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Protein

Heat shock protein 60, mitochondrial

Gene

HSP60

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins.

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • chaperone binding Source: SGD
  • DNA replication origin binding Source: SGD
  • protein binding involved in protein folding Source: GO_Central
  • single-stranded DNA binding Source: SGD
  • unfolded protein binding Source: SGD

GO - Biological processi

  • 'de novo' protein folding Source: SGD
  • apoptotic mitochondrial changes Source: GO_Central
  • chaperone-mediated protein complex assembly Source: SGD
  • chaperone-mediated protein folding Source: GO_Central
  • protein import into mitochondrial intermembrane space Source: SGD
  • protein maturation Source: SGD
  • protein refolding Source: SGD
  • protein stabilization Source: SGD
  • protein targeting to mitochondrion Source: Reactome

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32361-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 60, mitochondrial
Alternative name(s):
CPN60
P66
Stimulator factor I 66 kDa component
Gene namesi
Name:HSP60
Synonyms:MIF4
Ordered Locus Names:YLR259C
ORF Names:L8479.10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR259C.
SGDiS000004249. HSP60.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000000504426 – 572Heat shock protein 60, mitochondrialAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphothreonineCombined sources1
Modified residuei485PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP19882.
PRIDEiP19882.

2D gel databases

SWISS-2DPAGEiP19882.
UCD-2DPAGEiP19882.

PTM databases

iPTMnetiP19882.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RAD2P072762EBI-8586,EBI-14757

GO - Molecular functioni

  • chaperone binding Source: SGD
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi31527. 302 interactors.
DIPiDIP-7648N.
IntActiP19882. 247 interactors.
MINTiMINT-2783335.
STRINGi4932.YLR259C.

Structurei

3D structure databases

ProteinModelPortaliP19882.
SMRiP19882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00390000005727.
HOGENOMiHOG000076290.
InParanoidiP19882.
KOiK04077.
OMAiTDTDKME.
OrthoDBiEOG092C1JWK.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSSVVRSR ATLRPLLRRA YSSHKELKFG VEGRASLLKG VETLAEAVAA
60 70 80 90 100
TLGPKGRNVL IEQPFGPPKI TKDGVTVAKS IVLKDKFENM GAKLLQEVAS
110 120 130 140 150
KTNEAAGDGT TSATVLGRAI FTESVKNVAA GCNPMDLRRG SQVAVEKVIE
160 170 180 190 200
FLSANKKEIT TSEEIAQVAT ISANGDSHVG KLLASAMEKV GKEGVITIRE
210 220 230 240 250
GRTLEDELEV TEGMRFDRGF ISPYFITDPK SSKVEFEKPL LLLSEKKISS
260 270 280 290 300
IQDILPALEI SNQSRRPLLI IAEDVDGEAL AACILNKLRG QVKVCAVKAP
310 320 330 340 350
GFGDNRKNTI GDIAVLTGGT VFTEELDLKP EQCTIENLGS CDSITVTKED
360 370 380 390 400
TVILNGSGPK EAIQERIEQI KGSIDITTTN SYEKEKLQER LAKLSGGVAV
410 420 430 440 450
IRVGGASEVE VGEKKDRYDD ALNATRAAVE EGILPGGGTA LVKASRVLDE
460 470 480 490 500
VVVDNFDQKL GVDIIRKAIT RPAKQIIENA GEEGSVIIGK LIDEYGDDFA
510 520 530 540 550
KGYDASKSEY TDMLATGIID PFKVVRSGLV DASGVASLLA TTEVAIVDAP
560 570
EPPAAAGAGG MPGGMPGMPG MM
Length:572
Mass (Da):60,752
Last modified:February 1, 1991 - v1
Checksum:i279DC3AF5A2B0A3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33301 Genomic DNA. Translation: AAA34690.1.
U17244 Genomic DNA. Translation: AAB67380.1.
BK006945 Genomic DNA. Translation: DAA09572.1.
PIRiJQ0157.
RefSeqiNP_013360.1. NM_001182146.1.

Genome annotation databases

EnsemblFungiiYLR259C; YLR259C; YLR259C.
GeneIDi850963.
KEGGisce:YLR259C.

Similar proteinsi

Entry informationi

Entry nameiHSP60_YEAST
AccessioniPrimary (citable) accession number: P19882
Secondary accession number(s): D6VYQ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 22, 2017
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names