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Protein

Trans-Golgi network integral membrane protein TGN38

Gene

Ttgn1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • Golgi to endosome transport Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
R-RNO-432722. Golgi Associated Vesicle Biogenesis.
R-RNO-6811440. Retrograde transport at the Trans-Golgi-Network.
R-RNO-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-RNO-8856828. Clathrin-mediated endocytosis.
R-RNO-8957275. Post-translational protein phosphorylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-Golgi network integral membrane protein TGN38
Gene namesi
Name:Ttgn1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620445. Ttgn1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 303LumenalSequence analysisAdd BLAST286
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 357CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

  • cytosol Source: GOC
  • endosome Source: RGD
  • integral component of membrane Source: RGD
  • nucleoplasm Source: Ensembl
  • trans-Golgi network Source: MGI
  • trans-Golgi network transport vesicle Source: GO_Central

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi348S → A or D: Abolishes neurabin-1 and neurabin-2 binding. 1 Publication1
Mutagenesisi350Y → A: No effect on neurabin-1 and neurabin-2 binding. 1 Publication1
Mutagenesisi354 – 357Missing : No effect on neurabin-1 and neurabin-2 binding. 1 Publication4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002248818 – 357Trans-Golgi network integral membrane protein TGN38Add BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei74Dimethylated arginine1 Publication1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi147N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei234PhosphoserineCombined sources1
Modified residuei235PhosphoserineCombined sources1
Modified residuei271PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP19814.
PRIDEiP19814.

PTM databases

iPTMnetiP19814.
PhosphoSitePlusiP19814.

Expressioni

Gene expression databases

GenevisibleiP19814. RN.

Interactioni

Subunit structurei

Interacts with neurabin-1 and neurabin-2. Binds preferentially to the dimeric form of neurabin-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ap2m1P840924EBI-541446,EBI-297693

Protein-protein interaction databases

BioGridi251332. 2 interactors.
IntActiP19814. 7 interactors.
MINTiMINT-107256.
STRINGi10116.ENSRNOP00000019713.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKNX-ray1.85B348-353[»]
SMRiP19814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati133 – 14018
Repeati141 – 14828
Repeati149 – 15638
Repeati157 – 16448
Repeati165 – 17258
Repeati173 – 18068

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 1806 X 8 AA tandem repeats of [PT]-[TS]-G-[GVS]-D-[SN]-[DN]-[NK]Add BLAST48

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXPE. Eukaryota.
ENOG410XUUR. LUCA.
GeneTreeiENSGT00530000064712.
HOGENOMiHOG000089969.
HOVERGENiHBG060160.
InParanoidiP19814.
OMAiINQIHES.
OrthoDBiEOG091G02UO.
PhylomeDBiP19814.

Family and domain databases

InterProiView protein in InterPro
IPR026084. TGN38.
PANTHERiPTHR23211. PTHR23211. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFLVALLLL SVAVARALPS ASKPNNTSSE NNPPIQPSTP LPPGVDISQQ
60 70 80 90 100
VKTNRPTDQR LESDKEGQDK TVARTSASVS SGVESATNLN LDDSKKHPET
110 120 130 140 150
ADAKLKETLQ QLLPVDPKQE KSGQKFTKDS GSPTGGDSDN TTGGDSNKTT
160 170 180 190 200
GVDSDKTSGG DSNKPTGSDN DKPTGGDSNK PTSKVPSNTE TPKIDKVQLT
210 220 230 240 250
EKGQKPTLIS KTESGEKLAG DSDFSLKPEK GDKSSEPTED VETKEIEEGD
260 270 280 290 300
TEPEEGSPLE EENEKVLGPS SSENQEGTLT DSMKDEKDDH YKDNSGNTSA
310 320 330 340 350
ESSHFFAYLV TAAVLVAVLY IAYHNKRKII AFALEGKRSK VTRRPKASDY

QRLNLKL
Length:357
Mass (Da):38,305
Last modified:February 1, 1991 - v1
Checksum:i173B64C51CAD593B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53565 mRNA. Translation: CAA37637.1.
BC098512 mRNA. Translation: AAH98512.1.
RefSeqiNP_620195.1. NM_138840.2.
UniGeneiRn.11349.

Genome annotation databases

EnsembliENSRNOT00000019713; ENSRNOP00000019713; ENSRNOG00000014617.
GeneIDi192152.
KEGGirno:192152.
UCSCiRGD:620445. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTGON3_RAT
AccessioniPrimary (citable) accession number: P19814
Secondary accession number(s): Q4G0B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 5, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references