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P19783

- COX41_MOUSE

UniProt

P19783 - COX41_MOUSE

Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

Cox4i1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: InterPro

    GO - Biological processi

    1. response to nutrient Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
    Alternative name(s):
    Cytochrome c oxidase polypeptide IV
    Cytochrome c oxidase subunit IV isoform 1
    Short name:
    COX IV-1
    Gene namesi
    Name:Cox4i1
    Synonyms:Cox4, Cox4a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:88473. Cox4i1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: MGI
    2. mitochondrion Source: MGI
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionAdd
    BLAST
    Chaini23 – 169147Cytochrome c oxidase subunit 4 isoform 1, mitochondrialPRO_0000006085Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei29 – 291N6-acetyllysine; alternate1 Publication
    Modified residuei29 – 291N6-succinyllysine; alternate1 Publication
    Modified residuei60 – 601N6-acetyllysine; alternate1 Publication
    Modified residuei60 – 601N6-succinyllysine; alternate1 Publication
    Modified residuei67 – 671N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP19783.
    PaxDbiP19783.
    PRIDEiP19783.

    PTM databases

    PhosphoSiteiP19783.

    Expressioni

    Gene expression databases

    ArrayExpressiP19783.
    BgeeiP19783.
    CleanExiMM_COX4I1.
    GenevestigatoriP19783.

    Interactioni

    Protein-protein interaction databases

    BioGridi198840. 1 interaction.
    IntActiP19783. 4 interactions.
    MINTiMINT-1860013.

    Structurei

    3D structure databases

    ProteinModelPortaliP19783.
    SMRiP19783. Positions 26-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c oxidase IV family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG276242.
    GeneTreeiENSGT00390000002407.
    HOGENOMiHOG000231486.
    HOVERGENiHBG051087.
    InParanoidiP19783.
    KOiK02263.
    OMAiVAMQTKR.
    OrthoDBiEOG7BKCWF.
    PhylomeDBiP19783.
    TreeFamiTF105061.

    Family and domain databases

    Gene3Di1.10.442.10. 1 hit.
    InterProiIPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view]
    PfamiPF02936. COX4. 1 hit.
    [Graphical view]
    PRINTSiPR01873. CYTCOXIDASE4.
    SUPFAMiSSF81406. SSF81406. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P19783-1 [UniParc]FASTAAdd to Basket

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    MLASRALSLI GKRAISTSVC LRAHGSVVKS EDYAFPTYAD RRDYPLPDVA    50
    HVTMLSASQK ALKEKEKADW SSLSRDEKVQ LYRIQFNESF AEMNRGTNEW 100
    KTVVGMAMFF IGFTALVLIW EKSYVYGPIP HTFDRDWVAM QTKRMLDMKA 150
    NPIQGFSAKW DYDKNEWKK 169
    Length:169
    Mass (Da):19,530
    Last modified:October 1, 1993 - v2
    Checksum:iD30B1DBBE14FDBEA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti140 – 1412MQ → IE in AAB02139. (PubMed:1654830)Curated
    Sequence conflicti140 – 1412MQ → IE in AAB02140. (PubMed:1654830)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54691 mRNA. Translation: CAA38507.1.
    M37831, M58034 Genomic DNA. Translation: AAB02139.1.
    M37829 mRNA. Translation: AAB02140.1.
    AK012583 mRNA. Translation: BAB28333.1.
    AK019276 mRNA. Translation: BAB31643.1.
    AK150447 mRNA. Translation: BAE29569.1.
    CCDSiCCDS40498.1.
    PIRiS12142.
    UniGeneiMm.386758.

    Genome annotation databases

    EnsembliENSMUST00000034276; ENSMUSP00000034276; ENSMUSG00000031818.
    ENSMUST00000181586; ENSMUSP00000138019; ENSMUSG00000031818.
    KEGGimmu:12857.
    UCSCiuc009nrh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54691 mRNA. Translation: CAA38507.1 .
    M37831 , M58034 Genomic DNA. Translation: AAB02139.1 .
    M37829 mRNA. Translation: AAB02140.1 .
    AK012583 mRNA. Translation: BAB28333.1 .
    AK019276 mRNA. Translation: BAB31643.1 .
    AK150447 mRNA. Translation: BAE29569.1 .
    CCDSi CCDS40498.1.
    PIRi S12142.
    UniGenei Mm.386758.

    3D structure databases

    ProteinModelPortali P19783.
    SMRi P19783. Positions 26-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198840. 1 interaction.
    IntActi P19783. 4 interactions.
    MINTi MINT-1860013.

    PTM databases

    PhosphoSitei P19783.

    Proteomic databases

    MaxQBi P19783.
    PaxDbi P19783.
    PRIDEi P19783.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034276 ; ENSMUSP00000034276 ; ENSMUSG00000031818 .
    ENSMUST00000181586 ; ENSMUSP00000138019 ; ENSMUSG00000031818 .
    KEGGi mmu:12857.
    UCSCi uc009nrh.1. mouse.

    Organism-specific databases

    CTDi 1327.
    MGIi MGI:88473. Cox4i1.

    Phylogenomic databases

    eggNOGi NOG276242.
    GeneTreei ENSGT00390000002407.
    HOGENOMi HOG000231486.
    HOVERGENi HBG051087.
    InParanoidi P19783.
    KOi K02263.
    OMAi VAMQTKR.
    OrthoDBi EOG7BKCWF.
    PhylomeDBi P19783.
    TreeFami TF105061.

    Miscellaneous databases

    NextBioi 282412.
    PROi P19783.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P19783.
    Bgeei P19783.
    CleanExi MM_COX4I1.
    Genevestigatori P19783.

    Family and domain databases

    Gene3Di 1.10.442.10. 1 hit.
    InterProi IPR013288. Cyt_c_oxidase_su4.
    IPR004203. Cyt_c_oxidase_su4_fam.
    [Graphical view ]
    Pfami PF02936. COX4. 1 hit.
    [Graphical view ]
    PRINTSi PR01873. CYTCOXIDASE4.
    SUPFAMi SSF81406. SSF81406. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a mouse cDNA for subunit IV of cytochrome c oxidase."
      Grossman L.I., Akamatsu M.
      Nucleic Acids Res. 18:6454-6454(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Heart.
    2. "Cloning and characterization of the mouse cytochrome c oxidase subunit IV gene."
      Carter R.S., Avadhani N.G.
      Arch. Biochem. Biophys. 288:97-106(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 30-41; 43-60; 68-75; 84-95; 136-143 AND 160-169, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-29 AND LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29; LYS-60 AND LYS-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCOX41_MOUSE
    AccessioniPrimary (citable) accession number: P19783
    Secondary accession number(s): Q545A9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3