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Protein

Trehalase

Gene

TREH

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168SubstrateBy similarity1
Binding sitei212SubstrateBy similarity1
Binding sitei319Substrate; via carbonyl oxygenBy similarity1
Active sitei321Proton donor/acceptorBy similarity1
Active sitei514Proton donor/acceptorBy similarity1
Binding sitei528SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Gene namesi
Name:TREH
Synonyms:TREA
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001205520 – 555TrehalaseAdd BLAST536
PropeptideiPRO_0000012056556 – 578Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi261N-linked (GlcNAc...)Sequence analysis1
Glycosylationi369N-linked (GlcNAc...)Sequence analysis1
Glycosylationi417N-linked (GlcNAc...)Sequence analysis1
Lipidationi555GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Expressioni

Tissue specificityi

Small intestine, kidney, and lesser in liver.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008775.

Structurei

3D structure databases

ProteinModelPortaliP19813.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni175 – 176Substrate bindingBy similarity2
Regioni221 – 223Substrate bindingBy similarity3
Regioni286 – 288Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0602. Eukaryota.
COG1626. LUCA.
HOGENOMiHOG000215465.
HOVERGENiHBG014956.
InParanoidiP19813.
KOiK01194.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGSTWELHL LLLLGLGLGS EQALPPPCES QIYCHGELLH QVQMARLYPD
60 70 80 90 100
DKQFVDMPLS TAPDQVLQSF AELAATYNNT VPREQLEKFV QEHFQAVGQE
110 120 130 140 150
LESWTPGDWK ESPQFLQKIS DPKLRAWAEQ LHLLWKKLGK KIKPEVLSQP
160 170 180 190 200
ERFSLIYSQH PFIVPGGRFV EFYYWDSYWV MEGLLLSEMA ETVKGMLQNF
210 220 230 240 250
LDLVTAYGHI PNGGRVYYLQ RSQPPLLTLM MDRYVAHTGD LAFLRENIET
260 270 280 290 300
LALELDFWAE NRTISVSSGG NSHTLNRYHV PYGGPRPESY SKDTELAHTL
310 320 330 340 350
PEGSWETLWA ELKAGAESGW DFSSRWLVGS PNPDSLGSIR TSKLVPVDLN
360 370 380 390 400
AFLCQAEELL SGFYSRLGNE SQATKYRNLR AQRIAALTAL LWDEDKGAWF
410 420 430 440 450
DYDLENQKKN HEFYPSNLTP LWAGCFSDPA IADKALQYLQ DSQILNHRHG
460 470 480 490 500
IPTSLQNTGQ QWDFPNAWAP LQDLVIRGLA KSPSARTQEV AFQLAQNWIR
510 520 530 540 550
TNFDVYSQRS AMYEKYDISN AQPGGGGEYE VQEGFGWTNG VALMLLDRYG
560 570
DRLSSGTQLA LLEPHCLAAA LLLSFLTR
Length:578
Mass (Da):65,517
Last modified:February 1, 1991 - v1
Checksum:i9014B1189818CEAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55299 mRNA. Translation: AAA63460.1.
PIRiA35810.
RefSeqiNP_001075759.1. NM_001082290.1.
UniGeneiOcu.2019.

Genome annotation databases

GeneIDi100009126.
KEGGiocu:100009126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55299 mRNA. Translation: AAA63460.1.
PIRiA35810.
RefSeqiNP_001075759.1. NM_001082290.1.
UniGeneiOcu.2019.

3D structure databases

ProteinModelPortaliP19813.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008775.

Protein family/group databases

CAZyiGH37. Glycoside Hydrolase Family 37.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009126.
KEGGiocu:100009126.

Organism-specific databases

CTDi11181.

Phylogenomic databases

eggNOGiKOG0602. Eukaryota.
COG1626. LUCA.
HOGENOMiHOG000215465.
HOVERGENiHBG014956.
InParanoidiP19813.
KOiK01194.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR001661. Glyco_hydro_37.
IPR018232. Glyco_hydro_37_CS.
[Graphical view]
PANTHERiPTHR23403. PTHR23403. 1 hit.
PfamiPF01204. Trehalase. 1 hit.
[Graphical view]
PRINTSiPR00744. GLHYDRLASE37.
SUPFAMiSSF48208. SSF48208. 1 hit.
PROSITEiPS00927. TREHALASE_1. 1 hit.
PS00928. TREHALASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTREA_RABIT
AccessioniPrimary (citable) accession number: P19813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.