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P19876 (CXCL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 131. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 3
Alternative name(s):
GRO-gamma(1-73)
Growth-regulated protein gamma
Short name=GRO-gamma
Macrophage inflammatory protein 2-beta
Short name=MIP2-beta

Cleaved into the following chain:

  1. GRO-gamma(5-73)
Gene names
Name:CXCL3
Synonyms:GRO3, GROG, SCYB3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length107 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for CXCR2 By similarity. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Ref.7

Subcellular location

Secreted.

Post-translational modification

N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processimmune response

Inferred from electronic annotation. Source: InterPro

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

neutrophil chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from direct assay Ref.7. Source: UniProtKB

   Molecular_functionchemokine activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Ref.6
Chain35 – 10773C-X-C motif chemokine 3
PRO_0000005065
Chain39 – 10769GRO-gamma(5-73)
PRO_0000005066

Amino acid modifications

Disulfide bond43 ↔ 69 By similarity
Disulfide bond45 ↔ 85 By similarity

Natural variations

Natural variant31H → R.
Corresponds to variant rs352043 [ dbSNP | Ensembl ].
VAR_059210

Experimental info

Sequence conflict27 – 282AA → G in AAA63184. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P19876 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 97A69946B7F1F070

FASTA10711,342
        10         20         30         40         50         60 
MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ GIHLKNIQSV 

        70         80         90        100 
NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI LNKGSTN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues."
Tekamp-Olson P., Gallegos C., Bauer D., McClain J., Sherry B., Fabre M., van Deventer S., Cerami A.
J. Exp. Med. 172:911-919(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Histiocytic lymphoma.
[2]"Identification of three related human GRO genes encoding cytokine functions."
Haskill S., Peace A., Morris J., Sporn S.A., Anisowicz A., Lee S.W., Smith T., Martin G., Ralph P., Sager R.
Proc. Natl. Acad. Sci. U.S.A. 87:7732-7736(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 35-49.
[7]"Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
Wuyts A., Govaerts C., Struyf S., Lenaerts J.-P., Put W., Conings R., Proost P., Van Damme J.
Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 39-45, IDENTIFICATION OF GRO-GAMMA(5-73), PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
Tissue: Peripheral blood monocyte.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL3 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53800 mRNA. Translation: CAA37809.1.
M36821 mRNA. Translation: AAA63184.1.
AC097709 Genomic DNA. Translation: AAY41006.1.
CH471057 Genomic DNA. Translation: EAX05698.1.
BC016308 mRNA. Translation: AAH16308.1.
BC065743 mRNA. Translation: AAH65743.1.
CCDSCCDS34007.1.
PIRB38290. JH0282.
RefSeqNP_002081.2. NM_002090.2.
UniGeneHs.89690.

3D structure databases

ProteinModelPortalP19876.
SMRP19876. Positions 35-102.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-5909N.
STRING9606.ENSP00000296026.

Polymorphism databases

DMDM127086.

Proteomic databases

PaxDbP19876.
PRIDEP19876.

Protocols and materials databases

DNASU2921.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296026; ENSP00000296026; ENSG00000163734.
GeneID2921.
KEGGhsa:2921.
UCSCuc003hhl.3. human.

Organism-specific databases

CTD2921.
GeneCardsGC04M074891.
HGNCHGNC:4604. CXCL3.
MIM139111. gene.
neXtProtNX_P19876.
PharmGKBPA35052.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327267.
HOGENOMHOG000220915.
HOVERGENHBG107789.
InParanoidP19876.
KOK05505.
OMAACKLTIV.
OrthoDBEOG7NSB57.
PhylomeDBP19876.
TreeFamTF333433.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP19876.
BgeeP19876.
CleanExHS_CXCL3.
GenevestigatorP19876.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCXCL3.
GenomeRNAi2921.
NextBio11581.
PROP19876.
SOURCESearch...

Entry information

Entry nameCXCL3_HUMAN
AccessionPrimary (citable) accession number: P19876
Secondary accession number(s): Q4W5H9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM