PB1

Functionⁱ

RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.UniRule annotation

Catalytic activityⁱ

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functionⁱ

nucleotide binding Source: UniProtKB-KW
RNA binding Source: InterPro
RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

suppression by virus of host RNA polymerase II activity Source: UniProtKB-KW
viral RNA genome replication Source: InterPro
viral transcription Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological process	Eukaryotic host gene expression shutoff by virus, Eukaryotic host transcription shutoff by virus, Host gene expression shutoff by virus, Host-virus interaction, Inhibition of host RNA polymerase II by virus, Viral RNA replication, Viral transcription
Ligand	Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: RNA-directed RNA polymerase catalytic subunitUniRule annotation (EC:2.7.7.48UniRule annotation) Alternative name(s): Polymerase basic protein 1UniRule annotation Short name: PB1UniRule annotation RNA-directed RNA polymerase subunit P1UniRule annotation
Gene namesⁱ	Name:PB1UniRule annotation
Organismⁱ	Influenza C virus (strain C/JJ/1950)
Taxonomic identifierⁱ	11560 [NCBI]
Taxonomic lineageⁱ	Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus C › Influenza C virus
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606] Sus scrofa (Pig) [TaxID: 9823]

Subcellular locationⁱ

GO - Cellular componentⁱ

host cell cytoplasm Source: UniProtKB-SubCell
host cell nucleus Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cytoplasm, Host nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000078776	1 – 754	RNA-directed RNA polymerase catalytic subunitAdd BLAST		754

Post-translational modificationⁱ

Phosphorylated by host PRKCA.UniRule annotation

Keywords - PTMⁱ

Phosphoprotein

Interactionⁱ

Subunit structureⁱ

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PA (via C-terminus). Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation.UniRule annotation

Structureⁱ

3D structure databases

SMRⁱ	P19703.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	288 – 484	RdRp catalyticUniRule annotationAdd BLAST		197

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	251 – 258	Promoter-binding siteUniRule annotation		8

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	189 – 197	Nuclear localization signalUniRule annotation		9
Motifⁱ	205 – 218	Nuclear localization signalUniRule annotationAdd BLAST		14

Sequence similaritiesⁱ

Belongs to the influenza viruses polymerase PB1 family.UniRule annotation

Family and domain databases

HAMAPⁱ	MF_04065. INFV_RDRP. 1 hit.
InterProⁱ	View protein in InterPro IPR007099. RNA-dir_pol_NSvirus. IPR001407. RNA_pol_PB1_influenza.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00602. Flu_PB1. 1 hit.
PIRSFⁱ	PIRSF000827. RdRPol_OMV. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P19703-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEINPYLMFL NNDVTSLIST TYPYTGPPPM SHGSSTKYTL ETIKRTYDYS 
        60         70         80         90        100
RTSVEKTSKV FNIPRRKFCN CLEDKDDLVK PTGNVDISSL LGLAEMMEKR 
       110        120        130        140        150
MGEGFFKHCV MEAETEILKM HFSRLTEGRQ TYDWTSERNM PAATALQLTV 
       160        170        180        190        200
DAIKETEGPF KGTTMLEYCN KMIEMLDWKE VKFRKVKTMV RREKDKRSGK 
       210        220        230        240        250
EIKTKVPVMG IDSIKHDEFL IRALTINTMA KDGERGKLQR RAIATPGMIV 
       260        270        280        290        300
RPFSKIVETV AQKICEKLKE SGLPVGGNEK KAKLKTTVTS LNARMNSDQF 
       310        320        330        340        350
AVNITGDNSK WNECQQPEAY LALLAYITKD SSDLMKDLCS VAPVLFCNKF 
       360        370        380        390        400
VKLGQGIRLS NKRKTKEVII KAEKMGKYKN LMREEYKNLF EPLEKYIQKD 
       410        420        430        440        450
VCFLPGGMLM GMFNMLSTVL GVSTLCYMDE ELKAKGCFWT GLQSSDDFVL 
       460        470        480        490        500
FAVASNWSNI HWTIRRFNAV CKLIGINMSL EKSYGSLPEL FEFTSMFFDG 
       510        520        530        540        550
EFVSNLAMEL PAFTTAGVNE GVDFTAAMSI IKTNMINNSL SPSTALMALR 
       560        570        580        590        600
ICLQEFRATY RVHPWDSKVK GGRMKIINEF IKTIESKDGL LIADGGKLMN 
       610        620        630        640        650
NISTLHIPEE VLKFEKMDEQ YRNRVFNPKN PFTNFDKTID IFRAHGPIRV 
       660        670        680        690        700
EENEAVVSTH SFRTRANRTL LNTDMRAMMA EEKRYQMVCD IFKSVFESAD 
       710        720        730        740        750
INPPIGAMSI GEAIEEKLLE RAKMKRDIGA IEDSEYEEIK DIIRDAKKAR 

