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P19758

- HN_SENDF

UniProt

P19758 - HN_SENDF

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Sendai virus (strain Fushimi) (SeV)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Short name:
    HN protein
    Gene namesi
    Name:HN
    OrganismiSendai virus (strain Fushimi) (SeV)
    Taxonomic identifieri11195 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRespirovirus
    Virus hostiCavia cutleri (Guinea pig) [TaxID: 10144]
    Cricetidae sp. (Hamster) [TaxID: 36483]
    Mus musculus (Mouse) [TaxID: 10090]
    Rattus norvegicus (Rat) [TaxID: 10116]
    ProteomesiUP000006825: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 575575Hemagglutinin-neuraminidasePRO_0000142637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi77 – 771N-linked (GlcNAc...); by hostBy similarity
    Disulfide bondi129 – 129InterchainSequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...); by hostBy similarity
    Glycosylationi511 – 5111N-linked (GlcNAc...); by hostBy similarity

    Post-translational modificationi

    N-glycosylated; glycans consist of a mixture of high mannose-type oligosaccharides and of complex-type oligosaccharides.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    Homotetramer; composed of disulfide-linked homodimers. Interacts with F protein trimer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP19758.
    SMRiP19758. Positions 144-572.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3737IntravirionBy similarityAdd
    BLAST
    Topological domaini59 – 575517Virion surfaceBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei38 – 5821HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni10 – 145Incorporation in virionBy similarity
    Regioni59 – 14082Involved in interaction with F proteinBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P19758-1 [UniParc]FASTAAdd to Basket

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    MDGDRGKRDS YWSTSPSGST TKLASGWERS SKVDTWLLIL SFTQWALSIA    50
    TVIICIIISA RQGYSMKEYS MTVEALNMSS REVKESLTSL IRQEVIARAV 100
    NIQSSVQTGI PVLLNKNSRD VIQMIDKSCS RQELTQLCES TIAVHHAEGI 150
    APLEPHSFWR CPVGEPYLSS DPKISLLPGP SLLSGSTTIS GCVRLPSLSI 200
    GEAIYAYSSN LITQGCADIG KSYQVLQLGY ISLNSDMFPD LNPVVSHTYD 250
    INDNRKSCSV VATGTRGYQL CSMPTVDERT DYSSDGIEDL VLDVLDLKGS 300
    TKSHRYRNSE VDLDHPFSAL YPSVGNGIAT EGSLIFLGYG GLTTPLQGDT 350
    KCRTQGCQQV SQDTCNEALK ITWLGGKQVV SVIIQVNDYL SERPKIRVTT 400
    IPITQNYLGA EGRLLKLGDR VYIYTRSSGW HSQLQIGVLD VSHPLTINWT 450
    PHEALSRPGN EECNWYNTCP KECISGVYTD AYPLSPDAAN VATVTLYANT 500
    SRVNPTIMYS NTTNIINMLR IKDVQLEAAY TTTSCITHFG KGYCFHIIEI 550
    NQKSLNTLQP MLFKTSIPKL CKAES 575
    Length:575
    Mass (Da):63,348
    Last modified:February 1, 1991 - v1
    Checksum:i93FD0532F6147BF6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti86 – 861S → T.
    Natural varianti525 – 5251Q → K.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56131 Genomic RNA. Translation: CAA39596.1.
    U06433 Genomic RNA. Translation: AAC54272.1.
    PIRiS12135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56131 Genomic RNA. Translation: CAA39596.1 .
    U06433 Genomic RNA. Translation: AAC54272.1 .
    PIRi S12135.

    3D structure databases

    ProteinModelPortali P19758.
    SMRi P19758. Positions 144-572.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the HN gene of Sendai virus (strain Fushimi)."
      Neubert W.J., Willenbrink W.
      Nucleic Acids Res. 18:6427-6427(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Role of basic residues in the proteolytic activation of Sendai virus fusion glycoprotein."
      Heminaway B.R., Yang Y., Tanaka Y., Panin M., Huang Y.T., Galinski M.S.
      Virus Res. 36:15-35(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Kinetics of interactions of sendai virus envelope glycoproteins, F and HN, with endoplasmic reticulum-resident molecular chaperones, BiP, calnexin, and calreticulin."
      Tomita Y., Yamashita T., Sato H., Taira H.
      J. Biochem. 126:1090-1100(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CHAPERONES.

    Entry informationi

    Entry nameiHN_SENDF
    AccessioniPrimary (citable) accession number: P19758
    Secondary accession number(s): Q88413
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3