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Protein

Putative transposase InsK for insertion sequence element IS150

Gene

insK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the transposition of the insertion sequence IS150.

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • DNA integration Source: InterPro
  • DNA recombination Source: UniProtKB-KW
  • transposition Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA recombination, Transposition

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7777-MONOMER.
ECOL316407:JW3528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transposase InsK for insertion sequence element IS150
Gene namesi
Name:insK
Ordered Locus Names:b3558, JW3528
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG40011. insK.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Putative transposase InsK for insertion sequence element IS150PRO_0000075419Add
BLAST

Proteomic databases

PaxDbiP19769.

Interactioni

Protein-protein interaction databases

IntActiP19769. 3 interactions.
STRINGi511145.b3558.

Structurei

3D structure databases

ProteinModelPortaliP19769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini117 – 279163Integrase catalyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transposase IS3/IS150/IS904 family.Curated
Contains 1 integrase catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105DQ6. Bacteria.
COG2801. LUCA.
HOGENOMiHOG000023133.
InParanoidiP19769.
KOiK07497.
OMAiMLELRQH.
PhylomeDBiP19769.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR025948. HTH-like_dom.
IPR001584. Integrase_cat-core.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF13276. HTH_21. 1 hit.
PF00665. rve. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLNELRQF YPLDELLRAA EIPRSTFYYH LKALSKPDKY ADVKKRISEI
60 70 80 90 100
YHENRGRYGY RRVTLSLHRE GKQINHKAVQ RLMGTLSLKA AIKVKRYRSY
110 120 130 140 150
RGEVGQTAPN VLQRDFKATR PNEKWVTDVT EFAVNGRKLY LSPVIDLFNN
160 170 180 190 200
EVISYSLSER PVMNMVENML DQAFKKLNPH EHPVLHSDQG WQYRMRRYQN
210 220 230 240 250
ILKEHGIKQS MSRKGNCLDN AVVECFFGTL KSECFYLDEF SNISELKDAV
260 270 280
TEYIEYYNSR RISLKLKGLT PIEYRNQTYM PRV
Length:283
Mass (Da):33,477
Last modified:June 27, 2006 - v2
Checksum:i3EA86375D52C42CB
GO

Sequence cautioni

The sequence AAB18535 differs from that shown.B-168 has been translated as Asn.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti213 – 2131R → A in CAA30086 (PubMed:2841644).Curated
Sequence conflicti213 – 2131R → E no nucleotide entry (PubMed:2541046).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07037 Genomic DNA. Translation: CAA30086.1.
U00039 Genomic DNA. Translation: AAB18535.2. Sequence problems.
U00096 Genomic DNA. Translation: AAC76582.1.
AP009048 Genomic DNA. Translation: BAE77736.1.
RefSeqiNP_418015.1. NC_000913.3.
WP_000866395.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76582; AAC76582; b3558.
BAE77736; BAE77736; BAE77736.
GeneIDi948081.
KEGGiecj:JW3528.
eco:b3558.
PATRICi32122590. VBIEscCol129921_3672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07037 Genomic DNA. Translation: CAA30086.1.
U00039 Genomic DNA. Translation: AAB18535.2. Sequence problems.
U00096 Genomic DNA. Translation: AAC76582.1.
AP009048 Genomic DNA. Translation: BAE77736.1.
RefSeqiNP_418015.1. NC_000913.3.
WP_000866395.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP19769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19769. 3 interactions.
STRINGi511145.b3558.

Proteomic databases

PaxDbiP19769.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76582; AAC76582; b3558.
BAE77736; BAE77736; BAE77736.
GeneIDi948081.
KEGGiecj:JW3528.
eco:b3558.
PATRICi32122590. VBIEscCol129921_3672.

Organism-specific databases

EcoGeneiEG40011. insK.

Phylogenomic databases

eggNOGiENOG4105DQ6. Bacteria.
COG2801. LUCA.
HOGENOMiHOG000023133.
InParanoidiP19769.
KOiK07497.
OMAiMLELRQH.
PhylomeDBiP19769.

Enzyme and pathway databases

BioCyciEcoCyc:G7777-MONOMER.
ECOL316407:JW3528-MONOMER.

Miscellaneous databases

PROiP19769.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR025948. HTH-like_dom.
IPR001584. Integrase_cat-core.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF13276. HTH_21. 1 hit.
PF00665. rve. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50994. INTEGRASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINSK_ECOLI
AccessioniPrimary (citable) accession number: P19769
Secondary accession number(s): Q2M7M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: June 27, 2006
Last modified: September 7, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.