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Protein

Matrix Gla protein

Gene

Mgp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Gene namesi
Name:Mgp
Synonyms:Mglap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96976. Mgp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 10485Matrix Gla proteinPRO_0000011111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotation
Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotation
Modified residuei71 – 7114-carboxyglutamatePROSITE-ProRule annotation
Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

MaxQBiP19788.
PaxDbiP19788.
PRIDEiP19788.

PTM databases

PhosphoSiteiP19788.

Expressioni

Gene expression databases

BgeeiP19788.
CleanExiMM_MGP.
GenevisibleiP19788. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032342.

Structurei

3D structure databases

ProteinModelPortaliP19788.
SMRiP19788. Positions 69-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 9747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42431.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP19788.
OMAiAALCYES.
OrthoDBiEOG718KFT.
PhylomeDBiP19788.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLPLAIL AALAVATLCY ESHESMESYE ISPFINRRNA NTFMSPQQRW
60 70 80 90 100
RAKAQKRVQE RNKPAYEINR EACDDYKLCE RYAMVYGYNA AYNRYFRQRR

GAKY
Length:104
Mass (Da):12,359
Last modified:February 1, 1991 - v1
Checksum:i9056F6D47ABF3413
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251S → I in AAP31997 (PubMed:7754814).Curated
Sequence conflicti103 – 1031K → R in AAH36991 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00613 mRNA. Translation: BAA00488.1.
S77350 Genomic DNA. Translation: AAP31997.1.
AK018719 mRNA. Translation: BAB31365.1.
BC036991 mRNA. Translation: AAH36991.1.
CCDSiCCDS20659.1.
PIRiJQ0455. GEMSM1.
RefSeqiNP_032623.1. NM_008597.3.
UniGeneiMm.243085.

Genome annotation databases

EnsembliENSMUST00000032342; ENSMUSP00000032342; ENSMUSG00000030218.
GeneIDi17313.
KEGGimmu:17313.
UCSCiuc009eml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00613 mRNA. Translation: BAA00488.1.
S77350 Genomic DNA. Translation: AAP31997.1.
AK018719 mRNA. Translation: BAB31365.1.
BC036991 mRNA. Translation: AAH36991.1.
CCDSiCCDS20659.1.
PIRiJQ0455. GEMSM1.
RefSeqiNP_032623.1. NM_008597.3.
UniGeneiMm.243085.

3D structure databases

ProteinModelPortaliP19788.
SMRiP19788. Positions 69-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032342.

PTM databases

PhosphoSiteiP19788.

Proteomic databases

MaxQBiP19788.
PaxDbiP19788.
PRIDEiP19788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032342; ENSMUSP00000032342; ENSMUSG00000030218.
GeneIDi17313.
KEGGimmu:17313.
UCSCiuc009eml.1. mouse.

Organism-specific databases

CTDi4256.
MGIiMGI:96976. Mgp.

Phylogenomic databases

eggNOGiNOG42431.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP19788.
OMAiAALCYES.
OrthoDBiEOG718KFT.
PhylomeDBiP19788.
TreeFamiTF330920.

Miscellaneous databases

ChiTaRSiMgp. mouse.
NextBioi291872.
PROiP19788.
SOURCEiSearch...

Gene expression databases

BgeeiP19788.
CleanExiMM_MGP.
GenevisibleiP19788. MM.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PfamiPF00594. Gla. 1 hit.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence."
    Ikeda T., Yamaguchi A., Icho T., Tsuchida N., Yoshiki S.
    J. Bone Miner. Res. 6:1013-1017(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development."
    Luo G., D'Souza R., Hogue D., Karsenty G.
    J. Bone Miner. Res. 10:325-334(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiMGP_MOUSE
AccessioniPrimary (citable) accession number: P19788
Secondary accession number(s): Q6LD77, Q8JZW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.