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P19909

- SPG2_STRSG

UniProt

P19909 - SPG2_STRSG

Protein

Immunoglobulin G-binding protein G

Gene

spg

Organism
Streptococcus sp. group G
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Ligandi

    IgG-binding protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Immunoglobulin G-binding protein G
    Short name:
    IgG-binding protein G
    Gene namesi
    Name:spg
    OrganismiStreptococcus sp. group G
    Taxonomic identifieri1320 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

    Subcellular locationi

    Secretedcell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cell wall Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-KW
    3. membrane Source: InterPro

    Keywords - Cellular componenti

    Cell wall, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3333Add
    BLAST
    Chaini34 – 562529Immunoglobulin G-binding protein GPRO_0000005659Add
    BLAST
    Propeptidei563 – 59331Removed by sortasePROSITE-ProRule annotationPRO_0000005660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei562 – 5621Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation

    Keywords - PTMi

    Peptidoglycan-anchor

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1509283.

    Structurei

    Secondary structure

    1
    593
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi254 – 26815
    Helixi272 – 2798
    Helixi284 – 29613
    Beta strandi303 – 3097
    Beta strandi310 – 3123
    Beta strandi314 – 3207
    Helixi324 – 33714
    Beta strandi343 – 3475
    Helixi348 – 3503
    Beta strandi352 – 3565
    Beta strandi373 – 3797
    Beta strandi384 – 3907
    Beta strandi391 – 3933
    Helixi394 – 40714
    Beta strandi413 – 4175
    Turni418 – 4214
    Beta strandi422 – 4265
    Beta strandi444 – 4496
    Beta strandi454 – 4607
    Helixi464 – 47714
    Beta strandi483 – 4875
    Turni488 – 4914
    Beta strandi492 – 4965

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FCCX-ray3.20C/D372-427[»]
    1FCLNMR-A372-427[»]
    1FD6NMR-A372-427[»]
    1GB4NMR-A372-427[»]
    1GJSNMR-A254-299[»]
    1GJTNMR-A254-299[»]
    1IBXNMR-B-[»]
    1P7ENMR-A444-497[»]
    1P7FNMR-A444-497[»]
    1QKZX-ray1.95A368-430[»]
    1UWXX-ray2.20A/B368-430[»]
    1ZXHNMR-A453-495[»]
    2GI9X-ray1.14A303-357[»]
    2I2YNMR-A304-357[»]
    2I38NMR-A304-357[»]
    2IGGNMR-A367-430[»]
    2JSVNMR-X303-357[»]
    2JU6NMR-X304-357[»]
    2KHUNMR-A304-357[»]
    2KHWNMR-A304-357[»]
    2KN4NMR-A304-357[»]
    2KQ4NMR-X303-357[»]
    2KWDNMR-A/B/C/D/E304-357[»]
    2LUMNMR-A444-497[»]
    2OEDNMR-A444-497[»]
    2ON8X-ray1.35A373-427[»]
    2ONQX-ray1.70A375-427[»]
    2QMTX-ray1.05A303-357[»]
    3FILX-ray0.88A/B303-357[»]
    3UI3X-ray2.80A/B304-357[»]
    3V3XX-ray2.00A/B/C/D304-357[»]
    ProteinModelPortaliP19909.
    SMRiP19909. Positions 171-222, 246-299, 304-357, 367-430, 436-503.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP19909.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati104 – 140371-1Add
    BLAST
    Repeati179 – 215371-2Add
    BLAST
    Repeati254 – 290371-3Add
    BLAST
    Repeati303 – 357552-1Add
    BLAST
    Repeati373 – 427552-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni104 – 2901873 X 37 AA repeatsAdd
    BLAST
    Regioni303 – 4271252 X 55 AA repeatsAdd
    BLAST
    Regioni531 – 555255 X 5 AA repeats of [DE]-D-A-K-KAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi559 – 5635LPXTG sorting signalPROSITE-ProRule annotation

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi69 – 11143Ala-richAdd
    BLAST

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    InterProiIPR002988. G-related_albumin-bd.
    IPR019948. Gram-positive_anchor.
    IPR019950. Gram_pos_anchor.
    IPR009063. Ig/albumin-bd.
    IPR000724. IgG-bd_B.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view]
    PfamiPF01468. GA. 3 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF01378. IgG_binding_B. 3 hits.
    [Graphical view]
    PRINTSiPR00015. GPOSANCHOR.
    SUPFAMiSSF46997. SSF46997. 3 hits.
    TIGRFAMsiTIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEiPS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19909-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKEKKVKYF LRKSAFGLAS VSAAFLVGST VFAVDSPIED TPIIRNGGEL    50
    TNLLGNSETT LALRNEESAT ADLTAAAVAD TVAAAAAENA GAAAWEAAAA 100
    ADALAKAKAD ALKEFNKYGV SDYYKNLINN AKTVEGVKDL QAQVVESAKK 150
    ARISEATDGL SDFLKSQTPA EDTVKSIELA EAKVLANREL DKYGVSDYHK 200
    NLINNAKTVE GVKDLQAQVV ESAKKARISE ATDGLSDFLK SQTPAEDTVK 250
    SIELAEAKVL ANRELDKYGV SDYYKNLINN AKTVEGVKAL IDEILAALPK 300
    TDTYKLILNG KTLKGETTTE AVDAATAEKV FKQYANDNGV DGEWTYDDAT 350
    KTFTVTEKPE VIDASELTPA VTTYKLVING KTLKGETTTE AVDAATAEKV 400
    FKQYANDNGV DGEWTYDDAT KTFTVTEKPE VIDASELTPA VTTYKLVING 450
    KTLKGETTTK AVDAETAEKA FKQYANDNGV DGVWTYDDAT KTFTVTEMVT 500
    EVPGDAPTEP EKPEASIPLV PLTPATPIAK DDAKKDDTKK EDAKKPEAKK 550
    EDAKKAETLP TTGEGSNPFF TAAALAVMAG AGALAVASKR KED 593
    Length:593
    Mass (Da):63,292
    Last modified:February 1, 1991 - v1
    Checksum:i048BAA760D5B2920
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06173 Genomic DNA. Translation: CAA29540.1.
    Y00428 Genomic DNA. Translation: CAA68489.1.
    X04015 Genomic DNA. Translation: CAA27638.1.
    PIRiS00128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06173 Genomic DNA. Translation: CAA29540.1 .
    Y00428 Genomic DNA. Translation: CAA68489.1 .
    X04015 Genomic DNA. Translation: CAA27638.1 .
    PIRi S00128.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FCC X-ray 3.20 C/D 372-427 [» ]
    1FCL NMR - A 372-427 [» ]
    1FD6 NMR - A 372-427 [» ]
    1GB4 NMR - A 372-427 [» ]
    1GJS NMR - A 254-299 [» ]
    1GJT NMR - A 254-299 [» ]
    1IBX NMR - B - [» ]
    1P7E NMR - A 444-497 [» ]
    1P7F NMR - A 444-497 [» ]
    1QKZ X-ray 1.95 A 368-430 [» ]
    1UWX X-ray 2.20 A/B 368-430 [» ]
    1ZXH NMR - A 453-495 [» ]
    2GI9 X-ray 1.14 A 303-357 [» ]
    2I2Y NMR - A 304-357 [» ]
    2I38 NMR - A 304-357 [» ]
    2IGG NMR - A 367-430 [» ]
    2JSV NMR - X 303-357 [» ]
    2JU6 NMR - X 304-357 [» ]
    2KHU NMR - A 304-357 [» ]
    2KHW NMR - A 304-357 [» ]
    2KN4 NMR - A 304-357 [» ]
    2KQ4 NMR - X 303-357 [» ]
    2KWD NMR - A/B/C/D/E 304-357 [» ]
    2LUM NMR - A 444-497 [» ]
    2OED NMR - A 444-497 [» ]
    2ON8 X-ray 1.35 A 373-427 [» ]
    2ONQ X-ray 1.70 A 375-427 [» ]
    2QMT X-ray 1.05 A 303-357 [» ]
    3FIL X-ray 0.88 A/B 303-357 [» ]
    3UI3 X-ray 2.80 A/B 304-357 [» ]
    3V3X X-ray 2.00 A/B/C/D 304-357 [» ]
    ProteinModelPortali P19909.
    SMRi P19909. Positions 171-222, 246-299, 304-357, 367-430, 436-503.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1509283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P19909.

    Family and domain databases

    InterProi IPR002988. G-related_albumin-bd.
    IPR019948. Gram-positive_anchor.
    IPR019950. Gram_pos_anchor.
    IPR009063. Ig/albumin-bd.
    IPR000724. IgG-bd_B.
    IPR019931. LPXTG_anchor.
    IPR005877. YSIRK_signal_dom.
    [Graphical view ]
    Pfami PF01468. GA. 3 hits.
    PF00746. Gram_pos_anchor. 1 hit.
    PF01378. IgG_binding_B. 3 hits.
    [Graphical view ]
    PRINTSi PR00015. GPOSANCHOR.
    SUPFAMi SSF46997. SSF46997. 3 hits.
    TIGRFAMsi TIGR01167. LPXTG_anchor. 1 hit.
    TIGR01168. YSIRK_signal. 1 hit.
    PROSITEi PS50847. GRAM_POS_ANCHORING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and evolution of the repetitive gene encoding streptococcal protein G."
      Olsson A., Eliasson M., Guss B., Nilsson B., Hellman U., Lindberg M., Uhlen M.
      Eur. J. Biochem. 168:319-324(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: G148.
    2. "Nucleotide sequence of the protein G gene from Streptococcus GX7805, and comparison to previously reported sequences."
      Filpula D., Alexander P., Fahnestock S.R.
      Nucleic Acids Res. 15:7210-7210(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: GX7805.
    3. "Structure of the IgG-binding regions of streptococcal protein G."
      Guss B., Eliasson M., Olsson A., Uhlen M., Frej A.-K., Joernvall H., Flock J.-I., Lindberg M.
      EMBO J. 5:1567-1575(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 114-593.
      Strain: G148.
    4. "Design, structure and stability of a hyperthermophilic protein variant."
      Malakauskas S.M., Mayo S.L.
      Nat. Struct. Biol. 5:470-475(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 371-427.
      Strain: G148.

    Entry informationi

    Entry nameiSPG2_STRSG
    AccessioniPrimary (citable) accession number: P19909
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3