Reviewed, UniProtKB/Swiss-Prot P19900 (HEX_ADE12)

Names and origin

Protein names

Recommended name:
    Hexon protein
Alternative name(s):
    Late protein 2

Gene names

Name:

PII

Organism

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

Taxonomic identifier

28282 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Adenoviridae › Mastadenovirus › Human adenovirus A

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	919 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein is one of the structural proteins in the viral coat and is synthesized during late infection.
Subunit structure	Homotrimer By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the adenoviridae hexon protein family.

Ontologies

Keywords
Cellular component	Capsid protein Hexon protein Virion
Developmental stage	Late protein
Gene Ontology (GO)
Cellular component	viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 919	919	Hexon protein		PRO_0000221821

Sequences

	Sequence		Length	Mass (Da)
	P19900-1 [UniParc]. Last modified June 1, 1994. Version 2. Checksum: B37167885A516288	FASTA	919	103,040
	10 20 30 40 50 60 MATPSMMPQW SYMHIAGQDA SEYLSPGLVQ FARATDTYFT LGNKFRNPTV APTHDVTTDR 70 80 90 100 110 120 SQRLTLRFVP VDREDTTYSY KARFTLAVGD NRVLDMASSY FDIRGVLDRG PSFKPYSGTA 130 140 150 160 170 180 YNSLAPKGAP NASQWSDNAK LNTFAQAPYL SDTITAADGI KVGTDTAQAG AAVYANKTYQ 190 200 210 220 230 240 PEPQVGPSEW NTSIENVKAG GRALKQTTAM QPCYGSYARP TNEHGGQSKD DNIELKFFDS 250 260 270 280 290 300 ANNAANTAQV VFYTEDVNLE MPDTHLVFKP TVTNGTIASE SLLGQQAAPN RANYIAFRDN 310 320 330 340 350 360 FIGLMYYNST GNMGVLAGQA SQLNAVVDLQ DRNTELSYQL MLDALGDRTR YFSLWNSAVD 370 380 390 400 410 420 SYDPDVRVIE NHGVEDELPN YCFPLSAVGE IKNYKGIKPD NGGGGGWTAD NTVSEANHIG 430 440 450 460 470 480 IGNIAAMEIN LQANLWRSFL YSNVGLYLPD DLKYTPGNIK LPDNKNTYEY MNGRVTAPGL 490 500 510 520 530 540 VDTYVNIGAR WSPDVMDNVN PFNHHRNAGL RYRSMLLGNG RFVPFHIQVP QKFFAIRNLL 550 560 570 580 590 600 LLPGSYTYEW NFRKDVNMIL QSTLGNDLRV DGASVRFDNI ALYANFFPMA HNTASTLEAM 610 620 630 640 650 660 LRNDTNDQSF NDYLCAANML YPIPANATSV PISIPSRNWA AFRGWSFTRL KTKETPSLGS 670 680 690 700 710 720 GFDPYFVYSG TIPYLDGTFY LNHTFKKVSI MFDSSVSWPG NDRLLTPNEF EIKRSVDGEG 730 740 750 760 770 780 YNVAQCNMTK DWFLIQMLSH YNIGYQGFYI PESYKDRMYS FFRNFQPMSR QVVDTTEYKN 790 800 810 820 830 840 YKKVTVEFQH NNSGFVGYLG PTMREGQAYP ANYPYPLIGQ TAVESITQKK FLCDRVMWRI 850 860 870 880 890 900 PFSSNFMSMG ALTDLGQNML YANSAHALDM TFEVDPMDEP TLLYVLFEVF DVVRIHQPHR 910 GVIEAVYLRT PFSAGNATT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of human adenovirus type 12 DNA: comparative functional analysis." Sprengel J., Schmitz B., Heuss-Neitzel D., Zock C., Doerfler W. J. Virol. 68:379-389(1994) [PubMed: 8254750] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The primary structure of human adenovirus type 12 protease." Weber J.M., Houde A. Nucleic Acids Res. 16:7195-7195(1988) [PubMed: 3043380] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 888-919. Strain: Pereira 1131.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X73487 Genomic DNA. Translation: CAA51891.1. X07655 Genomic DNA. Translation: CAB37192.1.
PIR	S01730. S33942.
RefSeq	NP_040924.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1460858.
Family and domain databases
InterPro	IPR016112. Coat_hexon/vp54/p3_dsDNA-vir. IPR016111. Coat_hexon/vp54_sub4_dsDNA-vir. IPR016108. Coat_hexon_C_Adenovir. IPR016107. Coat_hexon_N_Adenovir. IPR016110. Coat_hexon_sub3_Adenovir. [Graphical view]
Gene3D	G3DSA:2.70.9.10. Coat_hexon/vp54_sub4_dsDNA-vir. 1 hit. G3DSA:3.90.249.10. Coat_hexon_sub3_Adenovir. 2 hits.
Pfam	PF01065. Adeno_hexon. 1 hit. PF03678. Adeno_hexon_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEX_ADE12

Accession

Primary (citable) accession number: P19900

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	June 1, 1994
Last modified:	November 24, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)