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Protein

Transaldolase

Gene

tal

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. Does not show fructose-6-P aldolase activity.1 Publication

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.1 Publication

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (tal)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Schiff-base intermediate with substrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pentose shunt

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciBSUB:BSU37110-MONOMER.
UniPathwayiUPA00115; UER00414.

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Alternative name(s):
20 kDa phosphoprotein OrfU
CSI9
Gene namesi
Name:tal
Synonyms:ywjH
Ordered Locus Names:BSU37110
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212TransaldolasePRO_0000173658Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP19669.

PTM databases

iPTMnetiP19669.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7631043,EBI-7631043

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiP19669. 1 interaction.
MINTiMINT-8300511.
STRINGi224308.Bsubs1_010100020061.

Structurei

Secondary structure

1
212
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 65Combined sources
Helixi10 – 189Combined sources
Beta strandi22 – 265Combined sources
Helixi29 – 335Combined sources
Helixi40 – 5011Combined sources
Beta strandi55 – 584Combined sources
Helixi64 – 7512Combined sources
Beta strandi81 – 888Combined sources
Helixi89 – 10012Combined sources
Beta strandi105 – 1106Combined sources
Helixi113 – 12210Combined sources
Beta strandi125 – 1306Combined sources
Helixi131 – 1366Combined sources
Helixi141 – 15515Combined sources
Beta strandi160 – 1656Combined sources
Helixi169 – 1779Combined sources
Beta strandi181 – 1855Combined sources
Helixi187 – 1937Combined sources
Helixi197 – 21014Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R8RX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/P/R/T/U/V/W1-212[»]
ProteinModelPortaliP19669.
SMRiP19669. Positions 1-212.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 3B subfamily.Curated

Phylogenomic databases

eggNOGiENOG4107XMI. Bacteria.
COG0176. LUCA.
HOGENOMiHOG000226073.
InParanoidiP19669.
KOiK00616.
OMAiVRHPMHV.
PhylomeDBiP19669.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFFVDTANI DEIREANELG ILAGVTTNPS LVAKEANVSF HDRLREITDV
60 70 80 90 100
VKGSVSAEVI SLKAEEMIEE GKELAKIAPN ITVKIPMTSD GLKAVRALTD
110 120 130 140 150
LGIKTNVTLI FNANQALLAA RAGATYVSPF LGRLDDIGHN GLDLISEVKQ
160 170 180 190 200
IFDIHGLDTQ IIAASIRHPQ HVTEAALRGA HIGTMPLKVI HALTKHPLTD
210
KGIEQFLADW NK
Length:212
Mass (Da):22,971
Last modified:July 28, 2009 - v4
Checksum:i59EA1748FB2CBCD6
GO

Sequence cautioni

The sequence CAA89874 differs from that shown. Reason: Frameshift at position 182. Curated
The sequence M22039 differs from that shown. Reason: Frameshift at position 182. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001D → G in M22039 (PubMed:2457578).Curated
Sequence conflicti100 – 1001D → G in CAA89874 (PubMed:9353933).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22039 Unassigned DNA. No translation available.
Z49782 Genomic DNA. Translation: CAA89874.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB15728.3.
PIRiF32354.
RefSeqiNP_391592.3. NC_000964.3.
WP_003227626.1. NZ_JNCM01000034.1.

Genome annotation databases

EnsemblBacteriaiCAB15728; CAB15728; BSU37110.
GeneIDi938462.
KEGGibsu:BSU37110.
PATRICi18979458. VBIBacSub10457_3891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22039 Unassigned DNA. No translation available.
Z49782 Genomic DNA. Translation: CAA89874.1. Frameshift.
AL009126 Genomic DNA. Translation: CAB15728.3.
PIRiF32354.
RefSeqiNP_391592.3. NC_000964.3.
WP_003227626.1. NZ_JNCM01000034.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R8RX-ray1.90A/B/C/D/E/F/G/H/I/J/K/L/M/N/P/R/T/U/V/W1-212[»]
ProteinModelPortaliP19669.
SMRiP19669. Positions 1-212.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP19669. 1 interaction.
MINTiMINT-8300511.
STRINGi224308.Bsubs1_010100020061.

PTM databases

iPTMnetiP19669.

Proteomic databases

PaxDbiP19669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB15728; CAB15728; BSU37110.
GeneIDi938462.
KEGGibsu:BSU37110.
PATRICi18979458. VBIBacSub10457_3891.

Phylogenomic databases

eggNOGiENOG4107XMI. Bacteria.
COG0176. LUCA.
HOGENOMiHOG000226073.
InParanoidiP19669.
KOiK00616.
OMAiVRHPMHV.
PhylomeDBiP19669.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00414.
BioCyciBSUB:BSU37110-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00494. Transaldolase_3b. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001585. TAL/FSA.
IPR022999. Transaldolase_3B.
IPR004731. Transaldolase_3B/F6P_aldolase.
IPR018225. Transaldolase_AS.
[Graphical view]
PANTHERiPTHR10683. PTHR10683. 1 hit.
PfamiPF00923. Transaldolase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00875. fsa_talC_mipB. 1 hit.
PROSITEiPS01054. TRANSALDOLASE_1. 1 hit.
PS00958. TRANSALDOLASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAL_BACSU
AccessioniPrimary (citable) accession number: P19669
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: July 28, 2009
Last modified: September 7, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.