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Protein

Tissue factor pathway inhibitor

Gene

TFPI

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei60 – 612Reactive bondBy similarity
Sitei131 – 1322Reactive bondBy similarity
Sitei223 – 2242Reactive bondBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Blood coagulation, Hemostasis

Protein family/group databases

MEROPSiI02.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Tissue factor pathway inhibitor
Short name:
TFPI
Alternative name(s):
Extrinsic pathway inhibitor
Short name:
EPI
Lipoprotein-associated coagulation inhibitor
Short name:
LACI
Gene namesi
Name:TFPI
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 300276Tissue factor pathway inhibitorPRO_0000016874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Disulfide bondi59 ↔ 83PROSITE-ProRule annotation
Disulfide bondi75 ↔ 96PROSITE-ProRule annotation
Disulfide bondi121 ↔ 171PROSITE-ProRule annotation
Disulfide bondi130 ↔ 154PROSITE-ProRule annotation
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi146 ↔ 167PROSITE-ProRule annotation
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi213 ↔ 263PROSITE-ProRule annotation
Disulfide bondi222 ↔ 246PROSITE-ProRule annotation
Disulfide bondi238 ↔ 259PROSITE-ProRule annotation
Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007133.

Structurei

3D structure databases

ProteinModelPortaliP19761.
SMRiP19761. Positions 117-173, 207-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 10051BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd
BLAST
Domaini121 – 17151BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd
BLAST
Domaini213 – 26351BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd
BLAST

Domaini

This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa (By similarity).By similarity

Sequence similaritiesi

Contains 3 BPTI/Kunitz inhibitor domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiP19761.
KOiK03909.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR029864. TFPI1.
[Graphical view]
PANTHERiPTHR10083:SF238. PTHR10083:SF238. 1 hit.
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKEHIFWTS ICLLLGLVPA PVSSAAEEDE EFTNITDIKP PLQKPTHSFC
60 70 80 90 100
AMKVDDGPCR AYIKRFFFNI LTHQCEEFIY GGCEGNENRF ESLEECKEKC
110 120 130 140 150
ARDYPKMTTK LTFQKGKPDF CFLEEDPGIC RGYITRYFYN NQSKQCERFK
160 170 180 190 200
YGGCLGNLNN FESLEECKNT CENPTSDFQV DDHRTQLNTV NNTLINQPTK
210 220 230 240 250
APRRWAFHGP SWCLPPADRG LCQANEIRFF YNAIIGKCRP FKYSGCGGNE
260 270 280 290 300
NNFTSKKACI TACKKGFIPK SIKGGLIKTK RKKKKQPVKI TYVETFVKKT
Length:300
Mass (Da):34,436
Last modified:August 1, 1992 - v2
Checksum:iA08DE36537708CA6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311Missing in AAB26836 (PubMed:8503123).Curated
Sequence conflicti269 – 2724PKSI → RNLS in AAB26836 (PubMed:8503123).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54708 mRNA. Translation: CAA38515.1. Sequence problems.
S61902 mRNA. Translation: AAB26836.1.
PIRiI46937.
S12143.
RefSeqiNP_001095184.1. NM_001101714.1.
UniGeneiOcu.3263.

Genome annotation databases

GeneIDi100009401.
KEGGiocu:100009401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54708 mRNA. Translation: CAA38515.1. Sequence problems.
S61902 mRNA. Translation: AAB26836.1.
PIRiI46937.
S12143.
RefSeqiNP_001095184.1. NM_001101714.1.
UniGeneiOcu.3263.

3D structure databases

ProteinModelPortaliP19761.
SMRiP19761. Positions 117-173, 207-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000007133.

Protein family/group databases

MEROPSiI02.011.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009401.
KEGGiocu:100009401.

Organism-specific databases

CTDi7035.

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
HOGENOMiHOG000231818.
HOVERGENiHBG056804.
InParanoidiP19761.
KOiK03909.

Family and domain databases

Gene3Di4.10.410.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR029864. TFPI1.
[Graphical view]
PANTHERiPTHR10083:SF238. PTHR10083:SF238. 1 hit.
PfamiPF00014. Kunitz_BPTI. 3 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 3 hits.
[Graphical view]
SUPFAMiSSF57362. SSF57362. 3 hits.
PROSITEiPS00280. BPTI_KUNITZ_1. 3 hits.
PS50279. BPTI_KUNITZ_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFPI1_RABIT
AccessioniPrimary (citable) accession number: P19761
Secondary accession number(s): Q28828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: August 1, 1992
Last modified: November 11, 2015
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.