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P19665

- SODF_PORGI

UniProt

P19665 - SODF_PORGI

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Protein
Superoxide dismutase [Mn/Fe]
Gene
sodB, PG_1545
Organism
Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Binds 1 manganese or iron ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271Manganese or iron
Metal bindingi74 – 741Manganese or iron
Metal bindingi157 – 1571Manganese or iron
Metal bindingi161 – 1611Manganese or iron

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciPGIN242619:GHX8-1394-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn/Fe] (EC:1.15.1.1)
Gene namesi
Name:sodB
Ordered Locus Names:PG_1545
OrganismiPorphyromonas gingivalis (strain ATCC BAA-308 / W83)
Taxonomic identifieri242619 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaePorphyromonas
ProteomesiUP000000588: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191Superoxide dismutase [Mn/Fe]
PRO_0000159993Add
BLAST

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi242619.PG1545.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni12 – 198
Helixi21 – 277
Turni28 – 303
Helixi31 – 4212
Turni43 – 453
Turni47 – 504
Helixi53 – 597
Helixi62 – 7918
Helixi91 – 10111
Helixi104 – 11714
Beta strandi120 – 1289
Beta strandi134 – 1407
Helixi145 – 1484
Beta strandi151 – 1577
Helixi160 – 1623
Helixi164 – 1674
Helixi171 – 1788
Helixi179 – 1813
Helixi184 – 1907

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QNNX-ray1.80A/B/C/D1-191[»]
1UERX-ray1.60A/B/C/D1-191[»]
1UESX-ray1.60A/B/C/D1-191[»]
ProteinModelPortaliP19665.
SMRiP19665. Positions 1-191.

Miscellaneous databases

EvolutionaryTraceiP19665.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
KOiK04564.
OMAiHANRELQ.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P19665-1 [UniParc]FASTAAdd to Basket

« Hide

MTHELISLPY AVDALAPVIS KETVEFHHGK HLKTYVDNLN KLIIGTEFEN    50
ADLNTIVQKS EGGIFNNAGQ TLNHNLYFTQ FRPGKGGAPK GKLGEAIDKQ 100
FGSFEKFKEE FNTAGTTLFG SGWVWLASDA NGKLSIEKEP NAGNPVRKGL 150
NPLLGFDVWE HAYYLTYQNR RADHLKDLWS IVDWDIVESR Y 191
Length:191
Mass (Da):21,501
Last modified:May 1, 1991 - v2
Checksum:iAA53419397BF6BA1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131D → Y in AAA25651. 1 Publication
Sequence conflicti29 – 291G → E AA sequence 1 Publication
Sequence conflicti112 – 1121N → D in AAA25651. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90152 Genomic DNA. Translation: BAA14182.1.
M60401 Genomic DNA. Translation: AAA25651.1.
AE015924 Genomic DNA. Translation: AAQ66583.1.
PIRiA43585.
RefSeqiNP_905684.1. NC_002950.2.

Genome annotation databases

EnsemblBacteriaiAAQ66583; AAQ66583; PG_1545.
GeneIDi2553021.
KEGGipgi:PG1545.
PATRICi22974068. VBIPorGin26334_0556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D90152 Genomic DNA. Translation: BAA14182.1 .
M60401 Genomic DNA. Translation: AAA25651.1 .
AE015924 Genomic DNA. Translation: AAQ66583.1 .
PIRi A43585.
RefSeqi NP_905684.1. NC_002950.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QNN X-ray 1.80 A/B/C/D 1-191 [» ]
1UER X-ray 1.60 A/B/C/D 1-191 [» ]
1UES X-ray 1.60 A/B/C/D 1-191 [» ]
ProteinModelPortali P19665.
SMRi P19665. Positions 1-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242619.PG1545.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAQ66583 ; AAQ66583 ; PG_1545 .
GeneIDi 2553021.
KEGGi pgi:PG1545.
PATRICi 22974068. VBIPorGin26334_0556.

Phylogenomic databases

eggNOGi COG0605.
KOi K04564.
OMAi HANRELQ.
OrthoDBi EOG63NMNT.

Enzyme and pathway databases

BioCyci PGIN242619:GHX8-1394-MONOMER.

Miscellaneous databases

EvolutionaryTracei P19665.

Family and domain databases

InterProi IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view ]
PANTHERi PTHR11404. PTHR11404. 1 hit.
Pfami PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000349. SODismutase. 1 hit.
PRINTSi PR01703. MNSODISMTASE.
SUPFAMi SSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEi PS00088. SOD_MN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The superoxide dismutase-encoding gene of the obligately anaerobic bacterium Bacteroides gingivalis."
    Nakayama K.
    Gene 96:149-150(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isolation, expression, and nucleotide sequence of the sod gene from Porphyromonas gingivalis."
    Choi J.I., Takahashi N., Kato T., Kuramitsu H.K.
    Infect. Immun. 59:1564-1566(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The primary structure of superoxide dismutase purified from anaerobically maintained Bacteroides gingivalis."
    Amano A., Shizukuishi S., Tsunemitsu A., Maekawa K., Tsunasawa S.
    FEBS Lett. 272:217-220(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: 381.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-308 / W83.
  5. "Characterization of superoxide dismutases purified from either anaerobically maintained or aerated Bacteroides gingivalis."
    Amano A., Shizukuishi S., Tamagawa H., Iwakura K., Tsunasawa S., Tsunemitsu A.
    J. Bacteriol. 172:1457-1463(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-12.
  6. "Crystal structure of cambialistic superoxide dismutase from Porphyromonas gingivalis."
    Sugio S., Hiraoka B.Y., Yamakura F.
    Eur. J. Biochem. 267:3487-3495(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Entry informationi

Entry nameiSODF_PORGI
AccessioniPrimary (citable) accession number: P19665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: May 1, 1991
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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