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P19837

- SPD1_NEPCL

UniProt

P19837 - SPD1_NEPCL

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Protein

Spidroin-1

Gene
N/A
Organism
Nephila clavipes (Golden silk orbweaver)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Spiders' major ampullate silk possesses unique characteristics of strength and elasticity. Fibroin consists of pseudocrystalline regions of antiparallel beta-sheet interspersed with elastic amorphous segments.

Keywords - Molecular functioni

Silk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Spidroin-1
Alternative name(s):
Dragline silk fibroin 1
OrganismiNephila clavipes (Golden silk orbweaver)
Taxonomic identifieri6915 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaNephilidaeNephila

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 748›748Spidroin-1PRO_0000221446Add
BLAST

Interactioni

Subunit structurei

Major subunit, with spidroin 2, of the dragline silk.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1 – 25251Add
BLAST
Repeati26 – 38132Add
BLAST
Repeati39 – 66283Add
BLAST
Repeati67 – 96304Add
BLAST
Repeati97 – 130345Add
BLAST
Repeati131 – 158286Add
BLAST
Repeati159 – 191337Add
BLAST
Repeati192 – 204138Add
BLAST
Repeati205 – 235319Add
BLAST
Repeati236 – 2622710Add
BLAST
Repeati263 – 2923011Add
BLAST
Repeati293 – 3051312Add
BLAST
Repeati306 – 3332813Add
BLAST
Repeati334 – 3602714Add
BLAST
Repeati361 – 3943415Add
BLAST
Repeati395 – 4243016Add
BLAST
Repeati425 – 4583417Add
BLAST
Repeati459 – 4852718Add
BLAST
Repeati486 – 5122719Add
BLAST
Repeati513 – 5251320Add
BLAST
Repeati526 – 5553021Add
BLAST
Repeati556 – 5822722Add
BLAST
Repeati583 – 6123023Add
BLAST
Repeati613 – 6423024Add
BLAST
Repeati643 – 6551325Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 65565525 X approximate tandem repeatsAdd
BLAST

Domaini

Highly repetitive protein characterized by regions of polyalanine and glycine-rich repeating units.

Sequence similaritiesi

Belongs to the silk fibroin family.Curated

Keywords - Domaini

Repeat

Family and domain databases

InterProiIPR021001. Spidroin_C.
[Graphical view]
PfamiPF11260. Spidroin_MaSp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P19837-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
QGAGAAAAAA GGAGQGGYGG LGGQGAGQGG YGGLGGQGAG QGAGAAAAAA
60 70 80 90 100
AGGAGQGGYG GLGSQGAGRG GQGAGAAAAA AGGAGQGGYG GLGSQGAGRG
110 120 130 140 150
GLGGQGAGAA AAAAAGGAGQ GGYGGLGNQG AGRGGQGAAA AAAGGAGQGG
160 170 180 190 200
YGGLGSQGAG RGGLGGQGAG AAAAAAGGAG QGGYGGLGGQ GAGQGGYGGL
210 220 230 240 250
GSQGAGRGGL GGQGAGAAAA AAAGGAGQGG LGGQGAGQGA GASAAAAGGA
260 270 280 290 300
GQGGYGGLGS QGAGRGGEGA GAAAAAAGGA GQGGYGGLGG QGAGQGGYGG
310 320 330 340 350
LGSQGAGRGG LGGQGAGAAA AGGAGQGGLG GQGAGQGAGA AAAAAGGAGQ
360 370 380 390 400
GGYGGLGSQG AGRGGLGGQG AGAVAAAAAG GAGQGGYGGL GSQGAGRGGQ
410 420 430 440 450
GAGAAAAAAG GAGQRGYGGL GNQGAGRGGL GGQGAGAAAA AAAGGAGQGG
460 470 480 490 500
YGGLGNQGAG RGGQGAAAAA GGAGQGGYGG LGSQGAGRGG QGAGAAAAAA
510 520 530 540 550
VGAGQEGIRG QGAGQGGYGG LGSQGSGRGG LGGQGAGAAA AAAGGAGQGG
560 570 580 590 600
LGGQGAGQGA GAAAAAAGGV RQGGYGGLGS QGAGRGGQGA GAAAAAAGGA
610 620 630 640 650
GQGGYGGLGG QGVGRGGLGG QGAGAAAAGG AGQGGYGGVG SGASAASAAA
660 670 680 690 700
SRLSSPQASS RVSSAVSNLV ASGPTNSAAL SSTISNVVSQ IGASNPGLSG
710 720 730 740
CDVLIQALLE VVSALIQILG SSSIGQVNYG SAGQATQIVG QSVYQALG
Length:748
Mass (Da):60,585
Last modified:October 5, 2010 - v3
Checksum:i70F50E44B0D649E0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti662 – 6621V → L in AAA29380. (PubMed:2402494)Curated
Sequence conflicti672 – 6721S → T in AAA29380. (PubMed:2402494)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37137 mRNA. Translation: AAA29380.2.
U03848 Unassigned DNA. Translation: AAB60212.1.
PIRiA36068.

Cross-referencesi

Web resourcesi

Protein Spotlight

The tiptoe of an airbus - Issue 24 of July 2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37137 mRNA. Translation: AAA29380.2 .
U03848 Unassigned DNA. Translation: AAB60212.1 .
PIRi A36068.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR021001. Spidroin_C.
[Graphical view ]
Pfami PF11260. Spidroin_MaSp. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure of a protein superfiber: spider dragline silk."
    Xu M., Lewis R.V.
    Proc. Natl. Acad. Sci. U.S.A. 87:7120-7124(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  2. Xu M., Lewis R.V.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "Sequence conservation in the C-terminal region of spider silk proteins (Spidroin) from Nephila clavipes (Tetragnathidae) and Araneus bicentenarius (Araneidae)."
    Beckwitt R., Arcidiacono S.
    J. Biol. Chem. 269:6661-6663(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 653-747.

Entry informationi

Entry nameiSPD1_NEPCL
AccessioniPrimary (citable) accession number: P19837
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 67 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3