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Protein

Pre-mRNA-splicing factor 6

Gene

PRP6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome.

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • spliceosomal tri-snRNP complex assembly Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

BioCyciYEAST:G3O-29026-MONOMER.
ReactomeiR-SCE-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor 6
Gene namesi
Name:PRP6
Synonyms:RNA6
Ordered Locus Names:YBR055C
ORF Names:YBR0508
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR055C.
SGDiS000000259. PRP6.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • U4/U6 snRNP Source: GO_Central
  • U4/U6 x U5 tri-snRNP complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057561 – 899Pre-mRNA-splicing factor 6Add BLAST899

Proteomic databases

MaxQBiP19735.
PRIDEiP19735.

Interactioni

Subunit structurei

Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRP3, PRP4, PRP6, PRP8, PRP18, PRP31, PRP38, SNU13, SNU23, SNU66, SNU114, SPP381, SMB1, SMD1, SMD2, SMD3, SMX2, SMX3, LSM2, LSM3, LSM4, LSM5, LSM6, LSM7, LSM8, BRR2 and DIB1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DIB1Q068193EBI-227,EBI-166

Protein-protein interaction databases

BioGridi32756. 116 interactors.
DIPiDIP-1290N.
IntActiP19735. 24 interactors.
MINTiMINT-392841.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCMelectron microscopy3.80G1-899[»]
5GANelectron microscopy3.60J1-899[»]
5GAPelectron microscopy3.60J1-899[»]
ProteinModelPortaliP19735.
SMRiP19735.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati221 – 253HAT 1Add BLAST33
Repeati255 – 287HAT 2Add BLAST33
Repeati289 – 318HAT 3Add BLAST30
Repeati319 – 350HAT 4Add BLAST32
Repeati352 – 381HAT 5Add BLAST30
Repeati383 – 414HAT 6Add BLAST32
Repeati493 – 525HAT 7Add BLAST33
Repeati545 – 578HAT 8Add BLAST34
Repeati608 – 645HAT 9Add BLAST38
Repeati648 – 680HAT 10Add BLAST33
Repeati682 – 714HAT 11Add BLAST33
Repeati751 – 783HAT 12Add BLAST33
Repeati819 – 851HAT 13Add BLAST33

Sequence similaritiesi

Contains 13 HAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00550000075016.
HOGENOMiHOG000246836.
InParanoidiP19735.
KOiK12855.
OrthoDBiEOG092C2JFR.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR003107. HAT.
IPR010491. PRP1_N.
IPR027108. Prp6/Prp1/STA1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11246:SF1. PTHR11246:SF1. 1 hit.
PfamiPF06424. PRP1_N. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.

Sequencei

Sequence statusi: Complete.

P19735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPSFLDQE PPAGYVPGIG RGATGFSTKE KQVVSNDDKG RRIPKRYREN
60 70 80 90 100
LNNHLQSQPK DDEDDEAANV FKTLELKLAQ KKKKRANEKD DDNSVDSSNV
110 120 130 140 150
KRQFADLKES LAAVTESEWM DIPDATDFTR RNKRNRIQEQ LNRKTYAAPD
160 170 180 190 200
SLIPGNVDLN KLTEEREKLL QSQIDENLAQ LTKNASNPIQ VNKPNAATDA
210 220 230 240 250
LSYLKDLEND RVNSLSDATL EDLQKMRTIL KSYRKADPTN PQGWIASARL
260 270 280 290 300
EEKARKFSVA KKIIENGCQE CPRSSDIWLE NIRLHESDVH YCKTLVATAI
310 320 330 340 350
NFNPTSPLLW FKAIDLESTT VNKYRVVRKA LQEIPRDEGL WKLAVSFEAD
360 370 380 390 400
KAQVIKMLEK ATQFIPQSMD LLTAYTNLQS YHNAKMTLNS FRKILPQEPE
410 420 430 440 450
IWIISTLLEE RNNPDIPVDK LVSLLKEGLL ELSKNGYKAT LSAWLKRAEA
460 470 480 490 500
LNDAPNSNLT CQAIVYAILE WLRESGEYES ELNNVDQILE KMPHSKVQIA
510 520 530 540 550
VLKKLIQWDP CDTVLWSRLK MATESYHKIE ELLAFFQELL FQTKNSDDIR
560 570 580 590 600
ANMREKSPGL LMMYVSEYWK AQKGDTRQTL VLIDQIIDFA PHNLDLRFFK
610 620 630 640 650
IKLLGRSLQL DELRDFFQQT FSSLEDFKIS GTERLYYKYV NFLRYQDLNE
660 670 680 690 700
EAIKFLNERC LKSFPICHKF FLQLGQIYHS MGNIEMSRET YLSGTRLVPN
710 720 730 740 750
CPLLWVSLSK IDEIDLKNPV RARSILDRGL LKNPDDVLFY IAKIQMEIRL
760 770 780 790 800
GNLDQAELLV TQALQKFPSN ALLWVEQIKL FKHGNKSSLK KTIFQDALRR
810 820 830 840 850
TQNDHRVLLE IGVSFYAEAQ YETSLKWLER ALKKCSRYGD TWVWLFRTYA
860 870 880 890
RLGKDTVDLY NMFDQCEPTY GPEWIAASKN VKMQYCTPRE ILLRLMNDK
Length:899
Mass (Da):104,229
Last modified:February 1, 1991 - v1
Checksum:i3E87F8AF63EAAC41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53465 Genomic DNA. Translation: CAA37559.1.
Z35924 Genomic DNA. Translation: CAA84998.1.
Z46260 Genomic DNA. Translation: CAA86398.1.
BK006936 Genomic DNA. Translation: DAA07174.1.
PIRiS12319.
RefSeqiNP_009611.1. NM_001178403.1.

Genome annotation databases

EnsemblFungiiYBR055C; YBR055C; YBR055C.
GeneIDi852344.
KEGGisce:YBR055C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53465 Genomic DNA. Translation: CAA37559.1.
Z35924 Genomic DNA. Translation: CAA84998.1.
Z46260 Genomic DNA. Translation: CAA86398.1.
BK006936 Genomic DNA. Translation: DAA07174.1.
PIRiS12319.
RefSeqiNP_009611.1. NM_001178403.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCMelectron microscopy3.80G1-899[»]
5GANelectron microscopy3.60J1-899[»]
5GAPelectron microscopy3.60J1-899[»]
ProteinModelPortaliP19735.
SMRiP19735.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32756. 116 interactors.
DIPiDIP-1290N.
IntActiP19735. 24 interactors.
MINTiMINT-392841.

Proteomic databases

MaxQBiP19735.
PRIDEiP19735.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR055C; YBR055C; YBR055C.
GeneIDi852344.
KEGGisce:YBR055C.

Organism-specific databases

EuPathDBiFungiDB:YBR055C.
SGDiS000000259. PRP6.

Phylogenomic databases

GeneTreeiENSGT00550000075016.
HOGENOMiHOG000246836.
InParanoidiP19735.
KOiK12855.
OrthoDBiEOG092C2JFR.

Enzyme and pathway databases

BioCyciYEAST:G3O-29026-MONOMER.
ReactomeiR-SCE-72165. mRNA Splicing - Minor Pathway.

Miscellaneous databases

PROiP19735.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR003107. HAT.
IPR010491. PRP1_N.
IPR027108. Prp6/Prp1/STA1.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR11246:SF1. PTHR11246:SF1. 1 hit.
PfamiPF06424. PRP1_N. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiPRP6_YEAST
AccessioniPrimary (citable) accession number: P19735
Secondary accession number(s): D6VQ54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2250 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.