Reviewed, UniProtKB/Swiss-Prot P19841 (LUXC_PHOPO)

Names and origin

Protein names

Recommended name:
    Acyl-CoA reductase
    EC=1.2.1.50

Gene names

Name:

luxC

Organism

Photobacterium phosphoreum

Taxonomic identifier

659 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Photobacterium

Protein attributes

Sequence length	382 AA.
Sequence status	Fragments.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
Catalytic activity	A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.
Pathway	Lipid metabolism; bioluminescent fatty acid reduction.
Sequence similarities	Belongs to the luxC family.

Ontologies

Keywords
Biological process	Luminescence
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	bioluminescence Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl-CoA reductase activity Inferred from electronic annotation. Source: InterPro long-chain-fatty-acyl-CoA reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Acyl-CoA reductase		PRO_0000220200
Experimental info
	Non-adjacent residues	371 – 372	2

Sequences

	Sequence		Length	Mass (Da)
	P19841-1 [UniParc]. Last modified February 1, 1995. Version 2. Checksum: B6C6316B49030EE9	FASTA	382	43,085
	10 20 30 40 50 60 MCNAEFKGDC MIKKIPMIIG GAERDTSEHE YRELTLNSYK VSIPIINQDD VEAIKSQNVE 70 80 90 100 110 120 NNLNINQIVN FLYTVGQKWK SENYSRRLTY IRDLVRFLGY SPEMAKLEAN WISMILSSKS 130 140 150 160 170 180 ALYDIVETEL GSRHIVDEWL PQGDCYVKAM PKGKSVHLLA GNVPLSGVTS IIRAILTKNE 190 200 210 220 230 240 CIIKTSSADP FTAIALASSF IDTDEHHPIS RSMSVMYWSH NEDIAIPQQI MNCADVVVSW 250 260 270 280 290 300 GGYDAIKWAT EHTPVNVDIL KFGPKKSIAI VDNPVDITAS AIGVAHDICF YDQQACFSTQ 310 320 330 340 350 360 DIYYIGDNID AFFDELVEQL NLYMDILPKG DQTFDEKASF SLIEKECQFA KYKVEKGDNQ 370 380 SWLLVKSPLG SLEEDKFLVF VP

References

[1]	"The lumazine protein gene in Photobacterium phosphoreum is linked to the lux operon." Prasher D.C., O'Kane D., Lee J., Woodward B. Nucleic Acids Res. 18:6450-6450(1990) [PubMed: 2243804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-371. Strain: A13.
[2]	"A lux-specific myristoyl transferase in luminescent bacteria related to eukaryotic serine esterases." Ferri S.R., Meighen E.A. J. Biol. Chem. 266:12852-12857(1991) [PubMed: 2071574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 372-382.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X54690 Genomic DNA. Translation: CAA38506.1. M64224 Genomic DNA. Translation: AAA25625.1.
PIR	B39853. S12116.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.2.1.50. 348.
Family and domain databases
InterPro	IPR016162. Ald_DH_N. IPR008670. LuxC. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF05893. LuxC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LUXC_PHOPO

Accession

Primary (citable) accession number: P19841

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1995
Last modified:	June 16, 2009
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)