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Protein

Matrix Gla protein

Gene

Mgp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Chondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Gene namesi
Name:Mgp
Synonyms:Mglap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96976. Mgp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 10485Matrix Gla proteinPRO_0000011111Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 2114-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei22 – 221PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei28 – 281PhosphoserineBy similarity
Modified residuei60 – 6014-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei67 – 6714-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei71 – 7114-carboxyglutamatePROSITE-ProRule annotationBy similarity
Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

MaxQBiP19788.
PaxDbiP19788.
PeptideAtlasiP19788.
PRIDEiP19788.

PTM databases

PhosphoSiteiP19788.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030218.
CleanExiMM_MGP.
GenevisibleiP19788. MM.

Interactioni

Protein-protein interaction databases

BioGridi201414. 17 interactions.
IntActiP19788. 17 interactions.
STRINGi10090.ENSMUSP00000032342.

Structurei

3D structure databases

ProteinModelPortaliP19788.
SMRiP19788. Positions 69-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 9747GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP19788.
KOiK19481.
OMAiFLNRRNA.
OrthoDBiEOG091G0XPC.
PhylomeDBiP19788.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19788-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLLPLAIL AALAVATLCY ESHESMESYE ISPFINRRNA NTFMSPQQRW
60 70 80 90 100
RAKAQKRVQE RNKPAYEINR EACDDYKLCE RYAMVYGYNA AYNRYFRQRR

GAKY
Length:104
Mass (Da):12,359
Last modified:February 1, 1991 - v1
Checksum:i9056F6D47ABF3413
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251S → I in AAP31997 (PubMed:7754814).Curated
Sequence conflicti103 – 1031K → R in AAH36991 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00613 mRNA. Translation: BAA00488.1.
S77350 Genomic DNA. Translation: AAP31997.1.
AK018719 mRNA. Translation: BAB31365.1.
BC036991 mRNA. Translation: AAH36991.1.
CCDSiCCDS20659.1.
PIRiJQ0455. GEMSM1.
RefSeqiNP_032623.1. NM_008597.3.
UniGeneiMm.243085.

Genome annotation databases

EnsembliENSMUST00000032342; ENSMUSP00000032342; ENSMUSG00000030218.
GeneIDi17313.
KEGGimmu:17313.
UCSCiuc009eml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00613 mRNA. Translation: BAA00488.1.
S77350 Genomic DNA. Translation: AAP31997.1.
AK018719 mRNA. Translation: BAB31365.1.
BC036991 mRNA. Translation: AAH36991.1.
CCDSiCCDS20659.1.
PIRiJQ0455. GEMSM1.
RefSeqiNP_032623.1. NM_008597.3.
UniGeneiMm.243085.

3D structure databases

ProteinModelPortaliP19788.
SMRiP19788. Positions 69-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201414. 17 interactions.
IntActiP19788. 17 interactions.
STRINGi10090.ENSMUSP00000032342.

PTM databases

PhosphoSiteiP19788.

Proteomic databases

MaxQBiP19788.
PaxDbiP19788.
PeptideAtlasiP19788.
PRIDEiP19788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032342; ENSMUSP00000032342; ENSMUSG00000030218.
GeneIDi17313.
KEGGimmu:17313.
UCSCiuc009eml.1. mouse.

Organism-specific databases

CTDi4256.
MGIiMGI:96976. Mgp.

Phylogenomic databases

eggNOGiENOG410IZCH. Eukaryota.
ENOG410Y2RM. LUCA.
GeneTreeiENSGT00390000003753.
HOGENOMiHOG000113581.
HOVERGENiHBG006353.
InParanoidiP19788.
KOiK19481.
OMAiFLNRRNA.
OrthoDBiEOG091G0XPC.
PhylomeDBiP19788.
TreeFamiTF330920.

Miscellaneous databases

ChiTaRSiMgp. mouse.
PROiP19788.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030218.
CleanExiMM_MGP.
GenevisibleiP19788. MM.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR027118. MGP.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PANTHERiPTHR10109. PTHR10109. 1 hit.
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMGP_MOUSE
AccessioniPrimary (citable) accession number: P19788
Secondary accession number(s): Q6LD77, Q8JZW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.