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P19788 (MGP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Matrix Gla protein

Short name=MGP
Gene names
Name:Mgp
Synonyms:Mglap
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length104 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Subcellular location

Secreted.

Post-translational modification

Requires vitamin K-dependent gamma-carboxylation for its function.

Sequence similarities

Belongs to the osteocalcin/matrix Gla protein family.

Contains 1 Gla (gamma-carboxy-glutamate) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 10485Matrix Gla protein
PRO_0000011111

Regions

Domain51 – 9747Gla

Amino acid modifications

Modified residue2114-carboxyglutamate By similarity
Modified residue221Phosphoserine By similarity
Modified residue251Phosphoserine By similarity
Modified residue281Phosphoserine By similarity
Modified residue6014-carboxyglutamate By similarity
Modified residue6714-carboxyglutamate By similarity
Modified residue7114-carboxyglutamate By similarity
Disulfide bond73 ↔ 79 By similarity

Experimental info

Sequence conflict251S → I in AAP31997. Ref.2
Sequence conflict1031K → R in AAH36991. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P19788 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 9056F6D47ABF3413

FASTA10412,359
        10         20         30         40         50         60 
MKSLLPLAIL AALAVATLCY ESHESMESYE ISPFINRRNA NTFMSPQQRW RAKAQKRVQE 

        70         80         90        100 
RNKPAYEINR EACDDYKLCE RYAMVYGYNA AYNRYFRQRR GAKY 

« Hide

References

« Hide 'large scale' references
[1]"cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence."
Ikeda T., Yamaguchi A., Icho T., Tsuchida N., Yoshiki S.
J. Bone Miner. Res. 6:1013-1017(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]"The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development."
Luo G., D'Souza R., Hogue D., Karsenty G.
J. Bone Miner. Res. 10:325-334(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Kidney.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00613 mRNA. Translation: BAA00488.1.
S77350 Genomic DNA. Translation: AAP31997.1.
AK018719 mRNA. Translation: BAB31365.1.
BC036991 mRNA. Translation: AAH36991.1.
CCDSCCDS20659.1.
PIRGEMSM1. JQ0455.
RefSeqNP_032623.1. NM_008597.3.
UniGeneMm.243085.

3D structure databases

ProteinModelPortalP19788.
SMRP19788. Positions 69-98.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP19788.

Proteomic databases

PaxDbP19788.
PRIDEP19788.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032342; ENSMUSP00000032342; ENSMUSG00000030218.
GeneID17313.
KEGGmmu:17313.
UCSCuc009eml.1. mouse.

Organism-specific databases

CTD4256.
MGIMGI:96976. Mgp.

Phylogenomic databases

eggNOGNOG42431.
GeneTreeENSGT00390000003753.
HOGENOMHOG000113581.
HOVERGENHBG006353.
InParanoidP19788.
OMAFLNRRNA.
OrthoDBEOG718KFT.
PhylomeDBP19788.
TreeFamTF330920.

Gene expression databases

BgeeP19788.
CleanExMM_MGP.
GenevestigatorP19788.

Family and domain databases

InterProIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERPTHR10109. PTHR10109. 1 hit.
PfamPF00594. Gla. 1 hit.
[Graphical view]
PRINTSPR00002. GLABONE.
SMARTSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMSSF57630. SSF57630. 1 hit.
PROSITEPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMGP. mouse.
NextBio291872.
PROP19788.
SOURCESearch...

Entry information

Entry nameMGP_MOUSE
AccessionPrimary (citable) accession number: P19788
Secondary accession number(s): Q6LD77, Q8JZW0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: July 9, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot