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P19909

- SPG2_STRSG

UniProt

P19909 - SPG2_STRSG

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Protein

Immunoglobulin G-binding protein G

Gene

spg

Organism
Streptococcus sp. group G
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Ligandi

IgG-binding protein

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin G-binding protein G
Short name:
IgG-binding protein G
Gene namesi
Name:spg
OrganismiStreptococcus sp. group G
Taxonomic identifieri1320 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. cell wall Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
  3. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell wall, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Add
BLAST
Chaini34 – 562529Immunoglobulin G-binding protein GPRO_0000005659Add
BLAST
Propeptidei563 – 59331Removed by sortasePROSITE-ProRule annotationPRO_0000005660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei562 – 5621Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

Keywords - PTMi

Peptidoglycan-anchor

Interactioni

Protein-protein interaction databases

MINTiMINT-1509283.

Structurei

Secondary structure

1
593
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi254 – 26815
Helixi272 – 2798
Helixi284 – 29613
Beta strandi303 – 3097
Beta strandi310 – 3123
Beta strandi314 – 3207
Helixi324 – 33714
Beta strandi343 – 3475
Helixi348 – 3503
Beta strandi352 – 3565
Beta strandi373 – 3797
Beta strandi384 – 3907
Beta strandi391 – 3933
Helixi394 – 40714
Beta strandi413 – 4175
Turni418 – 4214
Beta strandi422 – 4265
Beta strandi444 – 4496
Beta strandi454 – 4607
Helixi464 – 47714
Beta strandi483 – 4875
Turni488 – 4914
Beta strandi492 – 4965

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FCCX-ray3.20C/D372-427[»]
1FCLNMR-A372-427[»]
1FD6NMR-A372-427[»]
1GB4NMR-A372-427[»]
1GJSNMR-A254-299[»]
1GJTNMR-A254-299[»]
1IBXNMR-B-[»]
1P7ENMR-A444-497[»]
1P7FNMR-A444-497[»]
1QKZX-ray1.95A368-430[»]
1UWXX-ray2.20A/B368-430[»]
1ZXHNMR-A453-495[»]
2GI9X-ray1.14A303-357[»]
2I2YNMR-A304-357[»]
2I38NMR-A304-357[»]
2IGGNMR-A367-430[»]
2JSVNMR-X303-357[»]
2JU6NMR-X304-357[»]
2KHUNMR-A304-357[»]
2KHWNMR-A304-357[»]
2KN4NMR-A304-357[»]
2KQ4NMR-X303-357[»]
2KWDNMR-A/B/C/D/E304-357[»]
2LUMNMR-A444-497[»]
2OEDNMR-A444-497[»]
2ON8X-ray1.35A373-427[»]
2ONQX-ray1.70A375-427[»]
2QMTX-ray1.05A303-357[»]
3FILX-ray0.88A/B303-357[»]
3UI3X-ray2.80A/B304-357[»]
3V3XX-ray2.00A/B/C/D304-357[»]
4OZAX-ray2.20A302-357[»]
4OZBX-ray1.80A/B302-357[»]
4OZCX-ray2.30A302-357[»]
ProteinModelPortaliP19909.
SMRiP19909. Positions 171-222, 246-299, 304-357, 367-430, 436-503.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati104 – 140371-1Add
BLAST
Repeati179 – 215371-2Add
BLAST
Repeati254 – 290371-3Add
BLAST
Repeati303 – 357552-1Add
BLAST
Repeati373 – 427552-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni104 – 2901873 X 37 AA repeatsAdd
BLAST
Regioni303 – 4271252 X 55 AA repeatsAdd
BLAST
Regioni531 – 555255 X 5 AA repeats of [DE]-D-A-K-KAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi559 – 5635LPXTG sorting signalPROSITE-ProRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi69 – 11143Ala-richAdd
BLAST

Keywords - Domaini

Repeat, Signal

Family and domain databases

InterProiIPR002988. G-related_albumin-bd.
IPR019948. Gram-positive_anchor.
IPR019950. Gram_pos_anchor.
IPR009063. Ig/albumin-bd.
IPR000724. IgG-bd_B.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view]
PfamiPF01468. GA. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF01378. IgG_binding_B. 3 hits.
[Graphical view]
PRINTSiPR00015. GPOSANCHOR.
SUPFAMiSSF46997. SSF46997. 3 hits.
TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19909 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKEKKVKYF LRKSAFGLAS VSAAFLVGST VFAVDSPIED TPIIRNGGEL
60 70 80 90 100
TNLLGNSETT LALRNEESAT ADLTAAAVAD TVAAAAAENA GAAAWEAAAA
110 120 130 140 150
ADALAKAKAD ALKEFNKYGV SDYYKNLINN AKTVEGVKDL QAQVVESAKK
160 170 180 190 200
ARISEATDGL SDFLKSQTPA EDTVKSIELA EAKVLANREL DKYGVSDYHK
210 220 230 240 250
NLINNAKTVE GVKDLQAQVV ESAKKARISE ATDGLSDFLK SQTPAEDTVK
260 270 280 290 300
SIELAEAKVL ANRELDKYGV SDYYKNLINN AKTVEGVKAL IDEILAALPK
310 320 330 340 350
TDTYKLILNG KTLKGETTTE AVDAATAEKV FKQYANDNGV DGEWTYDDAT
360 370 380 390 400
KTFTVTEKPE VIDASELTPA VTTYKLVING KTLKGETTTE AVDAATAEKV
410 420 430 440 450
FKQYANDNGV DGEWTYDDAT KTFTVTEKPE VIDASELTPA VTTYKLVING
460 470 480 490 500
KTLKGETTTK AVDAETAEKA FKQYANDNGV DGVWTYDDAT KTFTVTEMVT
510 520 530 540 550
EVPGDAPTEP EKPEASIPLV PLTPATPIAK DDAKKDDTKK EDAKKPEAKK
560 570 580 590
EDAKKAETLP TTGEGSNPFF TAAALAVMAG AGALAVASKR KED
Length:593
Mass (Da):63,292
Last modified:February 1, 1991 - v1
Checksum:i048BAA760D5B2920
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06173 Genomic DNA. Translation: CAA29540.1.
Y00428 Genomic DNA. Translation: CAA68489.1.
X04015 Genomic DNA. Translation: CAA27638.1.
PIRiS00128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06173 Genomic DNA. Translation: CAA29540.1 .
Y00428 Genomic DNA. Translation: CAA68489.1 .
X04015 Genomic DNA. Translation: CAA27638.1 .
PIRi S00128.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FCC X-ray 3.20 C/D 372-427 [» ]
1FCL NMR - A 372-427 [» ]
1FD6 NMR - A 372-427 [» ]
1GB4 NMR - A 372-427 [» ]
1GJS NMR - A 254-299 [» ]
1GJT NMR - A 254-299 [» ]
1IBX NMR - B - [» ]
1P7E NMR - A 444-497 [» ]
1P7F NMR - A 444-497 [» ]
1QKZ X-ray 1.95 A 368-430 [» ]
1UWX X-ray 2.20 A/B 368-430 [» ]
1ZXH NMR - A 453-495 [» ]
2GI9 X-ray 1.14 A 303-357 [» ]
2I2Y NMR - A 304-357 [» ]
2I38 NMR - A 304-357 [» ]
2IGG NMR - A 367-430 [» ]
2JSV NMR - X 303-357 [» ]
2JU6 NMR - X 304-357 [» ]
2KHU NMR - A 304-357 [» ]
2KHW NMR - A 304-357 [» ]
2KN4 NMR - A 304-357 [» ]
2KQ4 NMR - X 303-357 [» ]
2KWD NMR - A/B/C/D/E 304-357 [» ]
2LUM NMR - A 444-497 [» ]
2OED NMR - A 444-497 [» ]
2ON8 X-ray 1.35 A 373-427 [» ]
2ONQ X-ray 1.70 A 375-427 [» ]
2QMT X-ray 1.05 A 303-357 [» ]
3FIL X-ray 0.88 A/B 303-357 [» ]
3UI3 X-ray 2.80 A/B 304-357 [» ]
3V3X X-ray 2.00 A/B/C/D 304-357 [» ]
4OZA X-ray 2.20 A 302-357 [» ]
4OZB X-ray 1.80 A/B 302-357 [» ]
4OZC X-ray 2.30 A 302-357 [» ]
ProteinModelPortali P19909.
SMRi P19909. Positions 171-222, 246-299, 304-357, 367-430, 436-503.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1509283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P19909.

Family and domain databases

InterProi IPR002988. G-related_albumin-bd.
IPR019948. Gram-positive_anchor.
IPR019950. Gram_pos_anchor.
IPR009063. Ig/albumin-bd.
IPR000724. IgG-bd_B.
IPR019931. LPXTG_anchor.
IPR005877. YSIRK_signal_dom.
[Graphical view ]
Pfami PF01468. GA. 3 hits.
PF00746. Gram_pos_anchor. 1 hit.
PF01378. IgG_binding_B. 3 hits.
[Graphical view ]
PRINTSi PR00015. GPOSANCHOR.
SUPFAMi SSF46997. SSF46997. 3 hits.
TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
TIGR01168. YSIRK_signal. 1 hit.
PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and evolution of the repetitive gene encoding streptococcal protein G."
    Olsson A., Eliasson M., Guss B., Nilsson B., Hellman U., Lindberg M., Uhlen M.
    Eur. J. Biochem. 168:319-324(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: G148.
  2. "Nucleotide sequence of the protein G gene from Streptococcus GX7805, and comparison to previously reported sequences."
    Filpula D., Alexander P., Fahnestock S.R.
    Nucleic Acids Res. 15:7210-7210(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: GX7805.
  3. "Structure of the IgG-binding regions of streptococcal protein G."
    Guss B., Eliasson M., Olsson A., Uhlen M., Frej A.-K., Joernvall H., Flock J.-I., Lindberg M.
    EMBO J. 5:1567-1575(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 114-593.
    Strain: G148.
  4. "Design, structure and stability of a hyperthermophilic protein variant."
    Malakauskas S.M., Mayo S.L.
    Nat. Struct. Biol. 5:470-475(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 371-427.
    Strain: G148.

Entry informationi

Entry nameiSPG2_STRSG
AccessioniPrimary (citable) accession number: P19909
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3