IESR

Length:754

Mass (Da):85,984

Last modified:February 1, 1991 - v1

Checksum:ⁱ49CBEA8A3E854606

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M28060 Genomic RNA. Translation: AAA43814.1.
PIRⁱ	B34225. P1IV50.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P19703	E0WL38	Influenza C virus (strain C/JJ/1950)	754	UniRef100_P19703	Cluster: RNA-directed RNA polymerase catalytic subunit	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P19703	Q9IMP4 Q6I7C3 A0A193PQ43 A0A193PPL7 A0A193PPP8 A0A193PQ33 Q9Q220 Q68C98 Q8B024 Q8B023 +203	Influenza C virus (strain C/Johannesburg/1/1966) Influenza C virus (strain C/Ann Arbor/1/1950) Influenza C virus (strain C/Kansas/1/1979) Influenza C virus (C/Georgia/1/69) Influenza C virus (strain C/Miyagi/5/1991) Influenza C virus (strain C/Yamagata/1964) Influenza C virus (C/Yamagata/9/88) Influenza C virus (C/Miyagi/2/94) Influenza C virus (C/Miyagi/3/94) Influenza C virus (C/Yamagata/1/86) And more	754	UniRef90_Q9IMP4	Cluster: RNA-directed RNA polymerase catalytic subunit	214

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P19703	Q9IMP4 A0A1B0RMT9 A0A193PQ92 A0A193PQC7 A0A193PPT0 A0A193PPT1 A0A193PPV6 A0A193PQA7 A0A193PPU0 A0A193PQ79 +230	Influenza C virus (strain C/Johannesburg/1/1966) Influenza C virus (C/India/P119564/2011) Influenza C virus (C/Yamagata/1/2012) Influenza C virus (C/Yamagata/16/2014) Influenza C virus (C/Yamagata/20/2006) Influenza C virus (C/Yamagata/14/2006) Influenza C virus (C/Yamagata/4/2012) Influenza C virus (C/Yamagata/35/2014) Influenza C virus (C/Yamagata/13/2006) Influenza C virus (C/Miyagi/28/2002) And more	754	UniRef50_Q9IMP4	Cluster: RNA-directed RNA polymerase catalytic subunit	241

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M28060 Genomic RNA. Translation: AAA43814.1.
PIRⁱ	B34225. P1IV50.

3D structure databases

SMRⁱ	P19703.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

HAMAPⁱ	MF_04065. INFV_RDRP. 1 hit.
InterProⁱ	View protein in InterPro IPR007099. RNA-dir_pol_NSvirus. IPR001407. RNA_pol_PB1_influenza.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00602. Flu_PB1. 1 hit.
PIRSFⁱ	PIRSF000827. RdRPol_OMV. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50525. RDRP_SSRNA_NEG_SEG. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RDRP_INCJJ
Accessionⁱ	P19703Primary (citable) accession number: P19703
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
	Last sequence update:	February 1, 1991
	Last modified:	January 31, 2018
	This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB - P19703 (RDRP_INCJJ)

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RNA-directed RNA polymerase catalytic subunit

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Post-translational modificationⁱ

Keywords - PTMⁱ

Interactionⁱ

Subunit structureⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Region

Motif

Sequence similaritiesⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P19703 (RDRP_INCJJ)

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RNA-directed RNA polymerase catalytic subunit

PB1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

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Sequence databases

3D structure databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