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Protein

C-X-C motif chemokine 2

Gene

CXCL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
R-HSA-6783783 Interleukin-10 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C motif chemokine 2
Alternative name(s):
Growth-regulated protein beta
Short name:
Gro-beta
Macrophage inflammatory protein 2-alpha
Short name:
MIP2-alpha
Cleaved into the following chain:
Alternative name(s):
GRO-beta-T
Hematopoietic synergistic factor
Short name:
HSF
SB-251353
Gene namesi
Name:CXCL2
Synonyms:GRO2, GROB, MIP2A, SCYB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000081041.8
HGNCiHGNC:4603 CXCL2
MIMi139110 gene
neXtProtiNX_P19875

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

GRO-beta(5-73) is available under the name Garnocestim as immunomodulator. It is used prior to hematopoietic transplantation for peripheral blood stem cell mobilization and reduction of incidence, duration, and/or severity of chemotherapy induced cytopenias.

Organism-specific databases

DisGeNETi2920
OpenTargetsiENSG00000081041
PharmGKBiPA35051

Chemistry databases

ChEMBLiCHEMBL3286076

Polymorphism and mutation databases

BioMutaiCXCL2
DMDMi127085

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000000506335 – 107C-X-C motif chemokine 2Add BLAST73
ChainiPRO_000000506439 – 107GRO-beta(5-73)Add BLAST69

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 69
Disulfide bondi45 ↔ 85

Post-translational modificationi

The N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP19875
PaxDbiP19875
PeptideAtlasiP19875
PRIDEiP19875

Miscellaneous databases

PMAP-CutDBiP19875

Expressioni

Gene expression databases

BgeeiENSG00000081041
CleanExiHS_CXCL2
ExpressionAtlasiP19875 baseline and differential
GenevisibleiP19875 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DPP4P274872EBI-2114901,EBI-2871277

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109177, 6 interactors
DIPiDIP-5908N
IntActiP19875, 3 interactors
MINTiP19875
STRINGi9606.ENSP00000427279

Chemistry databases

BindingDBiP19875

Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi49 – 51Combined sources3
Helixi54 – 56Combined sources3
Beta strandi57 – 63Combined sources7
Beta strandi69 – 71Combined sources3
Beta strandi73 – 78Combined sources6
Beta strandi83 – 86Combined sources4
Helixi91 – 101Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNKNMR-A/B39-107[»]
5OB5X-ray1.65A40-102[»]
ProteinModelPortaliP19875
SMRiP19875
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19875

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE Eukaryota
ENOG410ZT1C LUCA
GeneTreeiENSGT00530000062901
HOGENOMiHOG000220915
HOVERGENiHBG107789
InParanoidiP19875
KOiK05505
OMAiEVCLNPQ
OrthoDBiEOG091G14TE
PhylomeDBiP19875
TreeFamiTF333433

Family and domain databases

CDDicd00273 Chemokine_CXC, 1 hit
InterProiView protein in InterPro
IPR001089 Chemokine_CXC
IPR018048 Chemokine_CXC_CS
IPR001811 Chemokine_IL8-like_dom
IPR033899 CXC_Chemokine_domain
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR10179 PTHR10179, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR00437 SMALLCYTKCXC
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00471 SMALL_CYTOKINES_CXC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARATLSAAP SNPRLLRVAL LLLLLVAASR RAAGAPLATE LRCQCLQTLQ
60 70 80 90 100
GIHLKNIQSV KVKSPGPHCA QTEVIATLKN GQKACLNPAS PMVKKIIEKM

LKNGKSN
Length:107
Mass (Da):11,389
Last modified:February 1, 1991 - v1
Checksum:i740F277E928571BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53799 mRNA Translation: CAA37808.1
M36820 mRNA Translation: AAA63183.1
M57731 mRNA Translation: AAA63182.1
CR542171 mRNA Translation: CAG46968.1
CH471057 Genomic DNA Translation: EAX05700.1
BC015753 mRNA Translation: AAH15753.1
AF043340 mRNA Translation: AAC03540.1
CCDSiCCDS34008.1
PIRiJH0281
RefSeqiNP_002080.1, NM_002089.3
UniGeneiHs.75765

Genome annotation databases

EnsembliENST00000508487; ENSP00000427279; ENSG00000081041
GeneIDi2920
KEGGihsa:2920
UCSCiuc003hhm.5 human

Similar proteinsi

Entry informationi

Entry nameiCXCL2_HUMAN
AccessioniPrimary (citable) accession number: P19875
Secondary accession number(s): Q6FGD6, Q9UPB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: February 28, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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