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P19876

- CXCL3_HUMAN

UniProt

P19876 - CXCL3_HUMAN

Protein

C-X-C motif chemokine 3

Gene

CXCL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ligand for CXCR2 By similarity. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.By similarity1 Publication

    GO - Molecular functioni

    1. chemokine activity Source: UniProtKB

    GO - Biological processi

    1. immune response Source: InterPro
    2. inflammatory response Source: UniProtKB-KW
    3. neutrophil chemotaxis Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 3
    Alternative name(s):
    GRO-gamma(1-73)
    Growth-regulated protein gamma
    Short name:
    GRO-gamma
    Macrophage inflammatory protein 2-beta
    Short name:
    MIP2-beta
    Cleaved into the following chain:
    Gene namesi
    Name:CXCL3
    Synonyms:GRO3, GROG, SCYB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4604. CXCL3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35052.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 34341 PublicationAdd
    BLAST
    Chaini35 – 10773C-X-C motif chemokine 3PRO_0000005065Add
    BLAST
    Chaini39 – 10769GRO-gamma(5-73)PRO_0000005066Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 69By similarity
    Disulfide bondi45 ↔ 85By similarity

    Post-translational modificationi

    N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP19876.
    PRIDEiP19876.

    Expressioni

    Gene expression databases

    ArrayExpressiP19876.
    BgeeiP19876.
    CleanExiHS_CXCL3.
    GenevestigatoriP19876.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-5909N.
    STRINGi9606.ENSP00000296026.

    Structurei

    3D structure databases

    ProteinModelPortaliP19876.
    SMRiP19876. Positions 35-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG327267.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    InParanoidiP19876.
    KOiK05505.
    OMAiACKLTIV.
    OrthoDBiEOG7NSB57.
    PhylomeDBiP19876.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19876-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ    50
    GIHLKNIQSV NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI 100
    LNKGSTN 107
    Length:107
    Mass (Da):11,342
    Last modified:February 1, 1991 - v1
    Checksum:i97A69946B7F1F070
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 282AA → G in AAA63184. (PubMed:2217207)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31H → R.
    Corresponds to variant rs352043 [ dbSNP | Ensembl ].
    VAR_059210

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53800 mRNA. Translation: CAA37809.1.
    M36821 mRNA. Translation: AAA63184.1.
    AC097709 Genomic DNA. Translation: AAY41006.1.
    CH471057 Genomic DNA. Translation: EAX05698.1.
    BC016308 mRNA. Translation: AAH16308.1.
    BC065743 mRNA. Translation: AAH65743.1.
    CCDSiCCDS34007.1.
    PIRiJH0282. B38290.
    RefSeqiNP_002081.2. NM_002090.2.
    UniGeneiHs.89690.

    Genome annotation databases

    EnsembliENST00000296026; ENSP00000296026; ENSG00000163734.
    GeneIDi2921.
    KEGGihsa:2921.
    UCSCiuc003hhl.3. human.

    Polymorphism databases

    DMDMi127086.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL3 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53800 mRNA. Translation: CAA37809.1 .
    M36821 mRNA. Translation: AAA63184.1 .
    AC097709 Genomic DNA. Translation: AAY41006.1 .
    CH471057 Genomic DNA. Translation: EAX05698.1 .
    BC016308 mRNA. Translation: AAH16308.1 .
    BC065743 mRNA. Translation: AAH65743.1 .
    CCDSi CCDS34007.1.
    PIRi JH0282. B38290.
    RefSeqi NP_002081.2. NM_002090.2.
    UniGenei Hs.89690.

    3D structure databases

    ProteinModelPortali P19876.
    SMRi P19876. Positions 35-102.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-5909N.
    STRINGi 9606.ENSP00000296026.

    Polymorphism databases

    DMDMi 127086.

    Proteomic databases

    PaxDbi P19876.
    PRIDEi P19876.

    Protocols and materials databases

    DNASUi 2921.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000296026 ; ENSP00000296026 ; ENSG00000163734 .
    GeneIDi 2921.
    KEGGi hsa:2921.
    UCSCi uc003hhl.3. human.

    Organism-specific databases

    CTDi 2921.
    GeneCardsi GC04M074891.
    HGNCi HGNC:4604. CXCL3.
    MIMi 139111. gene.
    neXtProti NX_P19876.
    PharmGKBi PA35052.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327267.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    InParanoidi P19876.
    KOi K05505.
    OMAi ACKLTIV.
    OrthoDBi EOG7NSB57.
    PhylomeDBi P19876.
    TreeFami TF333433.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii CXCL3.
    GenomeRNAii 2921.
    NextBioi 11581.
    PROi P19876.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19876.
    Bgeei P19876.
    CleanExi HS_CXCL3.
    Genevestigatori P19876.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues."
      Tekamp-Olson P., Gallegos C., Bauer D., McClain J., Sherry B., Fabre M., van Deventer S., Cerami A.
      J. Exp. Med. 172:911-919(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Histiocytic lymphoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 35-49.
    7. "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
      Wuyts A., Govaerts C., Struyf S., Lenaerts J.-P., Put W., Conings R., Proost P., Van Damme J.
      Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 39-45, IDENTIFICATION OF GRO-GAMMA(5-73), PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
      Tissue: Peripheral blood monocyte.

    Entry informationi

    Entry nameiCXCL3_HUMAN
    AccessioniPrimary (citable) accession number: P19876
    Secondary accession number(s): Q4W5H9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3