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Reviewed, UniProtKB/Swiss-Prot P19912 (F16A3_RALEH)

Last modified November 3, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Fructose-1,6-bisphosphatase class 1 3
      Short name=FBPase class 1 3
    EC=3.1.3.11
Alternative name(s):
    D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 3
Gene names
Name: fbp3
Synonyms: cbbFP, cfxF
Ordered Locus Names: PHG422
Encoded onPlasmid megaplasmid pHG1
OrganismRalstonia eutropha (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)) [Complete proteome] [HAMAP]
Taxonomic identifier381666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Cupriavidus

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Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the FBPase class 1 family.

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Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological processcarbohydrate biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionfructose 1,6-bisphosphate 1-phosphatase activity

Inferred from electronic annotation. Source: HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Fructose-1,6-bisphosphatase class 1 3 HAMAP MF_01855
PRO_0000200480

Regions

Region126 – 1294Substrate binding By similarity

Sites

Metal binding1011Magnesium 1 By similarity
Metal binding1231Magnesium 1 By similarity
Metal binding1231Magnesium 2 By similarity
Metal binding1251Magnesium 1; via carbonyl oxygen By similarity
Metal binding1261Magnesium 2 By similarity
Metal binding2901Magnesium 2 By similarity
Binding site2181Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
P19912-1 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: D0F8DB93A6DD0FF1

FASTA36439,777
        10         20         30         40         50         60 
MPEVQRMTLT QFLIEERRRY PDASGGFNGL ILNVAMACKE IARAVAFGAL GGLHGKASTQ 

        70         80         90        100        110        120 
AGEEGAVNVQ GEIQQKLDVL SNTTFLRVNE WGGYLAGMAS EEMEAPYQIP ENYPRGKYLL 

       130        140        150        160        170        180 
VFDPLDGSSN IDVNVSVGSI FSVLRAPEGA DTVTEQDFLQ PGSAQVAAGY ALYGPTTMLV 

       190        200        210        220        230        240 
LTVGNGVNGF TLDPNLGEFF LTHPHLRVPP DTQEFAINAS NSRFWEAPVQ RYIGECMAGK 

       250        260        270        280        290        300 
SGPRGKDFNM RWIASMVAEA HRILMRGGVF MYPRDTKDPA KPGRLRLLYE ANPIAFLMEQ 

       310        320        330        340        350        360 
AGGRASTGRQ TLMSVAPGAL HQRIGVIFGS RNEVERIEGY HTNQTDPDLP SPLFNERSLF 


RASA

« Hide

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References

« Hide 'large scale' references
[1]"Analysis of the cbbF genes from Alcaligenes eutrophus that encode fructose-1,6-/sedoheptulose-1,7-bisphosphatase."
Yoo J.-G., Bowien B.
Curr. Microbiol. 31:55-61(1995) [PubMed: 7767230] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H(2)-based lithoautotrophy and anaerobiosis."
Schwartz E., Henne A., Cramm R., Eitinger T., Friedrich B., Gottschalk G.
J. Mol. Biol. 332:369-383(2003) [PubMed: 12948488] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Sequence analysis of the chromosomal and plasmid genes encoding phosphoribulokinase from Alcaligenes eutrophus."
Kossmann J., Klintworth R., Bowien B.
Gene 85:247-252(1989) [PubMed: 2559876] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 159-364.

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Cross-references

Sequence databases

U16792 Genomic DNA. Translation: AAA69974.1.
AY305378 Genomic DNA. Translation: AAP86171.1.
M33562 Genomic DNA. Translation: AAA21956.1.
PIRI39525.
RefSeqNP_943057.1.

3D structure databases

HSSPHSSP built from PDB template 1DBZ based on UniProtKB P46275.
ModBaseSearch...

Protein-protein interaction databases

STRINGP19912.

Genome annotation databases

GeneID2656766.
GenomeReviewsGene locus PHG422 in contig AY305378_GR.
KEGGreh:PHG422.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP19912.
OMASEENDAP.

Family and domain databases

HAMAPMF_01855.
[Tree]
InterProIPR000146. Fructose_bisphosphatase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERPTHR11556. In_FB_phphtase. 1 hit.
PfamPF00316. FBPase. 1 hit.
[Graphical view]
PRINTSPR00115. F16BPHPHTASE.
ProDomPD001491. In_FB_phphtase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameF16A3_RALEH
AccessionPrimary (citable) accession number: P19912
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1996
Last modified: November 3, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents