ITIH2

Functionⁱ

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

GO - Molecular functionⁱ

endopeptidase inhibitor activity
Source: ProtInc
Traceable author statementⁱ
- 2476436
serine-type endopeptidase inhibitor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein metabolic process Source: Reactome
hyaluronan metabolic process Source: InterPro
post-translational protein modification Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitor

Molecular function

Protease inhibitor, Serine protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). R-HSA-8957275. Post-translational protein phosphorylation.

Reactomeⁱ

R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-HSA-8957275. Post-translational protein phosphorylation.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Inter-alpha-trypsin inhibitor heavy chain H2 Short name: ITI heavy chain H2 Short name: ITI-HC2 Short name: Inter-alpha-inhibitor heavy chain 2 Alternative name(s): Inter-alpha-trypsin inhibitor complex component II Serum-derived hyaluronan-associated protein Short name: SHAP
Gene namesⁱ	Name:ITIH2 Synonyms:IGHEP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151655.17.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6167. ITIH2.
MIMⁱ	146640. gene.
neXtProtⁱ	NX_P19823.

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3698.
Open Targets More...OpenTargetsⁱ	ENSG00000151655.
PharmGKBⁱ	PA29965.

Polymorphism and mutation databases

BioMutaⁱ	ITIH2.
DMDMⁱ	229462889.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST	18
PropeptideⁱPRO_0000016517	19 – 54	Add BLAST	36
ChainⁱPRO_0000016518	55 – 702	Inter-alpha-trypsin inhibitor heavy chain H2Add BLAST	648
PropeptideⁱPRO_0000016519	703 – 946	Add BLAST	244

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	60	Phosphoserine; by FAM20CCombined sources1 Publication	1
Glycosylationⁱ	96	N-linked (GlcNAc...) asparagine1 Publication	1
GlycosylationⁱCAR_000140	118	N-linked (GlcNAc...) (complex) asparagine5 Publications	1
Disulfide bondⁱ	261 ↔ 264	1 Publication
Modified residueⁱ	282	4-carboxyglutamate1 Publication	1
Modified residueⁱ	283	4-carboxyglutamate1 Publication	1
Glycosylationⁱ	445	N-linked (GlcNAc...) asparagine1 Publication	1
Modified residueⁱ	466	Phosphoserine; by FAM20C1 Publication	1
Disulfide bondⁱ	650 ↔ 651	1 Publication
GlycosylationⁱCAR_000214	666	O-linked (GalNAc...) threonine; partial2 Publications	1
GlycosylationⁱCAR_000215	673	O-linked (GalNAc...) serine2 Publications	1
GlycosylationⁱCAR_000216	675	O-linked (GalNAc...) threonine2 Publications	1
GlycosylationⁱCAR_000217	691	O-linked (GalNAc...) threonine3 Publications	1
Modified residueⁱ	702	Aspartate 1-(chondroitin 4-sulfate)-ester	1
Modified residueⁱ	886	Phosphoserine; by FAM20C1 Publication	1

Post-translational modificationⁱ

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.7 Publications

Phosphorylated by FAM20C in the extracellular medium.1 Publication

Keywords - PTMⁱ

Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19823.
PaxDbⁱ	P19823.
PeptideAtlas More...PeptideAtlasⁱ	P19823.
PRIDEⁱ	P19823.

PTM databases

iPTMnetⁱ	P19823.
PhosphoSitePlusⁱ	P19823.
UniCarbKBⁱ	P19823.

Expressionⁱ

Tissue specificityⁱ

Plasma.

Gene expression databases

Bgeeⁱ	ENSG00000151655.
CleanExⁱ	HS_ITIH2.
ExpressionAtlasⁱ	P19823. baseline and differential.
Genevisibleⁱ	P19823. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA059150.

HPAⁱ

HPA059150.

Interactionⁱ

Subunit structureⁱ

I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.

Protein-protein interaction databases

BioGridⁱ	109904. 24 interactors.
IntActⁱ	P19823. 3 interactors.
STRINGⁱ	9606.ENSP00000351190.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P19823.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	56 – 185	VITPROSITE-ProRule annotationAdd BLAST		130
Domainⁱ	308 – 468	VWFAPROSITE-ProRule annotationAdd BLAST		161

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	665 – 679	O-glycosylated at three sitesAdd BLAST		15

Sequence similaritiesⁱ

Belongs to the ITIH family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IEJB. Eukaryota. COG2304. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074468.
HOVERGENⁱ	HBG057734.
InParanoidⁱ	P19823.
KEGG Orthology (KO) More...KOⁱ	K19015.
OMAⁱ	GLIGQFM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01HF.
PhylomeDBⁱ	P19823.
TreeFamⁱ	TF328982.

Family and domain databases

Gene3Dⁱ	3.40.50.410. 1 hit.
InterProⁱ	View protein in InterPro IPR010600. ITI_HC_C. IPR013694. VIT. IPR002035. VWF_A. IPR036465. vWFA_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06668. ITI_HC_C. 1 hit. PF08487. VIT. 1 hit. PF00092. VWA. 1 hit.
SMARTⁱ	View protein in SMART SM00609. VIT. 1 hit. SM00327. VWA. 1 hit.
SUPFAMⁱ	SSF53300. SSF53300. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51468. VIT. 1 hit. PS50234. VWFA. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P19823-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKRLTCFFIC FFLSEVSGFE IPINGLSEFV DYEDLVELAP GKFQLVAENR 
        60         70         80         90        100
RYQRSLPGES EEMMEEVDQV TLYSYKVQST ITSRMATTMI QSKVVNNSPQ 
       110        120        130        140        150
PQNVVFDVQI PKGAFISNFS MTVDGKTFRS SIKEKTVGRA LYAQARAKGK 
       160        170        180        190        200
TAGLVRSSAL DMENFRTEVN VLPGAKVQFE LHYQEVKWRK LGSYEHRIYL 
       210        220        230        240        250
QPGRLAKHLE VDVWVIEPQG LRFLHVPDTF EGHFDGVPVI SKGQQKAHVS 
       260        270        280        290        300
FKPTVAQQRI CPNCRETAVD GELVVLYDVK REEKAGELEV FNGYFVHFFA 
       310        320        330        340        350
PDNLDPIPKN ILFVIDVSGS MWGVKMKQTV EAMKTILDDL RAEDHFSVID 
       360        370        380        390        400
FNQNIRTWRN DLISATKTQV ADAKRYIEKI QPSGGTNINE ALLRAIFILN 
       410        420        430        440        450
EANNLGLLDP NSVSLIILVS DGDPTVGELK LSKIQKNVKE NIQDNISLFS 
       460        470        480        490        500
LGMGFDVDYD FLKRLSNENH GIAQRIYGNQ DTSSQLKKFY NQVSTPLLRN 
       510        520        530        540        550
VQFNYPHTSV TDVTQNNFHN YFGGSEIVVA GKFDPAKLDQ IESVITATSA 
       560        570        580        590        600
NTQLVLETLA QMDDLQDFLS KDKHADPDFT RKLWAYLTIN QLLAERSLAP 
       610        620        630        640        650
TAAAKRRITR SILQMSLDHH IVTPLTSLVI ENEAGDERML ADAPPQDPSC 
       660        670        680        690        700
CSGALYYGSK VVPDSTPSWA NPSPTPVISM LAQGSQVLES TPPPHVMRVE 
       710        720        730        740        750
NDPHFIIYLP KSQKNICFNI DSEPGKILNL VSDPESGIVV NGQLVGAKKP 
       760        770        780        790        800
NNGKLSTYFG KLGFYFQSED IKIEISTETI TLSHGSSTFS LSWSDTAQVT 
       810        820        830        840        850
NQRVQISVKK EKVVTITLDK EMSFSVLLHR VWKKHPVNVD FLGIYIPPTN 
       860        870        880        890        900
KFSPKAHGLI GQFMQEPKIH IFNERPGKDP EKPEASMEVK GQKLIITRGL 
       910        920        930        940 
QKDYRTDLVF GTDVTCWFVH NSGKGFIDGH YKDYFVPQLY SFLKRP

Length:946

Mass (Da):106,463

Last modified:May 5, 2009 - v2

Checksum:ⁱBA626B146DDC2A5F

GO

Sequence cautionⁱ

The sequence CAA30160 differs from that shown. Reason: Frameshift at positions 363 and 373.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	374	K → L AA sequence (PubMed:2476436).Curated	1
Sequence conflictⁱ	705	F → S in AAA60558 (PubMed:2446322).Curated	1
Sequence conflictⁱ	705	F → S in AAA59195 (PubMed:2462430).Curated	1
Sequence conflictⁱ	729	N → D in AAA60558 (PubMed:2446322).Curated	1
Sequence conflictⁱ	729	N → D in AAA59195 (PubMed:2462430).Curated	1
Sequence conflictⁱ	731	V → A in AAA60558 (PubMed:2446322).Curated	1
Sequence conflictⁱ	731	V → A in AAA59195 (PubMed:2462430).Curated	1

Mass spectrometryⁱ

Molecular mass is 76508 Da from positions 55 - 702. Determined by MALDI. 1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_055248	263	N → S1 PublicationCorresponds to variant dbSNP:rs7075296Ensembl.	1
Natural variantⁱVAR_055249	569	L → V. Corresponds to variant dbSNP:rs7084817Ensembl.	1
Natural variantⁱVAR_055250	674	P → A1 PublicationCorresponds to variant dbSNP:rs3740217Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07173 mRNA. Translation: CAA30160.1. Frameshift. AL158044 Genomic DNA. No translation available. M18193 mRNA. Translation: AAA60558.1. M33033 mRNA. Translation: AAA59195.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31141.1.
PIRⁱ	S00346. IYHU2.
NCBI Reference Sequences More...RefSeqⁱ	NP_002207.2. NM_002216.2.
UniGeneⁱ	Hs.75285.

Genome annotation databases

Ensemblⁱ	ENST00000358415; ENSP00000351190; ENSG00000151655.
GeneIDⁱ	3698.
KEGGⁱ	hsa:3698.
UCSC genome browser More...UCSCⁱ	uc001ijs.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P19823	A0A2I3SNF6 A0A2J8KYX8 UPI0007327C46 UPI00075F9BC2 D3DRR6 F7I714 G7N1J8 G7PE64 A2RTY6 F7DD08 +34	Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Homo sapiens (Human) Callithrix jacchus (White-tufted-ear marmoset) Gorilla gorilla gorilla (Western lowland gorilla) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) And more	946	UniRef90_P19823	Cluster: Inter-alpha-trypsin inhibitor heavy chain H2	45

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P19823	A0A2I3SNF6 A0A2J8KYX8 UPI0007327C46 UPI00075F9BC2 G7N1J8 F7I714 G7PE64 D3DRR6 A0A2K5MB02 G3R8I3 +111	Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Callithrix jacchus (White-tufted-ear marmoset) Homo sapiens (Human) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Gorilla gorilla gorilla (Western lowland gorilla) Saimiri boliviensis boliviensis (Bolivian squirrel monkey) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Cebus capucinus imitator And more	946	UniRef50_P19823	Cluster: Inter-alpha-trypsin inhibitor heavy chain H2	122

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07173 mRNA. Translation: CAA30160.1. Frameshift. AL158044 Genomic DNA. No translation available. M18193 mRNA. Translation: AAA60558.1. M33033 mRNA. Translation: AAA59195.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31141.1.
PIRⁱ	S00346. IYHU2.
NCBI Reference Sequences More...RefSeqⁱ	NP_002207.2. NM_002216.2.
UniGeneⁱ	Hs.75285.

3D structure databases

ProteinModelPortalⁱ	P19823.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109904. 24 interactors.
IntActⁱ	P19823. 3 interactors.
STRINGⁱ	9606.ENSP00000351190.

PTM databases

iPTMnetⁱ	P19823.
PhosphoSitePlusⁱ	P19823.
UniCarbKBⁱ	P19823.

Polymorphism and mutation databases

BioMutaⁱ	ITIH2.
DMDMⁱ	229462889.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P19823.
PaxDbⁱ	P19823.
PeptideAtlas More...PeptideAtlasⁱ	P19823.
PRIDEⁱ	P19823.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000358415; ENSP00000351190; ENSG00000151655.
GeneIDⁱ	3698.
KEGGⁱ	hsa:3698.
UCSC genome browser More...UCSCⁱ	uc001ijs.4. human.

Organism-specific databases

CTDⁱ	3698.
DisGeNET More...DisGeNETⁱ	3698.
EuPathDBⁱ	HostDB:ENSG00000151655.17.
GeneCardsⁱ	ITIH2.
H-InvDBⁱ	HIX0035419.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6167. ITIH2.
Human Protein Atlas More...HPAⁱ	HPA059150.
MIMⁱ	146640. gene.
neXtProtⁱ	NX_P19823.
Open Targets More...OpenTargetsⁱ	ENSG00000151655.
PharmGKBⁱ	PA29965.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEJB. Eukaryota. COG2304. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074468.
HOVERGENⁱ	HBG057734.
InParanoidⁱ	P19823.
KEGG Orthology (KO) More...KOⁱ	K19015.
OMAⁱ	GLIGQFM.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01HF.
PhylomeDBⁱ	P19823.
TreeFamⁱ	TF328982.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). R-HSA-8957275. Post-translational protein phosphorylation.

Reactomeⁱ

R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-HSA-8957275. Post-translational protein phosphorylation.

Miscellaneous databases

ChiTaRSⁱ	ITIH2. human.
GeneWikiⁱ	ITIH2.
GenomeRNAiⁱ	3698.
Protein Ontology More...PROⁱ	PR:P19823.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151655.
CleanExⁱ	HS_ITIH2.
ExpressionAtlasⁱ	P19823. baseline and differential.
Genevisibleⁱ	P19823. HS.

Family and domain databases

Gene3Dⁱ	3.40.50.410. 1 hit.
InterProⁱ	View protein in InterPro IPR010600. ITI_HC_C. IPR013694. VIT. IPR002035. VWF_A. IPR036465. vWFA_dom_sf.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF06668. ITI_HC_C. 1 hit. PF08487. VIT. 1 hit. PF00092. VWA. 1 hit.
SMARTⁱ	View protein in SMART SM00609. VIT. 1 hit. SM00327. VWA. 1 hit.
SUPFAMⁱ	SSF53300. SSF53300. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51468. VIT. 1 hit. PS50234. VWFA. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITIH2_HUMAN
Accessionⁱ	P19823Primary (citable) accession number: P19823 Secondary accession number(s): Q14659, Q15484, Q5T986
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	May 5, 2009
	Last modified:	February 28, 2018
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

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Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P19823 (ITIH2_HUMAN)

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Inter-alpha-trypsin inhibitor heavy chain H2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Mass spectrometryⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