Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P19788

- MGP_MOUSE

UniProt

P19788 - MGP_MOUSE

Protein

Matrix Gla protein

Gene

Mgp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. cartilage development Source: UniProtKB-KW
    2. cell differentiation Source: UniProtKB-KW
    3. ossification Source: UniProtKB-KW
    4. regulation of bone mineralization Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Chondrogenesis, Differentiation, Osteogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Matrix Gla protein
    Short name:
    MGP
    Gene namesi
    Name:Mgp
    Synonyms:Mglap
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96976. Mgp.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular matrix Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 10485Matrix Gla proteinPRO_0000011111Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei25 – 251PhosphoserineBy similarity
    Modified residuei28 – 281PhosphoserineBy similarity
    Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotation
    Modified residuei71 – 7114-carboxyglutamatePROSITE-ProRule annotation
    Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

    Post-translational modificationi

    Requires vitamin K-dependent gamma-carboxylation for its function.

    Keywords - PTMi

    Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

    Proteomic databases

    PaxDbiP19788.
    PRIDEiP19788.

    PTM databases

    PhosphoSiteiP19788.

    Expressioni

    Gene expression databases

    BgeeiP19788.
    CleanExiMM_MGP.
    GenevestigatoriP19788.

    Structurei

    3D structure databases

    ProteinModelPortaliP19788.
    SMRiP19788. Positions 69-98.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 9747GlaPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42431.
    GeneTreeiENSGT00390000003753.
    HOGENOMiHOG000113581.
    HOVERGENiHBG006353.
    InParanoidiP19788.
    OMAiFLNRRNA.
    OrthoDBiEOG718KFT.
    PhylomeDBiP19788.
    TreeFamiTF330920.

    Family and domain databases

    InterProiIPR000294. GLA_domain.
    IPR027118. MGP.
    IPR002384. Osteocalcin/MGP.
    [Graphical view]
    PANTHERiPTHR10109. PTHR10109. 1 hit.
    PfamiPF00594. Gla. 1 hit.
    [Graphical view]
    PRINTSiPR00002. GLABONE.
    SMARTiSM00069. GLA. 1 hit.
    [Graphical view]
    SUPFAMiSSF57630. SSF57630. 1 hit.
    PROSITEiPS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19788-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSLLPLAIL AALAVATLCY ESHESMESYE ISPFINRRNA NTFMSPQQRW    50
    RAKAQKRVQE RNKPAYEINR EACDDYKLCE RYAMVYGYNA AYNRYFRQRR 100
    GAKY 104
    Length:104
    Mass (Da):12,359
    Last modified:February 1, 1991 - v1
    Checksum:i9056F6D47ABF3413
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251S → I in AAP31997. (PubMed:7754814)Curated
    Sequence conflicti103 – 1031K → R in AAH36991. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00613 mRNA. Translation: BAA00488.1.
    S77350 Genomic DNA. Translation: AAP31997.1.
    AK018719 mRNA. Translation: BAB31365.1.
    BC036991 mRNA. Translation: AAH36991.1.
    CCDSiCCDS20659.1.
    PIRiJQ0455. GEMSM1.
    RefSeqiNP_032623.1. NM_008597.3.
    UniGeneiMm.243085.

    Genome annotation databases

    EnsembliENSMUST00000032342; ENSMUSP00000032342; ENSMUSG00000030218.
    GeneIDi17313.
    KEGGimmu:17313.
    UCSCiuc009eml.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00613 mRNA. Translation: BAA00488.1 .
    S77350 Genomic DNA. Translation: AAP31997.1 .
    AK018719 mRNA. Translation: BAB31365.1 .
    BC036991 mRNA. Translation: AAH36991.1 .
    CCDSi CCDS20659.1.
    PIRi JQ0455. GEMSM1.
    RefSeqi NP_032623.1. NM_008597.3.
    UniGenei Mm.243085.

    3D structure databases

    ProteinModelPortali P19788.
    SMRi P19788. Positions 69-98.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P19788.

    Proteomic databases

    PaxDbi P19788.
    PRIDEi P19788.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032342 ; ENSMUSP00000032342 ; ENSMUSG00000030218 .
    GeneIDi 17313.
    KEGGi mmu:17313.
    UCSCi uc009eml.1. mouse.

    Organism-specific databases

    CTDi 4256.
    MGIi MGI:96976. Mgp.

    Phylogenomic databases

    eggNOGi NOG42431.
    GeneTreei ENSGT00390000003753.
    HOGENOMi HOG000113581.
    HOVERGENi HBG006353.
    InParanoidi P19788.
    OMAi FLNRRNA.
    OrthoDBi EOG718KFT.
    PhylomeDBi P19788.
    TreeFami TF330920.

    Miscellaneous databases

    ChiTaRSi MGP. mouse.
    NextBioi 291872.
    PROi P19788.
    SOURCEi Search...

    Gene expression databases

    Bgeei P19788.
    CleanExi MM_MGP.
    Genevestigatori P19788.

    Family and domain databases

    InterProi IPR000294. GLA_domain.
    IPR027118. MGP.
    IPR002384. Osteocalcin/MGP.
    [Graphical view ]
    PANTHERi PTHR10109. PTHR10109. 1 hit.
    Pfami PF00594. Gla. 1 hit.
    [Graphical view ]
    PRINTSi PR00002. GLABONE.
    SMARTi SM00069. GLA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57630. SSF57630. 1 hit.
    PROSITEi PS00011. GLA_1. 1 hit.
    PS50998. GLA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and deduced amino acid sequence of mouse matrix gla protein: one of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence."
      Ikeda T., Yamaguchi A., Icho T., Tsuchida N., Yoshiki S.
      J. Bone Miner. Res. 6:1013-1017(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development."
      Luo G., D'Souza R., Hogue D., Karsenty G.
      J. Bone Miner. Res. 10:325-334(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiMGP_MOUSE
    AccessioniPrimary (citable) accession number: P19788
    Secondary accession number(s): Q6LD77, Q8JZW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3