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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

Cox4i1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:Cox4i1
Synonyms:Cox4, Cox4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:88473. Cox4i1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • membrane Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrial membrane Source: MGI
  • mitochondrial respiratory chain complex IV Source: GO_Central
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionAdd BLAST22
ChainiPRO_000000608523 – 169Cytochrome c oxidase subunit 4 isoform 1, mitochondrialAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-acetyllysine; alternateCombined sources1
Modified residuei29N6-succinyllysine; alternateCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei60N6-acetyllysine; alternateCombined sources1
Modified residuei60N6-succinyllysine; alternateCombined sources1
Modified residuei67N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP19783.
MaxQBiP19783.
PaxDbiP19783.
PeptideAtlasiP19783.
PRIDEiP19783.
TopDownProteomicsiP19783.

PTM databases

iPTMnetiP19783.
PhosphoSitePlusiP19783.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031818.
CleanExiMM_COX4I1.
ExpressionAtlasiP19783. baseline and differential.
GenevisibleiP19783. MM.

Interactioni

Protein-protein interaction databases

BioGridi198840. 1 interactor.
IntActiP19783. 4 interactors.
MINTiMINT-1860013.
STRINGi10090.ENSMUSP00000034276.

Structurei

3D structure databases

ProteinModelPortaliP19783.
SMRiP19783.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiP19783.
KOiK02263.
OMAiEKHYVYG.
OrthoDBiEOG091G0XDH.
PhylomeDBiP19783.
TreeFamiTF105061.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLASRALSLI GKRAISTSVC LRAHGSVVKS EDYAFPTYAD RRDYPLPDVA
60 70 80 90 100
HVTMLSASQK ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNRGTNEW
110 120 130 140 150
KTVVGMAMFF IGFTALVLIW EKSYVYGPIP HTFDRDWVAM QTKRMLDMKA
160
NPIQGFSAKW DYDKNEWKK
Length:169
Mass (Da):19,530
Last modified:October 1, 1993 - v2
Checksum:iD30B1DBBE14FDBEA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140 – 141MQ → IE in AAB02139 (PubMed:1654830).Curated2
Sequence conflicti140 – 141MQ → IE in AAB02140 (PubMed:1654830).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54691 mRNA. Translation: CAA38507.1.
M37831, M58034 Genomic DNA. Translation: AAB02139.1.
M37829 mRNA. Translation: AAB02140.1.
AK012583 mRNA. Translation: BAB28333.1.
AK019276 mRNA. Translation: BAB31643.1.
AK150447 mRNA. Translation: BAE29569.1.
CCDSiCCDS40498.1.
PIRiS12142.
RefSeqiNP_001280488.1. NM_001293559.1.
NP_034071.2. NM_009941.3.
UniGeneiMm.386758.

Genome annotation databases

EnsembliENSMUST00000034276; ENSMUSP00000034276; ENSMUSG00000031818.
ENSMUST00000181586; ENSMUSP00000138019; ENSMUSG00000031818.
GeneIDi12857.
KEGGimmu:12857.
UCSCiuc009nrh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54691 mRNA. Translation: CAA38507.1.
M37831, M58034 Genomic DNA. Translation: AAB02139.1.
M37829 mRNA. Translation: AAB02140.1.
AK012583 mRNA. Translation: BAB28333.1.
AK019276 mRNA. Translation: BAB31643.1.
AK150447 mRNA. Translation: BAE29569.1.
CCDSiCCDS40498.1.
PIRiS12142.
RefSeqiNP_001280488.1. NM_001293559.1.
NP_034071.2. NM_009941.3.
UniGeneiMm.386758.

3D structure databases

ProteinModelPortaliP19783.
SMRiP19783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198840. 1 interactor.
IntActiP19783. 4 interactors.
MINTiMINT-1860013.
STRINGi10090.ENSMUSP00000034276.

PTM databases

iPTMnetiP19783.
PhosphoSitePlusiP19783.

Proteomic databases

EPDiP19783.
MaxQBiP19783.
PaxDbiP19783.
PeptideAtlasiP19783.
PRIDEiP19783.
TopDownProteomicsiP19783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034276; ENSMUSP00000034276; ENSMUSG00000031818.
ENSMUST00000181586; ENSMUSP00000138019; ENSMUSG00000031818.
GeneIDi12857.
KEGGimmu:12857.
UCSCiuc009nrh.2. mouse.

Organism-specific databases

CTDi1327.
MGIiMGI:88473. Cox4i1.

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiP19783.
KOiK02263.
OMAiEKHYVYG.
OrthoDBiEOG091G0XDH.
PhylomeDBiP19783.
TreeFamiTF105061.

Miscellaneous databases

ChiTaRSiCox4i1. mouse.
PROiP19783.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031818.
CleanExiMM_COX4I1.
ExpressionAtlasiP19783. baseline and differential.
GenevisibleiP19783. MM.

Family and domain databases

CDDicd00922. Cyt_c_Oxidase_IV. 1 hit.
Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOX41_MOUSE
AccessioniPrimary (citable) accession number: P19783
Secondary accession number(s): Q545A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.