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P19837

- SPD1_NEPCL

UniProt

P19837 - SPD1_NEPCL

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Protein

Spidroin-1

Gene
N/A
Organism
Nephila clavipes (Golden silk orbweaver)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Spiders' major ampullate silk possesses unique characteristics of strength and elasticity. Fibroin consists of pseudocrystalline regions of antiparallel beta-sheet interspersed with elastic amorphous segments.

Keywords - Molecular functioni

Silk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Spidroin-1
Alternative name(s):
Dragline silk fibroin 1
OrganismiNephila clavipes (Golden silk orbweaver)
Taxonomic identifieri6915 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaNephilidaeNephila

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 748›748Spidroin-1PRO_0000221446Add
BLAST

Proteomic databases

ProMEXiP19837.

Interactioni

Subunit structurei

Major subunit, with spidroin 2, of the dragline silk.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 25251Add
BLAST
Repeati26 – 38132Add
BLAST
Repeati39 – 66283Add
BLAST
Repeati67 – 96304Add
BLAST
Repeati97 – 130345Add
BLAST
Repeati131 – 158286Add
BLAST
Repeati159 – 191337Add
BLAST
Repeati192 – 204138Add
BLAST
Repeati205 – 235319Add
BLAST
Repeati236 – 2622710Add
BLAST
Repeati263 – 2923011Add
BLAST
Repeati293 – 3051312Add
BLAST
Repeati306 – 3332813Add
BLAST
Repeati334 – 3602714Add
BLAST
Repeati361 – 3943415Add
BLAST
Repeati395 – 4243016Add
BLAST
Repeati425 – 4583417Add
BLAST
Repeati459 – 4852718Add
BLAST
Repeati486 – 5122719Add
BLAST
Repeati513 – 5251320Add
BLAST
Repeati526 – 5553021Add
BLAST
Repeati556 – 5822722Add
BLAST
Repeati583 – 6123023Add
BLAST
Repeati613 – 6423024Add
BLAST
Repeati643 – 6551325Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 65565525 X approximate tandem repeatsAdd
BLAST

Domaini

Highly repetitive protein characterized by regions of polyalanine and glycine-rich repeating units.

Sequence similaritiesi

Belongs to the silk fibroin family.

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR021001. Spidroin_C.
[Graphical view]
PfamiPF11260. Spidroin_MaSp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P19837-1 [UniParc]FASTAAdd to Basket

« Hide

QGAGAAAAAA GGAGQGGYGG LGGQGAGQGG YGGLGGQGAG QGAGAAAAAA    50
AGGAGQGGYG GLGSQGAGRG GQGAGAAAAA AGGAGQGGYG GLGSQGAGRG 100
GLGGQGAGAA AAAAAGGAGQ GGYGGLGNQG AGRGGQGAAA AAAGGAGQGG 150
YGGLGSQGAG RGGLGGQGAG AAAAAAGGAG QGGYGGLGGQ GAGQGGYGGL 200
GSQGAGRGGL GGQGAGAAAA AAAGGAGQGG LGGQGAGQGA GASAAAAGGA 250
GQGGYGGLGS QGAGRGGEGA GAAAAAAGGA GQGGYGGLGG QGAGQGGYGG 300
LGSQGAGRGG LGGQGAGAAA AGGAGQGGLG GQGAGQGAGA AAAAAGGAGQ 350
GGYGGLGSQG AGRGGLGGQG AGAVAAAAAG GAGQGGYGGL GSQGAGRGGQ 400
GAGAAAAAAG GAGQRGYGGL GNQGAGRGGL GGQGAGAAAA AAAGGAGQGG 450
YGGLGNQGAG RGGQGAAAAA GGAGQGGYGG LGSQGAGRGG QGAGAAAAAA 500
VGAGQEGIRG QGAGQGGYGG LGSQGSGRGG LGGQGAGAAA AAAGGAGQGG 550
LGGQGAGQGA GAAAAAAGGV RQGGYGGLGS QGAGRGGQGA GAAAAAAGGA 600
GQGGYGGLGG QGVGRGGLGG QGAGAAAAGG AGQGGYGGVG SGASAASAAA 650
SRLSSPQASS RVSSAVSNLV ASGPTNSAAL SSTISNVVSQ IGASNPGLSG 700
CDVLIQALLE VVSALIQILG SSSIGQVNYG SAGQATQIVG QSVYQALG 748
Length:748
Mass (Da):60,585
Last modified:October 5, 2010 - v3
Checksum:i70F50E44B0D649E0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti662 – 6621V → L in AAA29380. 1 Publication
Sequence conflicti672 – 6721S → T in AAA29380. 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37137 mRNA. Translation: AAA29380.2.
U03848 Unassigned DNA. Translation: AAB60212.1.
PIRiA36068.

Cross-referencesi

Web resourcesi

Protein Spotlight

The tiptoe of an airbus - Issue 24 of July 2002

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M37137 mRNA. Translation: AAA29380.2 .
U03848 Unassigned DNA. Translation: AAB60212.1 .
PIRi A36068.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

ProMEXi P19837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR021001. Spidroin_C.
[Graphical view ]
Pfami PF11260. Spidroin_MaSp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of a protein superfiber: spider dragline silk."
    Xu M., Lewis R.V.
    Proc. Natl. Acad. Sci. U.S.A. 87:7120-7124(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. Xu M., Lewis R.V.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "Sequence conservation in the C-terminal region of spider silk proteins (Spidroin) from Nephila clavipes (Tetragnathidae) and Araneus bicentenarius (Araneidae)."
    Beckwitt R., Arcidiacono S.
    J. Biol. Chem. 269:6661-6663(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 653-747.

Entry informationi

Entry nameiSPD1_NEPCL
AccessioniPrimary (citable) accession number: P19837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 5, 2010
Last modified: February 19, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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