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P19799

- TRY1_XENLA

UniProt

P19799 - TRY1_XENLA

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Protein
Trypsin
Gene
N/A
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Charge relay system By similarity
Metal bindingi72 – 721Calcium By similarity
Metal bindingi74 – 741Calcium; via carbonyl oxygen By similarity
Metal bindingi82 – 821Calcium By similarity
Active sitei104 – 1041Charge relay system By similarity
Sitei191 – 1911Required for specificity By similarity
Active sitei197 – 1971Charge relay system By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.126.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin (EC:3.4.21.4)
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 By similarity
Add
BLAST
Propeptidei16 – 205Activation peptide
PRO_0000028233
Chaini21 – 243223Trypsin
PRO_0000028234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 157 By similarity
Disulfide bondi45 ↔ 61 By similarity
Disulfide bondi129 ↔ 230 By similarity
Disulfide bondi136 ↔ 203 By similarity
Disulfide bondi168 ↔ 182 By similarity
Disulfide bondi193 ↔ 217 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP19799.
SMRiP19799. Positions 21-243.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 241221Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG013304.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19799-1 [UniParc]FASTAAdd to Basket

« Hide

MKFLLLCVLL GAAAAFDDDK IIGGATCAKS SVPYIVSLNS GYHFCGGSLI    50
TNQWVVSAAH CYKASIQVRL GEHNIALSEG TEQFISSSKV IRHSGYNSYT 100
LDNDIMLIKL SSPASLNAAV NTVPLPSGCS AAGTSCLISG WGNTLSNGSN 150
YPDLLQCLNA PILTNAQCNS AYPGEITANM ICVGYMEGGK DSCQGDSGGP 200
VVCNGQLQGV VSWGYGCAMR NYPGVYTKVC NYNAWIQNTI AAN 243
Length:243
Mass (Da):25,492
Last modified:February 1, 1991 - v1
Checksum:iC5B8345A8B3F8031
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53458 mRNA. Translation: CAA37538.1.
PIRiA35871.
UniGeneiXl.119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53458 mRNA. Translation: CAA37538.1 .
PIRi A35871.
UniGenei Xl.119.

3D structure databases

ProteinModelPortali P19799.
SMRi P19799. Positions 21-243.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S01.126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG013304.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Developmental and thyroid hormone-dependent regulation of pancreatic genes in Xenopus laevis."
    Shi Y.B., Brown D.D.
    Genes Dev. 4:1107-1113(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiTRY1_XENLA
AccessioniPrimary (citable) accession number: P19799
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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