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Protein

Carbon monoxide dehydrogenase small chain

Gene

coxS

Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of carbon monoxide to carbon dioxide.2 Publications

Catalytic activityi

CO + a quinone + H2O = CO2 + a quinol.2 Publications

Cofactori

[2Fe-2S] cluster2 PublicationsNote: Binds 2 [2Fe-2S] clusters.2 Publications

Kineticsi

  1. KM=16.4 µM for 1,4-benzoquinone1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Metal bindingi42Iron-sulfur 1 (2Fe-2S)2 Publications1
    Metal bindingi47Iron-sulfur 1 (2Fe-2S)2 Publications1
    Metal bindingi50Iron-sulfur 1 (2Fe-2S)2 Publications1
    Metal bindingi62Iron-sulfur 1 (2Fe-2S)2 Publications1
    Metal bindingi102Iron-sulfur 2 (2Fe-2S)2 Publications1
    Metal bindingi105Iron-sulfur 2 (2Fe-2S)2 Publications1
    Metal bindingi137Iron-sulfur 2 (2Fe-2S)2 Publications1
    Metal bindingi139Iron-sulfur 2 (2Fe-2S)2 Publications1

    GO - Molecular functioni

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-19676.
    BRENDAi1.2.99.2. 4399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbon monoxide dehydrogenase small chain (EC:1.2.5.32 Publications)
    Short name:
    CO dehydrogenase subunit S
    Short name:
    CO-DH S
    Gene namesi
    Name:coxS
    Ordered Locus Names:OCA5_pHCG300300
    Encoded oniPlasmid megaplasmid pHCG30 Publication
    OrganismiOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
    Taxonomic identifieri504832 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
    Proteomesi
    • UP000007730 Componenti: Plasmid pHCG3

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000798171 – 166Carbon monoxide dehydrogenase small chainAdd BLAST166

    Interactioni

    Subunit structurei

    Dimer of heterotrimers. Each heterotrimer consists of a large, a medium and a small subunit.1 Publication

    Chemistry databases

    BindingDBiP19921.

    Structurei

    Secondary structure

    1166
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Beta strandi4 – 10Combined sources7
    Beta strandi13 – 19Combined sources7
    Helixi25 – 31Combined sources7
    Beta strandi43 – 45Combined sources3
    Beta strandi51 – 54Combined sources4
    Beta strandi57 – 60Combined sources4
    Helixi61 – 63Combined sources3
    Helixi66 – 69Combined sources4
    Beta strandi73 – 75Combined sources3
    Helixi77 – 79Combined sources3
    Helixi89 – 96Combined sources8
    Helixi106 – 119Combined sources14
    Helixi125 – 131Combined sources7
    Turni132 – 134Combined sources3
    Beta strandi138 – 140Combined sources3
    Helixi143 – 157Combined sources15

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1N5WX-ray1.50A/D1-166[»]
    1N60X-ray1.19A/D1-166[»]
    1N61X-ray1.30A/D1-166[»]
    1N62X-ray1.09A/D1-166[»]
    1N63X-ray1.21A/D1-166[»]
    1ZXIX-ray1.70A/D1-166[»]
    ProteinModelPortaliP19921.
    SMRiP19921.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP19921.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini4 – 802Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST77

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK03518.
    OMAiCTPGMIT.

    Family and domain databases

    CDDicd00207. fer2. 1 hit.
    Gene3Di1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    InterProiIPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    [Graphical view]
    PfamiPF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P19921-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MAKAHIELTI NGHPVEALVE PRTLLIHFIR EQQNLTGAHI GCDTSHCGAC
    60 70 80 90 100
    TVDLDGMSVK SCTMFAVQAN GASITTIEGM AAPDGTLSAL QEGFRMMHGL
    110 120 130 140 150
    QCGYCTPGMI MRSHRLLQEN PSPTEAEIRF GIGGNLCRCT GYQNIVKAIQ
    160
    YAAAKINGVP FEEAAE
    Length:166
    Mass (Da):17,792
    Last modified:July 26, 2002 - v2
    Checksum:iE63AD31D726D22C1
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP002827 Genomic DNA. Translation: AEI08105.1.
    PIRiB56279.
    RefSeqiWP_013913729.1. NC_015689.1.

    Genome annotation databases

    EnsemblBacteriaiAEI08105; AEI08105; OCA5_pHCG300300.
    KEGGiocg:OCA5_pHCG300300.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP002827 Genomic DNA. Translation: AEI08105.1.
    PIRiB56279.
    RefSeqiWP_013913729.1. NC_015689.1.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1N5WX-ray1.50A/D1-166[»]
    1N60X-ray1.19A/D1-166[»]
    1N61X-ray1.30A/D1-166[»]
    1N62X-ray1.09A/D1-166[»]
    1N63X-ray1.21A/D1-166[»]
    1ZXIX-ray1.70A/D1-166[»]
    ProteinModelPortaliP19921.
    SMRiP19921.
    ModBaseiSearch...
    MobiDBiSearch...

    Chemistry databases

    BindingDBiP19921.

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAEI08105; AEI08105; OCA5_pHCG300300.
    KEGGiocg:OCA5_pHCG300300.

    Phylogenomic databases

    KOiK03518.
    OMAiCTPGMIT.

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-19676.
    BRENDAi1.2.99.2. 4399.

    Miscellaneous databases

    EvolutionaryTraceiP19921.

    Family and domain databases

    CDDicd00207. fer2. 1 hit.
    Gene3Di1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    InterProiIPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR012675. Beta-grasp_dom.
    [Graphical view]
    PfamiPF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Entry informationi

    Entry nameiDCMS_OLICO
    AccessioniPrimary (citable) accession number: P19921
    Secondary accession number(s): F8C0Z5, Q51324
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 26, 2002
    Last modified: November 2, 2016
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Plasmid, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.