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Protein

Inhibitor of trypsin and hageman factor

Gene
N/A
Organism
Cucurbita maxima (Pumpkin) (Winter squash)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically inhibits both trypsin and activated Hageman factor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei44 – 45Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI13.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of trypsin and hageman factor
Alternative name(s):
CMTI-V
OrganismiCucurbita maxima (Pumpkin) (Winter squash)
Taxonomic identifieri3661 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsCucurbitalesCucurbitaceaeCucurbiteaeCucurbita

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002176551 – 68Inhibitor of trypsin and hageman factorAdd BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylserine1 Publication1
Disulfide bondi3 ↔ 48

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PRIDEiP19873.

Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi17 – 27Combined sources11
Beta strandi32 – 37Combined sources6
Beta strandi50 – 56Combined sources7
Turni57 – 59Combined sources3
Beta strandi60 – 62Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HYMNMR-A1-44[»]
B45-68[»]
1MITNMR-A1-68[»]
1TINNMR-A1-68[»]
ProteinModelPortaliP19873.
SMRiP19873.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19873.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiIPR000864. Prot_inh_pot1.
[Graphical view]
PfamiPF00280. potato_inhibit. 1 hit.
[Graphical view]
PRINTSiPR00292. POTATOINHBTR.
ProDomiPD002604. Prot_inh_pot1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54654. SSF54654. 1 hit.
PROSITEiPS00285. POTATO_INHIBITOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19873-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SSCPGKSSWP HLVGVGGSVA KAIIERQNPN VKAVILEEGT PVTKDFRCNR
60
VRIWVNKRGL VVSPPRIG
Length:68
Mass (Da):7,363
Last modified:February 1, 1991 - v1
Checksum:iAF000AB56B0DFA6E
GO

Sequence databases

PIRiS12897.

Cross-referencesi

Sequence databases

PIRiS12897.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HYMNMR-A1-44[»]
B45-68[»]
1MITNMR-A1-68[»]
1TINNMR-A1-68[»]
ProteinModelPortaliP19873.
SMRiP19873.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI13.008.

Proteomic databases

PRIDEiP19873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP19873.

Family and domain databases

InterProiIPR000864. Prot_inh_pot1.
[Graphical view]
PfamiPF00280. potato_inhibit. 1 hit.
[Graphical view]
PRINTSiPR00292. POTATOINHBTR.
ProDomiPD002604. Prot_inh_pot1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54654. SSF54654. 1 hit.
PROSITEiPS00285. POTATO_INHIBITOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITH5_CUCMA
AccessioniPrimary (citable) accession number: P19873
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.