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Protein

Immunoglobulin G-binding protein G

Gene

spg

Organism
Streptococcus sp. group G
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin G-binding protein G
Short name:
IgG-binding protein G
Gene namesi
Name:spg
OrganismiStreptococcus sp. group G
Taxonomic identifieri1320 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Add
BLAST
Chaini34 – 562529Immunoglobulin G-binding protein GPRO_0000005659Add
BLAST
Propeptidei563 – 59331Removed by sortasePROSITE-ProRule annotationPRO_0000005660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei562 – 5621Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

MINTiMINT-1509283.

Structurei

Secondary structure

1
593
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi254 – 26815Combined sources
Helixi272 – 2798Combined sources
Helixi284 – 29613Combined sources
Beta strandi303 – 3097Combined sources
Beta strandi310 – 3123Combined sources
Beta strandi314 – 3207Combined sources
Helixi324 – 33714Combined sources
Beta strandi343 – 3475Combined sources
Helixi348 – 3503Combined sources
Beta strandi352 – 3565Combined sources
Beta strandi373 – 3797Combined sources
Beta strandi384 – 3907Combined sources
Beta strandi391 – 3933Combined sources
Helixi394 – 40714Combined sources
Beta strandi413 – 4175Combined sources
Turni418 – 4214Combined sources
Beta strandi422 – 4265Combined sources
Beta strandi444 – 4496Combined sources
Beta strandi454 – 4607Combined sources
Helixi464 – 47714Combined sources
Beta strandi483 – 4875Combined sources
Turni488 – 4914Combined sources
Beta strandi492 – 4965Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FCCX-ray3.20C/D372-427[»]
1FCLNMR-A372-427[»]
1FD6NMR-A372-427[»]
1GB4NMR-A372-427[»]
1GJSNMR-A254-299[»]
1GJTNMR-A254-299[»]
1IBXNMR-B-[»]
1P7ENMR-A444-497[»]
1P7FNMR-A444-497[»]
1QKZX-ray1.95A368-430[»]
1UWXX-ray2.20A/B368-430[»]
1ZXHNMR-A453-495[»]
2GI9X-ray1.14A303-357[»]
2I2YNMR-A304-357[»]
2I38NMR-A304-357[»]
2IGGNMR-A367-430[»]
2JSVNMR-X303-357[»]
2JU6NMR-X304-357[»]
2KHUNMR-A304-357[»]
2KHWNMR-A304-357[»]
2KN4NMR-A304-357[»]
2KQ4NMR-X303-357[»]
2KWDNMR-A/B/C/D/E304-357[»]
2LUMNMR-A444-497[»]
2OEDNMR-A444-497[»]
2ON8X-ray1.35A373-427[»]
2ONQX-ray1.70A375-427[»]
2QMTX-ray1.05A303-357[»]
3FILX-ray0.88A/B303-357[»]
3UI3X-ray2.80A/B304-357[»]
3V3XX-ray2.00A/B/C/D304-357[»]
4OZAX-ray2.20A302-357[»]
4OZBX-ray1.80A/B302-357[»]
4OZCX-ray2.30A302-357[»]
ProteinModelPortaliP19909.
SMRiP19909. Positions 171-222, 246-299, 304-357, 367-430, 436-503.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati104 – 140371-1Add
BLAST
Repeati179 – 215371-2Add
BLAST
Repeati254 – 290371-3Add
BLAST
Repeati303 – 357552-1Add
BLAST
Repeati373 – 427552-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 2901873 X 37 AA repeatsAdd
BLAST
Regioni303 – 4271252 X 55 AA repeatsAdd
BLAST
Regioni531 – 555255 X 5 AA repeats of [DE]-D-A-K-KAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi559 – 5635LPXTG sorting signalPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 11143Ala-richAdd
BLAST

