UniProtKB - P19823 (ITIH2_HUMAN)
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Protein
Inter-alpha-trypsin inhibitor heavy chain H2
Gene
ITIH2
Organism
Homo sapiens (Human)
Status
Functioni
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
GO - Molecular functioni
- endopeptidase inhibitor activity Source: ProtInc
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
GO - Biological processi
- cellular protein metabolic process Source: Reactome
- hyaluronan metabolic process Source: InterPro
- post-translational protein modification Source: Reactome
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitor |
Enzyme and pathway databases
Reactomei | R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). R-HSA-8957275. Post-translational protein phosphorylation. |
Names & Taxonomyi
Protein namesi | Recommended name: Inter-alpha-trypsin inhibitor heavy chain H2Short name: ITI heavy chain H2 Short name: ITI-HC2 Short name: Inter-alpha-inhibitor heavy chain 2 Alternative name(s): Inter-alpha-trypsin inhibitor complex component II Serum-derived hyaluronan-associated protein Short name: SHAP |
Gene namesi | Name:ITIH2 Synonyms:IGHEP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151655.17. |
HGNCi | HGNC:6167. ITIH2. |
MIMi | 146640. gene. |
neXtProti | NX_P19823. |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 3698. |
OpenTargetsi | ENSG00000151655. |
PharmGKBi | PA29965. |
Polymorphism and mutation databases
BioMutai | ITIH2. |
DMDMi | 229462889. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000016517 | 19 – 54 | Add BLAST | 36 | |
ChainiPRO_0000016518 | 55 – 702 | Inter-alpha-trypsin inhibitor heavy chain H2Add BLAST | 648 | |
PropeptideiPRO_0000016519 | 703 – 946 | Add BLAST | 244 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | Phosphoserine; by FAM20CCombined sources1 Publication | 1 | |
Glycosylationi | 96 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
GlycosylationiCAR_000140 | 118 | N-linked (GlcNAc...) (complex) asparagine5 Publications | 1 | |
Disulfide bondi | 261 ↔ 264 | 1 Publication | ||
Modified residuei | 282 | 4-carboxyglutamate1 Publication | 1 | |
Modified residuei | 283 | 4-carboxyglutamate1 Publication | 1 | |
Glycosylationi | 445 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 466 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 650 ↔ 651 | 1 Publication | ||
GlycosylationiCAR_000214 | 666 | O-linked (GalNAc...) threonine; partial2 Publications | 1 | |
GlycosylationiCAR_000215 | 673 | O-linked (GalNAc...) serine2 Publications | 1 | |
GlycosylationiCAR_000216 | 675 | O-linked (GalNAc...) threonine2 Publications | 1 | |
GlycosylationiCAR_000217 | 691 | O-linked (GalNAc...) threonine3 Publications | 1 | |
Modified residuei | 702 | Aspartate 1-(chondroitin 4-sulfate)-ester | 1 | |
Modified residuei | 886 | Phosphoserine; by FAM20C1 Publication | 1 |
Post-translational modificationi
Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.By similarity
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.7 Publications
Phosphorylated by FAM20C in the extracellular medium.1 Publication
Keywords - PTMi
Disulfide bond, Gamma-carboxyglutamic acid, Glycoprotein, Phosphoprotein, ProteoglycanProteomic databases
MaxQBi | P19823. |
PaxDbi | P19823. |
PeptideAtlasi | P19823. |
PRIDEi | P19823. |
PTM databases
iPTMneti | P19823. |
PhosphoSitePlusi | P19823. |
UniCarbKBi | P19823. |
Expressioni
Tissue specificityi
Plasma.
Gene expression databases
Bgeei | ENSG00000151655. |
CleanExi | HS_ITIH2. |
ExpressionAtlasi | P19823. baseline and differential. |
Genevisiblei | P19823. HS. |
Organism-specific databases
HPAi | HPA059150. |
Interactioni
Subunit structurei
I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin.
