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P19735

- PRP6_YEAST

UniProt

P19735 - PRP6_YEAST

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Protein

Pre-mRNA-splicing factor 6

Gene
PRP6, RNA6, YBR055C, YBR0508
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. mRNA splicing, via spliceosome Source: SGD
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-29026-MONOMER.
ReactomeiREACT_191540. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor 6
Gene namesi
Name:PRP6
Synonyms:RNA6
Ordered Locus Names:YBR055C
ORF Names:YBR0508
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR055c.
SGDiS000000259. PRP6.

Subcellular locationi

GO - Cellular componenti

  1. spliceosomal complex Source: UniProtKB-KW
  2. U4/U6 x U5 tri-snRNP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 899899Pre-mRNA-splicing factor 6PRO_0000205756Add
BLAST

Proteomic databases

MaxQBiP19735.
PaxDbiP19735.
PeptideAtlasiP19735.

Expressioni

Gene expression databases

GenevestigatoriP19735.

Interactioni

Subunit structurei

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DIB1Q068193EBI-227,EBI-166

Protein-protein interaction databases

BioGridi32756. 130 interactions.
DIPiDIP-1290N.
IntActiP19735. 24 interactions.
MINTiMINT-392841.
STRINGi4932.YBR055C.

Structurei

3D structure databases

ProteinModelPortaliP19735.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati221 – 25333HAT 1Add
BLAST
Repeati255 – 28733HAT 2Add
BLAST
Repeati289 – 31830HAT 3Add
BLAST
Repeati319 – 35032HAT 4Add
BLAST
Repeati352 – 38130HAT 5Add
BLAST
Repeati383 – 41432HAT 6Add
BLAST
Repeati493 – 52533HAT 7Add
BLAST
Repeati545 – 57834HAT 8Add
BLAST
Repeati608 – 64538HAT 9Add
BLAST
Repeati648 – 68033HAT 10Add
BLAST
Repeati682 – 71433HAT 11Add
BLAST
Repeati751 – 78333HAT 12Add
BLAST
Repeati819 – 85133HAT 13Add
BLAST

Sequence similaritiesi

Contains 13 HAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00550000075016.
HOGENOMiHOG000246836.
KOiK12855.
OMAiRQRFYAV.
OrthoDBiEOG7GXPM5.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR003107. HAT.
IPR010491. PRP1_N.
IPR027108. Prp6/Prp1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11246:SF1. PTHR11246:SF1. 1 hit.
PfamiPF06424. PRP1_N. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00028. TPR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19735-1 [UniParc]FASTAAdd to Basket

« Hide

MERPSFLDQE PPAGYVPGIG RGATGFSTKE KQVVSNDDKG RRIPKRYREN    50
LNNHLQSQPK DDEDDEAANV FKTLELKLAQ KKKKRANEKD DDNSVDSSNV 100
KRQFADLKES LAAVTESEWM DIPDATDFTR RNKRNRIQEQ LNRKTYAAPD 150
SLIPGNVDLN KLTEEREKLL QSQIDENLAQ LTKNASNPIQ VNKPNAATDA 200
LSYLKDLEND RVNSLSDATL EDLQKMRTIL KSYRKADPTN PQGWIASARL 250
EEKARKFSVA KKIIENGCQE CPRSSDIWLE NIRLHESDVH YCKTLVATAI 300
NFNPTSPLLW FKAIDLESTT VNKYRVVRKA LQEIPRDEGL WKLAVSFEAD 350
KAQVIKMLEK ATQFIPQSMD LLTAYTNLQS YHNAKMTLNS FRKILPQEPE 400
IWIISTLLEE RNNPDIPVDK LVSLLKEGLL ELSKNGYKAT LSAWLKRAEA 450
LNDAPNSNLT CQAIVYAILE WLRESGEYES ELNNVDQILE KMPHSKVQIA 500
VLKKLIQWDP CDTVLWSRLK MATESYHKIE ELLAFFQELL FQTKNSDDIR 550
ANMREKSPGL LMMYVSEYWK AQKGDTRQTL VLIDQIIDFA PHNLDLRFFK 600
IKLLGRSLQL DELRDFFQQT FSSLEDFKIS GTERLYYKYV NFLRYQDLNE 650
EAIKFLNERC LKSFPICHKF FLQLGQIYHS MGNIEMSRET YLSGTRLVPN 700
CPLLWVSLSK IDEIDLKNPV RARSILDRGL LKNPDDVLFY IAKIQMEIRL 750
GNLDQAELLV TQALQKFPSN ALLWVEQIKL FKHGNKSSLK KTIFQDALRR 800
TQNDHRVLLE IGVSFYAEAQ YETSLKWLER ALKKCSRYGD TWVWLFRTYA 850
RLGKDTVDLY NMFDQCEPTY GPEWIAASKN VKMQYCTPRE ILLRLMNDK 899
Length:899
Mass (Da):104,229
Last modified:February 1, 1991 - v1
Checksum:i3E87F8AF63EAAC41
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53465 Genomic DNA. Translation: CAA37559.1.
Z35924 Genomic DNA. Translation: CAA84998.1.
Z46260 Genomic DNA. Translation: CAA86398.1.
BK006936 Genomic DNA. Translation: DAA07174.1.
PIRiS12319.
RefSeqiNP_009611.1. NM_001178403.1.

