Reviewed,
UniProtKB/Swiss-Prot P19762 (HN_MUMP1)
Last modified
January 19, 2010.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Hemagglutinin-neuraminidase EC=3.2.1.18 | ||
| Gene names |
| ||
| Organism | Mumps virus (strain SBL-1) (MuV) | ||
| Taxonomic identifier | 11173 [NCBI] | ||
| Taxonomic lineage | Viruses › ssRNA negative-strand viruses › Mononegavirales › Paramyxoviridae › Paramyxovirinae › Rubulavirus | ||
| Virus host | Homo sapiens (Human) [TaxID: 9606] |
Protein attributes
| Sequence length | 582 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity. Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins By similarity. |
| Catalytic activity | Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. |
| Subcellular location | Virion membrane; Single-pass type II membrane protein Potential. Host cell membrane; Single-pass type II membrane protein Potential. |
| Sequence similarities | Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Envelope protein Host cell membrane Host membrane Membrane Virion |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Hemagglutinin Hydrolase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | viral infectious cycle Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell viral envelopeInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | exo-alpha-sialidase activity Inferred from electronic annotation. Source: EC host cell surface receptor bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 582 | 582 | Hemagglutinin-neuraminidase | PRO_0000142605 | |||||
Regions | |||||||||
| Topological domain | 1 – 34 | 34 | Cytoplasmic Potential | ||||||
| Transmembrane | 35 – 55 | 21 | Membrane anchor Potential | ||||||
| Topological domain | 56 – 582 | 527 | Extracellular Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 284 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 329 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 400 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 448 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
| Glycosylation | 507 | 1 | N-linked (GlcNAc...); by host Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete nucleotide sequence of the hemagglutinin-neuraminidase (HN) mRNA of mumps virus and comparison of paramyxovirus HN proteins." Koevamees J., Norrby E., Elango N. Virus Res. 12:87-96(1989) [PubMed: 2718627] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA]. |
| [2] | "Strain-variable editing during transcription of the P gene of mumps virus may lead to the generation of non-structural proteins NS1 (V) and NS2." Elliott G.D., Yeo R.P., Afzal M.A., Simpson E.J.B., Curran J.A., Rima B.K. J. Gen. Virol. 71:1555-1560(1990) [PubMed: 2165137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-153. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M55065 Genomic RNA. Translation: AAA74751.1. D00663 Genomic RNA. Translation: BAA00563.1. |
| PIR | HNNZSB. A42758. |
3D structure databases | |
| SMR | P19762. Positions 135-582. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GH83. Glycoside Hydrolase Family 83. |
Family and domain databases | |
| InterPro | IPR000665. Hemagglutn-neuramid_glycoprot. IPR016285. Hemagglutn-neuramid_paramyxo. IPR011040. Neuraminidase. [Graphical view] |
| Pfam | PF00423. HN. 1 hit. [Graphical view] |
| PIRSF | PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HN_MUMP1 | ||||||||
| Accession | Primary (citable) accession number: P19762 Secondary accession number(s): P33480 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