Protein-protein interaction databases
BioGridi | 109904. 24 interactors. |
IntActi | P19823. 3 interactors. |
STRINGi | 9606.ENSP00000351190. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 185 | VITPROSITE-ProRule annotationAdd BLAST | 130 | |
Domaini | 308 – 468 | VWFAPROSITE-ProRule annotationAdd BLAST | 161 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 665 – 679 | O-glycosylated at three sitesAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the ITIH family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG410IEJB. Eukaryota. COG2304. LUCA. |
GeneTreei | ENSGT00550000074468. |
HOVERGENi | HBG057734. |
InParanoidi | P19823. |
KOi | K19015. |
OMAi | GLIGQFM. |
OrthoDBi | EOG091G01HF. |
PhylomeDBi | P19823. |
TreeFami | TF328982. |
Family and domain databases
Gene3Di | 3.40.50.410. 1 hit. |
InterProi | View protein in InterPro IPR010600. ITI_HC_C. IPR013694. VIT. IPR002035. VWF_A. IPR036465. vWFA_dom_sf. |
Pfami | View protein in Pfam PF06668. ITI_HC_C. 1 hit. PF08487. VIT. 1 hit. PF00092. VWA. 1 hit. |
SMARTi | View protein in SMART SM00609. VIT. 1 hit. SM00327. VWA. 1 hit. |
SUPFAMi | SSF53300. SSF53300. 1 hit. |
PROSITEi | View protein in PROSITE PS51468. VIT. 1 hit. PS50234. VWFA. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P19823-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRLTCFFIC FFLSEVSGFE IPINGLSEFV DYEDLVELAP GKFQLVAENR
60 70 80 90 100
RYQRSLPGES EEMMEEVDQV TLYSYKVQST ITSRMATTMI QSKVVNNSPQ
110 120 130 140 150
PQNVVFDVQI PKGAFISNFS MTVDGKTFRS SIKEKTVGRA LYAQARAKGK
160 170 180 190 200
TAGLVRSSAL DMENFRTEVN VLPGAKVQFE LHYQEVKWRK LGSYEHRIYL
210 220 230 240 250
QPGRLAKHLE VDVWVIEPQG LRFLHVPDTF EGHFDGVPVI SKGQQKAHVS
260 270 280 290 300
FKPTVAQQRI CPNCRETAVD GELVVLYDVK REEKAGELEV FNGYFVHFFA
310 320 330 340 350
PDNLDPIPKN ILFVIDVSGS MWGVKMKQTV EAMKTILDDL RAEDHFSVID
360 370 380 390 400
FNQNIRTWRN DLISATKTQV ADAKRYIEKI QPSGGTNINE ALLRAIFILN
410 420 430 440 450
EANNLGLLDP NSVSLIILVS DGDPTVGELK LSKIQKNVKE NIQDNISLFS
460 470 480 490 500
LGMGFDVDYD FLKRLSNENH GIAQRIYGNQ DTSSQLKKFY NQVSTPLLRN
510 520 530 540 550
VQFNYPHTSV TDVTQNNFHN YFGGSEIVVA GKFDPAKLDQ IESVITATSA
560 570 580 590 600
NTQLVLETLA QMDDLQDFLS KDKHADPDFT RKLWAYLTIN QLLAERSLAP
610 620 630 640 650
TAAAKRRITR SILQMSLDHH IVTPLTSLVI ENEAGDERML ADAPPQDPSC
660 670 680 690 700
CSGALYYGSK VVPDSTPSWA NPSPTPVISM LAQGSQVLES TPPPHVMRVE
710 720 730 740 750
NDPHFIIYLP KSQKNICFNI DSEPGKILNL VSDPESGIVV NGQLVGAKKP
760 770 780 790 800
NNGKLSTYFG KLGFYFQSED IKIEISTETI TLSHGSSTFS LSWSDTAQVT
810 820 830 840 850
NQRVQISVKK EKVVTITLDK EMSFSVLLHR VWKKHPVNVD FLGIYIPPTN
860 870 880 890 900
KFSPKAHGLI GQFMQEPKIH IFNERPGKDP EKPEASMEVK GQKLIITRGL
910 920 930 940
QKDYRTDLVF GTDVTCWFVH NSGKGFIDGH YKDYFVPQLY SFLKRP
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 374 | K → L AA sequence (PubMed:2476436).Curated | 1 | |
Sequence conflicti | 705 | F → S in AAA60558 (PubMed:2446322).Curated | 1 | |
Sequence conflicti | 705 | F → S in AAA59195 (PubMed:2462430).Curated | 1 | |
Sequence conflicti | 729 | N → D in AAA60558 (PubMed:2446322).Curated | 1 | |
Sequence conflicti | 729 | N → D in AAA59195 (PubMed:2462430).Curated | 1 | |
Sequence conflicti | 731 | V → A in AAA60558 (PubMed:2446322).Curated | 1 | |
Sequence conflicti | 731 | V → A in AAA59195 (PubMed:2462430).Curated | 1 |
Mass spectrometryi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_055248 | 263 | N → S1 PublicationCorresponds to variant dbSNP:rs7075296Ensembl. | 1 | |
Natural variantiVAR_055249 | 569 | L → V. Corresponds to variant dbSNP:rs7084817Ensembl. | 1 | |
Natural variantiVAR_055250 | 674 | P → A1 PublicationCorresponds to variant dbSNP:rs3740217Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07173 mRNA. Translation: CAA30160.1. Frameshift. AL158044 Genomic DNA. No translation available. M18193 mRNA. Translation: AAA60558.1. M33033 mRNA. Translation: AAA59195.1. |
CCDSi | CCDS31141.1. |
PIRi | S00346. IYHU2. |
RefSeqi | NP_002207.2. NM_002216.2. |
UniGenei | Hs.75285. |
Genome annotation databases
Ensembli | ENST00000358415; ENSP00000351190; ENSG00000151655. |
GeneIDi | 3698. |
KEGGi | hsa:3698. |
UCSCi | uc001ijs.4. human. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | ITIH2_HUMAN | |
Accessioni | P19823Primary (citable) accession number: P19823 Secondary accession number(s): Q14659, Q15484, Q5T986 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1991 |
Last sequence update: | May 5, 2009 | |
Last modified: | February 28, 2018 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |