Superoxide dismutase [Mn/Fe] - Porphyromonas gingivalis (strain ATCC BAA-308 / W83)

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P19665 (SODF_PORGI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Superoxide dismutase [Mn/Fe]
EC=1.15.1.1

Gene names

Name:	sodB
Ordered Locus Names:	PG_1545

Organism

Porphyromonas gingivalis (strain ATCC BAA-308 / W83) [Complete proteome] [HAMAP]

Taxonomic identifier

242619 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Porphyromonas

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Catalytic activity	2 superoxide + 2 H⁺ = O₂ + H₂O₂.
Cofactor	Binds 1 manganese or iron ion per subunit.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the iron/manganese superoxide dismutase family.

Ontologies

Keywords
Ligand	Iron Manganese Metal-binding
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	superoxide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW superoxide dismutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 191

191

Superoxide dismutase [Mn/Fe]

PRO_0000159993

Sites

Metal binding

Manganese or iron

Metal binding

Manganese or iron

Metal binding

157

Manganese or iron

Metal binding

161

Manganese or iron

Experimental info

Sequence conflict

D → Y in AAA25651. Ref.2

Sequence conflict

G → E AA sequence Ref.3

Sequence conflict

112

N → D in AAA25651. Ref.2

Secondary structure

191

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P19665 [UniParc].

Last modified May 1, 1991. Version 2.
Checksum: AA53419397BF6BA1
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FASTA

191

21,501

        10         20         30         40         50         60 
MTHELISLPY AVDALAPVIS KETVEFHHGK HLKTYVDNLN KLIIGTEFEN ADLNTIVQKS 

        70         80         90        100        110        120 
EGGIFNNAGQ TLNHNLYFTQ FRPGKGGAPK GKLGEAIDKQ FGSFEKFKEE FNTAGTTLFG 

       130        140        150        160        170        180 
SGWVWLASDA NGKLSIEKEP NAGNPVRKGL NPLLGFDVWE HAYYLTYQNR RADHLKDLWS 

       190 
IVDWDIVESR Y

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The superoxide dismutase-encoding gene of the obligately anaerobic bacterium Bacteroides gingivalis." Nakayama K. Gene 96:149-150(1990) [PubMed: 2265754] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Isolation, expression, and nucleotide sequence of the sod gene from Porphyromonas gingivalis." Choi J.I., Takahashi N., Kato T., Kuramitsu H.K. Infect. Immun. 59:1564-1566(1991) [PubMed: 1840572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The primary structure of superoxide dismutase purified from anaerobically maintained Bacteroides gingivalis." Amano A., Shizukuishi S., Tsunemitsu A., Maekawa K., Tsunasawa S. FEBS Lett. 272:217-220(1990) [PubMed: 2226833] [Abstract] Cited for: PROTEIN SEQUENCE. Strain: 381.
[4]	"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83." Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H. Fraser C.M. J. Bacteriol. 185:5591-5601(2003) [PubMed: 12949112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-308 / W83.
[5]	"Characterization of superoxide dismutases purified from either anaerobically maintained or aerated Bacteroides gingivalis." Amano A., Shizukuishi S., Tamagawa H., Iwakura K., Tsunasawa S., Tsunemitsu A. J. Bacteriol. 172:1457-1463(1990) [PubMed: 2307656] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-12.
[6]	"Crystal structure of cambialistic superoxide dismutase from Porphyromonas gingivalis." Sugio S., Hiraoka B.Y., Yamakura F. Eur. J. Biochem. 267:3487-3495(2000) [PubMed: 10848964] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D90152 Genomic DNA. Translation: BAA14182.1.
M60401 Genomic DNA. Translation: AAA25651.1.
AE015924 Genomic DNA. Translation: AAQ66583.1.

PIR

A43585.

RefSeq

NP_905684.1. NC_002950.2.
YP_001928680.1. NC_010729.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QNN	X-ray	1.80	A/B/C/D	1-191	[»]
1UER	X-ray	1.60	A/B/C/D	1-191	[»]
1UES	X-ray	1.60	A/B/C/D	1-191	[»]

ProteinModelPortal

P19665.

SMR

P19665. Positions 1-191.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

2553021.
6329709.

GenomeReviews

Gene locus PG_1545 in contig AE015924_GR.

KEGG

pgi:PG1545.

NMPDR

fig|242619.1.peg.1325.

PATRIC

22974068. VBIPorGin26334_0556.

TIGR

PG_1545.

Phylogenomic databases

HOGENOM

HBG507761.

OMA

LNWEFAA.

PhylomeDB

P19665.

ProtClustDB

CLSK822299.

Enzyme and pathway databases

BioCyc

PGIN242619:PG_1545-MONOMER.

Family and domain databases

InterPro

IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]

K04564.

PANTHER

PTHR11404. SODismutase. 1 hit.

Pfam

PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000349. SODismutase. 1 hit.

PRINTS

PR01703. MNSODISMTASE.

SUPFAM

SSF46609. SODismutase. 1 hit.
SSF54719. SODismutase. 1 hit.

PROSITE

PS00088. SOD_MN. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

SODF_PORGI

Accession

Primary (citable) accession number: P19665

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1991
Last sequence update:	May 1, 1991
Last modified:	January 25, 2012
This is version 104 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents