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P19680

- KPYK_SPICI

UniProt

P19680 - KPYK_SPICI

Protein

Pyruvate kinase

Gene

pyk

Organism
Spiroplasma citri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411SubstrateBy similarity
    Metal bindingi43 – 431PotassiumBy similarity
    Metal bindingi45 – 451PotassiumBy similarity
    Metal bindingi75 – 751PotassiumBy similarity
    Metal bindingi76 – 761Potassium; via carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:pyk
    OrganismiSpiroplasma citri
    Taxonomic identifieri2133 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesEntomoplasmatalesSpiroplasmataceaeSpiroplasma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – ›192›192Pyruvate kinasePRO_0000112084Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP19680.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Family and domain databases

    Gene3Di3.20.20.60. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR015793. Pyrv_Knase_brl.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    [Graphical view]
    SUPFAMiSSF51621. SSF51621. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P19680-1 [UniParc]FASTAAdd to Basket

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    MDKFNINEKM KRTKIITTIG PSTHSPGAIE ELFKTGMTTI RLNFSHGDHA    50
    EQGARIVWAR EVSAKIGKPI SVLLDTKGPE IHWRIKGLLQ KSLNIYHQMN 100
    NSLMFSPSFC KFLHYHYTLL LSKKTKKQLL KIVKKLKKLQ SQHYNLAHGL 150
    RETWTSSFCF NERPSIWRLL SSFKQIVTSF KISLVSKVLI KL 192
    Length:192
    Mass (Da):22,209
    Last modified:February 1, 1991 - v1
    Checksum:iACF22444BF2CF807
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 192111HWRIK…VLIKL → RAGIMKGGKQEIVAGATVTI YSLPTEYQNREGTGTEITVS YDMSQDLKVGDVVLVDDGKL QLNVTGIKPGIIETKA in AAB69999. (PubMed:9732535)CuratedAdd
    BLAST
    Non-terminal residuei192 – 1921

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012877 Genomic DNA. Translation: AAB69999.1.
    PIRiF35270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF012877 Genomic DNA. Translation: AAB69999.1 .
    PIRi F35270.

    3D structure databases

    ProteinModelPortali P19680.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 3.20.20.60. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR015793. Pyrv_Knase_brl.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51621. SSF51621. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Organization and nucleotide sequences of the Spiroplasma citri genes for ribosomal protein S2, elongation factor Ts, spiralin, phosphofructokinase, pyruvate kinase, and an unidentified protein."
      Chevalier C., Saillard C., Bove J.M.
      J. Bacteriol. 172:2693-2703(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 27556 / NCPPB 2647 / R8A2.
    2. "Gene organization and transcriptional analysis of the Spiroplasma citri rpsB/tsf/x operon."
      Le Dantec L., Bove J.M., Saillard C.
      Curr. Microbiol. 37:269-273(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKPYK_SPICI
    AccessioniPrimary (citable) accession number: P19680
    Secondary accession number(s): O30600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1991
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3