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P19762 (HN_MUMP1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemagglutinin-neuraminidase

EC=3.2.1.18
Gene names
Name:HN
OrganismMumps virus (strain SBL-1) (MuV)
Taxonomic identifier11173 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.

Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity.

Catalytic activity

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

Subcellular location

Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Hemagglutinin-neuraminidase
PRO_0000142605

Regions

Topological domain1 – 3434Intravirion Potential
Transmembrane35 – 5521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain56 – 582527Virion surface Potential

Amino acid modifications

Glycosylation2841N-linked (GlcNAc...); by host Potential
Glycosylation3291N-linked (GlcNAc...); by host Potential
Glycosylation4001N-linked (GlcNAc...); by host Potential
Glycosylation4481N-linked (GlcNAc...); by host Potential
Glycosylation5071N-linked (GlcNAc...); by host Potential

Sequences

Sequence LengthMass (Da)Tools
P19762 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 18F95300AA33DC7F

FASTA58263,885
        10         20         30         40         50         60 
MEPSKLFIMS DNATVAPGPV VNAAGKKTFR TCFRILVLSV QAVTLILVIV TLGELIRMIN 

        70         80         90        100        110        120 
DQGLSNQLSS ITDKIRESAA VIASAVGVMN QVIHGVTVSL PLQIEGNQNQ LLSTLATICT 

       130        140        150        160        170        180 
NRNQVSNCST NIPLVNDLRF INGINKFIIE DYATHDFSIG NPLNMPSFIP TATSPNGCTR 

       190        200        210        220        230        240 
IPSFSLGKTH WCYTHNVINA NCKDHTSSNQ YVSMGILVQT ASGYPMFKTL KIQYLSDGLN 

       250        260        270        280        290        300 
RKSCSIATVP DGCAMYCYVS TQLEANDYAG SSPPTQKLTL LFYNDTITER TISPSGLEGN 

       310        320        330        340        350        360 
WATLVPGVGS GIYFENKLIF PAYGGVLPNS TLGVKSAREF FRPVNPYNPC SGPPQELDQR 

       370        380        390        400        410        420 
ALRSYFPRYF SSRRVQSAFL VCAWNQILVT NCELVVPSNN QTLMGAEGRV LLINNRLLYY 

       430        440        450        460        470        480 
QRSTSWWPYE LLYEISFTFT NSGQSSVNMS WIPIYSFTPP GSGNCSGKNV CPTVCVSGVY 

       490        500        510        520        530        540 
LDPWPLTPYS HQSGINRNFY FTGALLNSST TRVNPTLYVS ALNNLKVLAP YGTQGLFASY 

       550        560        570        580 
TTTTCFQDTG DASVYCVYIM ELASNIVGEF QILPVLARLT IT 

« Hide

References

[1]"Complete nucleotide sequence of the hemagglutinin-neuraminidase (HN) mRNA of mumps virus and comparison of paramyxovirus HN proteins."
Koevamees J., Norrby E., Elango N.
Virus Res. 12:87-96(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Strain-variable editing during transcription of the P gene of mumps virus may lead to the generation of non-structural proteins NS1 (V) and NS2."
Elliott G.D., Yeo R.P., Afzal M.A., Simpson E.J.B., Curran J.A., Rima B.K.
J. Gen. Virol. 71:1555-1560(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-153.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M55065 Genomic RNA. Translation: AAA74751.1.
D00663 Genomic RNA. Translation: BAA00563.1.
PIRHNNZSB. A42758.

3D structure databases

ProteinModelPortalP19762.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.120.10.10. 1 hit.
InterProIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamPF00423. HN. 1 hit.
[Graphical view]
PIRSFPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMSSF50939. SSF50939. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHN_MUMP1
AccessionPrimary (citable) accession number: P19762
Secondary accession number(s): P33480
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries