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P19783 (COX41_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name=COX IV-1
Gene names
Name:Cox4i1
Synonyms:Cox4, Cox4a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase IV family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2222Mitochondrion
Chain23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
PRO_0000006085

Amino acid modifications

Modified residue291N6-acetyllysine; alternate Ref.6
Modified residue291N6-succinyllysine; alternate Ref.5
Modified residue601N6-acetyllysine; alternate Ref.6
Modified residue601N6-succinyllysine; alternate Ref.5
Modified residue671N6-acetyllysine Ref.6

Experimental info

Sequence conflict140 – 1412MQ → IE in AAB02139. Ref.2
Sequence conflict140 – 1412MQ → IE in AAB02140. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P19783 [UniParc].

Last modified October 1, 1993. Version 2.
Checksum: D30B1DBBE14FDBEA

FASTA16919,530
        10         20         30         40         50         60 
MLASRALSLI GKRAISTSVC LRAHGSVVKS EDYAFPTYAD RRDYPLPDVA HVTMLSASQK 

        70         80         90        100        110        120 
ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNRGTNEW KTVVGMAMFF IGFTALVLIW 

       130        140        150        160 
EKSYVYGPIP HTFDRDWVAM QTKRMLDMKA NPIQGFSAKW DYDKNEWKK 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of a mouse cDNA for subunit IV of cytochrome c oxidase."
Grossman L.I., Akamatsu M.
Nucleic Acids Res. 18:6454-6454(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Heart.
[2]"Cloning and characterization of the mouse cytochrome c oxidase subunit IV gene."
Carter R.S., Avadhani N.G.
Arch. Biochem. Biophys. 288:97-106(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow.
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 30-41; 43-60; 68-75; 84-95; 136-143 AND 160-169, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[5]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-29 AND LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29; LYS-60 AND LYS-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54691 mRNA. Translation: CAA38507.1.
M37831, M58034 Genomic DNA. Translation: AAB02139.1.
M37829 mRNA. Translation: AAB02140.1.
AK012583 mRNA. Translation: BAB28333.1.
AK019276 mRNA. Translation: BAB31643.1.
AK150447 mRNA. Translation: BAE29569.1.
PIRS12142.
RefSeqNP_034071.1. NM_009941.2.
XP_006530702.1. XM_006530639.1.
UniGeneMm.386758.

3D structure databases

ProteinModelPortalP19783.
SMRP19783. Positions 26-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198840. 1 interaction.
IntActP19783. 4 interactions.
MINTMINT-1860013.

PTM databases

PhosphoSiteP19783.

Proteomic databases

PaxDbP19783.
PRIDEP19783.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034276; ENSMUSP00000034276; ENSMUSG00000031818.
ENSMUST00000181586; ENSMUSP00000138019; ENSMUSG00000031818.
GeneID12857.
KEGGmmu:12857.
UCSCuc009nrh.1. mouse.

Organism-specific databases

CTD1327.
MGIMGI:88473. Cox4i1.

Phylogenomic databases

eggNOGNOG276242.
GeneTreeENSGT00390000002407.
HOGENOMHOG000231486.
HOVERGENHBG051087.
InParanoidP19783.
KOK02263.
OMAVAMQTKR.
OrthoDBEOG7BKCWF.
PhylomeDBP19783.
TreeFamTF105061.

Gene expression databases

ArrayExpressP19783.
BgeeP19783.
CleanExMM_COX4I1.
GenevestigatorP19783.

Family and domain databases

Gene3D1.10.442.10. 1 hit.
InterProIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamPF02936. COX4. 1 hit.
[Graphical view]
PRINTSPR01873. CYTCOXIDASE4.
SUPFAMSSF81406. SSF81406. 1 hit.
ProtoNetSearch...

Other

NextBio282412.
PROP19783.
SOURCESearch...

Entry information

Entry nameCOX41_MOUSE
AccessionPrimary (citable) accession number: P19783
Secondary accession number(s): Q545A9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1993
Last modified: April 16, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot