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P19904

- GLNA_VIBAL

UniProt

P19904 - GLNA_VIBAL

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Protein

Glutamine synthetase

Gene

glnA

Organism
Vibrio alginolyticus
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
OrganismiVibrio alginolyticus
Taxonomic identifieri663 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Glutamine synthetasePRO_0000153275Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei397 – 3971O-AMP-tyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP19904.

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.

Structurei

3D structure databases

ProteinModelPortaliP19904.
SMRiP19904. Positions 2-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19904-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVEKVLSLI QENEVKFVDL RFTDTKGKEQ HISIPAHQID ADFFEEGKMF
60 70 80 90 100
DGSSVAGWKG INESDMVMMP DASSAVLDPF TEDATLNIRC DILEPATMQG
110 120 130 140 150
YDRDPRSIAK RAEDFMRSTG VADTVLIGPE PEFFLFDDVK FATDMSGSFF
160 170 180 190 200
KIDDVEAAWN TGSDYEEGNK GHRPGVKGGY FPVAPVDSSQ DIRSAMCLVM
210 220 230 240 250
EEMGLVVEAH HHEATAGQNE IATRFNTLTT KADEIQIYKY VVHNVAHAFG
260 270 280 290 300
KTATFMPKPL VGDNGSGMHV HQSLAKDGVN LFAGDKYGGL SEMALYYIGG
310 320 330 340 350
IIKHARAINA FANPSTNSYK RLVPGFEAPV MLAYSARNRS ASIRIPVVPS
360 370 380 390 400
PKARRIEVRF GDPAANPYLC FASMLMAGLD GIKNKIHPGE AMDKDLYDLP
410 420 430 440 450
AEESAEIPTV AYSLKDALAE LDADREFLTA GGVFSDDFID SYIELKSQDV
460
ERVNMTTHPV EFELYYSV
Length:468
Mass (Da):51,556
Last modified:February 1, 1991 - v1
Checksum:iABB66AA9C072D856
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08499 Genomic DNA. Translation: AAA27523.1.
PIRiJL0113. AJVCQA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08499 Genomic DNA. Translation: AAA27523.1 .
PIRi JL0113. AJVCQA.

3D structure databases

ProteinModelPortali P19904.
SMRi P19904. Positions 2-468.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P19904.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the Vibrio alginolyticus glnA region."
    Maharaj R., Rumbak E., Jones W.A., Robb S.M., Robb F.T., Woods D.R.
    Arch. Microbiol. 152:542-549(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiGLNA_VIBAL
AccessioniPrimary (citable) accession number: P19904
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3