P19893 (VIE2_HCMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
45 kDa immediate-early protein 2
Short name=IE2

Alternative name(s):
Protein UL122

Gene names

Name:

UL122

Organism

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) [Complete proteome]

Taxonomic identifier

10360 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Betaherpesvirinae › Cytomegalovirus

Virus host

Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length	580 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	Activates the E1.7 promoter. This activation is augmented by the IE1 protein. It down-regulates the transcription of genes under the control of the major IE promoter.
Subcellular location	Virion.
Sequence caution	The sequence CAA35324.1 differs from that shown. Reason: Frameshift at positions 25 and 87.

Ontologies

Keywords
Biological process	G1/S host cell cycle checkpoint dysregulation by virus Host-virus interaction Modulation of host cell cycle by virus Transcription Transcription regulation
Cellular component	Virion
Developmental stage	Early protein
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW regulation of viral reproduction Inferred from electronic annotation. Source: InterPro transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	host cell nucleus Inferred from electronic annotation. Source: InterPro virion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 580	580	45 kDa immediate-early protein 2		PRO_0000115351
Regions
	Zinc finger	427 – 453	27	Potential
	Compositional bias	258 – 320	63	Gly/Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	P19893 [UniParc]. Last modified February 15, 2005. Version 2. Checksum: 41D1753A02A077ED	FASTA	580	62,875
	10 20 30 40 50 60 MESSAKRKMD PDNPDEGPSS KVPRPETPVT KATTFLQTML RKEVNSQLSL GDPLFPELAE 70 80 90 100 110 120 ESLKTFEQVT EDCNENPEKD VLAELGDILA QAVNHAGIDS SSTGPTLTTH SCSVSSAPLN 130 140 150 160 170 180 KPTPTSVAVT NTPLPGASAT PELSPRKKPR KTTRPFKVII KPPVPPAPIM LPLIKQEDIK 190 200 210 220 230 240 PEPDFTIQYR NKIIDTAGCI VISDSEEEQG EEVETRGATA SSPSTGSGTP RVTSPTHPLS 250 260 270 280 290 300 QMNHPPLPDP LGRPDEDSSS SSSSSCSSAS DSESESEEMK CSSGGGASVT SSHHGRGGFG 310 320 330 340 350 360 GAASSSLLSC GHQSSGGAST GPRKKKSKRI SELDNEKVRN IMKDKNTPFC TPNVQTRRGR 370 380 390 400 410 420 VKIDEVSRMF RNTNRSLEYK NLPFTIPSMH QVLDEAIKAC KTMQVNNKGI QIIYTRNHEV 430 440 450 460 470 480 KSEVDAVRCR LGTMCNLALS TPFLMEHTMP VTHPPEVAQR TADACNEGVK AAWSLKELHT 490 500 510 520 530 540 HQLCPRSSDY RNMIIHAATP VDLLGALNLC LPLMQKFPKQ VMVRIFSTNQ GGFMLPIYET 550 560 570 580 AAKAYAVGQF EQPTETPPED LDTLSLAIEA AIQDLRNKSQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169." Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R., Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A., Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G. Curr. Top. Microbiol. Immunol. 154:125-169(1990) [PubMed: 2161319] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome." Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:17-28(2003) [PubMed: 12533697] [Abstract] Cited for: GENOME REANNOTATION, SEQUENCE REVISION.
[3]	Erratum Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J., Alcendor D.J., McGeoch D.J., Hayward G.S. J. Gen. Virol. 84:1053-1053(2003)
[4]	"Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome." Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:10960-10966(2004) [PubMed: 15452216] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Varnum S.M., Streblow D.N., Monroe M.E., Smith P., Auberry K.J., Pasa-Tolic L., Wang D., Camp D.G. II, Rodland K., Wiley S., Britt W., Shenk T., Smith R.D., Nelson J.A. J. Virol. 78:13395-13395(2004)

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17403 Genomic DNA. Translation: CAA35324.1. Frameshift. BK000394 Genomic DNA. Translation: DAA00111.1.
PIR	EDBEM4. S09889.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR010855. Cytomega_IE1. IPR005028. Herpes_IE2_3. [Graphical view]
Pfam	PF07340. Herpes_IE1. 1 hit. PF03361. Herpes_IE2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VIE2_HCMVA

Accession

Primary (citable) accession number: P19893
Secondary accession number(s): Q7M6S5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 15, 2005
Last modified:	May 31, 2011
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program