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Protein

Neurokinin-A

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Neurokinin-A
Alternative name(s):
Neuromedin-L
Substance K
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444251 – 10Neurokinin-A10

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Methionine amide1 Publication1

Keywords - PTMi

Amidation

Structurei

Secondary structure

110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 9Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1N6TNMR-A1-10[»]
SMRiP19851.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19851.

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR013055. Tachy_Neuro_lke_CS.
IPR008215. Tachykinin_dom.
PfamiView protein in Pfam
PF02202. Tachykinin. 1 hit.
PROSITEiView protein in PROSITE
PS00267. TACHYKININ. 1 hit.

Sequencei

Sequence statusi: Complete.

Length:10
Mass (Da):1,134
Last modified:February 1, 1991 - v1
Checksum:i8A6B4062C9D5BAB1
GO

Sequence databases

PIRiJN0024.

Entry informationi

Entry nameiTKNB_CHICK
AccessioniPrimary (citable) accession number: P19851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 12, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families