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Protein

Carbon monoxide dehydrogenase large chain

Gene

coxL

Organism
Oligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of carbon monoxide to carbon dioxide.2 Publications

Catalytic activityi

CO + a quinone + H2O = CO2 + a quinol.2 Publications

Cofactori

Protein has several cofactor binding sites:

Kineticsi

  1. KM=16.4 µM for 1,4-benzoquinone1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi388 – 3881Copper1 Publication
    Metal bindingi763 – 7631Molybdenum2 Publications

    GO - Molecular functioni

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Copper, Metal-binding, Molybdenum

    Enzyme and pathway databases

    BioCyciOCAR504832:GJPZ-3598-MONOMER.
    BRENDAi1.2.99.2. 4399.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbon monoxide dehydrogenase large chain (EC:1.2.5.32 Publications)
    Short name:
    CO dehydrogenase subunit L
    Short name:
    CO-DH L
    Gene namesi
    Name:coxL
    Ordered Locus Names:OCA5_pHCG300310
    Encoded oniPlasmid megaplasmid pHCG30 Publication
    OrganismiOligotropha carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5)
    Taxonomic identifieri504832 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeOligotropha
    Proteomesi
    • UP000007730 Componenti: Plasmid pHCG3

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 809809Carbon monoxide dehydrogenase large chainPRO_0000079810Add
    BLAST

    Interactioni

    Subunit structurei

    Dimer of heterotrimers. Each heterotrimer consists of a large, a medium and a small subunit.1 Publication

    Structurei

    Secondary structure

    1
    809
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 188Combined sources
    Helixi30 – 334Combined sources
    Turni34 – 363Combined sources
    Helixi41 – 433Combined sources
    Beta strandi50 – 567Combined sources
    Beta strandi60 – 689Combined sources
    Helixi70 – 745Combined sources
    Beta strandi78 – 836Combined sources
    Helixi84 – 874Combined sources
    Helixi88 – 903Combined sources
    Beta strandi93 – 964Combined sources
    Beta strandi100 – 1067Combined sources
    Beta strandi108 – 1114Combined sources
    Beta strandi117 – 1259Combined sources
    Helixi126 – 13510Combined sources
    Beta strandi137 – 1426Combined sources
    Helixi149 – 1513Combined sources
    Helixi162 – 1643Combined sources
    Beta strandi180 – 1878Combined sources
    Helixi189 – 19810Combined sources
    Beta strandi200 – 20910Combined sources
    Beta strandi221 – 2277Combined sources
    Turni228 – 2314Combined sources
    Beta strandi232 – 2376Combined sources
    Helixi242 – 25312Combined sources
    Helixi257 – 2593Combined sources
    Beta strandi260 – 2634Combined sources
    Turni271 – 2744Combined sources
    Helixi279 – 29113Combined sources
    Beta strandi295 – 2984Combined sources
    Helixi301 – 3077Combined sources
    Beta strandi314 – 3229Combined sources
    Beta strandi328 – 33811Combined sources
    Turni352 – 3554Combined sources
    Helixi356 – 3583Combined sources
    Turni359 – 3624Combined sources
    Beta strandi368 – 3758Combined sources
    Beta strandi382 – 3843Combined sources
    Turni389 – 3913Combined sources
    Helixi392 – 41019Combined sources
    Helixi414 – 4218Combined sources
    Helixi425 – 4273Combined sources
    Beta strandi429 – 4313Combined sources
    Helixi443 – 45412Combined sources
    Helixi456 – 47116Combined sources
    Beta strandi476 – 48712Combined sources
    Turni495 – 4973Combined sources
    Beta strandi507 – 5137Combined sources
    Beta strandi519 – 5246Combined sources
    Beta strandi528 – 5303Combined sources
    Helixi532 – 54413Combined sources
    Helixi548 – 5503Combined sources
    Beta strandi551 – 5544Combined sources
    Turni558 – 5603Combined sources
    Turni572 – 5754Combined sources
    Helixi576 – 59924Combined sources
    Helixi603 – 6053Combined sources
    Beta strandi606 – 6083Combined sources
    Beta strandi610 – 6156Combined sources
    Beta strandi618 – 6247Combined sources
    Helixi625 – 63410Combined sources
    Beta strandi642 – 6509Combined sources
    Beta strandi659 – 66911Combined sources
    Turni670 – 6723Combined sources
    Beta strandi675 – 68511Combined sources
    Helixi692 – 71120Combined sources
    Beta strandi723 – 7253Combined sources
    Turni728 – 7303Combined sources
    Turni736 – 7383Combined sources
    Beta strandi743 – 7464Combined sources
    Helixi764 – 78219Combined sources
    Turni783 – 7853Combined sources
    Helixi795 – 80410Combined sources
    Turni805 – 8084Combined sources

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1N5WX-ray1.50B/E1-809[»]
    1N60X-ray1.19B/E1-809[»]
    1N61X-ray1.30B/E1-809[»]
    1N62X-ray1.09B/E1-809[»]
    1N63X-ray1.21B/E1-809[»]
    1ZXIX-ray1.70B/E1-809[»]
    ProteinModelPortaliP19919.
    SMRiP19919. Positions 5-809.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP19919.

    Family & Domainsi

    Phylogenomic databases

    KOiK03520.
    OMAiPYPEDYI.

    Family and domain databases

    Gene3Di3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    IPR012780. CO_Mo_DH_lsu.
    [Graphical view]
    PfamiPF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view]
    SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.
    TIGRFAMsiTIGR02416. CO_dehy_Mo_lg. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P19919-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MNIQTTVEPT SAERAEKLQG MGCKRKRVED IRFTQGKGNY VDDVKLPGML
    60 70 80 90 100
    FGDFVRSSHA HARIKSIDTS KAKALPGVFA VLTAADLKPL NLHYMPTLAG
    110 120 130 140 150
    DVQAVLADEK VLFQNQEVAF VVAKDRYVAA DAIELVEVDY EPLPVLVDPF
    160 170 180 190 200
    KAMEPDAPLL REDIKDKMTG AHGARKHHNH IFRWEIGDKE GTDATFAKAE
    210 220 230 240 250
    VVSKDMFTYH RVHPSPLETC QCVASMDKIK GELTLWGTFQ APHVIRTVVS
    260 270 280 290 300
    LISGLPEHKI HVIAPDIGGG FGNKVGAYSG YVCAVVASIV LGVPVKWVED
    310 320 330 340 350
    RMENLSTTSF ARDYHMTTEL AATKDGKILA MRCHVLADHG AFDACADPSK
    360 370 380 390 400
    WPAGFMNICT GSYDMPVAHL AVDGVYTNKA SGGVAYRCSF RVTEAVYAIE
    410 420 430 440 450
    RAIETLAQRL EMDSADLRIK NFIQPEQFPY MAPLGWEYDS GNYPLAMKKA
    460 470 480 490 500
    MDTVGYHQLR AEQKAKQEAF KRGETREIMG IGISFFTEIV GAGPSKNCDI
    510 520 530 540 550
    LGVSMFDSAE IRIHPTGSVI ARMGTKSQGQ GHETTYAQII ATELGIPADD
    560 570 580 590 600
    IMIEEGNTDT APYGLGTYGS RSTPTAGAAT AVAARKIKAK AQMIAAHMLE
    610 620 630 640 650
    VHEGDLEWDV DRFRVKGLPE KFKTMKELAW ASYNSPPPNL EPGLEAVNYY
    660 670 680 690 700
    DPPNMTYPFG AYFCIMDIDV DTGVAKTRRF YALDDCGTRI NPMIIEGQVH
    710 720 730 740 750
    GGLTEAFAVA MGQEIRYDEQ GNVLGASFMD FFLPTAVETP KWETDYTVTP
    760 770 780 790 800
    SPHHPIGAKG VGESPHVGGV PCFSNAVNDA YAFLNAGHIQ MPHDAWRLWK

    VGEQLGLHV
    Length:809
    Mass (Da):88,739
    Last modified:July 11, 2002 - v2
    Checksum:i7F2F3D0EC996BDBD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61Missing AA sequence (PubMed:2818128).Curated
    Sequence conflicti11 – 122SA → AG AA sequence (PubMed:2818128).Curated

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP002827 Genomic DNA. Translation: AEI08106.1.
    PIRiC56279.
    RefSeqiWP_013913730.1. NC_015689.1.

    Genome annotation databases

    EnsemblBacteriaiAEI08106; AEI08106; OCA5_pHCG300310.
    KEGGiocg:OCA5_pHCG300310.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP002827 Genomic DNA. Translation: AEI08106.1.
    PIRiC56279.
    RefSeqiWP_013913730.1. NC_015689.1.

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1N5WX-ray1.50B/E1-809[»]
    1N60X-ray1.19B/E1-809[»]
    1N61X-ray1.30B/E1-809[»]
    1N62X-ray1.09B/E1-809[»]
    1N63X-ray1.21B/E1-809[»]
    1ZXIX-ray1.70B/E1-809[»]
    ProteinModelPortaliP19919.
    SMRiP19919. Positions 5-809.
    ModBaseiSearch...
    MobiDBiSearch...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblBacteriaiAEI08106; AEI08106; OCA5_pHCG300310.
    KEGGiocg:OCA5_pHCG300310.

    Phylogenomic databases

    KOiK03520.
    OMAiPYPEDYI.

    Enzyme and pathway databases

    BioCyciOCAR504832:GJPZ-3598-MONOMER.
    BRENDAi1.2.99.2. 4399.

    Miscellaneous databases

    EvolutionaryTraceiP19919.

    Family and domain databases

    Gene3Di3.30.365.10. 6 hits.
    3.90.1170.50. 1 hit.
    InterProiIPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    IPR012780. CO_Mo_DH_lsu.
    [Graphical view]
    PfamiPF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    [Graphical view]
    SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54665. SSF54665. 1 hit.
    SSF56003. SSF56003. 1 hit.
    TIGRFAMsiTIGR02416. CO_dehy_Mo_lg. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiDCML_OLICO
    AccessioniPrimary (citable) accession number: P19919
    Secondary accession number(s): F8C0Z6, Q51325
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: July 11, 2002
    Last modified: September 7, 2016
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Plasmid, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.