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Protein

Parvalbumin, thymic

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Appears to promote immune maturation in bone marrow cells in culture. Binds two calcium ions.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi91 – 102122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin, thymic
Alternative name(s):
Avian thymic hormone
Short name:
ATH
Thymus-specific antigen T1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 109108Parvalbumin, thymicPRO_0000073626Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19753.
PRIDEiP19753.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040286.

Structurei

Secondary structure

1
109
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Helixi9 – 1810Combined sources
Beta strandi19 – 213Combined sources
Turni22 – 243Combined sources
Helixi27 – 348Combined sources
Helixi36 – 383Combined sources
Helixi41 – 5111Combined sources
Beta strandi52 – 543Combined sources
Beta strandi56 – 594Combined sources
Helixi61 – 655Combined sources
Helixi68 – 703Combined sources
Helixi80 – 9011Combined sources
Beta strandi95 – 984Combined sources
Helixi100 – 1078Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KQYNMR-A2-109[»]
3FS7X-ray1.95A/B/C/D/E/F/G/H1-109[»]
ProteinModelPortaliP19753.
SMRiP19753. Positions 2-109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 10932EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP19753.
OMAiTMAITDI.
OrthoDBiEOG7TF7C9.
PhylomeDBiP19753.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITDILSAK DIESALSSCQ AADSFNYKSF FSTVGLSSKT PDQIKKVFGI
60 70 80 90 100
LDQDKSGFIE EEELQLFLKN FSSSARVLTS AETKAFLAAG DTDGDGKIGV

EEFQSLVKA
Length:109
Mass (Da):11,726
Last modified:January 23, 2007 - v2
Checksum:i8A532C55499CB632
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961G → D in AAA48606 (PubMed:2322274).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94894 mRNA. Translation: AAA48605.1.
M34330 mRNA. Translation: AAA48606.1.
PIRiS13911.
RefSeqiNP_001007478.1. NM_001007477.3.
UniGeneiGga.878.

Genome annotation databases

EnsembliENSGALT00000034318; ENSGALP00000033676; ENSGALG00000003465.
GeneIDi396531.
KEGGigga:396531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94894 mRNA. Translation: AAA48605.1.
M34330 mRNA. Translation: AAA48606.1.
PIRiS13911.
RefSeqiNP_001007478.1. NM_001007477.3.
UniGeneiGga.878.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KQYNMR-A2-109[»]
3FS7X-ray1.95A/B/C/D/E/F/G/H1-109[»]
ProteinModelPortaliP19753.
SMRiP19753. Positions 2-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040286.

Proteomic databases

PaxDbiP19753.
PRIDEiP19753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000034318; ENSGALP00000033676; ENSGALG00000003465.
GeneIDi396531.
KEGGigga:396531.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP19753.
OMAiTMAITDI.
OrthoDBiEOG7TF7C9.
PhylomeDBiP19753.

Miscellaneous databases

EvolutionaryTraceiP19753.
NextBioi20816567.
PROiP19753.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of the thymus-specific parvalbumin known as avian thymic hormone: isolation of a full length cDNA and expression of the recombinant protein in Escherichia coli."
    Palmisano W.A., Henzl M.T.
    Arch. Biochem. Biophys. 285:211-220(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The amino acid sequence of avian thymic hormone, a parvalbumin."
    Brewer J.M., Wunderlich J.K., Ragland W.L.
    Biochimie 72:653-660(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-109, ACETYLATION AT ALA-2.
    Tissue: Thymus.
  3. Cited for: PRELIMINARY PARTIAL PROTEIN SEQUENCE.
    Tissue: Thymus.
  4. "Partial nucleotide sequence of the parvalbumin from chicken thymus designated 'avian thymic hormone'."
    Palmisano W.A., Henzl M.T.
    Biochem. Biophys. Res. Commun. 167:1286-1293(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 41-103.
  5. "Structure of avian thymic hormone, a high-affinity avian beta-parvalbumin, in the Ca2+-free and Ca2+-bound states."
    Schuermann J.P., Tan A., Tanner J.J., Henzl M.T.
    J. Mol. Biol. 397:991-1002(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 2-109, X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS).

Entry informationi

Entry nameiPRVT_CHICK
AccessioniPrimary (citable) accession number: P19753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This parvalbumin has an isoelectric point of 4.3.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.