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Protein

Choline transport protein

Gene

HNM1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sole choline transporter in yeast.

GO - Molecular functioni

  • (R)-carnitine transmembrane transporter activity Source: SGD
  • antiporter activity Source: GO_Central
  • choline transmembrane transporter activity Source: SGD
  • ethanolamine transmembrane transporter activity Source: SGD
  • L-amino acid transmembrane transporter activity Source: GO_Central

GO - Biological processi

  • (R)-carnitine transport Source: SGD
  • choline transport Source: SGD
  • ethanolamine transport Source: SGD
  • glycine betaine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30578-MONOMER.

Protein family/group databases

TCDBi2.A.3.4.1. the amino acid-polyamine-organocation (apc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transport protein
Gene namesi
Name:HNM1
Synonyms:CTR, CTR1
Ordered Locus Names:YGL077C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL077C.
SGDiS000003045. HNM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 57ExtracellularSequence analysisAdd BLAST57
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 87CytoplasmicSequence analysis9
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 182ExtracellularSequence analysisAdd BLAST74
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 205CytoplasmicSequence analysis2
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 255ExtracellularSequence analysisAdd BLAST29
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 293CytoplasmicSequence analysisAdd BLAST17
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 342ExtracellularSequence analysisAdd BLAST28
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Topological domaini364 – 398CytoplasmicSequence analysisAdd BLAST35
Transmembranei399 – 417HelicalSequence analysisAdd BLAST19
Topological domaini418 – 426ExtracellularSequence analysis9
Transmembranei427 – 445HelicalSequence analysisAdd BLAST19
Topological domaini446 – 465CytoplasmicSequence analysisAdd BLAST20
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 491ExtracellularSequence analysis5
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Topological domaini513 – 563CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000541551 – 563Choline transport proteinAdd BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1
Modified residuei22PhosphoserineCombined sources1
Modified residuei42PhosphoserineCombined sources1
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP19807.
PRIDEiP19807.

PTM databases

iPTMnetiP19807.

Interactioni

Protein-protein interaction databases

BioGridi33173. 92 interactors.
DIPiDIP-7965N.
IntActiP19807. 59 interactors.
MINTiMINT-4485703.

Structurei

3D structure databases

ProteinModelPortaliP19807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP19807.
KOiK19564.
OMAiPKRWHIF.
OrthoDBiEOG092C1NT7.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004756. AA_permease.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00907. 2A0304. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIRNDNASG GYMQPDQSSN ASMHKRDLRV EEEIKPLDDM DSKGAVAADG
60 70 80 90 100
EVHLRKSFSL WSILGVGFGL TNSWFGISTS MVAGISSGGP MMIVYGIIIV
110 120 130 140 150
ALISICIGTS LGELSSAYPH AGGQFWWSLK LAPPKYKRFA AYMCGSFAYA
160 170 180 190 200
GSVFTSASTT LSVATEVVGM YALTHPEFIP KRWHIFVCFE LLHLFLMFFN
210 220 230 240 250
CYGKSLPIIS SSSLYISLLS FFTITITVLA CSHGKFNDAK FVFATFNNET
260 270 280 290 300
GWKNGGIAFI VGLINPAWSF SCLDCATHMA FEVEKPERVI PIAIMGTVAI
310 320 330 340 350
GFVTSFCYVI AMFFSIQDLD AVLSSTTGAP ILDIYNQALG NKSGAIFLGC
360 370 380 390 400
LILFTSFGCV IACHTWQARL CWSFARDNGL PLSRLWSQVN PHTGVPLNAH
410 420 430 440 450
LMSCAWITLI GLLYLASSTA FQSLITGCIA FLLLSYIIPV ICLLAKKRNI
460 470 480 490 500
AHGPFWLGKF GFFSNIVLLG WTVFSVVFFS FPPVLPVTKD NMNYVCVVIV
510 520 530 540 550
GYTAYSILYW KYKGKKEFHA LEESENEQAE YSNNFDTIED SREFSVAASD
560
VELENEHVPW GKK
Length:563
Mass (Da):62,056
Last modified:February 1, 1991 - v1
Checksum:i1A71E1D146DB7807
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05603 Genomic DNA. Translation: AAA34537.1.
Z72599 Genomic DNA. Translation: CAA96782.1.
AY723806 Genomic DNA. Translation: AAU09723.1.
BK006941 Genomic DNA. Translation: DAA08028.1.
PIRiS11175.
RefSeqiNP_011438.1. NM_001180942.1.

Genome annotation databases

EnsemblFungiiYGL077C; YGL077C; YGL077C.
GeneIDi852803.
KEGGisce:YGL077C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05603 Genomic DNA. Translation: AAA34537.1.
Z72599 Genomic DNA. Translation: CAA96782.1.
AY723806 Genomic DNA. Translation: AAU09723.1.
BK006941 Genomic DNA. Translation: DAA08028.1.
PIRiS11175.
RefSeqiNP_011438.1. NM_001180942.1.

3D structure databases

ProteinModelPortaliP19807.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33173. 92 interactors.
DIPiDIP-7965N.
IntActiP19807. 59 interactors.
MINTiMINT-4485703.

Protein family/group databases

TCDBi2.A.3.4.1. the amino acid-polyamine-organocation (apc) family.

PTM databases

iPTMnetiP19807.

Proteomic databases

MaxQBiP19807.
PRIDEiP19807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL077C; YGL077C; YGL077C.
GeneIDi852803.
KEGGisce:YGL077C.

Organism-specific databases

EuPathDBiFungiDB:YGL077C.
SGDiS000003045. HNM1.

Phylogenomic databases

GeneTreeiENSGT00530000067168.
HOGENOMiHOG000162166.
InParanoidiP19807.
KOiK19564.
OMAiPKRWHIF.
OrthoDBiEOG092C1NT7.

Enzyme and pathway databases

BioCyciYEAST:G3O-30578-MONOMER.

Miscellaneous databases

PROiP19807.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR004756. AA_permease.
IPR004840. Amoino_acid_permease_CS.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsiTIGR00907. 2A0304. 1 hit.
PROSITEiPS00218. AMINO_ACID_PERMEASE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNM1_YEAST
AccessioniPrimary (citable) accession number: P19807
Secondary accession number(s): D6VU67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibition of activity by intracellular choline.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.