Genome annotation databases

EnsemblFungiiYBR055C; YBR055C; YBR055C.
GeneIDi852344.
KEGGisce:YBR055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53465 Genomic DNA. Translation: CAA37559.1 .
Z35924 Genomic DNA. Translation: CAA84998.1 .
Z46260 Genomic DNA. Translation: CAA86398.1 .
BK006936 Genomic DNA. Translation: DAA07174.1 .
PIRi S12319.
RefSeqi NP_009611.1. NM_001178403.1.

3D structure databases

ProteinModelPortali P19735.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32756. 130 interactions.
DIPi DIP-1290N.
IntActi P19735. 24 interactions.
MINTi MINT-392841.
STRINGi 4932.YBR055C.

Proteomic databases

MaxQBi P19735.
PaxDbi P19735.
PeptideAtlasi P19735.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR055C ; YBR055C ; YBR055C .
GeneIDi 852344.
KEGGi sce:YBR055C.

Organism-specific databases

CYGDi YBR055c.
SGDi S000000259. PRP6.

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00550000075016.
HOGENOMi HOG000246836.
KOi K12855.
OMAi RQRFYAV.
OrthoDBi EOG7GXPM5.

Enzyme and pathway databases

BioCyci YEAST:G3O-29026-MONOMER.
Reactomei REACT_191540. mRNA Splicing - Minor Pathway.

Miscellaneous databases

NextBioi 971082.
PROi P19735.

Gene expression databases

Genevestigatori P19735.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR003107. HAT.
IPR010491. PRP1_N.
IPR027108. Prp6/Prp1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view ]
PANTHERi PTHR11246:SF1. PTHR11246:SF1. 1 hit.
Pfami PF06424. PRP1_N. 1 hit.
[Graphical view ]
SMARTi SM00386. HAT. 7 hits.
SM00028. TPR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The molecular characterization of PRP6 and PRP9 yeast genes reveals a new cysteine/histidine motif common to several splicing factors."
    Legrain P., Choulika A.
    EMBO J. 9:2775-2781(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  2. "Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae."
    Aljinovic G., Pohl T.M.
    Yeast 11:475-479(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP."
    Gottschalk A., Neubauer G., Banroques J., Mann M., Luehrmann R., Fabrizio P.
    EMBO J. 18:4535-4548(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN THE U4/U5/U6 TRI-SNRNP COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy."
    Hacker I., Sander B., Golas M.M., Wolf E., Karagoz E., Kastner B., Stark H., Fabrizio P., Luhrmann R.
    Nat. Struct. Mol. Biol. 15:1206-1212(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, IDENTIFICATION IN THE U4/U5/U6 TRI-SNRNP COMPLEX, ELECTRON MICROSCOPY.

Entry informationi

Entry nameiPRP6_YEAST
AccessioniPrimary (citable) accession number: P19735
Secondary accession number(s): D6VQ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: September 3, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3

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