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Protein

Major capsid protein 10A

Gene

10

Organism
Enterobacteria phage T7 (Bacteriophage T7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Assembles, with minor capsid protein 10B, to form an icosahedral capsid with a T=7 symmetry, about 60 nm in diameter, and consisting of 415 capsid proteins (PubMed:20962334). The major and minor capsid proteins are incorporated into the capsid in about a 90/10 ratio respectively. Once the capsid formed, encapsidates one single copy of the T7 genome.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid protein 10A1 Publication
Alternative name(s):
Gene product 10A1 Publication
Short name:
Gp10A1 Publication
Major head protein 10ACurated
Gene namesi
Ordered Locus Names:10
OrganismiEnterobacteria phage T7 (Bacteriophage T7)
Taxonomic identifieri10760 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesPodoviridaeAutographivirinaeT7virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000000840 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, T=7 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001065221 – 345Major capsid protein 10AAdd BLAST345

Interactioni

Subunit structurei

Interacts with connector protein gp8 and capsid protein 10B (PubMed:20962334, PubMed:23580619). Interacts with the capsid assembly scaffolding protein; capsid proteins and scaffolding proteins form building blocks that assemble to form the procapsid (PubMed:25313071).3 Publications

Protein-protein interaction databases

DIPiDIP-29317N.
IntActiP19726. 1 interactor.
MINTiMINT-1513500.

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 12Combined sources3
Turni47 – 49Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi59 – 66Combined sources8
Beta strandi89 – 95Combined sources7
Beta strandi98 – 107Combined sources10
Helixi108 – 112Combined sources5
Helixi118 – 147Combined sources30
Turni155 – 158Combined sources4
Helixi171 – 173Combined sources3
Helixi178 – 196Combined sources19
Beta strandi206 – 209Combined sources4
Helixi211 – 220Combined sources10
Beta strandi221 – 223Combined sources3
Turni234 – 236Combined sources3
Beta strandi245 – 249Combined sources5
Beta strandi260 – 266Combined sources7
Beta strandi285 – 287Combined sources3
Beta strandi290 – 293Combined sources4
Beta strandi295 – 313Combined sources19
Turni314 – 317Combined sources4
Beta strandi318 – 330Combined sources13
Beta strandi338 – 341Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XVRelectron microscopy10.80A/B/C/D/E/F/G1-345[»]
3IZGelectron microscopy-A/B/C/D/E/F/G1-345[»]
3J7Velectron microscopy4.50A/B/C/D/E/F/G1-345[»]
3J7Welectron microscopy3.50A/B/C/D/E/F/G1-345[»]
3J7Xelectron microscopy3.80A/B/C/D/E/F/G1-345[»]
SMRiP19726.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19726.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000DO.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Isoform VC10A (identifier: P19726-1) [UniParc]FASTAAdd to basket
Also known as: Major capsid protein 10A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASMTGGQQM GTNQGKGVVA AGDKLALFLK VFGGEVLTAF ARTSVTTSRH
60 70 80 90 100
MVRSISSGKS AQFPVLGRTQ AAYLAPGENL DDKRKDIKHT EKVITIDGLL
110 120 130 140 150
TADVLIYDIE DAMNHYDVRS EYTSQLGESL AMAADGAVLA EIAGLCNVES
160 170 180 190 200
KYNENIEGLG TATVIETTQN KAALTDQVAL GKEIIAALTK ARAALTKNYV
210 220 230 240 250
PAADRVFYCD PDSYSAILAA LMPNAANYAA LIDPEKGSIR NVMGFEVVEV
260 270 280 290 300
PHLTAGGAGT AREGTTGQKH VFPANKGEGN VKVAKDNVIG LFMHRSAVGT
310 320 330 340
VKLRDLALER ARRANFQADQ IIAKYAMGHG GLRPEAAGAV VFKVE
Length:345
Mass (Da):36,546
Last modified:February 1, 1991 - v1
Checksum:i0CB7973954FE69F5
GO
Isoform VC10B (identifier: P19727-1) [UniParc]FASTAAdd to basket
Also known as: Minor capsid protein 10B
The sequence of this isoform can be found in the external entry P19727.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:398
Mass (Da):41,830
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA. Translation: CAA24427.1.
PIRiA04344. VABPA7.
RefSeqiNP_041998.1. NC_001604.1. [P19726-1]

Genome annotation databases

GeneIDi1261026.
KEGGivg:1261026.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01146 Genomic DNA. Translation: CAA24427.1.
PIRiA04344. VABPA7.
RefSeqiNP_041998.1. NC_001604.1. [P19726-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XVRelectron microscopy10.80A/B/C/D/E/F/G1-345[»]
3IZGelectron microscopy-A/B/C/D/E/F/G1-345[»]
3J7Velectron microscopy4.50A/B/C/D/E/F/G1-345[»]
3J7Welectron microscopy3.50A/B/C/D/E/F/G1-345[»]
3J7Xelectron microscopy3.80A/B/C/D/E/F/G1-345[»]
SMRiP19726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29317N.
IntActiP19726. 1 interactor.
MINTiMINT-1513500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1261026.
KEGGivg:1261026.

Phylogenomic databases

OrthoDBiVOG090000DO.

Miscellaneous databases

EvolutionaryTraceiP19726.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCAPSA_BPT7
AccessioniPrimary (citable) accession number: P19726
Secondary accession number(s): P03717
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: February 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.