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Protein

Follistatin

Gene

FST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

GO - Molecular functioni

  • activin binding Source: UniProtKB
  • heparan sulfate proteoglycan binding Source: Ensembl
  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: UniProtKB
  • negative regulation of activin receptor signaling pathway Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of hair follicle development Source: MGI

Enzyme and pathway databases

ReactomeiR-HSA-2473224 Antagonism of Activin by Follistatin
SIGNORiP19883

Protein family/group databases

MEROPSiI01.966

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin
Short name:
FS
Alternative name(s):
Activin-binding protein
Gene namesi
Name:FST
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000134363.11
HGNCiHGNC:3971 FST
MIMi136470 gene
neXtProtiNX_P19883

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10468
OpenTargetsiENSG00000134363
Orphaneti3185 Polycystic ovary syndrome
PharmGKBiPA28388

Chemistry databases

DrugBankiDB01666 D-Myo-Inositol-Hexasulphate

Polymorphism and mutation databases

BioMutaiFST
DMDMi23831079

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000001010330 – 344FollistatinAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 55PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi42 ↔ 88PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi56 ↔ 91PROSITE-ProRule annotationCombined sources4 Publications
Disulfide bondi95 ↔ 106Combined sources4 Publications
Disulfide bondi100 ↔ 116Combined sources4 Publications
Disulfide bondi118 ↔ 150Combined sources4 Publications
Disulfide bondi122 ↔ 143Combined sources4 Publications
Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi132 ↔ 164Combined sources4 Publications
Disulfide bondi168 ↔ 179Combined sources4 Publications
Disulfide bondi173 ↔ 189Combined sources4 Publications
Disulfide bondi192 ↔ 225Combined sources4 Publications
Disulfide bondi196 ↔ 218Combined sources4 Publications
Disulfide bondi207 ↔ 239Combined sources4 Publications
Disulfide bondi245 ↔ 256Combined sources4 Publications
Disulfide bondi250 ↔ 267Combined sources4 Publications
Disulfide bondi270 ↔ 302Combined sources4 Publications
Disulfide bondi274 ↔ 295Combined sources4 Publications
Disulfide bondi284 ↔ 316Combined sources4 Publications
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP19883
PaxDbiP19883
PeptideAtlasiP19883
PRIDEiP19883

PTM databases

iPTMnetiP19883
PhosphoSitePlusiP19883
UniCarbKBiP19883

Expressioni

Tissue specificityi

Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.1 Publication

Gene expression databases

BgeeiENSG00000134363
CleanExiHS_FST
ExpressionAtlasiP19883 baseline and differential
GenevisibleiP19883 HS

Organism-specific databases

HPAiCAB026025
HPA018155

Interactioni

Subunit structurei

Monomer. Isoform 2/FS-288 interacts with GDF11 (PubMed:28257634).Curated1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115731, 8 interactors
IntActiP19883, 13 interactors
MINTiP19883
STRINGi9606.ENSP00000256759

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 36Combined sources6
Beta strandi42 – 49Combined sources8
Helixi52 – 55Combined sources4
Beta strandi64 – 66Combined sources3
Helixi72 – 81Combined sources10
Beta strandi82 – 87Combined sources6
Beta strandi89 – 91Combined sources3
Beta strandi93 – 95Combined sources3
Beta strandi104 – 108Combined sources5
Turni110 – 112Combined sources3
Beta strandi114 – 118Combined sources5
Helixi123 – 125Combined sources3
Beta strandi131 – 133Combined sources3
Beta strandi138 – 141Combined sources4
Helixi142 – 151Combined sources10
Beta strandi158 – 163Combined sources6
Beta strandi166 – 168Combined sources3
Beta strandi178 – 181Combined sources4
Beta strandi185 – 190Combined sources6
Beta strandi202 – 204Combined sources3
Beta strandi206 – 208Combined sources3
Beta strandi213 – 216Combined sources4
Helixi217 – 227Combined sources11
Beta strandi233 – 237Combined sources5
Helixi245 – 247Combined sources3
Turni251 – 253Combined sources3
Beta strandi255 – 259Combined sources5
Turni260 – 263Combined sources4
Beta strandi264 – 268Combined sources5
Beta strandi283 – 285Combined sources3
Beta strandi290 – 293Combined sources4
Helixi294 – 304Combined sources11
Beta strandi310 – 314Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B0UX-ray2.80C/D30-317[»]
2P6AX-ray3.40C/D30-344[»]
3HH2X-ray2.15C/D30-317[»]
5JHWX-ray2.35C/D30-317[»]
ProteinModelPortaliP19883
SMRiP19883
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19883

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 103TBPROSITE-ProRule annotationAdd BLAST74
Domaini94 – 117Follistatin-like 1Add BLAST24
Domaini112 – 166Kazal-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini167 – 190Follistatin-like 2Add BLAST24
Domaini186 – 241Kazal-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini244 – 268Follistatin-like 3Add BLAST25
Domaini264 – 318Kazal-like 3PROSITE-ProRule annotationAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 333Asp/Glu-rich (highly acidic)Add BLAST13

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IP0F Eukaryota
ENOG410YM8Q LUCA
GeneTreeiENSGT00440000033501
HOGENOMiHOG000261649
HOVERGENiHBG051666
InParanoidiP19883
KOiK04661
OMAiDEAVCAS
OrthoDBiEOG091G09I0
PhylomeDBiP19883
TreeFamiTF106409

Family and domain databases

Gene3Di3.90.290.10, 1 hit
InterProiView protein in InterPro
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR017878 TB_dom
IPR036773 TB_dom_sf
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF07648 Kazal_2, 3 hits
SMARTiView protein in SMART
SM00274 FOLN, 3 hits
SM00280 KAZAL, 3 hits
SUPFAMiSSF100895 SSF100895, 3 hits
SSF57581 SSF57581, 1 hit
PROSITEiView protein in PROSITE
PS51465 KAZAL_2, 3 hits
PS51364 TB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P19883-1) [UniParc]FASTAAdd to basket
Also known as: FS315, FS-315

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRARHQPGG LCLLLLLLCQ FMEDRSAQAG NCWLRQAKNG RCQVLYKTEL
60 70 80 90 100
SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC
110 120 130 140 150
GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC
160 170 180 190 200
KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA
210 220 230 240 250
SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC
260 270 280 290 300
TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA
310 320 330 340
ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW
Length:344
Mass (Da):38,007
Last modified:October 10, 2002 - v2
Checksum:iD9BB45055D84AC90
GO
Isoform 2 (identifier: P19883-2) [UniParc]FASTAAdd to basket
Also known as: FS288, FS-288

The sequence of this isoform differs from the canonical sequence as follows:
     318-344: Missing.

Show »
Length:317
Mass (Da):34,803
Checksum:iB516643224C7F8FF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049091152E → Q. Corresponds to variant dbSNP:rs11745088Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001565318 – 344Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19481, M19480 Genomic DNA Translation: AAA35851.1
AB451330 mRNA Translation: BAG70144.1
AB451474 mRNA Translation: BAG70288.1
CH471123 Genomic DNA Translation: EAW54880.1
BC004107 mRNA Translation: AAH04107.1
CCDSiCCDS3959.1 [P19883-1]
CCDS43315.1 [P19883-2]
PIRiA32141
RefSeqiNP_006341.1, NM_006350.3 [P19883-2]
NP_037541.1, NM_013409.2 [P19883-1]
UniGeneiHs.9914

Genome annotation databases

EnsembliENST00000256759; ENSP00000256759; ENSG00000134363 [P19883-1]
ENST00000396947; ENSP00000380151; ENSG00000134363 [P19883-2]
GeneIDi10468
KEGGihsa:10468
UCSCiuc003jpc.4 human [P19883-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFST_HUMAN
AccessioniPrimary (citable) accession number: P19883
Secondary accession number(s): B5BU94, Q9BTH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 10, 2002
Last modified: March 28, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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