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR002988. G-related_albumin-bd.
IPR019948. Gram-positive_anchor.
IPR019950. Gram_pos_anchor.
IPR009063. Ig/albumin-bd.
IPR000724. IgG-bd_B.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF01468. GA. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF01378. IgG_binding_B. 3 hits.
[Graphical view]
PRINTSiPR00015. GPOSANCHOR.
SUPFAMiSSF46997. SSF46997. 3 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKEKKVKYF LRKSAFGLAS VSAAFLVGST VFAVDSPIED TPIIRNGGEL
60 70 80 90 100
TNLLGNSETT LALRNEESAT ADLTAAAVAD TVAAAAAENA GAAAWEAAAA
110 120 130 140 150
ADALAKAKAD ALKEFNKYGV SDYYKNLINN AKTVEGVKDL QAQVVESAKK
160 170 180 190 200
ARISEATDGL SDFLKSQTPA EDTVKSIELA EAKVLANREL DKYGVSDYHK
210 220 230 240 250
NLINNAKTVE GVKDLQAQVV ESAKKARISE ATDGLSDFLK SQTPAEDTVK
260 270 280 290 300
SIELAEAKVL ANRELDKYGV SDYYKNLINN AKTVEGVKAL IDEILAALPK
310 320 330 340 350
TDTYKLILNG KTLKGETTTE AVDAATAEKV FKQYANDNGV DGEWTYDDAT
360 370 380 390 400
KTFTVTEKPE VIDASELTPA VTTYKLVING KTLKGETTTE AVDAATAEKV
410 420 430 440 450
FKQYANDNGV DGEWTYDDAT KTFTVTEKPE VIDASELTPA VTTYKLVING
460 470 480 490 500
KTLKGETTTK AVDAETAEKA FKQYANDNGV DGVWTYDDAT KTFTVTEMVT
510 520 530 540 550
EVPGDAPTEP EKPEASIPLV PLTPATPIAK DDAKKDDTKK EDAKKPEAKK
560 570 580 590
EDAKKAETLP TTGEGSNPFF TAAALAVMAG AGALAVASKR KED
Length:593
Mass (Da):63,292
Last modified:February 1, 1991 - v1
Checksum:i048BAA760D5B2920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06173 Genomic DNA. Translation: CAA29540.1.
Y00428 Genomic DNA. Translation: CAA68489.1.
X04015 Genomic DNA. Translation: CAA27638.1.
PIRiS00128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06173 Genomic DNA. Translation: CAA29540.1.
Y00428 Genomic DNA. Translation: CAA68489.1.
X04015 Genomic DNA. Translation: CAA27638.1.
PIRiS00128.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FCCX-ray3.20C/D372-427[»]
1FCLNMR-A372-427[»]
1FD6NMR-A372-427[»]
1GB4NMR-A372-427[»]
1GJSNMR-A254-299[»]
1GJTNMR-A254-299[»]
1IBXNMR-B-[»]
1P7ENMR-A444-497[»]
1P7FNMR-A444-497[»]
1QKZX-ray1.95A368-430[»]
1UWXX-ray2.20A/B368-430[»]
1ZXHNMR-A453-495[»]
2GI9X-ray1.14A303-357[»]
2I2YNMR-A304-357[»]
2I38NMR-A304-357[»]
2IGGNMR-A367-430[»]
2JSVNMR-X303-357[»]
2JU6NMR-X304-357[»]
2KHUNMR-A304-357[»]
2KHWNMR-A304-357[»]
2KN4NMR-A304-357[»]
2KQ4NMR-X303-357[»]
2KWDNMR-A/B/C/D/E304-357[»]
2LUMNMR-A444-497[»]
2OEDNMR-A444-497[»]
2ON8X-ray1.35A373-427[»]
2ONQX-ray1.70A375-427[»]
2QMTX-ray1.05A303-357[»]
3FILX-ray0.88A/B303-357[»]
3UI3X-ray2.80A/B304-357[»]
3V3XX-ray2.00A/B/C/D304-357[»]
4OZAX-ray2.20A302-357[»]
4OZBX-ray1.80A/B302-357[»]
4OZCX-ray2.30A302-357[»]
ProteinModelPortaliP19909.
SMRiP19909. Positions 171-222, 246-299, 304-357, 367-430, 436-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1509283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP19909.

Family and domain databases

InterProiIPR002988. G-related_albumin-bd.
IPR019948. Gram-positive_anchor.
IPR019950. Gram_pos_anchor.
IPR009063. Ig/albumin-bd.
IPR000724. IgG-bd_B.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF01468. GA. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF01378. IgG_binding_B. 3 hits.
[Graphical view]
PRINTSiPR00015. GPOSANCHOR.
SUPFAMiSSF46997. SSF46997. 3 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and evolution of the repetitive gene encoding streptococcal protein G."
    Olsson A., Eliasson M., Guss B., Nilsson B., Hellman U., Lindberg M., Uhlen M.
    Eur. J. Biochem. 168:319-324(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: G148.
  2. "Nucleotide sequence of the protein G gene from Streptococcus GX7805, and comparison to previously reported sequences."
    Filpula D., Alexander P., Fahnestock S.R.
    Nucleic Acids Res. 15:7210-7210(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GX7805.
  3. "Structure of the IgG-binding regions of streptococcal protein G."
    Guss B., Eliasson M., Olsson A., Uhlen M., Frej A.-K., Joernvall H., Flock J.-I., Lindberg M.
    EMBO J. 5:1567-1575(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 114-593.
    Strain: G148.
  4. "Design, structure and stability of a hyperthermophilic protein variant."
    Malakauskas S.M., Mayo S.L.
    Nat. Struct. Biol. 5:470-475(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 371-427.
    Strain: G148.

Entry informationi

Entry nameiSPG2_STRSG
AccessioniPrimary (citable) accession number: P19909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: January 7, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.