P19827 (ITIH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inter-alpha-trypsin inhibitor heavy chain H1
Short name=ITI heavy chain H1
Short name=ITI-HC1
Short name=Inter-alpha-inhibitor heavy chain 1

Alternative name(s):
Inter-alpha-trypsin inhibitor complex component III
Serum-derived hyaluronan-associated protein
Short name=SHAP

Gene names

Name:	ITIH1
Synonyms:	IGHEP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	911 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
Subunit structure	I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.
Subcellular location	Secreted.
Post-translational modification	Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage. The S-linked glycan is composed of two 6-carbon sugars, possibly Glc or Gal.
Polymorphism	There are 3 common alleles; ITIH1*1 with Glu-585/Gln-595, ITIH1*2 with Val-585/Arg-595 and ITIH1*3 with Glu-585/Arg-595.
Sequence similarities	Belongs to the ITIH family. Contains 1 VIT domain. Contains 1 VWFA domain.
Mass spectrometry	Molecular mass is 76258 Da from positions 28 - 672. Determined by MALDI. Ref.15

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond Glycoprotein Phosphoprotein Proteoglycan
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	hyaluronan metabolic process Non-traceable author statement. Source: UniProtKB leukocyte activation Non-traceable author statement. Source: UniProtKB
Cellular_component	extracellular region Non-traceable author statement PubMed 14718574. Source: UniProtKB
Molecular_function	calcium ion binding Traceable author statement Ref.11. Source: ProtInc serine-type endopeptidase inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P19827-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P19827-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-142: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: P19827-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-288: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Potential
	Propeptide	28 – 34	7			PRO_0000016506
	Chain	35 – 672	638	Inter-alpha-trypsin inhibitor heavy chain H1		PRO_0000016507
	Propeptide	673 – 911	239			PRO_0000016508
Regions
	Domain	37 – 166	130	VIT
	Domain	290 – 450	161	VWFA
	Region	387 – 911	525	Hyaluronan-binding
	Motif	181 – 184	4	Phagocytosis uptake signal Potential
Amino acid modifications
	Modified residue	402	1	Phosphothreonine Ref.19
	Modified residue	407	1	Phosphothreonine Ref.19
	Modified residue	672	1	Aspartate 1-(chondroitin 4-sulfate)-ester
	Glycosylation	60	1	S-linked (Hex...) Ref.16
	Glycosylation	285	1	N-linked (GlcNAc...) (complex) Ref.15 Ref.16 Ref.17		CAR_000138
	Glycosylation	588	1	N-linked (GlcNAc...) (complex) Ref.15 Ref.16 Ref.18		CAR_000139
	Glycosylation	653	1	O-linked (GalNAc...) Ref.16		CAR_000213
	Glycosylation	750	1	N-linked (GlcNAc...) Ref.20
	Disulfide bond	244 ↔ 247		Ref.16
	Disulfide bond	268 ↔ 540		Ref.16
Natural variations
	Alternative sequence	1 – 288	288	Missing in isoform 3.		VSP_045419
	Alternative sequence	1 – 142	142	Missing in isoform 2.		VSP_045420
	Natural variant	263	1	S → T. Ref.1 Corresponds to variant rs1042777 [ dbSNP | Ensembl ].		VAR_011873
	Natural variant	585	1	E → V in allele ITIH1*2. Ref.1 Ref.3 Ref.21 Corresponds to variant rs678 [ dbSNP | Ensembl ].		VAR_004019
	Natural variant	595	1	Q → R in allele ITIH1*2 and allele ITIH1*3. Ref.1 Ref.3 Ref.21 Corresponds to variant rs1042779 [ dbSNP | Ensembl ].		VAR_004020
	Natural variant	695	1	G → C. Corresponds to variant rs1042904 [ dbSNP | Ensembl ].		VAR_011874
	Natural variant	844	1	D → E. Corresponds to variant rs1042849 [ dbSNP | Ensembl ].		VAR_011875
Experimental info
	Sequence conflict	51	1	V → T AA sequence Ref.8
