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Protein

Parvalbumin, thymic

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Appears to promote immune maturation in bone marrow cells in culture. Binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi91 – 1022PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin, thymic
Alternative name(s):
Avian thymic hormone
Short name:
ATH
Thymus-specific antigen T1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000736262 – 109Parvalbumin, thymicAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19753.
PRIDEiP19753.

Expressioni

Gene expression databases

BgeeiENSGALG00000003465.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040286.

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Helixi9 – 18Combined sources10
Beta strandi19 – 21Combined sources3
Turni22 – 24Combined sources3
Helixi27 – 34Combined sources8
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Beta strandi52 – 54Combined sources3
Beta strandi56 – 59Combined sources4
Helixi61 – 65Combined sources5
Helixi68 – 70Combined sources3
Helixi80 – 90Combined sources11
Beta strandi95 – 98Combined sources4
Helixi100 – 107Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KQYNMR-A2-109[»]
3FS7X-ray1.95A/B/C/D/E/F/G/H1-109[»]
ProteinModelPortaliP19753.
SMRiP19753.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP19753.
OMAiTMAITDI.
OrthoDBiEOG091G0XK0.
PhylomeDBiP19753.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITDILSAK DIESALSSCQ AADSFNYKSF FSTVGLSSKT PDQIKKVFGI
60 70 80 90 100
LDQDKSGFIE EEELQLFLKN FSSSARVLTS AETKAFLAAG DTDGDGKIGV

EEFQSLVKA
Length:109
Mass (Da):11,726
Last modified:January 23, 2007 - v2
Checksum:i8A532C55499CB632
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96G → D in AAA48606 (PubMed:2322274).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94894 mRNA. Translation: AAA48605.1.
M34330 mRNA. Translation: AAA48606.1.
PIRiS13911.
RefSeqiNP_001007478.1. NM_001007477.3.
UniGeneiGga.878.

Genome annotation databases

EnsembliENSGALT00000034318; ENSGALP00000033676; ENSGALG00000003465.
GeneIDi396531.
KEGGigga:396531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94894 mRNA. Translation: AAA48605.1.
M34330 mRNA. Translation: AAA48606.1.
PIRiS13911.
RefSeqiNP_001007478.1. NM_001007477.3.
UniGeneiGga.878.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KQYNMR-A2-109[»]
3FS7X-ray1.95A/B/C/D/E/F/G/H1-109[»]
ProteinModelPortaliP19753.
SMRiP19753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040286.

Proteomic databases

PaxDbiP19753.
PRIDEiP19753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000034318; ENSGALP00000033676; ENSGALG00000003465.
GeneIDi396531.
KEGGigga:396531.

Organism-specific databases

CTDi4951.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP19753.
OMAiTMAITDI.
OrthoDBiEOG091G0XK0.
PhylomeDBiP19753.

Miscellaneous databases

EvolutionaryTraceiP19753.
PROiP19753.

Gene expression databases

BgeeiENSGALG00000003465.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRVT_CHICK
AccessioniPrimary (citable) accession number: P19753
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This parvalbumin has an isoelectric point of 4.3.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.