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Protein

Superoxide dismutase [Mn/Fe]

Gene

sodB

Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+, Fe2+Note: Binds 1 Mn2+ or Fe2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27Manganese or iron1
Metal bindingi74Manganese or iron1
Metal bindingi157Manganese or iron1
Metal bindingi161Manganese or iron1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandIron, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodB
Ordered Locus Names:PG_1545
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
Proteomesi
  • UP000000588 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001599931 – 191Superoxide dismutase [Mn/Fe]Add BLAST191

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi242619.PG1545

Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni12 – 19Combined sources8
Helixi21 – 27Combined sources7
Turni28 – 30Combined sources3
Helixi31 – 42Combined sources12
Turni43 – 45Combined sources3
Turni47 – 50Combined sources4
Helixi53 – 59Combined sources7
Helixi62 – 79Combined sources18
Helixi91 – 101Combined sources11
Helixi104 – 117Combined sources14
Beta strandi120 – 128Combined sources9
Beta strandi134 – 140Combined sources7
Helixi145 – 148Combined sources4
Beta strandi151 – 157Combined sources7
Helixi160 – 162Combined sources3
Helixi164 – 167Combined sources4
Helixi171 – 178Combined sources8
Helixi179 – 181Combined sources3
Helixi184 – 190Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QNNX-ray1.80A/B/C/D1-191[»]
1UERX-ray1.60A/B/C/D1-191[»]
1UESX-ray1.60A/B/C/D1-191[»]
ProteinModelPortaliP19665
SMRiP19665
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP19665

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4 Bacteria
COG0605 LUCA
KOiK04564
OMAiYEGWKGE

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

P19665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHELISLPY AVDALAPVIS KETVEFHHGK HLKTYVDNLN KLIIGTEFEN
60 70 80 90 100
ADLNTIVQKS EGGIFNNAGQ TLNHNLYFTQ FRPGKGGAPK GKLGEAIDKQ
110 120 130 140 150
FGSFEKFKEE FNTAGTTLFG SGWVWLASDA NGKLSIEKEP NAGNPVRKGL
160 170 180 190
NPLLGFDVWE HAYYLTYQNR RADHLKDLWS IVDWDIVESR Y
Length:191
Mass (Da):21,501
Last modified:May 1, 1991 - v2
Checksum:iAA53419397BF6BA1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13D → Y in AAA25651 (PubMed:1840572).Curated1
Sequence conflicti29G → E AA sequence (PubMed:2226833).Curated1
Sequence conflicti112N → D in AAA25651 (PubMed:1840572).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90152 Genomic DNA Translation: BAA14182.1
M60401 Genomic DNA Translation: AAA25651.1
AE015924 Genomic DNA Translation: AAQ66583.1
PIRiA43585
RefSeqiWP_004585361.1, NC_002950.2

Genome annotation databases

EnsemblBacteriaiAAQ66583; AAQ66583; PG_1545
GeneIDi29255789
KEGGipgi:PG_1545

Similar proteinsi

Entry informationi

Entry nameiSODF_PORGI
AccessioniPrimary (citable) accession number: P19665
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 1991
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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