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Protein

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei60 – 61Reactive bondBy similarity2
Sitei131 – 132Reactive bondBy similarity2
Sitei223 – 224Reactive bondBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
Biological processBlood coagulation, Hemostasis

Protein family/group databases

MEROPSiI02.950.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor
Short name:
TFPI
Alternative name(s):
Extrinsic pathway inhibitor
Short name:
EPI
Lipoprotein-associated coagulation inhibitor
Short name:
LACI
Gene namesi
Name:TFPI
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001687425 – 300Tissue factor pathway inhibitorAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Disulfide bondi59 ↔ 83PROSITE-ProRule annotation
Disulfide bondi75 ↔ 96PROSITE-ProRule annotation
Disulfide bondi121 ↔ 171PROSITE-ProRule annotation
Disulfide bondi130 ↔ 154PROSITE-ProRule annotation
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi146 ↔ 167PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi213 ↔ 263PROSITE-ProRule annotation
Disulfide bondi222 ↔ 246PROSITE-ProRule annotation
Disulfide bondi238 ↔ 259PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP19761.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007133.

Structurei

3D structure databases

ProteinModelPortaliP19761.
SMRiP19761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 100BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini121 – 171BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini213 – 263BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51

Domaini

This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).By similarity

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiP19761.
KOiK03909.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiView protein in InterPro
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
PfamiView protein in Pfam
PF00014. Kunitz_BPTI. 3 hits.
PRINTSiPR00759. BASICPTASE.
SMARTiView protein in SMART
SM00131. KU. 3 hits.
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiView protein in PROSITE
PS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEHIFWTS ICLLLGLVPA PVSSAAEEDE EFTNITDIKP PLQKPTHSFC
60 70 80 90 100
AMKVDDGPCR AYIKRFFFNI LTHQCEEFIY GGCEGNENRF ESLEECKEKC
110 120 130 140 150
ARDYPKMTTK LTFQKGKPDF CFLEEDPGIC RGYITRYFYN NQSKQCERFK
160 170 180 190 200
YGGCLGNLNN FESLEECKNT CENPTSDFQV DDHRTQLNTV NNTLINQPTK
210 220 230 240 250
APRRWAFHGP SWCLPPADRG LCQANEIRFF YNAIIGKCRP FKYSGCGGNE
260 270 280 290 300
NNFTSKKACI TACKKGFIPK SIKGGLIKTK RKKKKQPVKI TYVETFVKKT
Length:300
Mass (Da):34,436
Last modified:August 1, 1992 - v2
Checksum:iA08DE36537708CA6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31Missing in AAB26836 (PubMed:8503123).Curated1
Sequence conflicti269 – 272PKSI → RNLS in AAB26836 (PubMed:8503123).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54708 mRNA. Translation: CAA38515.1. Sequence problems.
S61902 mRNA. Translation: AAB26836.1.
PIRiI46937.
S12143.
RefSeqiNP_001095184.1. NM_001101714.1.
UniGeneiOcu.3263.

Genome annotation databases

GeneIDi100009401.
KEGGiocu:100009401.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTFPI1_RABIT
AccessioniPrimary (citable) accession number: P19761
Secondary accession number(s): Q28828
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 1, 1992
Last modified: May 10, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome