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P19875

- CXCL2_HUMAN

UniProt

P19875 - CXCL2_HUMAN

Protein

C-X-C motif chemokine 2

Gene

CXCL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.1 Publication

    GO - Molecular functioni

    1. chemokine activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. chemotaxis Source: ProtInc
    3. immune response Source: InterPro
    4. inflammatory response Source: ProtInc
    5. response to molecule of bacterial origin Source: BHF-UCL

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C motif chemokine 2
    Alternative name(s):
    Growth-regulated protein beta
    Short name:
    Gro-beta
    Macrophage inflammatory protein 2-alpha
    Short name:
    MIP2-alpha
    Cleaved into the following chain:
    Alternative name(s):
    GRO-beta-T
    Hematopoietic synergistic factor
    Short name:
    HSF
    SB-251353
    Gene namesi
    Name:CXCL2
    Synonyms:GRO2, GROB, MIP2A, SCYB2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:4603. CXCL2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias.

    Organism-specific databases

    PharmGKBiPA35051.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Add
    BLAST
    Chaini35 – 10773C-X-C motif chemokine 2PRO_0000005063Add
    BLAST
    Chaini39 – 10769GRO-beta(5-73)PRO_0000005064Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 69
    Disulfide bondi45 ↔ 85

    Post-translational modificationi

    The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.1 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP19875.
    PRIDEiP19875.

    Miscellaneous databases

    PMAP-CutDBP19875.

    Expressioni

    Gene expression databases

    ArrayExpressiP19875.
    BgeeiP19875.
    CleanExiHS_CXCL2.
    GenevestigatoriP19875.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DPP4P274872EBI-2114901,EBI-2871277

    Protein-protein interaction databases

    BioGridi109177. 3 interactions.
    DIPiDIP-5908N.
    IntActiP19875. 3 interactions.
    MINTiMINT-6491498.
    STRINGi9606.ENSP00000264492.

    Structurei

    Secondary structure

    1
    107
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi49 – 513
    Turni54 – 563
    Beta strandi57 – 637
    Beta strandi73 – 786
    Beta strandi83 – 864
    Turni93 – 953
    Turni98 – 1025

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QNKNMR-A/B39-107[»]
    ProteinModelPortaliP19875.
    SMRiP19875. Positions 39-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP19875.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG83801.
    HOGENOMiHOG000220915.
    HOVERGENiHBG107789.
    KOiK05505.
    OMAiFFSAPMA.
    OrthoDBiEOG7NSB57.
    PhylomeDBiP19875.
    TreeFamiTF333433.

    Family and domain databases

    InterProiIPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PANTHERiPTHR10179. PTHR10179. 1 hit.
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    PRINTSiPR00437. SMALLCYTKCXC.
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19875-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ    50
    GIHLKNIQSV KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM 100
    LKNGKSN 107
    Length:107
    Mass (Da):11,389
    Last modified:February 1, 1991 - v1
    Checksum:i740F277E928571BA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53799 mRNA. Translation: CAA37808.1.
    M36820 mRNA. Translation: AAA63183.1.
    M57731 mRNA. Translation: AAA63182.1.
    CR542171 mRNA. Translation: CAG46968.1.
    CH471057 Genomic DNA. Translation: EAX05700.1.
    BC015753 mRNA. Translation: AAH15753.1.
    AF043340 mRNA. Translation: AAC03540.1.
    CCDSiCCDS34008.1.
    PIRiJH0281.
    RefSeqiNP_002080.1. NM_002089.3.
    UniGeneiHs.75765.

    Genome annotation databases

    EnsembliENST00000508487; ENSP00000427279; ENSG00000081041.
    GeneIDi2920.
    KEGGihsa:2920.
    UCSCiuc003hhm.4. human.

    Polymorphism databases

    DMDMi127085.

    Cross-referencesi

    Web resourcesi

    Wikipedia

    CXCL2 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53799 mRNA. Translation: CAA37808.1 .
    M36820 mRNA. Translation: AAA63183.1 .
    M57731 mRNA. Translation: AAA63182.1 .
    CR542171 mRNA. Translation: CAG46968.1 .
    CH471057 Genomic DNA. Translation: EAX05700.1 .
    BC015753 mRNA. Translation: AAH15753.1 .
    AF043340 mRNA. Translation: AAC03540.1 .
    CCDSi CCDS34008.1.
    PIRi JH0281.
    RefSeqi NP_002080.1. NM_002089.3.
    UniGenei Hs.75765.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QNK NMR - A/B 39-107 [» ]
    ProteinModelPortali P19875.
    SMRi P19875. Positions 39-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109177. 3 interactions.
    DIPi DIP-5908N.
    IntActi P19875. 3 interactions.
    MINTi MINT-6491498.
    STRINGi 9606.ENSP00000264492.

    Polymorphism databases

    DMDMi 127085.

    Proteomic databases

    PaxDbi P19875.
    PRIDEi P19875.

    Protocols and materials databases

    DNASUi 2920.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000508487 ; ENSP00000427279 ; ENSG00000081041 .
    GeneIDi 2920.
    KEGGi hsa:2920.
    UCSCi uc003hhm.4. human.

    Organism-specific databases

    CTDi 2920.
    GeneCardsi GC04M074962.
    HGNCi HGNC:4603. CXCL2.
    MIMi 139110. gene.
    neXtProti NX_P19875.
    PharmGKBi PA35051.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG83801.
    HOGENOMi HOG000220915.
    HOVERGENi HBG107789.
    KOi K05505.
    OMAi FFSAPMA.
    OrthoDBi EOG7NSB57.
    PhylomeDBi P19875.
    TreeFami TF333433.

    Enzyme and pathway databases

    Reactomei REACT_15344. Chemokine receptors bind chemokines.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P19875.
    GenomeRNAii 2920.
    NextBioi 11577.
    PMAP-CutDB P19875.
    PROi P19875.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19875.
    Bgeei P19875.
    CleanExi HS_CXCL2.
    Genevestigatori P19875.

    Family and domain databases

    InterProi IPR001089. Chemokine_CXC.
    IPR018048. Chemokine_CXC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    PANTHERi PTHR10179. PTHR10179. 1 hit.
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    PRINTSi PR00437. SMALLCYTKCXC.
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00471. SMALL_CYTOKINES_CXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues."
      Tekamp-Olson P., Gallegos C., Bauer D., McClain J., Sherry B., Fabre M., van Deventer S., Cerami A.
      J. Exp. Med. 172:911-919(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Histiocytic lymphoma.
    2. "Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue."
      Iida N., Grotendorst G.R.
      Mol. Cell. Biol. 10:5596-5599(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    7. Jang J.S., Kim B.E.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-107.
    8. "Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair."
      Sporn S.A., Eierman D.F., Johnson C.E., Morris J., Martin G., Ladner M., Haskill S.
      J. Immunol. 144:4434-4441(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-107.
    9. "Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities."
      King A.G., Johanson K., Frey C.L., DeMarsh P.L., White J.R., McDevitt P., McNulty D., Balcarek J., Jonak Z.L., Bhatnagar P.K., Pelus L.M.
      J. Immunol. 164:3774-3782(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 39-56, IDENTIFICATION OF GRO-BETA(5-73) BY MASS SPECTROMETRY, PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
    10. "Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8."
      Qian Y.Q., Johanson K.O., McDevitt P.
      J. Mol. Biol. 294:1065-1072(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 39-107.

    Entry informationi

    Entry nameiCXCL2_HUMAN
    AccessioniPrimary (citable) accession number: P19875
    Secondary accession number(s): Q6FGD6, Q9UPB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3