P19876 (CXCL3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C motif chemokine 3

Alternative name(s):
GRO-gamma(1-73)
Growth-regulated protein gamma
Short name=GRO-gamma
Macrophage inflammatory protein 2-beta
Short name=MIP2-beta

Cleaved into the following chain:

1. GRO-gamma(5-73)

Gene names

Name:	CXCL3
Synonyms:	GRO3, GROG, SCYB3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ligand for CXCR2 By similarity. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Ref.7
Subcellular location	Secreted.
Post-translational modification	N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Sequence similarities	Belongs to the intercrine alpha (chemokine CxC) family.

Ontologies

Keywords
Biological process	Chemotaxis Inflammatory response
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	immune response Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW neutrophil chemotaxis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular space Inferred from direct assay Ref.7. Source: UniProtKB
Molecular_function	chemokine activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Ref.6
	Chain	35 – 107	73	C-X-C motif chemokine 3		PRO_0000005065
	Chain	39 – 107	69	GRO-gamma(5-73)		PRO_0000005066
Amino acid modifications
	Disulfide bond	43 ↔ 69		By similarity
	Disulfide bond	45 ↔ 85		By similarity
Natural variations
	Natural variant	3	1	H → R. Corresponds to variant rs352043 [ dbSNP | Ensembl ].		VAR_059210
Experimental info
	Sequence conflict	27 – 28	2	AA → G in AAA63184. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P19876 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 97A69946B7F1F070	FASTA	107	11,342
	10 20 30 40 50 60 MAHATLSAAP SNPRLLRVAL LLLLLVAASR RAAGASVVTE LRCQCLQTLQ GIHLKNIQSV 70 80 90 100 NVRSPGPHCA QTEVIATLKN GKKACLNPAS PMVQKIIEKI LNKGSTN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues." Tekamp-Olson P., Gallegos C., Bauer D., McClain J., Sherry B., Fabre M., van Deventer S., Cerami A. J. Exp. Med. 172:911-919(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Histiocytic lymphoma.
[2]	"Identification of three related human GRO genes encoding cytokine functions." Haskill S., Peace A., Morris J., Sporn S.A., Anisowicz A., Lee S.W., Smith T., Martin G., Ralph P., Sager R. Proc. Natl. Acad. Sci. U.S.A. 87:7732-7736(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[6]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 35-49.
[7]	"Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms." Wuyts A., Govaerts C., Struyf S., Lenaerts J.-P., Put W., Conings R., Proost P., Van Damme J. Eur. J. Biochem. 260:421-429(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 39-45, IDENTIFICATION OF GRO-GAMMA(5-73), PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION. Tissue: Peripheral blood monocyte.
+	Additional computationally mapped references.

Web resources

Wikipedia

CXCL3 entry

Cross-references

Sequence databases
EMBL GenBank DDBJ	X53800 mRNA. Translation: CAA37809.1. M36821 mRNA. Translation: AAA63184.1. AC097709 Genomic DNA. Translation: AAY41006.1. CH471057 Genomic DNA. Translation: EAX05698.1. BC016308 mRNA. Translation: AAH16308.1. BC065743 mRNA. Translation: AAH65743.1.
IPI	IPI00218180.
PIR	B38290. JH0282.
RefSeq	NP_002081.2. NM_002090.2.
UniGene	Hs.89690.
3D structure databases
ProteinModelPortal	P19876.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5909N.
STRING	9606.ENSP00000296026.
Polymorphism databases
DMDM	127086.
Proteomic databases
PaxDb	P19876.
PRIDE	P19876.
Protocols and materials databases
DNASU	2921.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000296026; ENSP00000296026; ENSG00000163734.
GeneID	2921.
KEGG	hsa:2921.
UCSC	uc003hhl.3. human.
Organism-specific databases
CTD	2921.
GeneCards	GC04M074891.
HGNC	HGNC:4604. CXCL3.
MIM	139111. gene.
neXtProt	NX_P19876.
PharmGKB	PA35052.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG327267.
HOGENOM	HOG000220915.
HOVERGEN	HBG107789.
InParanoid	P19876.
KO	K05505.
OMA	NGKKACL.
OrthoDB	EOG4Z8XZ6.
PhylomeDB	P19876.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P19876.
Bgee	P19876.
CleanEx	HS_CXCL3.
Genevestigator	P19876.
GermOnline	ENSG00000163734. Homo sapiens.
Family and domain databases
InterPro	IPR001089. Chemokine_CXC. IPR018048. Chemokine_CXC_CS. IPR001811. Chemokine_IL8-like_dom. [Graphical view]
PANTHER	PTHR10179. PTHR10179. 1 hit.
Pfam	PF00048. IL8. 1 hit. [Graphical view]
PRINTS	PR00437. SMALLCYTKCXC.
SMART	SM00199. SCY. 1 hit. [Graphical view]
SUPFAM	SSF54117. Chemokine_IL8. 1 hit.
PROSITE	PS00471. SMALL_CYTOKINES_CXC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2921.
NextBio	11581.
SOURCE	Search...

Entry information

Entry name

CXCL3_HUMAN

Accession

Primary (citable) accession number: P19876
Secondary accession number(s): Q4W5H9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.