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Protein

Parvalbumin, thymic

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Appears to promote immune maturation in bone marrow cells in culture. Binds two calcium ions.

Miscellaneous

This parvalbumin has an isoelectric point of 4.3.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi91 – 1022PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin, thymic
Alternative name(s):
Avian thymic hormone
Short name:
ATH
Thymus-specific antigen T1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000736262 – 109Parvalbumin, thymicAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP19753.
PRIDEiP19753.

Expressioni

Gene expression databases

BgeeiENSGALG00000003465.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000040286.

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Helixi9 – 18Combined sources10
Beta strandi19 – 21Combined sources3
Turni22 – 24Combined sources3
Helixi27 – 34Combined sources8
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Beta strandi52 – 54Combined sources3
Beta strandi56 – 59Combined sources4
Helixi61 – 65Combined sources5
Helixi68 – 70Combined sources3
Helixi80 – 90Combined sources11
Beta strandi95 – 98Combined sources4
Helixi100 – 107Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KQYNMR-A2-109[»]
3FS7X-ray1.95A/B/C/D/E/F/G/H1-109[»]
ProteinModelPortaliP19753.
SMRiP19753.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP19753.
OMAiTMAITDI.
OrthoDBiEOG091G0XK0.
PhylomeDBiP19753.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P19753-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITDILSAK DIESALSSCQ AADSFNYKSF FSTVGLSSKT PDQIKKVFGI
60 70 80 90 100
LDQDKSGFIE EEELQLFLKN FSSSARVLTS AETKAFLAAG DTDGDGKIGV

EEFQSLVKA
Length:109
Mass (Da):11,726
Last modified:January 23, 2007 - v2
Checksum:i8A532C55499CB632
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96G → D in AAA48606 (PubMed:2322274).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94894 mRNA. Translation: AAA48605.1.
M34330 mRNA. Translation: AAA48606.1.
PIRiS13911.
RefSeqiNP_001007478.1. NM_001007477.3.
UniGeneiGga.878.

Genome annotation databases

EnsembliENSGALT00000034318; ENSGALP00000033676; ENSGALG00000003465.
GeneIDi396531.
KEGGigga:396531.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRVT_CHICK
AccessioniPrimary (citable) accession number: P19753
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families