P19828 (ANGR_VIBAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein AngR

Gene names

Name:

angR

Encoded on

Plasmid pJM1

Organism

Vibrio anguillarum (Listonella anguillarum)

Taxonomic identifier

55601 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Listonella

Protein attributes

Sequence length	1048 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	According to Ref.1: a trans-acting transcriptional activator for the iron uptake system of V.anguillarum. Allows the bacterium to grow in the iron-deficient environment of the fish. Ref.3 According to Ref.3: an enzyme involved in the biosynthesis of anguibactin; an iron-binding siderophore. Ref.3
Pathway	Siderophore biosynthesis; anguibactin biosynthesis.
Induction	AngR transcription is regulated by iron.
Miscellaneous	The sequence shown is that of strain 775.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. Contains 1 acyl carrier domain.
Caution	Lacks the conserved Ser at position 1000 required for covalent attachment of 4-phosphpantetheine.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transcription Transcription regulation Transport
Ligand	DNA-binding Iron
Molecular function	Activator Ligase
Technical term	Plasmid
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro ligase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1048	1048	Protein AngR		PRO_0000193064
Regions
	Domain	970 – 1036	67	Acyl carrier
Natural variations
	Natural variant	267	1	H → N in strain: 531A.

Sequences

	Sequence		Length	Mass (Da)
	P19828 [UniParc]. Last modified February 1, 1991. Version 1. Checksum: 53CF4B81D25A3CC4	FASTA	1,048	118,421
	10 20 30 40 50 60 MNQNEHPFAF PETKLPLTSN QNWQLSTQRQ RTEKKSITNF TYQEFDYENI SRDTLERCLT 70 80 90 100 110 120 TIIKHHPIFG AKLSDDFYLH FPSKTHIETF AVNDLSNALK QDIDKQLADT RSAVTKSRSQ 130 140 150 160 170 180 AIISIMFSIL PKNIIRLHVR FNSVVVDNPS VTLFFEQLTQ LLSGSPLSFL NQEQTISAYN 190 200 210 220 230 240 HKVNNELLSV DLESARWNEY ILTLPSSANL PTICEPEKLD ETDITRRCIT LSQRKWQQLV 250 260 270 280 290 300 TVSKKHNVTP EITLASIFST VLSLWGHQKY LMMRFDITKI NDYTGIIGQF TEPLLVGMSG 310 320 330 340 350 360 FEQSFLSLVK NNQKKFEEAY HYDVKVPVFQ CVNKLSNISD SHRYPANITF SSELLNTNHS 370 380 390 400 410 420 KKAVWGCRQS ANTWLSLHAV IEQEQLVLQW DSQDAIFPKD MIKDMLHSYT DLLDLLSQKD 430 440 450 460 470 480 VNWAQPLPTL LPKHQESIRN KINQQGDLEL TKELLHQRFF KNVESTPNAL AIIHGQESLD 490 500 510 520 530 540 YITLASYAKS CAGALTEAGV KSGDRVAVTM NKGIGQIVAV LGILYAGAIY VPVSLDQPQE 550 560 570 580 590 600 RRESIYQGAG INVILINESD SKNSPSNDLF FFLDWQTAIK SEPMRSPQDV APSQPAYIIY 610 620 630 640 650 660 TSGSTGTPKG VVISHQGALN TCIAINRRYQ IGKNDRVLAL SALHFDLSVY DIFGLLSAGG 670 680 690 700 710 720 TIVLVSELER RDPIAWCQAI EEHNVTMWNS VPALFDMLLT YATCFNSIAP SKLRLTMLSG 730 740 750 760 770 780 DWIGLDLPQR YRNYRVDGQF IAMGGATEAS IWSNVFDVEK VPMEWRSIPY GYPLPRQQYR 790 800 810 820 830 840 VVDDLGRDCP DWVAGELWIG GDGIALGYFD DELKTQAQFL HIDGHAWYRT GDMGCYWPDG 850 860 870 880 890 900 TLEFLGRRDK QVKVGGYRIE LGEIEVALNN IPGVQRAVAI AVGNKDKTLA AFIVMDSEQA 910 920 930 940 950 960 PIVTAPLDAE EVQLLLNKQL PNYMVPKRII FLETFPLTAN GKVDHKALTR MTNREKKTSQ 970 980 990 1000 1010 1020 SINKPIITAS EDRVAKIWND VLGPTELYKS SDFFLSGGDA YNAIEVVKRC HKAGYLIKLS 1030 1040 MLYRYSTIEA FAIIMDRCRL APQEEAEL

References

[1]	"A regulatory gene, angR, of the iron uptake system of Vibrio anguillarum: similarity with phage P22 cro and regulation by iron." Farrell D.H., Mikesell P., Actis L.A., Crosa J.H. Gene 86:45-51(1990) [PubMed: 2311935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 775.
[2]	"A single amino acid change in AngR, a protein encoded by pJM1-like virulence plasmids, results in hyperproduction of anguibactin." Tolmasky M.E., Actis L.A., Crosa J.H. Infect. Immun. 61:3228-3233(1993) [PubMed: 8335354] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 531A.
[3]	Bairoch A. Unpublished observations (MAY-1991) Cited for: POSSIBLE FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M34504 Genomic DNA. Translation: AAA79860.1. Z12000 Genomic DNA. Translation: CAA78044.1.
PIR	YGVCAR. JQ0416.
3D structure databases
ProteinModelPortal	P19828.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
ProtClustDB	CLSK923885.
Family and domain databases
InterPro	IPR010071. AA_adenyl_domain. IPR009081. Acyl_carrier_prot-like. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. IPR001242. Condensatn. IPR006163. Phsphopanteth-bd. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF00668. Condensation. 1 hit. PF00550. PP-binding. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR01733. AA-adenyl-dom. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANGR_VIBAN

Accession

Primary (citable) accession number: P19828

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	February 1, 1991
Last modified:	September 21, 2011
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program