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P19783

- COX41_MOUSE

UniProt

P19783 - COX41_MOUSE

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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

Cox4i1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: InterPro

GO - Biological processi

  1. response to nutrient Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:Cox4i1
Synonyms:Cox4, Cox4a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:88473. Cox4i1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. mitochondrial inner membrane Source: MGI
  3. mitochondrion Source: MGI
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222MitochondrionAdd
BLAST
Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine; alternate1 Publication
Modified residuei29 – 291N6-succinyllysine; alternate1 Publication
Modified residuei60 – 601N6-acetyllysine; alternate1 Publication
Modified residuei60 – 601N6-succinyllysine; alternate1 Publication
Modified residuei67 – 671N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP19783.
PaxDbiP19783.
PRIDEiP19783.

PTM databases

PhosphoSiteiP19783.

Expressioni

Gene expression databases

BgeeiP19783.
CleanExiMM_COX4I1.
ExpressionAtlasiP19783. differential.
GenevestigatoriP19783.

Interactioni

Protein-protein interaction databases

BioGridi198840. 1 interaction.
IntActiP19783. 4 interactions.
MINTiMINT-1860013.

Structurei

3D structure databases

ProteinModelPortaliP19783.
SMRiP19783. Positions 26-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG276242.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiP19783.
KOiK02263.
OMAiVAMQTKR.
OrthoDBiEOG7BKCWF.
PhylomeDBiP19783.
TreeFamiTF105061.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19783-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLASRALSLI GKRAISTSVC LRAHGSVVKS EDYAFPTYAD RRDYPLPDVA
60 70 80 90 100
HVTMLSASQK ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNRGTNEW
110 120 130 140 150
KTVVGMAMFF IGFTALVLIW EKSYVYGPIP HTFDRDWVAM QTKRMLDMKA
160
NPIQGFSAKW DYDKNEWKK
Length:169
Mass (Da):19,530
Last modified:October 1, 1993 - v2
Checksum:iD30B1DBBE14FDBEA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1412MQ → IE in AAB02139. (PubMed:1654830)Curated
Sequence conflicti140 – 1412MQ → IE in AAB02140. (PubMed:1654830)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54691 mRNA. Translation: CAA38507.1.
M37831, M58034 Genomic DNA. Translation: AAB02139.1.
M37829 mRNA. Translation: AAB02140.1.
AK012583 mRNA. Translation: BAB28333.1.
AK019276 mRNA. Translation: BAB31643.1.
AK150447 mRNA. Translation: BAE29569.1.
CCDSiCCDS40498.1.
PIRiS12142.
RefSeqiNP_001280488.1. NM_001293559.1.
NP_034071.2. NM_009941.3.
UniGeneiMm.386758.

Genome annotation databases

EnsembliENSMUST00000034276; ENSMUSP00000034276; ENSMUSG00000031818.
ENSMUST00000181586; ENSMUSP00000138019; ENSMUSG00000031818.
GeneIDi12857.
KEGGimmu:12857.
UCSCiuc009nrh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X54691 mRNA. Translation: CAA38507.1 .
M37831 , M58034 Genomic DNA. Translation: AAB02139.1 .
M37829 mRNA. Translation: AAB02140.1 .
AK012583 mRNA. Translation: BAB28333.1 .
AK019276 mRNA. Translation: BAB31643.1 .
AK150447 mRNA. Translation: BAE29569.1 .
CCDSi CCDS40498.1.
PIRi S12142.
RefSeqi NP_001280488.1. NM_001293559.1.
NP_034071.2. NM_009941.3.
UniGenei Mm.386758.

3D structure databases

ProteinModelPortali P19783.
SMRi P19783. Positions 26-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198840. 1 interaction.
IntActi P19783. 4 interactions.
MINTi MINT-1860013.

PTM databases

PhosphoSitei P19783.

Proteomic databases

MaxQBi P19783.
PaxDbi P19783.
PRIDEi P19783.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034276 ; ENSMUSP00000034276 ; ENSMUSG00000031818 .
ENSMUST00000181586 ; ENSMUSP00000138019 ; ENSMUSG00000031818 .
GeneIDi 12857.
KEGGi mmu:12857.
UCSCi uc009nrh.1. mouse.

Organism-specific databases

CTDi 1327.
MGIi MGI:88473. Cox4i1.

Phylogenomic databases

eggNOGi NOG276242.
GeneTreei ENSGT00390000002407.
HOGENOMi HOG000231486.
HOVERGENi HBG051087.
InParanoidi P19783.
KOi K02263.
OMAi VAMQTKR.
OrthoDBi EOG7BKCWF.
PhylomeDBi P19783.
TreeFami TF105061.

Miscellaneous databases

NextBioi 282412.
PROi P19783.
SOURCEi Search...

Gene expression databases

Bgeei P19783.
CleanExi MM_COX4I1.
ExpressionAtlasi P19783. differential.
Genevestigatori P19783.

Family and domain databases

Gene3Di 1.10.442.10. 1 hit.
InterProi IPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view ]
Pfami PF02936. COX4. 1 hit.
[Graphical view ]
PRINTSi PR01873. CYTCOXIDASE4.
SUPFAMi SSF81406. SSF81406. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a mouse cDNA for subunit IV of cytochrome c oxidase."
    Grossman L.I., Akamatsu M.
    Nucleic Acids Res. 18:6454-6454(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Heart.
  2. "Cloning and characterization of the mouse cytochrome c oxidase subunit IV gene."
    Carter R.S., Avadhani N.G.
    Arch. Biochem. Biophys. 288:97-106(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 30-41; 43-60; 68-75; 84-95; 136-143 AND 160-169, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-29 AND LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29; LYS-60 AND LYS-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCOX41_MOUSE
AccessioniPrimary (citable) accession number: P19783
Secondary accession number(s): Q545A9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3