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Protein

C-X-C motif chemokine 3

Gene

CXCL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163734-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 3
Alternative name(s):
GRO-gamma(1-73)
Growth-regulated protein gamma
Short name:
GRO-gamma
Macrophage inflammatory protein 2-beta
Short name:
MIP2-beta
Cleaved into the following chain:
Gene namesi
Name:CXCL3
Synonyms:GRO3, GROG, SCYB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4604. CXCL3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi2921.
OpenTargetsiENSG00000163734.
PharmGKBiPA35052.

Polymorphism and mutation databases

BioMutaiCXCL3.
DMDMi127086.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 341 PublicationAdd BLAST34
ChainiPRO_000000506535 – 107C-X-C motif chemokine 3Add BLAST73
ChainiPRO_000000506639 – 107GRO-gamma(5-73)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 69By similarity
Disulfide bondi45 ↔ 85By similarity

Post-translational modificationi

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP19876.
PeptideAtlasiP19876.
PRIDEiP19876.

Expressioni

Gene expression databases

BgeeiENSG00000163734.
CleanExiHS_CXCL3.
GenevisibleiP19876. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5909N.
STRINGi9606.ENSP00000296026.

Structurei

3D structure databases

ProteinModelPortaliP19876.
SMRiP19876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP19876.
KOiK05505.
OMAiNGKKACL.
OrthoDBiEOG091G14TE.
PhylomeDBiP19876.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ
60 70 80 90 100
GIHLKNIQSV NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI

LNKGSTN
Length:107
Mass (Da):11,342
Last modified:February 1, 1991 - v1
Checksum:i97A69946B7F1F070
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28AA → G in AAA63184 (PubMed:2217207).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0592103H → R.Corresponds to variant rs352043dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53800 mRNA. Translation: CAA37809.1.
M36821 mRNA. Translation: AAA63184.1.
AC097709 Genomic DNA. Translation: AAY41006.1.
CH471057 Genomic DNA. Translation: EAX05698.1.
BC016308 mRNA. Translation: AAH16308.1.
BC065743 mRNA. Translation: AAH65743.1.
CCDSiCCDS34007.1.
PIRiJH0282. B38290.
RefSeqiNP_002081.2. NM_002090.2.
UniGeneiHs.89690.

Genome annotation databases

EnsembliENST00000296026; ENSP00000296026; ENSG00000163734.
GeneIDi2921.
KEGGihsa:2921.
UCSCiuc003hhl.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXCL3 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53800 mRNA. Translation: CAA37809.1.
M36821 mRNA. Translation: AAA63184.1.
AC097709 Genomic DNA. Translation: AAY41006.1.
CH471057 Genomic DNA. Translation: EAX05698.1.
BC016308 mRNA. Translation: AAH16308.1.
BC065743 mRNA. Translation: AAH65743.1.
CCDSiCCDS34007.1.
PIRiJH0282. B38290.
RefSeqiNP_002081.2. NM_002090.2.
UniGeneiHs.89690.

3D structure databases

ProteinModelPortaliP19876.
SMRiP19876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5909N.
STRINGi9606.ENSP00000296026.

Polymorphism and mutation databases

BioMutaiCXCL3.
DMDMi127086.

Proteomic databases

PaxDbiP19876.
PeptideAtlasiP19876.
PRIDEiP19876.

Protocols and materials databases

DNASUi2921.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296026; ENSP00000296026; ENSG00000163734.
GeneIDi2921.
KEGGihsa:2921.
UCSCiuc003hhl.5. human.

Organism-specific databases

CTDi2921.
DisGeNETi2921.
GeneCardsiCXCL3.
HGNCiHGNC:4604. CXCL3.
MIMi139111. gene.
neXtProtiNX_P19876.
OpenTargetsiENSG00000163734.
PharmGKBiPA35052.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP19876.
KOiK05505.
OMAiNGKKACL.
OrthoDBiEOG091G14TE.
PhylomeDBiP19876.
TreeFamiTF333433.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000163734-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiCXCL3.
GenomeRNAii2921.
PROiP19876.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163734.
CleanExiHS_CXCL3.
GenevisibleiP19876. HS.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL3_HUMAN
AccessioniPrimary (citable) accession number: P19876
Secondary accession number(s): Q4W5H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.