokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.3
	Chain	2 – 292	291	Phosphoribulokinase, chromosomal		PRO_0000201951
Regions
	Nucleotide binding	12 – 20	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P19923 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 7707185622E4ED5A	FASTA	292	33,316
	10 20 30 40 50 60 MSERYPIIAI TGSSGAGTTS VTRTFENIFR REGVKSVVIE GDSFHRYDRA EMKVKMAEAE 70 80 90 100 110 120 RTGNMNFSHF GEENNLFGEL ENLFRSYAET GTGMHRHYLH SPEEAAPFGQ EPGTFTQWEP 130 140 150 160 170 180 LPADTDLLFY EGLHGGVVTD SVNVAQYPNL LIGVVPVINL EWIQKLWRDK KQRGYSTEAV 190 200 210 220 230 240 TDTILRRMPD YVNYICPQFS RTHVNFQRVP CVDTSNPFIS REIPAPDESM VVIRFANPKG 250 260 270 280 290 IDFQYLLSMI HDSFMSRANT IVVPGGKMEL AMQLIFTPFV LRMMERRKRA AQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of the chromosomal and plasmid genes encoding phosphoribulokinase from Alcaligenes eutrophus." Kossmann J., Klintworth R., Bowien B. Gene 85:247-252(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia eutropha H16." Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R., Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I., Gottschalk G., Steinbuechel A., Friedrich B., Bowien B. Nat. Biotechnol. 24:1257-1262(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17699 / H16 / DSM 428 / Stanier 337.
[3]	"Chromosomal and plasmid locations for phosphoribulokinase genes in Alcaligenes eutrophus." Klintworth R., Husemann M., Salnikow J., Bowien B. J. Bacteriol. 164:954-956(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-18.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M33563 Genomic DNA. Translation: AAA21959.1. AM260480 Genomic DNA. Translation: CAJ96178.1.
PIR	JQ0399.
RefSeq	YP_840908.1. NC_008314.1.
3D structure databases
ProteinModelPortal	P19923.
SMR	P19923. Positions 2-288.
ModBase	Search...
Protein-protein interaction databases
STRING	381666.H16_B1389.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAJ96178; CAJ96178; H16_B1389.
GeneID	4456348.
KEGG	reh:H16_B1389.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3954.
HOGENOM	HOG000272991.
KO	K00855.
ProtClustDB	PRK15453.
Enzyme and pathway databases
BioCyc	CNEC381666:GJUJ-5094-MONOMER.
UniPathway	UPA00116.
Family and domain databases
InterPro	IPR006082. PRK. IPR006083. PRK/URK. [Graphical view]
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00478. PHRIBLKINASE.
PROSITE	PS00567. PHOSPHORIBULOKINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPPR2_CUPNH

Accession

Primary (citable) accession number: P19923
Secondary accession number(s): Q0K1E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 81 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program