##gff-version 3 P19785 UniProtKB Chain 1 599 . . . ID=PRO_0000053621;Note=Estrogen receptor P19785 UniProtKB Domain 315 551 . . . Note=NR LBD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01189 P19785 UniProtKB DNA binding 189 254 . . . Note=Nuclear receptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 P19785 UniProtKB Zinc finger 189 209 . . . Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 P19785 UniProtKB Zinc finger 225 249 . . . Note=NR C4-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00407 P19785 UniProtKB Region 1 188 . . . Note=Modulating (transactivation AF-1)%3B mediates interaction with MACROD1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P19785 UniProtKB Region 35 178 . . . Note=Interaction with DDX5%3B self-association;Ontology_term=ECO:0000250;evidence=ECO:0000250 P19785 UniProtKB Region 35 47 . . . Note=Required for interaction with NCOA1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P19785 UniProtKB Region 147 175 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P19785 UniProtKB Region 189 314 . . . Note=Mediates interaction with DNTTIP2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P19785 UniProtKB Region 255 314 . . . Note=Hinge P19785 UniProtKB Region 266 599 . . . Note=Interaction with AKAP13;Ontology_term=ECO:0000250;evidence=ECO:0000250 P19785 UniProtKB Region 268 599 . . . Note=Self-association;Ontology_term=ECO:0000250;evidence=ECO:0000250 P19785 UniProtKB Region 315 599 . . . Note=Transactivation AF-2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P19785 UniProtKB Region 557 581 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P19785 UniProtKB Compositional bias 564 581 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P19785 UniProtKB Modified residue 108 108 . . . Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03372 P19785 UniProtKB Modified residue 110 110 . . . Note=Phosphoserine%3B by CDK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03372 P19785 UniProtKB Modified residue 122 122 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03372 P19785 UniProtKB Modified residue 171 171 . . . Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03372 P19785 UniProtKB Modified residue 264 264 . . . Note=Asymmetric dimethylarginine%3B by PRMT1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03372 P19785 UniProtKB Modified residue 541 541 . . . Note=Phosphotyrosine%3B by Tyr-kinases;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P03372 P19785 UniProtKB Lipidation 451 451 . . . Note=S-palmitoyl cysteine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22031296;Dbxref=PMID:22031296 P19785 UniProtKB Glycosylation 10 10 . . . Note=O-linked (GlcNAc) serine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11226831;Dbxref=PMID:11226831 P19785 UniProtKB Glycosylation 50 50 . . . Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11226831;Dbxref=PMID:11226831 P19785 UniProtKB Glycosylation 575 575 . . . ID=CAR_000137;Note=O-linked (GlcNAc) threonine;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11226831,ECO:0000269|PubMed:8999954;Dbxref=PMID:11226831,PMID:8999954 P19785 UniProtKB Natural variant 591 591 . . . Note=In strain: SJL/J. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|Ref.4 P19785 UniProtKB Mutagenesis 362 362 . . . Note=No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1%3B when associated with A-376 and A-380. I->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 362 362 . . . Note=Abolishes transcriptional activity and estrogen-induced interaction with NCOA1. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 366 366 . . . Note=Greatly reduces transcriptional activity and estrogen-induced interaction with NCOA1. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 366 366 . . . Note=Abolishes transcriptional activity and estrogen-induced interaction with NCOA1. K->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 366 366 . . . Note=Reduces transcriptional activity and estrogen-induced interaction with NCOA1. K->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 371 371 . . . Note=Abolishes estrogen-dependent NF-kappa B transcriptional repression%2C impairs transcriptional activity%2C abolishes estrogen-induced interaction with NCOA1. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 376 376 . . . Note=Reduces transcriptional activity%2C no effect on estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1%3B when associated with A-362 and A-380. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 376 376 . . . Note=Reduces transcriptional activity and estrogen-induced interaction with NCOA1. L->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 380 380 . . . Note=No effect on transcriptional activity and estrogen-induced interaction with NCOA1. Abolishes estrogen-induced interaction with NCOA1%3B when associated with A-362 and A-376. V->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 380 380 . . . Note=Abolishes transcriptional activity and estrogen-induced interaction with NCOA1. V->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 451 451 . . . Note=Loss of ZDHHC7 and ZDHHC21 binding. Loss of palmitoylation. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22031296;Dbxref=PMID:22031296 P19785 UniProtKB Mutagenesis 508 508 . . . Note=Reduces DNA-binding%2C attenuates transcriptional activity%2C does not effect estrogen-dependent NF-kappa B transcriptional repression%3B when associated with E-512 and E-515. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 508 508 . . . Note=Abolishes DNA-binding%2C abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression%3B when associated with E-512 and E-515. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 509 509 . . . Note=Reduces DNA-binding%2C%2C attenuates transcriptional activity%2C does not effect estrogen-dependent NF-kappa B transcriptional repression. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 512 512 . . . Note=Reduces DNA-binding%2C attenuates transcriptional activity%2C does not effect estrogen-dependent NF-kappa B transcriptional repression%3B when associated with E-508 and E-515. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 512 512 . . . Note=Abolishes DNA-binding%2C abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression%3B when associated with E-508 and E-515. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 515 515 . . . Note=Reduces DNA-binding%2C attenuates transcriptional activity%2C does not effect estrogen-dependent NF-kappa B transcriptional repression%3B when associated with E-508 and E-512. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 515 515 . . . Note=Abolishes DNA-binding%2C abolishes transcriptional activity and estrogen-dependent NF-kappa B transcriptional repression%3B when associated with E-508 and E-512. L->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 525 525 . . . Note=Abolishes estrogen binding%3B impairs repression of NF-kappa activity. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 542 542 . . . Note=Abolishes estrogen-dependent NF-kappa B transcriptional repression%2C impairs transcriptional activity%2C impairs estrogen-induced interaction with NCOA1%3B when associated with Q-546 and N-548. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 543 544 . . . Note=Abolishes estrogen-dependent NF-kappa B transcriptional repression%2C abolishes estrogen-induced interaction with NCOA1. LL->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 543 543 . . . Note=Abolishes estrogen-induced interaction with NCOA1. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10207113;Dbxref=PMID:10207113 P19785 UniProtKB Mutagenesis 546 546 . . . Note=Abolishes estrogen-dependent NF-kappa B transcriptional repression%2C impairs transcriptional activity%2C impairs estrogen-induced interaction with NCOA1%3B when associated with N-542 and N-548. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 547 548 . . . Note=No effect on estrogen-dependent NF-kappa B transcriptional repression%2C greatly impairs transcriptional activity%2C abolishes estrogen-induced interaction with NCOA1. ML->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Mutagenesis 549 549 . . . Note=Abolishes estrogen-dependent NF-kappa B transcriptional repression%2C impairs transcriptional activity%2C impairs estrogen-induced interaction with NCOA1%3B when associated with N-542 and Q-546. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:10840033;Dbxref=PMID:10840033 P19785 UniProtKB Sequence conflict 269 269 . . . Note=L->M;Ontology_term=ECO:0000305;evidence=ECO:0000305