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Protein

C-X-C motif chemokine 2

Gene

CXCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.1 Publication

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • CXCR chemokine receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

BioCyciZFISH:ENSG00000081041-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 2
Alternative name(s):
Growth-regulated protein beta
Short name:
Gro-beta
Macrophage inflammatory protein 2-alpha
Short name:
MIP2-alpha
Cleaved into the following chain:
Alternative name(s):
GRO-beta-T
Hematopoietic synergistic factor
Short name:
HSF
SB-251353
Gene namesi
Name:CXCL2
Synonyms:GRO2, GROB, MIP2A, SCYB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:4603. CXCL2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias.

Organism-specific databases

DisGeNETi2920.
OpenTargetsiENSG00000081041.
PharmGKBiPA35051.

Chemistry databases

ChEMBLiCHEMBL3286076.

Polymorphism and mutation databases

BioMutaiCXCL2.
DMDMi127085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000000506335 – 107C-X-C motif chemokine 2Add BLAST73
ChainiPRO_000000506439 – 107GRO-beta(5-73)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 69
Disulfide bondi45 ↔ 85

Post-translational modificationi

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP19875.
PaxDbiP19875.
PeptideAtlasiP19875.
PRIDEiP19875.

Miscellaneous databases

PMAP-CutDBP19875.

Expressioni

Gene expression databases

BgeeiENSG00000081041.
CleanExiHS_CXCL2.
ExpressionAtlasiP19875. baseline and differential.
GenevisibleiP19875. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-2114901,EBI-2871277

GO - Molecular functioni

  • chemokine activity Source: ProtInc
  • CXCR chemokine receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109177. 3 interactors.
DIPiDIP-5908N.
IntActiP19875. 3 interactors.
MINTiMINT-6491498.
STRINGi9606.ENSP00000427279.

Chemistry databases

BindingDBiP19875.

Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi49 – 51Combined sources3
Turni54 – 56Combined sources3
Beta strandi57 – 63Combined sources7
Beta strandi73 – 78Combined sources6
Beta strandi83 – 86Combined sources4
Turni93 – 95Combined sources3
Turni98 – 102Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNKNMR-A/B39-107[»]
ProteinModelPortaliP19875.
SMRiP19875.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19875.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP19875.
KOiK05505.
OMAiTMQGIHL.
OrthoDBiEOG091G14TE.
PhylomeDBiP19875.
TreeFamiTF333433.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ
60 70 80 90 100
GIHLKNIQSV KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM

LKNGKSN
Length:107
Mass (Da):11,389
Last modified:February 1, 1991 - v1
Checksum:i740F277E928571BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53799 mRNA. Translation: CAA37808.1.
M36820 mRNA. Translation: AAA63183.1.
M57731 mRNA. Translation: AAA63182.1.
CR542171 mRNA. Translation: CAG46968.1.
CH471057 Genomic DNA. Translation: EAX05700.1.
BC015753 mRNA. Translation: AAH15753.1.
AF043340 mRNA. Translation: AAC03540.1.
CCDSiCCDS34008.1.
PIRiJH0281.
RefSeqiNP_002080.1. NM_002089.3.
UniGeneiHs.75765.

Genome annotation databases

EnsembliENST00000508487; ENSP00000427279; ENSG00000081041.
GeneIDi2920.
KEGGihsa:2920.
UCSCiuc003hhm.5. human.

Cross-referencesi

Web resourcesi

Wikipedia

CXCL2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53799 mRNA. Translation: CAA37808.1.
M36820 mRNA. Translation: AAA63183.1.
M57731 mRNA. Translation: AAA63182.1.
CR542171 mRNA. Translation: CAG46968.1.
CH471057 Genomic DNA. Translation: EAX05700.1.
BC015753 mRNA. Translation: AAH15753.1.
AF043340 mRNA. Translation: AAC03540.1.
CCDSiCCDS34008.1.
PIRiJH0281.
RefSeqiNP_002080.1. NM_002089.3.
UniGeneiHs.75765.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNKNMR-A/B39-107[»]
ProteinModelPortaliP19875.
SMRiP19875.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109177. 3 interactors.
DIPiDIP-5908N.
IntActiP19875. 3 interactors.
MINTiMINT-6491498.
STRINGi9606.ENSP00000427279.

Chemistry databases

BindingDBiP19875.
ChEMBLiCHEMBL3286076.

Polymorphism and mutation databases

BioMutaiCXCL2.
DMDMi127085.

Proteomic databases

MaxQBiP19875.
PaxDbiP19875.
PeptideAtlasiP19875.
PRIDEiP19875.

Protocols and materials databases

DNASUi2920.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000508487; ENSP00000427279; ENSG00000081041.
GeneIDi2920.
KEGGihsa:2920.
UCSCiuc003hhm.5. human.

Organism-specific databases

CTDi2920.
DisGeNETi2920.
GeneCardsiCXCL2.
HGNCiHGNC:4603. CXCL2.
MIMi139110. gene.
neXtProtiNX_P19875.
OpenTargetsiENSG00000081041.
PharmGKBiPA35051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOGENOMiHOG000220915.
HOVERGENiHBG107789.
InParanoidiP19875.
KOiK05505.
OMAiTMQGIHL.
OrthoDBiEOG091G14TE.
PhylomeDBiP19875.
TreeFamiTF333433.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000081041-MONOMER.
ReactomeiR-HSA-380108. Chemokine receptors bind chemokines.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiP19875.
GenomeRNAii2920.
PMAP-CutDBP19875.
PROiP19875.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000081041.
CleanExiHS_CXCL2.
ExpressionAtlasiP19875. baseline and differential.
GenevisibleiP19875. HS.

Family and domain databases

CDDicd00273. Chemokine_CXC. 1 hit.
InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR033899. CXC_Chemokine_domain.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCL2_HUMAN
AccessioniPrimary (citable) accession number: P19875
Secondary accession number(s): Q6FGD6, Q9UPB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.