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P19875 (CXCL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C motif chemokine 2
Alternative name(s):
Growth-regulated protein beta
Short name=Gro-beta
Macrophage inflammatory protein 2-alpha
Short name=MIP2-alpha

Cleaved into the following chain:

  1. GRO-beta(5-73)
    Alternative name(s):
    GRO-beta-T
    Hematopoietic synergistic factor
    Short name=HSF
    SB-251353
Gene names
Name:CXCL2
Synonyms:GRO2, GROB, MIP2A, SCYB2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length107 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Ref.9

Subcellular location

Secreted.

Post-translational modification

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.

Pharmaceutical use

GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias.

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DPP4P274872EBI-2114901,EBI-2871277

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434
Chain35 – 10773C-X-C motif chemokine 2
PRO_0000005063
Chain39 – 10769GRO-beta(5-73)
PRO_0000005064

Amino acid modifications

Disulfide bond43 ↔ 69
Disulfide bond45 ↔ 85

Secondary structure

.............. 107
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P19875 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 740F277E928571BA

FASTA10711,389
        10         20         30         40         50         60 
MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ GIHLKNIQSV 

        70         80         90        100 
KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM LKNGKSN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues."
Tekamp-Olson P., Gallegos C., Bauer D., McClain J., Sherry B., Fabre M., van Deventer S., Cerami A.
J. Exp. Med. 172:911-919(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Histiocytic lymphoma.
[2]"Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue."
Iida N., Grotendorst G.R.
Mol. Cell. Biol. 10:5596-5599(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of three related human GRO genes encoding cytokine functions."
Haskill S., Peace A., Morris J., Sporn S.A., Anisowicz A., Lee S.W., Smith T., Martin G., Ralph P., Sager R.
Proc. Natl. Acad. Sci. U.S.A. 87:7732-7736(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[7]Jang J.S., Kim B.E.
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 35-107.
[8]"Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair."
Sporn S.A., Eierman D.F., Johnson C.E., Morris J., Martin G., Ladner M., Haskill S.
J. Immunol. 144:4434-4441(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 56-107.
[9]"Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities."
King A.G., Johanson K., Frey C.L., DeMarsh P.L., White J.R., McDevitt P., McNulty D., Balcarek J., Jonak Z.L., Bhatnagar P.K., Pelus L.M.
J. Immunol. 164:3774-3782(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 39-56, IDENTIFICATION OF GRO-BETA(5-73) BY MASS SPECTROMETRY, PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.
[10]"Nuclear magnetic resonance solution structure of truncated human GRObeta [5-73] and its structural comparison with CXC chemokine family members GROalpha and IL-8."
Qian Y.Q., Johanson K.O., McDevitt P.
J. Mol. Biol. 294:1065-1072(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 39-107.
+Additional computationally mapped references.

Web resources

Wikipedia

CXCL2 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X53799 mRNA. Translation: CAA37808.1.
M36820 mRNA. Translation: AAA63183.1.
M57731 mRNA. Translation: AAA63182.1.
CR542171 mRNA. Translation: CAG46968.1.
CH471057 Genomic DNA. Translation: EAX05700.1.
BC015753 mRNA. Translation: AAH15753.1.
AF043340 mRNA. Translation: AAC03540.1.
CCDSCCDS34008.1.
PIRJH0281.
RefSeqNP_002080.1. NM_002089.3.
UniGeneHs.75765.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QNKNMR-A/B39-107[»]
ProteinModelPortalP19875.
SMRP19875. Positions 39-107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109177. 3 interactions.
DIPDIP-5908N.
IntActP19875. 3 interactions.
MINTMINT-6491498.
STRING9606.ENSP00000264492.

Polymorphism databases

DMDM127085.

Proteomic databases

PaxDbP19875.
PRIDEP19875.

Protocols and materials databases

DNASU2920.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000508487; ENSP00000427279; ENSG00000081041.
GeneID2920.
KEGGhsa:2920.
UCSCuc003hhm.4. human.

Organism-specific databases

CTD2920.
GeneCardsGC04M074962.
HGNCHGNC:4603. CXCL2.
MIM139110. gene.
neXtProtNX_P19875.
PharmGKBPA35051.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG83801.
HOGENOMHOG000220915.
HOVERGENHBG107789.
KOK05505.
OMAFFSAPMA.
OrthoDBEOG7NSB57.
PhylomeDBP19875.
TreeFamTF333433.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP19875.
BgeeP19875.
CleanExHS_CXCL2.
GenevestigatorP19875.

Family and domain databases

InterProIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERPTHR10179. PTHR10179. 1 hit.
PfamPF00048. IL8. 1 hit.
[Graphical view]
PRINTSPR00437. SMALLCYTKCXC.
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP19875.
GenomeRNAi2920.
NextBio11577.
PMAP-CutDBP19875.
PROP19875.
SOURCESearch...

Entry information

Entry nameCXCL2_HUMAN
AccessionPrimary (citable) accession number: P19875
Secondary accession number(s): Q6FGD6, Q9UPB8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM