P19865 (CRG2_SCOWA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Gamma-II crystallin
Organism	Scoliodon walbeemii (Shark)
Taxonomic identifier	34770 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Chondrichthyes › Elasmobranchii › Galeomorphii › Galeoidea › Carcharhiniformes › Carcharhinidae › Rhizoprionodon

Protein attributes

Sequence length	30 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Crystallins are the dominant structural components of the vertebrate eye lens.
Subunit structure	Monomer By similarity.
Domain	Has a two-domain beta-structure, folded into four very similar Greek key motifs.
Sequence similarities	Belongs to the beta/gamma-crystallin family. Contains at least 1 beta/gamma crystallin 'Greek key' domain.

Ontologies

Keywords
Domain	Repeat
Molecular function	Eye lens protein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Molecular function	structural constituent of eye lens Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – ›30

›30

Gamma-II crystallin

PRO_0000057579

Regions

Region

1 – ›30

›30

Beta/gamma crystallin 'Greek key'

Experimental info

Non-terminal residue

30

1

Secondary structure

1

.

.

.

.

.

.

.

30

Helix Strand Turn

Details...

Beta strand

3 – 8

6

Turn

9 – 11

3

Beta strand

12 – 20

9

Turn

26 – 28

3

Sequences

	Sequence		Length	Mass (Da)
	P19865 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 229E65B93CD7F68E	FASTA	30	3,543
	10 20 30 GKITFYEDRN FQGRCYECST DCPDLSPYFS

References

[1]	"Comparison of the gamma-crystallins isolated from eye lenses of shark and carp. Unique secondary and tertiary structure of shark gamma-crystallin." Chiou S.-H., Chen S.-W., Itoh T., Kaji H., Samejima T. FEBS Lett. 275:111-113(1990) [PubMed: 2261977] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Lens.
+	Additional computationally mapped references.

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2GS1	model	-	A	1-30	[»]

ProteinModelPortal

P19865.

SMR

P19865. Positions 1-30.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]

Gene3D

G3DSA:2.60.20.10. Crystallin. 1 hit.

Pfam

PF00030. Crystall. 1 hit.
[Graphical view]

SUPFAM

SSF49695. G_crystallin_SF. 1 hit.

PROSITE

PS50915. CRYSTALLIN_BETA_GAMMA. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

CRG2_SCOWA

Accession

Primary (citable) accession number: P19865

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	November 30, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program