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P19876

- CXCL3_HUMAN

UniProt

P19876 - CXCL3_HUMAN

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Protein
C-X-C motif chemokine 3
Gene
CXCL3, GRO3, GROG, SCYB3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ligand for CXCR2 By similarity. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.1 Publication

GO - Molecular functioni

  1. chemokine activity Source: UniProtKB

GO - Biological processi

  1. immune response Source: InterPro
  2. inflammatory response Source: UniProtKB-KW
  3. neutrophil chemotaxis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 3
Alternative name(s):
GRO-gamma(1-73)
Growth-regulated protein gamma
Short name:
GRO-gamma
Macrophage inflammatory protein 2-beta
Short name:
MIP2-beta
Cleaved into the following chain:
Gene namesi
Name:CXCL3
Synonyms:GRO3, GROG, SCYB3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:4604. CXCL3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35052.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 34341 Publication
Add
BLAST
Chaini35 – 10773C-X-C motif chemokine 3
PRO_0000005065Add
BLAST
Chaini39 – 10769GRO-gamma(5-73)
PRO_0000005066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 69 By similarity
Disulfide bondi45 ↔ 85 By similarity

Post-translational modificationi

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP19876.
PRIDEiP19876.

Expressioni

Gene expression databases

ArrayExpressiP19876.
BgeeiP19876.
CleanExiHS_CXCL3.
GenevestigatoriP19876.

Interactioni

Protein-protein interaction databases

DIPiDIP-5909N.
STRINGi9606.ENSP00000296026.

Structurei

3D structure databases

ProteinModelPortaliP19876.
SMRiP19876. Positions 35-102.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG327267.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP19876.
KOiK05505.
OMAiACKLTIV.
OrthoDBiEOG7NSB57.
PhylomeDBiP19876.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19876-1 [UniParc]FASTAAdd to Basket

« Hide

MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ    50
GIHLKNIQSV NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI 100
LNKGSTN 107
Length:107
Mass (Da):11,342
Last modified:February 1, 1991 - v1
Checksum:i97A69946B7F1F070
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31H → R.
Corresponds to variant rs352043 [ dbSNP | Ensembl ].
VAR_059210

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 282AA → G in AAA63184. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53800 mRNA. Translation: CAA37809.1.
M36821 mRNA. Translation: AAA63184.1.
AC097709 Genomic DNA. Translation: AAY41006.1.
CH471057 Genomic DNA. Translation: EAX05698.1.
BC016308 mRNA. Translation: AAH16308.1.
BC065743 mRNA. Translation: AAH65743.1.
CCDSiCCDS34007.1.
PIRiJH0282. B38290.
RefSeqiNP_002081.2. NM_002090.2.
UniGeneiHs.89690.

Genome annotation databases

EnsembliENST00000296026; ENSP00000296026; ENSG00000163734.
GeneIDi2921.
KEGGihsa:2921.
UCSCiuc003hhl.3. human.

Polymorphism databases

DMDMi127086.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

CXCL3 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53800 mRNA. Translation: CAA37809.1 .
M36821 mRNA. Translation: AAA63184.1 .
AC097709 Genomic DNA. Translation: AAY41006.1 .
CH471057 Genomic DNA. Translation: EAX05698.1 .
BC016308 mRNA. Translation: AAH16308.1 .
BC065743 mRNA. Translation: AAH65743.1 .
CCDSi CCDS34007.1.
PIRi JH0282. B38290.
RefSeqi NP_002081.2. NM_002090.2.
UniGenei Hs.89690.

3D structure databases

ProteinModelPortali P19876.
SMRi P19876. Positions 35-102.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-5909N.
STRINGi 9606.ENSP00000296026.

Polymorphism databases

DMDMi 127086.

Proteomic databases

PaxDbi P19876.
PRIDEi P19876.

Protocols and materials databases

DNASUi 2921.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296026 ; ENSP00000296026 ; ENSG00000163734 .
GeneIDi 2921.
KEGGi hsa:2921.
UCSCi uc003hhl.3. human.

Organism-specific databases

CTDi 2921.
GeneCardsi GC04M074891.
HGNCi HGNC:4604. CXCL3.
MIMi 139111. gene.
neXtProti NX_P19876.
PharmGKBi PA35052.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327267.
HOGENOMi HOG000220915.
HOVERGENi HBG107789.
InParanoidi P19876.
KOi K05505.
OMAi ACKLTIV.
OrthoDBi EOG7NSB57.
PhylomeDBi P19876.
TreeFami TF333433.

Enzyme and pathway databases

Reactomei REACT_15344. Chemokine receptors bind chemokines.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii CXCL3.
GenomeRNAii 2921.
NextBioi 11581.
PROi P19876.
SOURCEi Search...

Gene expression databases

ArrayExpressi P19876.
Bgeei P19876.
CleanExi HS_CXCL3.
Genevestigatori P19876.

Family and domain databases

InterProi IPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
PANTHERi PTHR10179. PTHR10179. 1 hit.
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
PRINTSi PR00437. SMALLCYTKCXC.
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues."
    Tekamp-Olson P., Gallegos C., Bauer D., McClain J., Sherry B., Fabre M., van Deventer S., Cerami A.
    J. Exp. Med. 172:911-919(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Histiocytic lymphoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 35-49.
  7. "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
    Wuyts A., Govaerts C., Struyf S., Lenaerts J.-P., Put W., Conings R., Proost P., Van Damme J.
    Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 39-45, IDENTIFICATION OF GRO-GAMMA(5-73), PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
    Tissue: Peripheral blood monocyte.

Entry informationi

Entry nameiCXCL3_HUMAN
AccessioniPrimary (citable) accession number: P19876
Secondary accession number(s): Q4W5H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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