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Reviewed, UniProtKB/Swiss-Prot P19732 (DMPN_PSEUF)

Last modified November 4, 2008. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Phenol hydroxylase P3 protein
    EC=1.14.13.7
Alternative name(s):
    Phenol 2-monooxygenase P3 component
Gene names
Name: dmpN
Synonyms: pheA4
Encoded onPlasmid pVI150
OrganismPseudomonas sp. (strain CF600)
Taxonomic identifier79676 [NCBI]
Taxonomic lineageBacteria › Proteobacteria

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Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existencePredicted.

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General annotation (Comments)

Function

Catabolizes phenol, and some of its methylated derivatives. P3 is required for growth on phenol, and for in vitro phenol hydroxylase activity.

Catalytic activity

Phenol + NADPH + O2 = catechol + NADP+ + H2O.

Cofactor

FAD.

Fe2+.

Pathway

Aromatic compound metabolism; phenol degradation.

Subunit structure

The multicomponent enzyme phenol hydroxylase is formed by P0, P1, P2, P3, P4 and P5 polypeptides.

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Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandFAD
Flavoprotein
Iron
NADP
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termPlasmid
Gene Ontology (GO)
   Biological processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioniron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phenol 2-monooxygenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Phenol hydroxylase P3 protein
PRO_0000079945

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Sequences

Sequence LengthMass (Da)Tools
P19732-1 [UniParc].

Last modified February 1, 1991. Version 1.
Checksum: 4EFD4EB40ED73F9C

FASTA51760,523
        10         20         30         40         50         60 
MATHNKKRLN LKDKYRYLTR DLAWETTYQK KEDVFPLEHF EGIKITDWDK WEDPFRLTMD 

        70         80         90        100        110        120 
TYWKYQAEKE KKLYAIFDAF AQNNGHQNIS DARYVNALKL FLTAVSPLEY QAFQGFSRVG 

       130        140        150        160        170        180 
RQFSGAGARV ACQMQAIDEL RHVQTQVHAM SHYNKHFDGL HDFAHMYDRV WYLSVPKSYM 

       190        200        210        220        230        240 
DDARTAGPFE FLTAVSFSFE YVLTNLLFVP FMSGAAYNGD MATVTFGFSA QSDEARHMTL 

       250        260        270        280        290        300 
GLEVIKFMLE QHEDNVPIIQ RWIDKWFWRG YRLLTLIGMM MDYMLPNKVM SWSEAWGVYF 

       310        320        330        340        350        360 
EQAGGALFKD LERYGIRPPK YVEQTTIGKE HITHQVWGAL YQYSKATSFH TWIPGDEELN 

       370        380        390        400        410        420 
WLSEKYPDTF DKYYRPRFEF WREQQAKGER FYNDTLPHLC QVCQLPVIFT EPDDPTKLSL 

       430        440        450        460        470        480 
RSLVHEGERY QFCSDGCCDI FKNEPVKYIQ AWLPVHQIYQ GNCEGGDVET VVQKYYHIKS 

       490        500        510 
GVDNLEYLGS PEHQRWLALK GQTPPTAAPA DKSLGAA

« Hide

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References

[1]"Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600."
Nordlund I., Powlowski J., Shingler V.
J. Bacteriol. 172:6826-6833(1990) [PubMed: 2254258] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Takeo M., Maeda Y., Okada H., Miyama K., Mori K., Ike M., Fujita M.
Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BH.

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Cross-references

Sequence databases

M60276 Genomic DNA. Translation: AAA25942.1.
D28864 Genomic DNA. Translation: BAA06017.1.

3D structure databases

SMRP19732. Positions 7-500.
ModBaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MON-12797.

Family and domain databases

InterProIPR003430. Phenol_Hydrox.
IPR012348. Ribncl_red_rel.
IPR007029. YHS.
[Graphical view]
Gene3DG3DSA:1.10.620.20. Ribncl_red_rel. 1 hit.
PfamPF02332. Phenol_Hydrox. 1 hit.
PF04945. YHS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDMPN_PSEUF
AccessionPrimary (citable) accession number: P19732
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: November 4, 2008
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents