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Reviewed, UniProtKB/Swiss-Prot P19735 (PRP6_YEAST)

Last modified November 24, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Pre-mRNA-splicing factor 6
Gene names
Name: PRP6
Synonyms: RNA6
Ordered Locus Names: YBR055C
ORF Names: YBR0508
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length899 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Involved in pre-mRNA splicing.

Subcellular location

Nucleus.

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Contains 13 HAT repeats.

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Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
   DomainRepeat
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnuclear mRNA splicing, via spliceosome

Inferred from physical interaction. Source: SGD

   Cellular componentU4/U6 x U5 tri-snRNP complex

Inferred from direct assay. Source: SGD

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Q062041EBI-227,EBI-37403
DIB1Q068192EBI-227,EBI-166
HSL7P382741EBI-227,EBI-21618

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 899899Pre-mRNA-splicing factor 6
PRO_0000205756

Regions

Repeat221 – 25333HAT 1
Repeat255 – 28733HAT 2
Repeat289 – 31830HAT 3
Repeat319 – 35032HAT 4
Repeat352 – 38130HAT 5
Repeat383 – 41432HAT 6
Repeat493 – 52533HAT 7
Repeat545 – 57834HAT 8
Repeat608 – 64538HAT 9
Repeat648 – 68033HAT 10
Repeat682 – 71433HAT 11
Repeat751 – 78333HAT 12
Repeat819 – 85133HAT 13

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Sequences

Sequence LengthMass (Da)Tools
P19735-1 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 3E87F8AF63EAAC41

FASTA899104,229
        10         20         30         40         50         60 
MERPSFLDQE PPAGYVPGIG RGATGFSTKE KQVVSNDDKG RRIPKRYREN LNNHLQSQPK 

        70         80         90        100        110        120 
DDEDDEAANV FKTLELKLAQ KKKKRANEKD DDNSVDSSNV KRQFADLKES LAAVTESEWM 

       130        140        150        160        170        180 
DIPDATDFTR RNKRNRIQEQ LNRKTYAAPD SLIPGNVDLN KLTEEREKLL QSQIDENLAQ 

       190        200        210        220        230        240 
LTKNASNPIQ VNKPNAATDA LSYLKDLEND RVNSLSDATL EDLQKMRTIL KSYRKADPTN 

       250        260        270        280        290        300 
PQGWIASARL EEKARKFSVA KKIIENGCQE CPRSSDIWLE NIRLHESDVH YCKTLVATAI 

       310        320        330        340        350        360 
NFNPTSPLLW FKAIDLESTT VNKYRVVRKA LQEIPRDEGL WKLAVSFEAD KAQVIKMLEK 

       370        380        390        400        410        420 
ATQFIPQSMD LLTAYTNLQS YHNAKMTLNS FRKILPQEPE IWIISTLLEE RNNPDIPVDK 

       430        440        450        460        470        480 
LVSLLKEGLL ELSKNGYKAT LSAWLKRAEA LNDAPNSNLT CQAIVYAILE WLRESGEYES 

       490        500        510        520        530        540 
ELNNVDQILE KMPHSKVQIA VLKKLIQWDP CDTVLWSRLK MATESYHKIE ELLAFFQELL 

       550        560        570        580        590        600 
FQTKNSDDIR ANMREKSPGL LMMYVSEYWK AQKGDTRQTL VLIDQIIDFA PHNLDLRFFK 

       610        620        630        640        650        660 
IKLLGRSLQL DELRDFFQQT FSSLEDFKIS GTERLYYKYV NFLRYQDLNE EAIKFLNERC 

       670        680        690        700        710        720 
LKSFPICHKF FLQLGQIYHS MGNIEMSRET YLSGTRLVPN CPLLWVSLSK IDEIDLKNPV 

       730        740        750        760        770        780 
RARSILDRGL LKNPDDVLFY IAKIQMEIRL GNLDQAELLV TQALQKFPSN ALLWVEQIKL 

       790        800        810        820        830        840 
FKHGNKSSLK KTIFQDALRR TQNDHRVLLE IGVSFYAEAQ YETSLKWLER ALKKCSRYGD 

       850        860        870        880        890 
TWVWLFRTYA RLGKDTVDLY NMFDQCEPTY GPEWIAASKN VKMQYCTPRE ILLRLMNDK

« Hide

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References

« Hide 'large scale' references
[1]"The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors."
Legrain P., Choulika A.
EMBO J. 9:2775-2781(1990) [PubMed: 2118103] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: S288c / GRF88.
[2]"Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae."
Aljinovic G., Pohl T.M.
Yeast 11:475-479(1995) [PubMed: 7597852] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Complete DNA sequence of yeast chromosome II."
Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C. expand/collapse author list , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
EMBO J. 13:5795-5809(1994) [PubMed: 7813418] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

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Cross-references

Sequence databases

X53465 Genomic DNA. Translation: CAA37559.1.
Z35924 Genomic DNA. Translation: CAA84998.1.
Z46260 Genomic DNA. Translation: CAA86398.1.
PIRS12319.
RefSeqNP_009611.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:1290N.
IntActP19735. 69 interactions.
STRINGP19735.

Proteomic databases

PeptideAtlasP19735.
PRIDEP19735.

Genome annotation databases

EnsemblYBR055C; YBR055C; YBR055C; Saccharomyces cerevisiae. [Genome view]
GeneID852344.
KEGGsce:YBR055C.
NMPDRfig|4932.3.peg.306.

Organism-specific databases

CYGDYBR055c.
SGDS000000259. PRP6.

Phylogenomic databases

HOGENOMP19735.
OMAPQGWIAS
OrthoDBEOG9PZKPV

Gene expression databases

ArrayExpressP19735.
GenevestigatorP19735.
GermOnlineYBR055C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR003107. HAT.
IPR010491. PRP1_N.
IPR011990. TPR-like_helical.
IPR013026. TPR_region.
IPR019734. TPR_repeat.
[Graphical view]
Gene3DG3DSA:1.25.40.10. TPR-like_helical. 1 hit.
PfamPF06424. PRP1_N. 1 hit.
[Graphical view]
SMARTSM00386. HAT. 7 hits.
SM00028. TPR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio971082.

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Entry information

Entry namePRP6_YEAST
AccessionPrimary (citable) accession number: P19735
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 24, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome II

Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents