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Protein

60S acidic ribosomal protein P0

Gene

RpLP0

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ribosomal protein P0 is the functional equivalent of E.coli protein L10.

Catalytic activityi

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

GO - Molecular functioni

  • calcium ion binding Source: CAFA
  • class I DNA-(apurinic or apyrimidinic site) endonuclease activity Source: UniProtKB-EC
  • class II DNA-(apurinic or apyrimidinic site) endonuclease activity Source: FlyBase
  • DNA-(apurinic or apyrimidinic site) endonuclease activity Source: CAFA
  • endonuclease activity Source: CAFA
  • magnesium ion binding Source: CAFA
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • base-excision repair Source: CAFA
  • cytoplasmic translation Source: FlyBase
  • nucleic acid phosphodiester bond hydrolysis Source: CAFA
  • ribosome biogenesis Source: InterPro

Keywordsi

Molecular functionLyase, Ribonucleoprotein, Ribosomal protein
Biological processDNA damage, DNA repair

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Protein family/group databases

MoonProtiP19889

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P0
Alternative name(s):
Apurinic-apyrimidinic endonuclease
DNA-(apurinic or apyrimidinic site) lyase (EC:4.2.99.18)
Gene namesi
Name:RpLP0
Synonyms:AP3, Ape, RpP0
ORF Names:CG7490
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000100 RpLP0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001547691 – 31760S acidic ribosomal protein P0Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei302Phosphoserine1 Publication1
Modified residuei304Phosphoserine; by CK1Sequence analysis1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19889
PRIDEiP19889

PTM databases

iPTMnetiP19889

Expressioni

Developmental stagei

All stages of development. A larger transcript is restricted to the embryonic and early larval stages.

Gene expression databases

BgeeiFBgn0000100
ExpressionAtlasiP19889 baseline and differential
GenevisibleiP19889 DM

Interactioni

Subunit structurei

P0 forms a pentameric complex by interaction with dimers of P1 and P2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
RpLP1P085704EBI-195497,EBI-125901

Protein-protein interaction databases

BioGridi65690, 24 interactors
DIPiDIP-21968N
IntActiP19889, 4 interactors
MINTiP19889
STRINGi7227.FBpp0306232

Structurei

3D structure databases

ProteinModelPortaliP19889
SMRiP19889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0815 Eukaryota
COG0244 LUCA
GeneTreeiENSGT00390000017839
InParanoidiP19889
KOiK02941
OMAiMAHVAEW
OrthoDBiEOG091G0F47
PhylomeDBiP19889

Family and domain databases

InterProiView protein in InterPro
IPR030670 L10E_eukaryotes
IPR001790 Ribosomal_L10P
PfamiView protein in Pfam
PF00466 Ribosomal_L10, 1 hit
PIRSFiPIRSF039087 L10E, 1 hit

Sequencei

Sequence statusi: Complete.

P19889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRENKAAWK AQYFIKVVEL FDEFPKCFIV GADNVGSKQM QNIRTSLRGL
60 70 80 90 100
AVVLMGKNTM MRKAIRGHLE NNPQLEKLLP HIKGNVGFVF TKGDLAEVRD
110 120 130 140 150
KLLESKVRAP ARPGAIAPLH VIIPAQNTGL GPEKTSFFQA LSIPTKISKG
160 170 180 190 200
TIEIINDVPI LKPGDKVGAS EATLLNMLNI SPFSYGLIVN QVYDSGSIFS
210 220 230 240 250
PEILDIKPED LRAKFQQGVA NLAAVCLSVG YPTIASAPHS IANGFKNLLA
260 270 280 290 300
IAATTEVEFK EATTIKEYIK DPSKFAAAAS ASAAPAAGGA TEKKEEAKKP
310
ESESEEEDDD MGFGLFD
Length:317
Mass (Da):34,202
Last modified:February 1, 1991 - v1
Checksum:i36E9DD5DD8CF7E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25772 mRNA Translation: AAA53372.1
AE014296 Genomic DNA Translation: AAF51807.1
AY075528 mRNA Translation: AAL68335.1
BT021447 mRNA Translation: AAX33595.1
PIRiA30223 R5FFP0
RefSeqiNP_001262202.1, NM_001275273.1
NP_524211.1, NM_079487.4
UniGeneiDm.7933

Genome annotation databases

EnsemblMetazoaiFBtr0078481; FBpp0078134; FBgn0000100
FBtr0334113; FBpp0306232; FBgn0000100
GeneIDi40451
KEGGidme:Dmel_CG7490

Similar proteinsi

Entry informationi

Entry nameiRLA0_DROME
AccessioniPrimary (citable) accession number: P19889
Secondary accession number(s): Q5BHX7, Q9VNV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: May 23, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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