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P19909 (SPG2_STRSG) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Immunoglobulin G-binding protein G

Short name=IgG-binding protein G
Gene names
Name:spg
OrganismStreptococcus sp. group G
Taxonomic identifier1320 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length593 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secretedcell wall; Peptidoglycan-anchor Potential.

Ontologies

Keywords
   Cellular componentCell wall
Secreted
   DomainRepeat
Signal
   LigandIgG-binding protein
   PTMPeptidoglycan-anchor
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcell wall

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular region

Inferred from electronic annotation. Source: UniProtKB-KW

membrane

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3333
Chain34 – 562529Immunoglobulin G-binding protein G
PRO_0000005659
Propeptide563 – 59331Removed by sortase Potential
PRO_0000005660

Regions

Repeat104 – 140371-1
Repeat179 – 215371-2
Repeat254 – 290371-3
Repeat303 – 357552-1
Repeat373 – 427552-2
Region104 – 2901873 X 37 AA repeats
Region303 – 4271252 X 55 AA repeats
Region531 – 555255 X 5 AA repeats of [DE]-D-A-K-K
Motif559 – 5635LPXTG sorting signal Potential
Compositional bias69 – 11143Ala-rich

Amino acid modifications

Modified residue5621Pentaglycyl murein peptidoglycan amidated threonine Potential

Secondary structure

....................................... 593
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P19909 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 048BAA760D5B2920

FASTA59363,292
        10         20         30         40         50         60 
MEKEKKVKYF LRKSAFGLAS VSAAFLVGST VFAVDSPIED TPIIRNGGEL TNLLGNSETT 

        70         80         90        100        110        120 
LALRNEESAT ADLTAAAVAD TVAAAAAENA GAAAWEAAAA ADALAKAKAD ALKEFNKYGV 

       130        140        150        160        170        180 
SDYYKNLINN AKTVEGVKDL QAQVVESAKK ARISEATDGL SDFLKSQTPA EDTVKSIELA 

       190        200        210        220        230        240 
EAKVLANREL DKYGVSDYHK NLINNAKTVE GVKDLQAQVV ESAKKARISE ATDGLSDFLK 

       250        260        270        280        290        300 
SQTPAEDTVK SIELAEAKVL ANRELDKYGV SDYYKNLINN AKTVEGVKAL IDEILAALPK 

       310        320        330        340        350        360 
TDTYKLILNG KTLKGETTTE AVDAATAEKV FKQYANDNGV DGEWTYDDAT KTFTVTEKPE 

       370        380        390        400        410        420 
VIDASELTPA VTTYKLVING KTLKGETTTE AVDAATAEKV FKQYANDNGV DGEWTYDDAT 

       430        440        450        460        470        480 
KTFTVTEKPE VIDASELTPA VTTYKLVING KTLKGETTTK AVDAETAEKA FKQYANDNGV 

       490        500        510        520        530        540 
DGVWTYDDAT KTFTVTEMVT EVPGDAPTEP EKPEASIPLV PLTPATPIAK DDAKKDDTKK 

       550        560        570        580        590 
EDAKKPEAKK EDAKKAETLP TTGEGSNPFF TAAALAVMAG AGALAVASKR KED 

« Hide

References

[1]"Structure and evolution of the repetitive gene encoding streptococcal protein G."
Olsson A., Eliasson M., Guss B., Nilsson B., Hellman U., Lindberg M., Uhlen M.
Eur. J. Biochem. 168:319-324(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: G148.
[2]"Nucleotide sequence of the protein G gene from Streptococcus GX7805, and comparison to previously reported sequences."
Filpula D., Alexander P., Fahnestock S.R.
Nucleic Acids Res. 15:7210-7210(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: GX7805.
[3]"Structure of the IgG-binding regions of streptococcal protein G."
Guss B., Eliasson M., Olsson A., Uhlen M., Frej A.-K., Joernvall H., Flock J.-I., Lindberg M.
EMBO J. 5:1567-1575(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 114-593.
Strain: G148.
[4]"Design, structure and stability of a hyperthermophilic protein variant."
Malakauskas S.M., Mayo S.L.
Nat. Struct. Biol. 5:470-475(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 371-427.
Strain: G148.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X06173 Genomic DNA. Translation: CAA29540.1.
Y00428 Genomic DNA. Translation: CAA68489.1.
X04015 Genomic DNA. Translation: CAA27638.1.
PIRS00128.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FCCX-ray3.20C/D372-427[»]
1FCLNMR-A372-427[»]
1FD6NMR-A372-427[»]
1GB4NMR-A372-427[»]
1GJSNMR-A254-299[»]
1GJTNMR-A254-299[»]
1IBXNMR-B-[»]
1P7ENMR-A444-497[»]
1P7FNMR-A444-497[»]
1QKZX-ray1.95A368-430[»]
1UWXX-ray2.20A/B368-430[»]
1ZXHNMR-A453-495[»]
2GI9X-ray1.14A303-357[»]
2I2YNMR-A304-357[»]
2I38NMR-A304-357[»]
2IGGNMR-A367-430[»]
2JSVNMR-X303-357[»]
2JU6NMR-X304-357[»]
2KHUNMR-A304-357[»]
2KHWNMR-A304-357[»]
2KN4NMR-A304-357[»]
2KQ4NMR-X303-357[»]
2KWDNMR-A/B/C/D/E304-357[»]
2LUMNMR-A444-497[»]
2OEDNMR-A444-497[»]
2ON8X-ray1.35A373-427[»]
2ONQX-ray1.70A375-427[»]
2QMTX-ray1.05A303-357[»]
3FILX-ray0.88A/B303-357[»]
3UI3X-ray2.80A/B304-357[»]
3V3XX-ray2.00A/B/C/D304-357[»]
ProteinModelPortalP19909.
SMRP19909. Positions 171-222, 246-299, 304-357, 367-430, 436-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1509283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002988. G-related_albumin-bd.
IPR005877. Gpos_YSIRK.
IPR019948. Gram-positive_anchor.
IPR019950. Gram_pos_anchor.
IPR009063. Ig/albumin-bd.
IPR000724. IgG-bd_B.
IPR019931. LPXTG_anchor.
[Graphical view]
PfamPF01468. GA. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF01378. IgG_binding_B. 3 hits.
[Graphical view]
PRINTSPR00015. GPOSANCHOR.
SUPFAMSSF46997. SSF46997. 3 hits.
TIGRFAMsTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP19909.

Entry information

Entry nameSPG2_STRSG
AccessionPrimary (citable) accession number: P19909
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references