	Sequence conflict	54	1	R → A AA sequence Ref.8
	Sequence conflict	266	1	K → E in CAA45188. Ref.1
	Sequence conflict	539	1	T → A in BAH12794. Ref.3
	Sequence conflict	798	1	V → A in BAH12794. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 15, 1998. Version 3. Checksum: 8FE715FF223FC917	FASTA	911	101,389
	10 20 30 40 50 60 MDGAMGPRGL LLCMYLVSLL ILQAMPALGS ATGRSKSSEK RQAVDTAVDG VFIRSLKVNC 70 80 90 100 110 120 KVTSRFAHYV VTSQVVNTAN EAREVAFDLE IPKTAFISDF AVTADGNAFI GDIKDKVTAW 130 140 150 160 170 180 KQYRKAAISG ENAGLVRASG RTMEQFTIHL TVNPQSKVTF QLTYEEVLKR NHMQYEIVIK 190 200 210 220 230 240 VKPKQLVHHF EIDVDIFEPQ GISKLDAQAS FLPKELAAQT IKKSFSGKKG HVLFRPTVSQ 250 260 270 280 290 300 QQSCPTCSTS LLNGHFKVTY DVSRDKICDL LVANNHFAHF FAPQNLTNMN KNVVFVIDIS 310 320 330 340 350 360 GSMRGQKVKQ TKEALLKILG DMQPGDYFDL VLFGTRVQSW KGSLVQASEA NLQAAQDFVR 370 380 390 400 410 420 GFSLDEATNL NGGLLRGIEI LNQVQESLPE LSNHASILIM LTDGDPTEGV TDRSQILKNV 430 440 450 460 470 480 RNAIRGRFPL YNLGFGHNVD FNFLEVMSME NNGRAQRIYE DHDATQQLQG FYSQVAKPLL 490 500 510 520 530 540 VDVDLQYPQD AVLALTQNHH KQYYEGSEIV VAGRIADNKQ SSFKADVQAH GEGQEFSITC 550 560 570 580 590 600 LVDEEEMKKL LRERGHMLEN HVERLWAYLT IQELLAKRMK VDREERANLS SQALQMSLDY 610 620 630 640 650 660 GFVTPLTSMS IRGMADQDGL KPTIDKPSED SPPLEMLGPR RTFVLSALQP SPTHSSSNTQ 670 680 690 700 710 720 RLPDRVTGVD TDPHFIIHVP QKEDTLCFNI NEEPGVILSL VQDPNTGFSV NGQLIGNKAR 730 740 750 760 770 780 SPGQHDGTYF GRLGIANPAT DFQLEVTPQN ITLNPGFGGP VFSWRDQAVL RQDGVVVTIN 790 800 810 820 830 840 KKRNLVVSVD DGGTFEVVLH RVWKGSSVHQ DFLGFYVLDS HRMSARTHGL LGQFFHPIGF 850 860 870 880 890 900 EVSDIHPGSD PTKPDATMVV RNRRLTVTRG LQKDYSKDPW HGAEVSCWFI HNNGAGLIDG 910 AYTDYIVPDI F
	Isoform 2 [UniParc]. Checksum: 9447D42CB083BC9F	FASTA	769	86,192
	10 20 30 40 50 60 MEQFTIHLTV NPQSKVTFQL TYEEVLKRNH MQYEIVIKVK PKQLVHHFEI DVDIFEPQGI 70 80 90 100 110 120 SKLDAQASFL PKELAAQTIK KSFSGKKGHV LFRPTVSQQQ SCPTCSTSLL NGHFKVTYDV 130 140 150 160 170 180 SRDKICDLLV ANNHFAHFFA PQNLTNMNKN VVFVIDISGS MRGQKVKQTK EALLKILGDM 190 200 210 220 230 240 QPGDYFDLVL FGTRVQSWKG SLVQASEANL QAAQDFVRGF SLDEATNLNG GLLRGIEILN 250 260 270 280 290 300 QVQESLPELS NHASILIMLT DGDPTEGVTD RSQILKNVRN AIRGRFPLYN LGFGHNVDFN 310 320 330 340 350 360 FLEVMSMENN GRAQRIYEDH DATQQLQGFY SQVAKPLLVD VDLQYPQDAV LALTQNHHKQ 370 380 390 400 410 420 YYEGSEIVVA GRIADNKQSS FKADVQAHGE GQEFSITCLV DEEEMKKLLR ERGHMLENHV 430 440 450 460 470 480 ERLWAYLTIQ ELLAKRMKVD REERANLSSQ ALQMSLDYGF VTPLTSMSIR GMADQDGLKP 490 500 510 520 530 540 TIDKPSEDSP PLEMLGPRRT FVLSALQPSP THSSSNTQRL PDRVTGVDTD PHFIIHVPQK 550 560 570 580 590 600 EDTLCFNINE EPGVILSLVQ DPNTGFSVNG QLIGNKARSP GQHDGTYFGR LGIANPATDF 610 620 630 640 650 660 QLEVTPQNIT LNPGFGGPVF SWRDQAVLRQ DGVVVTINKK RNLVVSVDDG GTFEVVLHRV 670 680 690 700 710 720 WKGSSVHQDF LGFYVLDSHR MSARTHGLLG QFFHPIGFEV SDIHPGSDPT KPDATMVVRN 730 740 750 760 RRLTVTRGLQ KDYSKDPWHG AEVSCWFIHN NGAGLIDGAY TDYIVPDIF
	Isoform 3 [UniParc]. Checksum: EBB1BB3250D74DA7	FASTA	623	69,495
	10 20 30 40 50 60 MNKNVVFVID ISGSMRGQKV KQTKEALLKI LGDMQPGDYF DLVLFGTRVQ SWKGSLVQAS 70 80 90 100 110 120 EANLQAAQDF VRGFSLDEAT NLNGGLLRGI EILNQVQESL PELSNHASIL IMLTDGDPTE 130 140 150 160 170 180 GVTDRSQILK NVRNAIRGRF PLYNLGFGHN VDFNFLEVMS MENNGRAQRI YEDHDATQQL 190 200 210 220 230 240 QGFYSQVAKP LLVDVDLQYP QDAVLALTQN HHKQYYEGSE IVVAGRIADN KQSSFKADVQ 250 260 270 280 290 300 AHGEGQEFSI TCLVDEEEMK KLLRERGHML ENHVERLWAY LTIQELLAKR MKVDREERAN 310 320 330 340 350 360 LSSQALQMSL DYGFVTPLTS MSIRGMADQD GLKPTIDKPS EDSPPLEMLG PRRTFVLSAL 370 380 390 400 410 420 QPSPTHSSSN TQRLPDRVTG VDTDPHFIIH VPQKEDTLCF NINEEPGVIL SLVQDPNTGF 430 440 450 460 470 480 SVNGQLIGNK ARSPGQHDGT YFGRLGIANP ATDFQLEVTP QNITLNPGFG GPVFSWRDQA 490 500 510 520 530 540 VLRQDGVVVT INKKRNLVVS VDDGGTFEVV LHRVWKGSSV HQDFLGFYVL DSHRMSARTH 550 560 570 580 590 600 GLLGQFFHPI GFEVSDIHPG SDPTKPDATM VVRNRRLTVT RGLQKDYSKD PWHGAEVSCW 610 620 FIHNNGAGLI DGAYTDYIVP DIF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human inter-alpha-trypsin inhibitor: full-length cDNA sequence of the heavy chain H1." Diarra-Mehrpour M., Bourguignon J., Bost F., Sesboue R., Muschio F., Sarafan N., Martin J.-P. Biochim. Biophys. Acta 1132:114-118(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-263; VAL-585 AND ARG-595. Tissue: Blood and Liver.
[2]	"Isolation and characterization of the human inter-alpha-trypsin inhibitor heavy-chain H1 gene." Bost F., Bourguignon J., Martin J.-P., Sesboue R., Thiberville L., Diarra-Mehrpour M. Eur. J. Biochem. 218:283-291(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANTS VAL-585 AND ARG-595. Tissue: Liver and Thymus.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[7]	"The heavy chains of human plasma inter-alpha-trypsin inhibitor: their isolation, their identification by electrophoresis and partial sequencing. Differential reactivity with concanavalin A." Malki N., Balduyck M., Maes P., Capon C., Mizon C., Han K.K., Tartar A., Fournet B., Mizon J. Biol. Chem. Hoppe-Seyler 373:1009-1018(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-34; 117-119; 126-137; 318-329; 342-355 AND 478-501. Tissue: Plasma.
[8]	"Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan." Enghild J.J., Thoegersen I.B., Pizzo S.V., Salvesen G. J. Biol. Chem. 264:15975-15981(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 35-54; 110-124; 333-347 AND 399-435. Tissue: Plasma.
[9]	"Two out of the three kinds of subunits of inter-alpha-trypsin inhibitor are structurally related." Gebhard W., Schreitmueller T., Hochstrasser K., Wachter E. Eur. J. Biochem. 181:571-576(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-911 (ISOFORM 1), PARTIAL PROTEIN SEQUENCE. Tissue: Liver.
[10]	"A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor." Huang L., Yoneda M., Kimata K. J. Biol. Chem. 268:26725-26730(1993) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 177-211 AND 387-428, HYALURONAN BINDING. Tissue: Serum.
[11]	"Isolation and characterization of cDNAs encoding the heavy chain of human inter-alpha-trypsin inhibitor (I alpha TI): unambiguous evidence for multipolypeptide chain structure of I alpha TI." Salier J.-P., Diarra-Mehrpour M., Sesboue R., Bourguignon J., Benarous R., Ohkubo I., Kurachi S., Kurachi K., Martin J.-P. Proc. Natl. Acad. Sci. U.S.A. 84:8272-8276(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 399-723 (ISOFORM 1/2/3).
[12]	"cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins." Schreitmueller T., Hochstrasser K., Resinger P.W.M., Wachter E., Gebhard W. Biol. Chem. Hoppe-Seyler 368:963-970(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 535-685 (ISOFORM 1/2/3).
[13]	"Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor." Morelle W., Capon C., Balduyck M., Sautiere P., Kouach M., Michalski C., Fournet B., Mizon J. Eur. J. Biochem. 221:881-888(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 669-672, COVALENT LINKAGE WITH CHONDROITIN SULFATE. Tissue: Plasma.
[14]	"Tandem orientation of the inter-alpha-trypsin inhibitor heavy chain H1 and H3 genes." Diarra-Mehrpour M., Bourguignon J., Sarafan N., Bost F., Sesbouee R., Muschio-Bonnet F., Martin J.-P. Biochim. Biophys. Acta 1219:551-554(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 870-911.
[15]	"Glycosylation pattern of human inter-alpha-inhibitor heavy chains." Flahaut C., Capon C., Balduyck M., Ricart G., Sautiere P., Mizon J. Biochem. J. 333:749-756(1998) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-285 AND ASN-588, MASS SPECTROMETRY.
[16]	"Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2." Olsen E.H.N., Rahbek-Nielsen H., Thoegersen I.B., Roepstorff P., Enghild J.J. Biochemistry 37:408-416(1998) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT CYS-60; ASN-285; ASN-588 AND THR-653, DISULFIDE BONDS, MASS SPECTROMETRY.
[17]	"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-285.
[18]	"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R. Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-588, MASS SPECTROMETRY. Tissue: Plasma.
[19]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-402 AND THR-407, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[20]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-750, MASS SPECTROMETRY. Tissue: Liver.
[21]	"Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism." Ding M., Umetsu K., Yuasa I., Sato M., Harada A., Suzuki T. Hum. Genet. 95:435-436(1995) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS VAL-585 AND ARG-595.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X63652 mRNA. Translation: CAA45188.1. X69532 , X69533, X69534, X69535, X69536, X69537, X69538, X69539, X69540, X69541, X69542, X69543, X69544, X69545, X69546, X69547 Genomic DNA. Translation: CAA49279.1. AK292750 mRNA. Translation: BAF85439.1. AK298455 mRNA. Translation: BAH12794.1. AK303156 mRNA. Translation: BAH13906.1. AK314198 mRNA. Translation: BAG36876.1. AC006254 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW65259.1. BC069464 mRNA. Translation: AAH69464.1. X16260 mRNA. Translation: CAA34346.1. M18192 mRNA. Translation: AAA60557.1. X75318 Genomic DNA. Translation: CAA53067.1.
IPI	IPI00292530. IPI00877852. IPI00953675.
PIR	A39967. S39527.
RefSeq	NP_001159906.1. NM_001166434.2. NP_001159907.1. NM_001166435.2. NP_002206.2. NM_002215.3.
UniGene	Hs.420257. Hs.76716.
3D structure databases
ProteinModelPortal	P19827.
ModBase	Search...
Protein-protein interaction databases
IntAct	P19827. 2 interactions.
STRING	9606.ENSP00000273283.
PTM databases
GlycoSuiteDB	P19827.
PhosphoSite	P19827.
Polymorphism databases
DMDM	2851501.
Proteomic databases
PaxDb	P19827.
PeptideAtlas	P19827.
PRIDE	P19827.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273283; ENSP00000273283; ENSG00000055957. ENST00000537050; ENSP00000443847; ENSG00000055957. ENST00000540715; ENSP00000443973; ENSG00000055957.
GeneID	3697.
KEGG	hsa:3697.
UCSC	uc003dfs.3. human.
Organism-specific databases
CTD	3697.
GeneCards	GC03P052787.
HGNC	HGNC:6166. ITIH1.
HPA	HPA041639. HPA042049.
MIM	147270. gene.
neXtProt	NX_P19827.
PharmGKB	PA29964.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2304.
HOGENOM	HOG000000680.
HOVERGEN	HBG057734.
InParanoid	P19827.
OMA	RIYEDHD.
OrthoDB	EOG4J6RQ3.
PhylomeDB	P19827.
Gene expression databases
ArrayExpress	P19827.
Bgee	P19827.
CleanEx	HS_ITIH1.
Genevestigator	P19827.
GermOnline	ENSG00000055957. Homo sapiens.
Family and domain databases
InterPro	IPR010600. ITI_HC_C. IPR013694. VIT. IPR002035. VWF_A. [Graphical view]
Pfam	PF06668. ITI_HC_C. 1 hit. PF08487. VIT. 1 hit. PF00092. VWA. 1 hit. [Graphical view]
SMART	SM00609. VIT. 1 hit. SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS51468. VIT. 1 hit. PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3697.
NextBio	14491.
SOURCE	Search...

Entry information

Entry name

ITIH1_HUMAN

Accession

Primary (citable) accession number: P19827
Secondary accession number(s): A8K9N5 , B2RAH9, B7Z558, B7Z8C0, F5H165, F5H7Y8, P78455, Q01746, Q562G1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 140 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.